Pamukkale Medical Journal最新文献

{"title":"Evaluation of Factors that Affect Remission and Recurrence after Endonasal Endoscopic Approach in Cushing Disease","authors":"M. C. Kilinc, G. Kahilogullari, B. C. Alpergin, Savaş Haşi̇moğlu, A. B. Bahçecioğlu, S. Beton, C. Meço, Mustafa Ağahan Ünlü","doi":"10.31362/patd.1244037","DOIUrl":"https://doi.org/10.31362/patd.1244037","url":null,"abstract":"Abstract \u0000Aim of the Study: Clinical consequences of endoscopic endonasal approach (EEA) for Cushing Diseases (CD) were investigated in a single-center series based on definitions and assessments of recurrence and remission. \u0000Materials and Methods: 825 patients evaluated, including 64 patients with CD, who underwent EEA at the Ankara University Neurosurgery Department and evaluated retrospectively between the years 2014 and 2021. Postoperative next-morning cortisol and adrenocorticotrophic hormone (ACTH) values were used to assess postoperative endocrinological remission. \u0000Results: Twenty-two patients had macroadenoma, and 40 had microadenoma. In 2 patients, no lesions were detected in the sellar region, a diagnosis of magnetic resonance imaging (−) CD was made. Clinical and biochemical follow-ups in Cushing's disease are very important due to risk of recurrence. Regardless of remission, the effect of duration of glucocorticoid use after surgery on recurrence was examined. Glucocorticoid therapy was given in 46 patients (71%) after pituitary surgery. No recurrence was observed in 20 patients whose treatment duration was longer than 1 year. In 12 patients, the glucocorticoid therapy duration was ranged from 6 months to 12 months, and 4 patients showed recurrence. The glucocorticoid therapy duration of >6 months predicted that recurrence would not occur (p 6 months after surgery predicts that recurrence will not occur. Long-term glucocorticoid therapy after surgery suggests surgical success. The mainstay of CD treatment is appropriate postoperative follow-up and administration of the necessary medical and surgical interventions. \u0000Keywords: ACTH, Cortisol, Cushing disease, Endonasal endoscopic approach, Recurrence, Remission \u0000 \u0000ÖZET \u0000Çalışmanın Amacı: Bu çalışmada, Cushing Hastalığı (CH) için endoskopik endonazal yaklaşımın (EEY) klinik sonuçları, remisyon ve nüks tanımları ve değerlendirmelerine dayalı olarak tek merkezli bir seride araştırıldı. \u0000Gereç ve Yöntemler: Ankara Üniversitesi İbni Sina Hastanesi Nöroşirürji Anabilim Dalı'nda 2014-2021 yılları arasında EEY uygulanan 825 hasta arasında CH’ lığı tanısı alan 64 hastanın verileri retrospektif olarak değerlendirildi. Postoperatif ertesi sabah kortizol ve adrenokortikotropik hormon (ACTH) değerleri postoperatif endokrinolojik remisyonu değerlendirmek için kullanıldı. \u0000Bulgular: Yirmi iki hastada makroadenom ve 40 hastada mikroadenom saptandı. 2 hastada sellar bölgede lezyon saptanmadı, manyetik rezonans görüntüleme (-) CH tanısı kondu. Kırk hasta kadın, 12 hasta erkekti. CH'de yüksek nüks insidansı nedeniyle, yıllık klinik ve biyokimyasal takipler çok önemlidir. Remisyondan bağımsız olarak ameliyat sonrası glukokortikoid kullanım süresinin nüks üzerine etkisi incelendi. Hipofiz cerrahisi sonrası 46 hastaya (%71) glukokortikoid tedavisi verildi. Tedavi süresi 1 yıldan uzun olan 20 hastada nüks gözlenmedi. 12 hastada glukokortikoid tedavi süresi 6 ay ile 1 yıl arasında değişmekteydi ve 4 hastada n","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81698326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatic Carditis Presented with Only Palpitation","authors":"E. Aslan, C. Karadeniz","doi":"10.31362/patd.1248280","DOIUrl":"https://doi.org/10.31362/patd.1248280","url":null,"abstract":"Acute rheumatic fever (ARF) remains a serious problem for public health, and it is common in developing countries. It has a wide range of presentation and in some settings it can appear a dramatic event. Various rhythm problems such as first, second and third-degree atrioventricular blocks, premature contractions, accelerated junctional rhythm, ventricular tachycardia, and Torsades de pointes may occur during the acute stage of the disease. \u0000We report a case of narrow QRS tachycardia in whom a palpitation was the only symptom of rheumatic carditis. The tachycardia returns to normal after the disease becomes inactive with acetylsalicylic acid treatment.