Purpose: Serum surfactant protein D (SP-D) plays roles in the body such as protection against viral infection, bacterial and fungal clearance, clearance of apoptotic cells and suppression of inflammation. This study aims to examine the relationship between SP-D level and coronavirus disease (COVID-19) severity. Methods: 80 patients (30 with mild disease and 50 with severe/critical COVID-19), and 50 healthy volunteers were enrolled in the study. SP-D levels were analyzed by ELISA in serum samples. Results: The median of SP-D was found to be 2.47 (1.67-7.79) ng/ml in mild disease and 5.65 (3.09-16.55) ng/ml in severe/critical disease groups, while 2.89 (10.8-6.24) ng/ml in the healthy controls. The differences in SP-D levels between the severe/critical disease group compared to both mild disease and control groups were found statistically significant (p=0.007 and 0.001, respectively). ROC analysis showed greater AUC for the serum SP-D levels of the severe/critical COVID-19 patients compared to mild COVID-19 disease patients (AUC=0.691, 95% CI=0.56-0.822; p=0.004). Furthermore, SP-D levels were 86% sensitive and 51.6% specific at 2.44 ng/ml level (p=0.004) to detect severe/critical patients. Conclusion: SP-D levels is useful for COVID-19 patients in the prediction of clinical severity and prognosis. SP-D is a valuable biomarker for predicting the clinical severity and prognosis.
{"title":"Sürfaktan Protein D Düzeyleri ile COVID-19 Klinik Şiddeti Arasındaki İlişkinin Değerlendirilmesi: Bir Vaka Kontrol Çalışması","authors":"Emre Karslı, Ramazan Sabirli, Tarık Gören, Aykut Kemanci, Denizhan Karış, İ̇brahim Türkçüer, Özgür Kurt, Aylin Koseler","doi":"10.31362/patd.1159512","DOIUrl":"https://doi.org/10.31362/patd.1159512","url":null,"abstract":"Purpose: Serum surfactant protein D (SP-D) plays roles in the body such as protection against viral infection, bacterial and fungal clearance, clearance of apoptotic cells and suppression of inflammation. This study aims to examine the relationship between SP-D level and coronavirus disease (COVID-19) severity. \u0000Methods: 80 patients (30 with mild disease and 50 with severe/critical COVID-19), and 50 healthy volunteers were enrolled in the study. SP-D levels were analyzed by ELISA in serum samples. \u0000Results: The median of SP-D was found to be 2.47 (1.67-7.79) ng/ml in mild disease and 5.65 (3.09-16.55) ng/ml in severe/critical disease groups, while 2.89 (10.8-6.24) ng/ml in the healthy controls. The differences in SP-D levels between the severe/critical disease group compared to both mild disease and control groups were found statistically significant (p=0.007 and 0.001, respectively). ROC analysis showed greater AUC for the serum SP-D levels of the severe/critical COVID-19 patients compared to mild COVID-19 disease patients (AUC=0.691, 95% CI=0.56-0.822; p=0.004). Furthermore, SP-D levels were 86% sensitive and 51.6% specific at 2.44 ng/ml level (p=0.004) to detect severe/critical patients. \u0000Conclusion: SP-D levels is useful for COVID-19 patients in the prediction of clinical severity and prognosis. SP-D is a valuable biomarker for predicting the clinical severity and prognosis.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86476362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Doğan, Mücahit Seçme, Yasemin Şahin, Osman Çi̇ftçi̇
Purpose: Endometrial cancer is one of the most common gynecological cancers in the world. Glabridin is a main isoflavone in Glycyrrhiza glabra (licorice) root. It has several therapeutic effects such as anti-proliferative and anti-inflammatory. Long non-coding RNAs (LncRNAs) play a role in a variety of cellular processes, and their abnormal expression may contribute to tumor development and progression. In this study, the effects of glabridin on LncRNAs gene expression and viability of HEC-1B human endometrial cancer cell lines have been investigated. Materials and methods: Glabridin was applied to HEC-1B cells in concentrations of 1 μM, 10 μM, 20 μM, 40 μM, 60 μM, and 80 μM. Glabridin's effect on HEC-1B cell proliferation was also evaluated using MTS assay. Expression profiles of LncRNAs such as H19, RNU43, LNC-MYC-3:1 and ABCC5-AS1:1 were determined by real-time PCR. Results: Glabridin reduced the viability of HEC-1B cells in a time- and dose-dependent manner. The half maximal inhibitory concentration (IC50) dose in HEC-1B cells was detected to be 21.32 μM and 13.5 μM at the 24th and 48 hours, respectively. Glabridin has been observed to cause a significant decrease in the expression of H19 and RNU43 while increasing in the expression of LNC-MYC-3:1 and ABCC5-AS1:1. Conclusion: Glabridin could induce HEC-1B cell death by regulating LncRNAs expression. As a result, glabridin is a potential candidate for a more effective therapeutic agent against human endometrial cancer.
