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Pain therapy in multiple myeloma — clinical experience from an observational study 多发性骨髓瘤的疼痛治疗——一项观察性研究的临床经验
Pub Date : 2006-04-01 DOI: 10.1163/156856906776760380
H. Lannert
Abstract Aim: The aim of the present study was the documentation and evaluation of analgesic therapy in patients with multiple myeloma. Method: As part of a chemotherapy optimisation study, the patients' pain therapy was documented. The severity of pain was recorded using a visual analogue scale (VAS) from 0 (neither pain nor impairment) to 10 (greatest imaginable pain, and very severe impairment). Follow-up examinations took place after 3 days, 1 month and 3 months. Results: 123 patients (60.9%) of 202 patients with multiple myeloma stage III, were treated with analgesics because of severe pain. The average duration of documentation was 11.6 months. One hundred patients received analgesics orally or transdermally, and 32 of these patients received oral controlled-release hydromorphone (Palladon® retard). The remaining patients received analgesic treatment with bisphosponates i.v. and non-medication measures. Four patients (n = 19) were treated with a transdermal system and 8 patients who received a diffe...
摘要目的:本研究的目的是记录和评价多发性骨髓瘤患者的镇痛治疗。方法:作为化疗优化研究的一部分,记录了患者的疼痛治疗。使用视觉模拟评分(VAS)记录疼痛的严重程度,从0(无疼痛和损害)到10(可想象的最大疼痛和非常严重的损害)。随访时间分别为3天、1个月和3个月。结果:202例多发性骨髓瘤III期患者中,123例(60.9%)因疼痛剧烈而使用了镇痛药。记录的平均时间为11.6个月。100例患者口服或经皮给药,其中32例患者口服控释氢吗啡酮(Palladon®retard)。其余患者接受双膦酸盐静脉注射镇痛和非药物治疗。4例患者(n = 19)接受透皮系统治疗,8例患者接受差异治疗。
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引用次数: 3
Clinical Evaluation of Pain 疼痛的临床评价
Pub Date : 2006-04-01 DOI: 10.1163/156856906776760461
M. Zoppi, M. Maresca
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引用次数: 1
Prevalence of pain among adults in Turkey 土耳其成年人疼痛的患病率
Pub Date : 2006-04-01 DOI: 10.1163/156856906776760489
O. Hamzaoglu, Ozlem Ozkan, S. Erdine, Ecehan Balta, Mehmet Domac
Abstract Background: Epidemiological studies suggest that pain is an important public health problem. Aim: To determine prevalence of pain and the characteristics of pain symptoms. Method: A cross-sectional study was performed on the adult population in Turkey. This study was carried out in 15 cities selected from five demographic regions with a questionnaire consisting of 28 questions, and 2994 participants were interviewed with face-to-face interviews. Data were analyzed with chi-squared and Fisher exact tests. Results: The prevalence of pain among adults in Turkey was 63.7%. The prevalence increased with age and was higher in females, urban residents, in western and central regions than in males, rural residents and other demographic regions (p < 0.001). The most involved age was 55–65 years. The prevalence of pain in head, lower back, lower extremities and abdomen was 34.4%, 14.1%, 12.0% and 10.9%, respectively.
背景:流行病学研究表明,疼痛是一个重要的公共卫生问题。目的:了解疼痛的患病率和疼痛症状的特点。方法:对土耳其成年人进行横断面研究。本研究选取5个人口区域的15个城市进行调查,问卷共28个问题,对2994名参与者进行了面对面访谈。数据分析采用卡方检验和Fisher精确检验。结果:土耳其成人疼痛患病率为63.7%。随着年龄的增长,女性、城市居民和中西部地区的患病率高于男性、农村居民和其他人口统计地区(p < 0.001)。最常见的年龄是55-65岁。头部、下背部、下肢和腹部疼痛的发生率分别为34.4%、14.1%、12.0%和10.9%。
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引用次数: 7
The role of nitric oxide on the analgesic effect of tramadol 一氧化氮对曲马多镇痛作用的影响
Pub Date : 2006-04-01 DOI: 10.1163/156856906776760498
D. Karaaslan, T. Peker, T. Karaaslan, S. Özmen, F. Gultekin, Emin Şavik
Abstract Aims: The involvement of NO modulation in tramadol's mechanism of action is demonstrated indirectly by the alteration of the effect with the use of nitric oxide synthase inhibitor nitroG-L-arginine methyl ester (L-NAME). We aimed to investigate the alterations in serum and spinal cord NO levels following tramadol used alone or in combination with L-NAME or specific neuronal nitric oxide synthase (NOS) inhibitor 7-nitroindazole (7-NI), beside the changes in tail immersion reponses. Methods: Seventy-seven rats were randomly allocated into 7 groups. Group 1: sham group; Group 2: no drug; Group 3: tramadol 10 mg kg−1; Group 4: L-NAME 5 mg kg−1 + tramadol 10 mg kg−1; Group 5: L-NAME 10 mg kg−1 + tramadol 10 mg kg−1; Group 6: 7-NI 50 mg kg−1 + tramadol 10 mg kg−1; Group 7: 7-NI 100 mg kg−1 + tramadol 10 mg kg−1. Apart from Group 1, all the animals were exposed to a tail immersion test before medications (baseline) and 15 min after the tramadol injection. Following the tail-immersion test, a blood sampl...