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73996553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathologic features of inflammatory fibroid polyps and risk of cancer development: A case series","authors":"Erdem Çomut, Yeliz Arman Karakaya, Mustafa Celik, N. Demirkan","doi":"10.31362/patd.1270475","DOIUrl":"https://doi.org/10.31362/patd.1270475","url":null,"abstract":"Introduction \u0000Inflammatory fibroid polyp (IFP) is seen in the gastrointestinal tract. In most cases, somatic mutations in PDGFRA gene were observed and the true neoplastic origin of this entity was understood. It is a benign mesenchymal tumor and rarely recurs. The aim of the study was to reveal the histopathologic features of our IFP cases and to investigate the risk of cancer in one case. \u0000 \u0000Materials and Methods \u0000We performed a retrospective clinicopathological analysis of patients (n=12) who were reported as IFP between 2012 and 2022. Formalin-fixed, paraffin-embedded and hematoxylin-eosin (H&E)- stained slides of the cases were re-examined by two pathologists microscopically. \u0000 \u0000Results \u0000All patients were adults and ranged in age from 30 to 85. Male to female ratio was 1:2. One polyp was localized in small intestine, one in colon, and the others in stomach. Histologically, there were hyperplastic epithelial changes (7/12), low-grade (3/12), and high-grade dysplasia (1/12) accompanying IFPs. One case was associated with early gastric adenocarcinoma. \u0000 \u0000Discussion \u0000Although IFP appears as a benign mesenchymal tumor, it should be kept in mind that dysplasia and rarely carcinoma may accompany this lesion. Larger case series are needed to elucidate the mechanisms of dysplasia and carcinoma development associated with IFP.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73423526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relations of vitamin D receptor gene polymorphisms with risk of obesity, metabolic syndrome, hepatostetosis in Turkish children","authors":"B. Özhan, Elif Bi̇lgi̇han, Ozan Çetin, Kadir Ağladıoğlu","doi":"10.31362/patd.1249471","DOIUrl":"https://doi.org/10.31362/patd.1249471","url":null,"abstract":"Purpose: The aim of study was to determine the relation of vitamin D receptor gene (VDR) polymorphisms of TaqI (rs731236), ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) with the risk of obesity, metabolic syndrome and hepatosteatosis in children.Materials and methods: 130 obese and 130 healthy children of age range between 10-16 years included in this study. Anthropometric measurements, biochemical evaluations and abdominal USG of all children were done. Obese and healty children were analyzed for the most common polymorphisms of the VDR gene by restriction fragment length polymorphism’s technique. The diagnosis of metabolic syndrome was made using the International Diabetes Federation criteria.Results: Genotypic distribution of BsmI, FokI, and TaqI polymorphism were found statistically different between obese patients and control group, but genotypic distribution of all studied polymorphisms were not found statistically different in obese patients with metabolic syndrome or hepatosteotosis. Conclusion: BsmI polymorphism (rs1544410) was found to have a significant positive effect on the development of obesity, metabolic syndrome and hepatosteatosis. Children who carry risk factors for childhood obesity could be screened before the development of obesity and associated metabolic complications using the BsmI polymorphism of the VDR gene.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80496325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LOKAL İLERİ REZEKE EDİLEMEYEN VE METASTATİK MİDE KANSERİNDE TEDAVİ ÖNCESİ İNFLAMASYON YANITI BELİRTEÇLERİNİN SAĞKALIM ÜZERİNE ETKİSİ: RETROSPEKTİF CROSS-SECTIONALÇALIŞMA","authors":"Tolga Doğan, Arzu Yaren, A. G. Demi̇ray, Burcu YAPAR TAŞKÖYLÜ, Burçin ÇAKAN DEMİREL, Melek Özdemi̇r, Taliha GÜÇLÜ KANTAR, Serkan Deği̇rmenci̇oğlu, Gamze GOKOZ DOGU","doi":"10.31362/patd.1265291","DOIUrl":"https://doi.org/10.31362/patd.1265291","url":null,"abstract":"Abstract \u0000Purpose:We evaluated the effect of pre-treatment inflammation response markers on overall survival (OS) and progression-free survival (PFS) in patients with locally advanced unresectable and metastatic gastric cancer. \u0000Material and Method:Patients with locally advanced unresectable and metastatic gastric cancer between January 2016 and December 2021 were included. Among these patients, 114 patients with ECOG (Eastern Cooperative Oncology Group) Performance status 0-2, who received at least one line of chemotherapy, had no comorbidities and brain metastases were included in the study. Pre-treatment platelet, lymphocyte, leukocyte, neutrophil, monocyte, albumin, C-reactive protein (CRP), lactatedehydrogenase (LDH) levels, histology types, age, surgical history, treatment history and ECOG Performance status were retrospectively analysed from their files. Threshold values of all