{"title":"HEC-1B hücrelerinde glabridinin hücre proliferasyonu ve uzun kodlamayan rna ekspresyonu üzerindeki etkileri","authors":"M. Doğan, Mücahit Seçme, Yasemin Şahin, Osman Çi̇ftçi̇","doi":"10.31362/patd.1172097","DOIUrl":"https://doi.org/10.31362/patd.1172097","url":null,"abstract":"Purpose: Endometrial cancer is one of the most common gynecological cancers in the world. Glabridin is a main isoflavone in Glycyrrhiza glabra (licorice) root. It has several therapeutic effects such as anti-proliferative and anti-inflammatory. Long non-coding RNAs (LncRNAs) play a role in a variety of cellular processes, and their abnormal expression may contribute to tumor development and progression. In this study, the effects of glabridin on LncRNAs gene expression and viability of HEC-1B human endometrial cancer cell lines have been investigated. \u0000Materials and methods: Glabridin was applied to HEC-1B cells in concentrations of 1 μM, 10 μM, 20 μM, 40 μM, 60 μM, and 80 μM. Glabridin's effect on HEC-1B cell proliferation was also evaluated using MTS assay. Expression profiles of LncRNAs such as H19, RNU43, LNC-MYC-3:1 and ABCC5-AS1:1 were determined by real-time PCR. \u0000Results: Glabridin reduced the viability of HEC-1B cells in a time- and dose-dependent manner. The half maximal inhibitory concentration (IC50) dose in HEC-1B cells was detected to be 21.32 μM and 13.5 μM at the 24th and 48 hours, respectively. Glabridin has been observed to cause a significant decrease in the expression of H19 and RNU43 while increasing in the expression of LNC-MYC-3:1 and ABCC5-AS1:1. \u0000Conclusion: Glabridin could induce HEC-1B cell death by regulating LncRNAs expression. As a result, glabridin is a potential candidate for a more effective therapeutic agent against human endometrial cancer.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90479716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: In addition to the known etiological and predisposing factors of urethral stricture, we aimed to examine unknown and not clearly defined factors. Materials and Methods: Medical records of 317 patients who underwent visual internal urethrotome (VIU) surgery in our clinic between 2017 and 2022 were retrospectively reviewed. The effect of other parameters on the total number of VIU operations was investigated. Additionally, the factors affecting the total strictural segment length of urethra and stricture localization were investigated. Results: The presence of history of endourological surgery and history of cardiovascular disease were independently associated with a higher number of VIU operations (p
{"title":"Üretra darlıklarında nüks sayısı, darlık uzunluğu ve lokalizasyonu öngören parametreler","authors":"M. Temel, Sezgin Okçelik","doi":"10.31362/patd.1126035","DOIUrl":"https://doi.org/10.31362/patd.1126035","url":null,"abstract":"Purpose: In addition to the known etiological and predisposing factors of urethral stricture, we aimed to examine unknown and not clearly defined factors. \u0000Materials and Methods: Medical records of 317 patients who underwent visual internal urethrotome (VIU) surgery in our clinic between 2017 and 2022 were retrospectively reviewed. The effect of other parameters on the total number of VIU operations was investigated. Additionally, the factors affecting the total strictural segment length of urethra and stricture localization were investigated. \u0000Results: The presence of history of endourological surgery and history of cardiovascular disease were independently associated with a higher number of VIU operations (p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83629735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuğba Sari, Belda Dursun, Mevlüt Çeri, H. Turgut, Murat Özban