摘要目的:一氧化氮合酶抑制剂硝基- l -精氨酸甲酯(L-NAME)对曲马多作用的改变间接证明了NO调节参与曲马多的作用机制。我们的目的是研究曲马多单独使用或与L-NAME或特异性神经元一氧化氮合酶(NOS)抑制剂7-硝基吲唑(7-NI)联合使用后血清和脊髓NO水平的变化,以及尾部浸泡反应的变化。方法:77只大鼠随机分为7组。第1组:假手术组;第二组:未用药;第三组:曲马多10 mg kg−1;第4组:L-NAME 5 mg kg−1 +曲马多10 mg kg−1;第5组:L-NAME 10 mg kg−1 +曲马多10 mg kg−1;第6组:7-NI 50 mg kg−1 +曲马多10 mg kg−1;第7组:7- ni 100 mg kg−1 +曲马多10 mg kg−1。除第1组外,所有动物在用药前(基线)和曲马多注射后15 min进行尾浸试验。在尾浸试验之后,血液样本…
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引用次数: 4
Does spinal anesthesia decrease the incidence of phantom pain 脊髓麻醉能降低幻肢痛的发生率吗
Pub Date : 2006-04-01 DOI: 10.1163/156856906776760353
F. Uğur, Alive Esmaoglu, A. Akin, S. Ors, H. Aydoğan, N. Gulcu, A. Boyaci
Abstract The objective of this retrospective study is to evaluate the effects of anesthesia type on phantom pain or sensation. A questionnaire of ten questions on phantom pain and sensation was sent by mail to patients who underwent lower extremity amputation surgery between 1996 and 2003 at Erciyes University Hospital. A total of 40 patients (age 51.0 ± 10.7 years, 80% male) who had general anesthesia and 27 patients (age 56.3 ± 14.0 years, 78% male) who had spinal anesthesia returned the questionnaire.Phantom pain incidences were defined as 33% in the spinal anesthesia group and 65% in the general anesthesia group and the difference was statistically significant. Phantom sensation incidences were 74% in the spinal anesthesia group and 77% in the general anesthesia group and the difference was not statistically significant. In conclusion, phantom pain incidence was lower in amputees treated with spinal anesthesia.
摘要本回顾性研究的目的是评估麻醉类型对幻肢痛或感觉的影响。1996年至2003年间,在埃尔西耶斯大学医院(Erciyes University Hospital)接受过下肢截肢手术的患者通过邮件收到了一份包含10个问题的幻痛和感觉问卷。共有40例全麻患者(年龄51.0±10.7岁,男性占80%)和27例腰麻患者(年龄56.3±14.0岁,男性占78%)进行问卷调查。定义腰麻组幻肢痛发生率为33%,全麻组为65%,差异有统计学意义。脊髓麻醉组幻感发生率为74%,全身麻醉组为77%,差异无统计学意义。综上所述,脊髓麻醉治疗的截肢患者幻肢痛发生率较低。
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引用次数: 1
Comparison between effectiveness of intravenous patient-controlled analgesia and epidural analgesia in patients undergoing Cesarean section 剖宫产术患者静脉自控镇痛与硬膜外镇痛效果比较
Pub Date : 2006-03-03 DOI: 10.1163/156856906775249758
Y. Chen, Kuan-Hung Chen, Chien-Hui Yang, A. Concejero, C.-H. Wang, Tsung Shing Lee, K. W. Cheng, C. Tseng, B. Jawan
Abstract The aim of this study is to compare the effectiveness of epidural versus intravenous patient-controlled analgesia (PCA) during the post-cesarean section (CS) period. The anesthesia records and pain control charts of 90 patients undergoing CS from July 2003 to April 2004 were retrospectively analyzed. Twelve patients for emergency delivery and patients who refused to undergo regional anesthesia were grouped in Group I (GI); 78 patients received epidural anesthesia and were put in Group II (GII). Fourteen per cent of our patients received intravenous PCA following general anesthesia for CS. No differences in age, weight and Visual Analogue Scale (VAS) values on days 1–3 after intervention were observed between groups, but the total dose of morphine requirement to achieve adequate post-CS pain relief was significantly higher in GI than in GII.