values were determined by ROC analysis. Kaplan-Meier survival analyses were used for survival analyses. Hazardratio (HR) and confidence intervals (CI) of the factors affecting overall survival (OS) and progression-free survival (PFS) were calculated using Coxproportional-hazards model. \u0000Results:The median age of the patients was 63.5±11.9(28-80) years. Among the patients, 69(60.5%) were in metastatic stage. One hundred and six (93.0%) patients had poorly differentiated carcinoma histology. Progression developed in 88.6% (101) of patients and 98 patients (86%) were deceased. In the whole group, mPFS was 9.4+0.9 (95%CI 7.7-11.0) months and mOS was 14.1+1.6 (95%CI 10.8-17.2) months. When the Coxproportional-hazards model was used, the factors affecting OS were advanced age, metastatic stage, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), derived neutrophil lymphocyte ratio (dNLR) and lactate dehydrogenase (LDH), while the factors affecting PFS were advanced age, metastatic stage, NLR, dNLR and LDH. \u0000Conclusion: While NLR, PLR, dNLR, dNLR and LDH affect OS, LDH affects PFS. Systemic inflammatory markers of locally advanced unresectable and metastatic gastric cancers before chemotherapy can be used to predict prognosis.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86908785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A puzzling case presenting as a polypoid mass in the cecum in an adult patient: Appendiceal intussusception","authors":"Erdem Çomut, Hande Karabaş, U. Ozgen, Murat Özban, N. Demirkan","doi":"10.31362/patd.1269591","DOIUrl":"https://doi.org/10.31362/patd.1269591","url":null,"abstract":"Appendiceal intussusception is a rare condition in an adult patient and may not be initially considered in the differential diagnosis clinically or radiologically. It occurs due to an organic cause or idiopathically. We report a 74-year-old patient who had a polypoid lesion in the cecum on colonoscopy with no radiologic imaging and was ultimately diagnosed grossly and histopathologically as appendiceal intussusception. In conclusion, physicians are advised to consider appendiceal intussusception as an alternative diagnosis in all patients presenting with a suspected cecal mass.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73142762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventriculo-peritoneal shunt obstructions in the absence of radiological abnormalities: retrospective analysis of a pediatric cohort","authors":"Reyhan Kasab, M. Ö. Taşkapilioğlu","doi":"10.31362/patd.1248327","DOIUrl":"https://doi.org/10.31362/patd.1248327","url":null,"abstract":"Introduction: Ventriculoperitoneal shunts are still the mainstay treatment for pediatric \u0000hydrocephalus. They have a high complication and failure rate, requiring multiple revisions. \u0000In this study, we aim to investigate patients who required shunt replacement without any \u0000radiological findings. \u0000Methods: The files of patients under the age of 18, who underwent shunt revision between \u0000December 2015 and December 2020 in Bursa Uludag University Medical Faculty Neurosurgery clinic were reviewed retrospectively. All the radiological studies, laboratory results and clinical condition of the patients were examined. \u0000Results: We identified 127 patients who required a revision of ventriculoperitoneal shunt for suspected mechanical obstruction. 6 patients (5%) had symptoms of raised \u0000intracranial pressure, but showed no radiographic evidence of progressive ventricular \u0000dilatation. \u0000Conclusion: Dysfunction of a ventriculoperitoneal shunt does not always lead to associated radiological alterations. In a patient with signs of intracranial hypertension, revision of the system should be considered even in the absence of progressive ventricular dilatation on radiological studies.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"35 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72940881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atnalı böbrekte nutcracker sendromu beklenen bir vasküler anomali midir?","authors":"Hatice Kübra Zora, İlknur Gi̇ri̇şgen, Ayşe Rüksan Ütebey, Furkan Ufuk, Tülay Beceri̇r, Selçuk Yüksel","doi":"10.31362/patd.1252453","DOIUrl":"https://doi.org/10.31362/patd.1252453","url":null,"abstract":"Purpose: Horseshoe kidney is the most common fusion anomaly that congenital systemic and urological anomalies accompany most of the patients. In this study, we aimed to investigate its association with vascular anomalies and especially nutcracker syndrome along with accompanying urological and other systemic anomalies in children with horseshoe kidney. \u0000Materials and methods: Twenty-six