Introduction:After renal transplantation, urinary tract infection (UTI) is observed in 23-75% of cases. In this study, we aimed to investigate the incidence of UTIs after renal transplantation, the causative pathogens and the predisposing factors that increase the risk. Methodology: Patients who underwent renal transplantation in our hospital between 2016-2017 were included in the study. Results: Twenty-five patients who underwent kidney transplantation were included in the study. UTI was detected in 12 patients (48%). One patient had neurogenic bladder, three had nephrolithiasis and one had vesicoureteral reflux. 8 of the patients had at least two UTI attacks. In total 38 UTI attacks; There were 7 (18.4%) nitrite positivity. UTI was detected in 15 (39.5%) patients during the first 3 months after transplantation. While 7 (18.4%) of the urine cultures were gram positive and 27 (71.1%) were gram negative bacteria, 4 (10.5%) were found as contamination. Escherichia coli (34.2%) was the most common causative agent, followed by Klebsiella pneumoniae (21.1%), Enterococcus faecium (18.4%), Pseudomonas aeruginosa (5.3%) and other gram negative (%). 10.5) uropathogens were found to be followed. When compared with basal and UTI GFR (glomerular filtration rate) levels, the GFR values detected during UTI were decreased significantly (p = 0.00). The most frequently preferred antibiotics in UTI treatment were ertapenem 42.1%, levofloxacin 10.5%, seftriaxon 10.5% and fosfomycin 10.5%. Discussion: Improperly treated UTI negatively affects the outcome of transplantation and increases mortality. Therefore, risk factors, antibiotic resistance and empirical treatments should be reviewed and treatment success should be increased.
{"title":"Renal transplant sonrası iki yıllık izlemde gelişen üriner sistem enfeksiyonlarının değerlendirilmesi: Tek merkez deneyimi","authors":"Tuğba Sari, Belda Dursun, Mevlüt Çeri, H. Turgut, Murat Özban","doi":"10.31362/patd.1162235","DOIUrl":"https://doi.org/10.31362/patd.1162235","url":null,"abstract":"Introduction:After renal transplantation, urinary tract infection (UTI) is observed in 23-75% of cases. In this study, we aimed to investigate the incidence of UTIs after renal transplantation, the causative pathogens and the predisposing factors that increase the risk. Methodology: Patients who underwent renal transplantation in our hospital between 2016-2017 were included in the study. Results: Twenty-five patients who underwent kidney transplantation were included in the study. UTI was detected in 12 patients (48%). One patient had neurogenic bladder, three had nephrolithiasis and one had vesicoureteral reflux. 8 of the patients had at least two UTI attacks. In total 38 UTI attacks; There were 7 (18.4%) nitrite positivity. UTI was detected in 15 (39.5%) patients during the first 3 months after transplantation. While 7 (18.4%) of the urine cultures were gram positive and 27 (71.1%) were gram negative bacteria, 4 (10.5%) were found as contamination. Escherichia coli (34.2%) was the most common causative agent, followed by Klebsiella pneumoniae (21.1%), Enterococcus faecium (18.4%), Pseudomonas aeruginosa (5.3%) and other gram negative (%). 10.5) uropathogens were found to be followed. When compared with basal and UTI GFR (glomerular filtration rate) levels, the GFR values detected during UTI were decreased significantly (p = 0.00). The most frequently preferred antibiotics in UTI treatment were ertapenem 42.1%, levofloxacin 10.5%, seftriaxon 10.5% and fosfomycin 10.5%. Discussion: Improperly treated UTI negatively affects the outcome of transplantation and increases mortality. Therefore, risk factors, antibiotic resistance and empirical treatments should be reviewed and treatment success should be increased.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89758183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Influenza is a contagious respiratory disease that causes widespread epidemics and pandemics in the community. While it is usually self-limiting, it can cause significant morbidity and mortality due to complications. It was aimed to evaluate the clinical, laboratory and prognoses of adult patients hospitalized with a preliminary diagnosis of seasonal influenza. Materials and Methods: This is a descriptive study based on the information of 50 patients hospitalized with a preliminary diagnosis of seasonal influenza between 1 December 2015 and 31 January 2016. Results: The mean age of the patients was 55.44±17.17 (20-89), and 64% were female. 36% of the cases were H1N1 positive, 30% were H3N2 positive, and 34% had negative PCR results. The time from the onset of symptoms to admission to the hospital was 3.72±2.51 days (1-11). 38 (76%) patients had comorbidities. It resulted in mortality in four patients. Conclusion: Influenza can cause severe illness and death in healthy and young adults. Avoiding contact with infected patients, hand washing and vaccination are important to reduce these complications.