摘要:本研究的目的是比较剖宫产后(CS)期间硬膜外镇痛与静脉自控镇痛(PCA)的有效性。回顾性分析2003年7月至2004年4月90例CS患者的麻醉记录和疼痛控制图。12例紧急分娩患者和拒绝区域麻醉患者分为I组(GI);78例患者行硬膜外麻醉,设II组(GII)。14%的患者在全身麻醉后接受静脉PCA治疗。干预后1-3天,各组患者的年龄、体重和视觉模拟评分(VAS)均无差异,但GI组为达到cs后疼痛缓解所需吗啡总剂量明显高于GII组。
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引用次数: 0
The effects of heat on osteoarthritis of the knee 热对膝关节骨关节炎的影响
Pub Date : 2006-01-01 DOI: 10.1163/156856906775249802
K. Öneş, S. Tetik, C. Tetik, Nadir Öneş
AbstractThe aim of our study was to evaluate the effects of the manual physical therapy methods conducted by superficial and deep heat treatments of primary bilateral knee osteoarthritis. A randomized, controlled trial was carried out. Eighty patients (160 knees) were included in the analysis. The patients were separated into two groups. Group I (n: 80 knees) performed daily physical therapy programs (ultrasounds, hot packs and exercises) in a period of fifteen days. Group II (n: 80 knees) performed only daily exercise programs in this period.Pain was evaluated by visual analogue scale (VAS) and WOMAC pain scale. Stiffness and functional capacity were measured by WOMAC osteoarthritis index at baseline, at the third and sixteenth weeks. At the third and sixteenth weeks, significant improvement in VAS, WOMAC were observed in both groups, when compared to baseline measures (Group I: p < 0.01, Group II: p < 0.05). At the sixteenth week, more significant improvement was observed in Group 1 than in Group II (p ...
摘要本研究的目的是评价浅层热疗和深层热疗对原发性双侧膝骨关节炎的治疗效果。进行了一项随机对照试验。80例患者(160个膝关节)纳入分析。将患者分为两组。第一组(80个膝盖)在15天内每天进行物理治疗项目(超声波、热敷和锻炼)。第二组(80个膝盖)在此期间只进行日常锻炼。采用视觉模拟评分法(VAS)和WOMAC疼痛评分法评估疼痛。在基线、第3周和第16周采用WOMAC骨关节炎指数测量僵硬度和功能能力。在第3周和第16周,两组患者的VAS、WOMAC均较基线值有显著改善(I组:p < 0.01, II组:p < 0.05)。在第16周,第1组比第2组有更显著的改善(p < 0.05)。
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引用次数: 10
Reliability and validity of a pain matching method of a pain induction apparatus 疼痛感应装置疼痛匹配方法的信度和效度
Pub Date : 2006-01-01 DOI: 10.1163/156856906775249785
J. Lewis, D. Fishbain, Alesia Jones Parra Sipes, S. Asfour, B. Cole, R. Cutler, R. S. Rosomoff, H. Rosomoff
Abstract Aims: Measuring clinical pain is hampered by few methods which properly compare values across patients. The purpose of this study is to describe a method to induce pain, assess pain threshold and tolerance, and determine a matching score for the visual analog scale. Method: An experimental apparatus was used to induce pain. Thirty-six healthy subjects and 10 patients participated. Healthy subjects and pain patients were assessed for strength, pain threshold, and pain tolerance on both hands, and the patients were measured on the matching score and the visual analog scale. Data were evaluated for internal consistency, test–retest reliability, and convergent validity. Results: The apparatus was internally consistent and reliable in provoking experimental pain. Validity was found between the visual analog scale and the matching pain score. Strength correlated with pain for healthy subjects, but not among patients. Conclusions: The apparatus was useful for inducing and studying experimental pain and ...