patients are diagnosed with horseshoe kidney in our clinic and 22 healthy children of the same age and sex were included in the study. All children were prospectively evaluated using Doppler ultrasonography in terms of renal artery and renal vein flow velocities, lumen diameters and vascular anomalies and presence of nutcracker syndrome. \u0000Results: Urological anomaly was found in 50% of the children with horseshoe kidneys, and systemic anomaly in 44% of them. In Doppler ultrasonographic evaluations performed on patients to detect vascular pathologies and nutcracker syndrome; findings of nutcracker syndrome were present in 2 patients in the horseshoe kidney group, while they were detected incidentally in 1 patient in the control group. An accessory renal artery originating from the left common iliac artery was found in a case with horseshoe kidney, and a circumaortic left renal vein in one case. \u0000Conclusions: In our study in which we investigated nutcracker syndrome based on the presence of vascular anomalies accompanying horseshoe kidneys in children, nutcracker syndrome findings were found in similar numbers in both groups. However, we think that these children should be followed for a long time in terms of vascular pathologies (aneurysm, rupture) and malignancies that may occur in adulthood, as well as congenital vascular anomalies.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90105306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of graft bypass surgery and endovascular ınterventional techniques ın ıliofemoral and above knee femoropopliteal arterial occlusion","authors":"M. Bozkurt, Mohammad Alsalaldeh","doi":"10.31362/patd.1188532","DOIUrl":"https://doi.org/10.31362/patd.1188532","url":null,"abstract":"ÖZ \u0000Amaç: Periferik damar hastalığı önemli morbidite ve mortalite ile ilişkilidir. Bu çalışmada iliofemoral ve diz üstü femoropopliteal arter tıkanıklığında cerrahi baypas greftleme ile endovasküler stentleme arasında bir karşılaştırma yaparak her bir tedavi yönteminin avantaj ve dezavantajlarını ortaya çıkarmaya çalıştık. \u0000Yöntemler: Ocak 2015 ile Aralık 2020 arasında 60 hasta bu çalışmaya dahil edildi. Hastalar tedavi yöntemlerine göre iki gruba ayrıldı. Grup I 33 hastadan oluşuyordu ve cerrahi baypas greftleme ile ameliyat edildi, grup II ise endovasküler girişim ile 27 hastadan oluşuyordu. Hastaların morbiditeleri, görüntüleme yöntemleri, tıkanıklığın lokalizasyonu, greft tipi ve endovasküler işlem, damar açıklığı, hastanede kalış süresi, kan transfüzyonu, revizyon ve komplikasyonlar değerlendirildi ve analiz edildi. \u0000Bulgular: Grup I'de femoral arter tıkanıklığı (%72.7) çoğunluktayken, Grup II'de iliak arter (%66.7) idi. Grup I'de 3, Grup II'de balon uygulanan 14 hasta vardı. Vasküler açıklık açısından Grup I'de 10 (%45,5) hastada greftler, Grup II'de ise 12 (%54,5) hastada stent tıkandı. Grup I'de on beş hastaya, Grup II'de altı hastaya kan transfüzyonu yapıldı. \u0000Sonuç Grup I'de greft açıklık oranı daha yüksek, cerrahi tedavinin yeniden revaskülarizasyon oranı endovasküler tedaviye göre daha düşüktü. En yüksek greft açıklık oranı, safen venlerden sonra Dakron greftlerde görüldü. Grup I hastalara Grup II hastalarından daha fazla kan transfüzyonu yapıldı ve hastanede kalış süreleri uzatıldı.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80158289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using small size grafts in live donor liver transplantation: Is graft size important?","authors":"Eryiğit Eren, A. Dinckan","doi":"10.31362/patd.1265140","DOIUrl":"https://doi.org/10.31362/patd.1265140","url":null,"abstract":"Purpose: In living donor liver transplantation, it is preferred that the ratio of the weight of the graft to the weight of the recipient (GRWR) be higher than 0.8%. We aimed to compare recipients with a GRWR greater than 0.8% and those with a small GRWR regarding post-transplant complications and outcomes. \u0000Materials and Methods: Data of the patients who had undergone living donor liver transplant surgery in Istinye University Hospital Liver Transplant Unit between January 2017 and July 2022 were reviewed. The study group patients were classified as GRWR1% (Group 3) and compared regarding clinical data, complications, and mortality rates. \u0000Results: Liver transplant recipients from 220 living donors were included. The mean recipient age was 53.6 (18-79). The comparative analysis between Group 1 (n=29), Group 2 (n=70), and Group 3 (n=121) revealed significant differences concerning the rates of bile leak and the length of hospital stay (p=0.033, p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79392596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}