{"title":"Evaluation of clinical, laboratory and prognosis of patients in an influenza epidemic","authors":"Türkan Tüzün, Duru Mıstanoğlu Özatağ, Şebnem Emine Parsbur, Ayşenur BEYAZIT ÜÇGÜN","doi":"10.31362/patd.1178708","DOIUrl":"https://doi.org/10.31362/patd.1178708","url":null,"abstract":"Purpose: Influenza is a contagious respiratory disease that causes widespread epidemics and pandemics in the community. While it is usually self-limiting, it can cause significant morbidity and mortality due to complications. It was aimed to evaluate the clinical, laboratory and prognoses of adult patients hospitalized with a preliminary diagnosis of seasonal influenza. \u0000Materials and Methods: This is a descriptive study based on the information of 50 patients hospitalized with a preliminary diagnosis of seasonal influenza between 1 December 2015 and 31 January 2016. \u0000Results: The mean age of the patients was 55.44±17.17 (20-89), and 64% were female. 36% of the cases were H1N1 positive, 30% were H3N2 positive, and 34% had negative PCR results. The time from the onset of symptoms to admission to the hospital was 3.72±2.51 days (1-11). 38 (76%) patients had comorbidities. It resulted in mortality in four patients. \u0000Conclusion: Influenza can cause severe illness and death in healthy and young adults. Avoiding contact with infected patients, hand washing and vaccination are important to reduce these complications.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"340 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91419200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amaç: Bu çalışmada, Tip 2 diyabetli bireylerin kardiyovasküler hastalıklar risk faktörleri bilgi düzeyleri ve etkileyen faktörlerin belirlemesi amaçlandı.Gereç ve yöntem: Tek merkezli, tanımlayıcı ve kesitsel tipteki bu çalışma Eylül-Aralık 2021 tarihleri arasında Pamukkale Üniversitesi Hastaneleri Sağlık Araştırma Uygulama Merkez Müdürlüğü Endokrin polikliniğine kontrol amacı ile gelen hastalarda (n=207) yürütüldü.Bulgular: Tip 2 diyabetli bireylerin yaş ortalaması 60,99±13,74 yaş olup, ortalama 12,22±9,86 yıldır diyabet hastasıdır. Kardiyovasküler hastalıklar risk faktörleri bilgi düzeyi ölçeği toplam puan ortalamaları 17,90±3,33 olarak bulundu. Araştırma kapsamına alınan bireylerin %51,2’sinin kadın, %31,9’unun DM öyküsü ve %52,2’sinin kalp hastalığı öyküsü olduğu belirlendi. Sağlığı koruyucu davranışları incelendiğinde çok azının eğersiz yaptığı fakat sağlıklı beslenmeye özen gösterdikleri tespit edildi. Hastaların kardiyovasküler risk faktörleri bilgi düzeyi açısından sosyodemografik değişkenler arasında istatistiksel olarak anlamlı fark saptanmadı (p>0,05). Fakat kalp sağlığı koruyucu davranışlarına ait bazı değişkenler arasında (egzersiz yapma durumu, günlük tüketilen mevye/sebze miktarı, ara öğünlerde tercih besinler, kan şekeri/kollesterol düzeyini takip etme, EKG çektirme ve kalp damar sağlığını kontrol ettirme durumu) istatistiksel olarak anlamlı farklılık olduğu belirlendi (p<0,05).Sonuç: Çalışmaya alınan hastaların kardiyovasküler hastalık risk faktörleri bilgi düzeyleri ölçek puan ortalamasının altındaydı. Bilgi düzeyleri çok düşük olmamakla birlikte geliştirdikleri sağlıklı yaşam biçimi davranışlarının genel risk faktörleri bilgi düzeyine oranı oldukça düşük bulundu. Koruyucu sağlık davranışına sahip ve olumlu beslenme alışkanlığı sergileyen Tip-2 DM’li bireylerin bilgi düzeyleri diğerlerine göre daha yüksektir.