摘要目的:测量临床疼痛的方法很少,无法正确地比较患者之间的值。本研究的目的是描述一种方法来诱导疼痛,评估疼痛阈值和耐受性,并确定视觉模拟量表的匹配评分。方法:采用实验装置诱导疼痛。36名健康受试者和10名患者参与。对健康受试者和疼痛患者进行双手强度、疼痛阈值和疼痛耐受性评估,并对患者进行匹配评分和视觉模拟量表的测量。评估数据的内部一致性、重测信度和收敛效度。结果:该装置在引起实验性疼痛方面具有内在一致性和可靠性。视觉模拟量表与匹配疼痛评分之间存在效度。在健康受试者中,力量与疼痛相关,但在患者中则不然。结论:该装置可用于实验性疼痛的诱导和研究。
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引用次数: 4
Management of CRPS type II unresponsive to sympathetic nerve block with trigger points injection 触发点注射治疗交感神经阻滞无反应的CRPS II型
Pub Date : 2006-01-01 DOI: 10.1163/156856906775249866
S. Yoon, H. Lee, H. Lim, S. Yoon, S. Chang
Abstract Objective: Complex regional pain syndromes (CRPS) type II (causalgia) is one of the causes of neuropathic pain. For the management of CRPS type II, various kinds of medications, nerve block, intravenous lidocaine and neurostimulation are used. We report good results by injection of trigger points around the left calf and lateral dorsum of the foot after unsuccessful different treatments in a patient with CRPS type II. Case Report: The authors describe a twenty-three year old female patient with CRPS type II after damage to the left sciatic and tibial nerves. The continuous epidural administration of opioids and local anesthetics, and oral medication with phenoxybenzamine did not sufficiently control the pain. Pain control was satisfactory with injections into the trigger points in the involved limb muscles. After six years, the patient complains of only slight tingling sensations around the left little toe.
目的:复杂区域疼痛综合征(CRPS) II型(causalgia)是神经性疼痛的病因之一。II型CRPS的治疗采用多种药物治疗,包括神经阻滞、静脉注射利多卡因和神经刺激。我们报道了一名II型CRPS患者在不同治疗失败后,通过注射左小腿和足外侧背周围的触发点取得了良好的效果。病例报告:作者描述了一位23岁的女性患者,在左侧坐骨神经和胫神经损伤后出现CRPS II型。持续硬膜外给药阿片类药物和局部麻醉剂以及口服苯氧苄胺不能充分控制疼痛。在受累肢体肌肉的触发点注射,疼痛控制令人满意。六年后,病人抱怨只有左小脚趾周围有轻微的刺痛感。
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引用次数: 2
Fibromyalgia, obesity and obesity related measurements 纤维肌痛,肥胖和肥胖相关的测量
Pub Date : 2006-01-01 DOI: 10.1163/156856906775249884
Hayal Güler, G. Sahin, Ismet As
Abstract Objective: To evaluate the relationship between obesity and fibromyalgia (FM). Methods: 241 female patients with FM were seen consecutively in outpatient clinic and they were analyzed. Spearman correlation was used. The relationship between FM and obesity was compared with respect to the BMI (body mass index) value. A p value of 0.05 was accepted as significant. Results: Body mass index was significantly correlated with age in FM patients. BMI was also correlated with waist/hip ratio. A significant positive correlation was found between health assessment questionnaire (HAQ) and VAS score in all patients. HAQ was also correlated positively with tender points (P 25 were considered as obese. Obese patients were older than non-obese patients. The values of waist/hip ratio and skin fold thickness and number of tender points were higher in obese patients. Also, the mean duration of disea...
摘要目的:探讨肥胖与纤维肌痛(FM)的关系。方法:对门诊就诊的241例女性FM患者进行分析。采用Spearman相关。比较FM与肥胖之间的BMI(身体质量指数)值关系。p值0.05为显著性。结果:FM患者体重指数与年龄有显著相关性。BMI也与腰臀比相关。所有患者的健康评估问卷(HAQ)与VAS评分均呈显著正相关。HAQ与压痛点呈正相关(p25为肥胖)。肥胖患者比非肥胖患者年龄大。肥胖患者腰臀比、皮肤褶皱厚度、压痛点数较高。而且,平均患病时间…
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引用次数: 2
期刊
Pain Clinic
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