{"title":"Tip 2 diyabetli bireylerin kardiyovasküler hastalık risk faktörleri bilgisi ve ilişkili faktörlerler","authors":"Fadime Gök","doi":"10.31362/patd.1149533","DOIUrl":"https://doi.org/10.31362/patd.1149533","url":null,"abstract":"Amaç: Bu çalışmada, Tip 2 diyabetli bireylerin kardiyovasküler hastalıklar risk faktörleri bilgi düzeyleri ve etkileyen faktörlerin belirlemesi amaçlandı.Gereç ve yöntem: Tek merkezli, tanımlayıcı ve kesitsel tipteki bu çalışma Eylül-Aralık 2021 tarihleri arasında Pamukkale Üniversitesi Hastaneleri Sağlık Araştırma Uygulama Merkez Müdürlüğü Endokrin polikliniğine kontrol amacı ile gelen hastalarda (n=207) yürütüldü.Bulgular: Tip 2 diyabetli bireylerin yaş ortalaması 60,99±13,74 yaş olup, ortalama 12,22±9,86 yıldır diyabet hastasıdır. Kardiyovasküler hastalıklar risk faktörleri bilgi düzeyi ölçeği toplam puan ortalamaları 17,90±3,33 olarak bulundu. Araştırma kapsamına alınan bireylerin %51,2’sinin kadın, %31,9’unun DM öyküsü ve %52,2’sinin kalp hastalığı öyküsü olduğu belirlendi. Sağlığı koruyucu davranışları incelendiğinde çok azının eğersiz yaptığı fakat sağlıklı beslenmeye özen gösterdikleri tespit edildi. Hastaların kardiyovasküler risk faktörleri bilgi düzeyi açısından sosyodemografik değişkenler arasında istatistiksel olarak anlamlı fark saptanmadı (p>0,05). Fakat kalp sağlığı koruyucu davranışlarına ait bazı değişkenler arasında (egzersiz yapma durumu, günlük tüketilen mevye/sebze miktarı, ara öğünlerde tercih besinler, kan şekeri/kollesterol düzeyini takip etme, EKG çektirme ve kalp damar sağlığını kontrol ettirme durumu) istatistiksel olarak anlamlı farklılık olduğu belirlendi (p<0,05).Sonuç: Çalışmaya alınan hastaların kardiyovasküler hastalık risk faktörleri bilgi düzeyleri ölçek puan ortalamasının altındaydı. Bilgi düzeyleri çok düşük olmamakla birlikte geliştirdikleri sağlıklı yaşam biçimi davranışlarının genel risk faktörleri bilgi düzeyine oranı oldukça düşük bulundu. Koruyucu sağlık davranışına sahip ve olumlu beslenme alışkanlığı sergileyen Tip-2 DM’li bireylerin bilgi düzeyleri diğerlerine göre daha yüksektir.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90781106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Orgun, Birgül Varan, İlkay Erdoğan, N. Tokel, A. Gürsu, M. Özkan, Mehmet Sait Aşlamaci
Purpose: Scimitar syndrome is a rare congenital cardiac anomaly in which pulmonary veins are drained to the inferior vena cava (IVC) instead of the left atrium and it is often associated with additional cardiac and pulmonary anomalies. Scimitar syndrome has a wide range of anatomic and clinical variations. In this article, the different clinical features of five pediatric patients with Scimitar syndrome are reported. Material and methods: Five patients with scimitar syndrome were diagnosed in our hospital between 2000 and 2020. The clinical findings, angiographic and surgical procedures, and follow-up of the patients are evaluated. Results: Five pediatric patients aged between 1.5 months and 10 years were diagnosed as Scimitar syndrome; two of the five patients were infants. All patients were symptomatic. One patient had cor triatriatum and pulmonary venous stenosis, one patient had left atrial isomerism and absence of the IVC (azygous continuity), and another patient had coarctation of the aorta. One patient had dual drainage: the IVC and left atrium with meandering pulmonary veins, which we determined as a Scimitar variant. One infant patient with pulmonary hypertension and two patients with pulmonary to systemic flow ratio (Qp/Qs) >1.5 were treated surgically with the reanastomosis technique. Transcatheter occlusion of the aortopulmonary collaterals was performed in two patients using vascular plugs, coils, and onyx. Conclusion: In this article, the clinical findings of five pediatric patients with Scimitar syndrome were evaluated in detailed. Treatment should be planned individually in this syndrome due to Scimitar syndrome has a wide range of anatomic and clinical variations.
{"title":"Çocuk Hastalarda Farklı Özellikleriyle Scimitar Sendromu: Tek Merkez Deneyimi","authors":"Ali Orgun, Birgül Varan, İlkay Erdoğan, N. Tokel, A. Gürsu, M. Özkan, Mehmet Sait Aşlamaci","doi":"10.31362/patd.1094198","DOIUrl":"https://doi.org/10.31362/patd.1094198","url":null,"abstract":"Purpose: Scimitar syndrome is a rare congenital cardiac anomaly in which pulmonary veins are drained to the inferior vena cava (IVC) instead of the left atrium and it is often associated with additional cardiac and pulmonary anomalies. Scimitar syndrome has a wide range of anatomic and clinical variations. In this article, the different clinical features of five pediatric patients with Scimitar syndrome are reported. \u0000Material and methods: Five patients with scimitar syndrome were diagnosed in our hospital between 2000 and 2020. The clinical findings, angiographic and surgical procedures, and follow-up of the patients are evaluated. \u0000Results: Five pediatric patients aged between 1.5 months and 10 years were diagnosed as Scimitar syndrome; two of the five patients were infants. All patients were symptomatic. One patient had cor triatriatum and pulmonary venous stenosis, one patient had left atrial isomerism and absence of the IVC (azygous continuity), and another patient had coarctation of the aorta. One patient had dual drainage: the IVC and left atrium with meandering pulmonary veins, which we determined as a Scimitar variant. One infant patient with pulmonary hypertension and two patients with pulmonary to systemic flow ratio (Qp/Qs) >1.5 were treated surgically with the reanastomosis technique. Transcatheter occlusion of the aortopulmonary collaterals was performed in two patients using vascular plugs, coils, and onyx. \u0000Conclusion: In this article, the clinical findings of five pediatric patients with Scimitar syndrome were evaluated in detailed. Treatment should be planned individually in this syndrome due to Scimitar syndrome has a wide range of anatomic and clinical variations.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85066616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Şule SUBAŞI GÖKŞİN, Buket Er Urgancı, Işıl Göğem İmren, I. Açıkbaş
Purpose: Bullous pemphigoid (BP) is an autoimmune disease increasing by age. miRNA-1291 is a microRNA that plays major role in many immune-mediated cutaneous diseases. We aimed to investigate the role of miRNA-1291 in BP by comparing its expression levels in serum and lesional skin and its correlation with other BP biomarkers (CCL17, anti-BP180, and anti-BP230). Materials and methods: Twenty three patients with BP and 23 healthy control patients were included in the study. The miRNeasy Mini Kits was used for RNA isolation from serum and biopsy samples. Qiagen-miRCURY LNA RT Kit was used for conversion of cDNA. miRNA-1291 expression was performed by Real-Time PCR with the original primer and SYBR Green master mix. Serum CCL17, anti-BP180, and anti-BP230 levels were measured with use of ELISA. SPSS 25.0 (IBM SPSS Statistics 25 software) was used for statistical evaluation. Results: The expression of miRNA-1291 in serum and biopsy samples were 7.02 and 4.77-fold significantly upregulated than that of control group respectively (p=0.001, p=0.007). The serum levels of anti-BP-180, anti-BP-230 and CCL17 in BP patients were significantly higher compared to control group (p=0.0049, p=0.0071, p=0.001). Anti-BP180, anti-BP230, CCL17 levels and serum miRNA-1291 expression were correlated positively in BP patients. Additionally, serum miRNA-1291 expression were correlated well with lesional miRNA-1291 expression. Conclusion: The increase in miRNA-1291 levels in serum and lesional tissue compared to non-lesional tissue suggests that miRNA-1291 may play a role in the pathogenesis of BP. As miRNA-1291 correlates with other BP biomarkers, it may serve as an important biomarker for BP.
{"title":"Büllöz pemfigoidli hastalarda serum ve lezyonel miRNA-1291 ekspresyonlarının karşılaştırılması","authors":"Şule SUBAŞI GÖKŞİN, Buket Er Urgancı, Işıl Göğem İmren, I. Açıkbaş","doi":"10.31362/patd.1174388","DOIUrl":"https://doi.org/10.31362/patd.1174388","url":null,"abstract":"Purpose: Bullous pemphigoid (BP) is an autoimmune disease increasing by age. miRNA-1291 is a microRNA that plays major role in many immune-mediated cutaneous diseases. We aimed to investigate the role of miRNA-1291 in BP by comparing its expression levels in serum and lesional skin and its correlation with other BP biomarkers (CCL17, anti-BP180, and anti-BP230). \u0000Materials and methods: Twenty three patients with BP and 23 healthy control patients were included in the study. The miRNeasy Mini Kits was used for RNA isolation from serum and biopsy samples. Qiagen-miRCURY LNA RT Kit was used for conversion of cDNA. miRNA-1291 expression was performed by Real-Time PCR with the original primer and SYBR Green master mix. Serum CCL17, anti-BP180, and anti-BP230 levels were measured with use of ELISA. SPSS 25.0 (IBM SPSS Statistics 25 software) was used for statistical evaluation. \u0000Results: The expression of miRNA-1291 in serum and biopsy samples were 7.02 and 4.77-fold significantly upregulated than that of control group respectively (p=0.001, p=0.007). The serum levels of anti-BP-180, anti-BP-230 and CCL17 in BP patients were significantly higher compared to control group (p=0.0049, p=0.0071, p=0.001). Anti-BP180, anti-BP230, CCL17 levels and serum miRNA-1291 expression were correlated positively in BP patients. Additionally, serum miRNA-1291 expression were correlated well with lesional miRNA-1291 expression. \u0000Conclusion: The increase in miRNA-1291 levels in serum and lesional tissue compared to non-lesional tissue suggests that miRNA-1291 may play a role in the pathogenesis of BP. As miRNA-1291 correlates with other BP biomarkers, it may serve as an important biomarker for BP.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83011408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duygu YALINBAŞ YETER, Erman Bozali̇, Caner. Kara, S. Sarı, Demet Dursun
Purpose: To compare non-cycloplegic refraction measurements of two photoscreeners and the hand-held autorefractometer with cycloplegic measurements of the autorefractometer in patients with attention deficit hyperactivity disorder (ADHD). Meterials and methods: This cross-sectional, comparative study consisted of 53 children who were newly diagnosed with ADHD. We compared spherical, cylindrical, cylindrical axis and spherical equivalent (SE) measurements in Plusoptix A12, Spot Vision Screener, and Retinomax K-plus Screen with Tonoref II. Reliability was analyzed by using the interclass correlation coefficient (ICC) and Bland-Altman plot was used to evaluate the agreement between devices. Results: The mean age of children was 9.45 ± 1.68. All of the devices measured spherical power and SE significantly more myopic than the Tonoref II. While The Spot Vision Screener, PlusoptiX A12, and Tonoref II provided similar cylindrical power, Retinomax K-plus Screen measured significantly lower than the Tonoref II. The excellent reliability was detected in spherical power, cylindrical power, SE and J0 between Tonoref II and PlusoptiX A12 (ICC:0.930, 0.921, 0.927 and 0.920, respectively. All of the hand-held devices showed excellent reliability in terms of cylindrical power and J0 (ICC>0.90, for all) and good reliability for J45 (ICC:0.75-0.90 for all). Conclusion: Despite all devices having advantages or disadvantages, Plusoptix A12 showed excellent reliability for detecting refractive errors in children with ADHD.
{"title":"Yeni tanı konmuş dikkat eksikliği hiperaktivite bozukluğu olan çocuklarda fotoscreener ve el tipi otorefraktometrenin sikloplejik otorefraktometri ile karşılaştırılması","authors":"Duygu YALINBAŞ YETER, Erman Bozali̇, Caner. Kara, S. Sarı, Demet Dursun","doi":"10.31362/patd.1140073","DOIUrl":"https://doi.org/10.31362/patd.1140073","url":null,"abstract":"Purpose: To compare non-cycloplegic refraction measurements of two photoscreeners and the hand-held autorefractometer with cycloplegic measurements of the autorefractometer in patients with attention deficit hyperactivity disorder (ADHD). \u0000Meterials and methods: This cross-sectional, comparative study consisted of 53 children who were newly diagnosed with ADHD. We compared spherical, cylindrical, cylindrical axis and spherical equivalent (SE) measurements in Plusoptix A12, Spot Vision Screener, and Retinomax K-plus Screen with Tonoref II. Reliability was analyzed by using the interclass correlation coefficient (ICC) and Bland-Altman plot was used to evaluate the agreement between devices. \u0000Results: The mean age of children was 9.45 ± 1.68. All of the devices measured spherical power and SE significantly more myopic than the Tonoref II. While The Spot Vision Screener, PlusoptiX A12, and Tonoref II provided similar cylindrical power, Retinomax K-plus Screen measured significantly lower than the Tonoref II. The excellent reliability was detected in spherical power, cylindrical power, SE and J0 between Tonoref II and PlusoptiX A12 (ICC:0.930, 0.921, 0.927 and 0.920, respectively. All of the hand-held devices showed excellent reliability in terms of cylindrical power and J0 (ICC>0.90, for all) and good reliability for J45 (ICC:0.75-0.90 for all). \u0000Conclusion: Despite all devices having advantages or disadvantages, Plusoptix A12 showed excellent reliability for detecting refractive errors in children with ADHD.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91043678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
-Purpose: To investigate whether there is a difference in the gluteus medius and minimus muscle thicknesses between the cases with Graf method type IIa and normal subjects. -Methods: A total of 200 cases, 1-3 months old infants, who applied to our hospital for developmental hip dysplasia ultrasound scanning between January 2021 and March 2021 were included in our study. The cases were evaluated with a standard coronal plane with a 9-12 MHz linear array probe according to the Graf method at the level of the triradiate cartilage by the same radiologist. The largest gluteus medius and minimus muscle thickness were measured. -Results: The female to male ratio was 0.9. and the mean age was 43.9 ± 13.7 days. The present study had 159 (79.5%) Graf type I (Group A) and 41 newborns (20.5%) with Graf type IIa (Group B). Demographic and clinical characteristics were similar in both groups (p>0.05). The mean lengths of the gluteus medius and minimus muscles were similar in newborns with Graf type I and IIa (p=0.975 and p=0.069, respectively). A significant difference was found in the mean length of the gluteus minimus muscle between male and female newborns (p=0.001). The muscle length was statistically shorter in the female newborns than the male newborns (3.4 ± 0.5 mm vs. 3.6 ± 0.5 mm). -Conclusion: Since there was no difference in gluteal muscle thickness between mature and immature hips; Gluteal muscle lengths are not a diagnostic landmark in the hip ultrasound scan.
{"title":"Gluteus Medius ve Minimus Kas Kalınlığının Üç Aya Kadar Gelişimsel Kalça Displazisi Üzerine Etkisi","authors":"A. Arslan, Bahadır Balkanli","doi":"10.31362/patd.1127536","DOIUrl":"https://doi.org/10.31362/patd.1127536","url":null,"abstract":"-Purpose: To investigate whether there is a difference in the gluteus medius and minimus muscle thicknesses between the cases with Graf method type IIa and normal subjects. \u0000 \u0000-Methods: A total of 200 cases, 1-3 months old infants, who applied to our hospital for developmental hip dysplasia ultrasound scanning between January 2021 and March 2021 were included in our study. The cases were evaluated with a standard coronal plane with a 9-12 MHz linear array probe according to the Graf method at the level of the triradiate cartilage by the same radiologist. The largest gluteus medius and minimus muscle thickness were measured. \u0000 \u0000-Results: The female to male ratio was 0.9. and the mean age was 43.9 ± 13.7 days. The present study had 159 (79.5%) Graf type I (Group A) and 41 newborns (20.5%) with Graf type IIa (Group B). Demographic and clinical characteristics were similar in both groups (p>0.05). The mean lengths of the gluteus medius and minimus muscles were similar in newborns with Graf type I and IIa (p=0.975 and p=0.069, respectively). A significant difference was found in the mean length of the gluteus minimus muscle between male and female newborns (p=0.001). The muscle length was statistically shorter in the female newborns than the male newborns (3.4 ± 0.5 mm vs. 3.6 ± 0.5 mm). \u0000 \u0000-Conclusion: Since there was no difference in gluteal muscle thickness between mature and immature hips; Gluteal muscle lengths are not a diagnostic landmark in the hip ultrasound scan.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80706412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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