Pub Date : 2006-10-01DOI: 10.1179/016911106779498984
Esmeralda García-Fernández, Juan F. Godoy-Garcia, J. Jiménez-Alonso, D. Godoy-Izquierdo, M. Pérez-García, I. López-Chicheri
Abstract Aims: The objective of this study was to establish the reliability and validity of the measurement of the pressure pain threshold using the Dolorimetro Electronico Portatil (Portable Electronic Dolorimeter) (DEP®) in persons without pain (12 men and 18 women) and in patients with chronic pain (16 women with systemic lupus erythematosus, 16 women with fibromyalgia and 15 women with rheumatoid arthritis). Methods: The assessment of the pressure pain threshold using the DEP® was done over three sessions with a 15 minute interval between the first and second session, and a 7 day interval between the second and third session. Each session comprised two trials in which 24 pressure points were evaluated. Results: Regarding reliability, high correlation coefficients were obtained in the three temporal conditions (within sessions without interval: ρ = 0.922, p < 0.001; inmediate, or brief interval between sessions (15 min): ρ = 0.932, p < 0.001; demorated, or long interval between sessions (7 days): ρ = 0...
摘要目的:本研究的目的是建立在无痛人群(12名男性和18名女性)和慢性疼痛患者(16名患有系统性红斑狼疮的女性、16名患有纤维肌痛的女性和15名患有类风湿关节炎的女性)中使用Dolorimetro Electronico Portatil(便携式电子疼痛计)(DEP®)测量压力痛阈值的信度和效度。方法:使用DEP®评估压力痛阈值分为三个阶段，第一阶段和第二阶段之间间隔15分钟，第二阶段和第三阶段之间间隔7天。每个疗程包括两个试验，其中24个压力点进行评估。结果:在信度方面，三种时间条件下(无间隔时段内)均获得较高的相关系数:ρ = 0.922, p < 0.001;两组间的即时或短暂间隔(15分钟):ρ = 0.932, p < 0.001;士气低落，或会议间隔时间长(7天):ρ = 0…
{"title":"Reliability and validity of the pain threshold measurement with the Dolorímetro Electrónico Portátil ® (Portable Electronic Dolorimeter) in healthy individuals and patients with musculoskeletal pain","authors":"Esmeralda García-Fernández, Juan F. Godoy-Garcia, J. Jiménez-Alonso, D. Godoy-Izquierdo, M. Pérez-García, I. López-Chicheri","doi":"10.1179/016911106779498984","DOIUrl":"https://doi.org/10.1179/016911106779498984","url":null,"abstract":"Abstract Aims: The objective of this study was to establish the reliability and validity of the measurement of the pressure pain threshold using the Dolorimetro Electronico Portatil (Portable Electronic Dolorimeter) (DEP®) in persons without pain (12 men and 18 women) and in patients with chronic pain (16 women with systemic lupus erythematosus, 16 women with fibromyalgia and 15 women with rheumatoid arthritis). Methods: The assessment of the pressure pain threshold using the DEP® was done over three sessions with a 15 minute interval between the first and second session, and a 7 day interval between the second and third session. Each session comprised two trials in which 24 pressure points were evaluated. Results: Regarding reliability, high correlation coefficients were obtained in the three temporal conditions (within sessions without interval: ρ = 0.922, p < 0.001; inmediate, or brief interval between sessions (15 min): ρ = 0.932, p < 0.001; demorated, or long interval between sessions (7 days): ρ = 0...","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"14 1","pages":"377-386"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89503785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-10-01DOI: 10.1163/156856906778704641
M. Fukusaki, M. Miyako, C. Inadomi, K. Yamashita, Y. Terao, K. Sumikawa
Abstract Aim: This study was carried out to determine the dose–response relationship of the effects of prostaglandin E1 (PGE1) on the nerve root blood flow and the neurologic symptoms after lumbar decompressive surgery using laser Doppler flowmetry. Methods: Fifty-four patients undergoing lumbar laminectomy were randomly assigned to one of three groups. Each group received intravenously one of three test solutions; 10 ml of saline in group A (N = 18), 10 ml of saline containing PGE1, 20 μg, in group B (N = 18), and 10 ml of saline containing PGE1, 50 μg, in group C (N = 18). After lumbar laminectomy, a probe of laser Doppler flowmetry was placed directly on the lumbar nerve root. Nerve root blood flow (RBF) velocity was measured before the injection of test solution (T1), at 5 min (T2) and 10 min (T3) after starting injection, and 10 min after the end of injection (T4). A visual analogue scale (VAS) and the walking distance were measured for assessment of neurologic symptoms before and after surgery. Resu...
摘要目的:本研究采用激光多普勒血流法，探讨前列腺素E1 (PGE1)对腰椎减压术后神经根血流及神经系统症状影响的量效关系。方法:54例腰椎椎板切除术患者随机分为三组。每组静脉注射三种测试溶液中的一种;A组生理盐水10 ml (N = 18)， B组生理盐水10 ml (N = 18)，含PGE1生理盐水20 μg, C组生理盐水10 ml (N = 18)。腰椎椎板切除术后，激光多普勒血流仪探头直接置于腰神经根。测定试验液注射前(T1)、开始注射后5 min (T2)、10 min (T3)、注射结束后10 min (T4)时神经根血流速度(RBF)。采用视觉模拟量表(VAS)和步行距离评估手术前后神经系统症状。效果……
{"title":"A dose–response study of prostaglandin E1 on nerve root blood flow velocity and neurologic symptoms after lumbar spinal decompression in surgical patients","authors":"M. Fukusaki, M. Miyako, C. Inadomi, K. Yamashita, Y. Terao, K. Sumikawa","doi":"10.1163/156856906778704641","DOIUrl":"https://doi.org/10.1163/156856906778704641","url":null,"abstract":"Abstract Aim: This study was carried out to determine the dose–response relationship of the effects of prostaglandin E1 (PGE1) on the nerve root blood flow and the neurologic symptoms after lumbar decompressive surgery using laser Doppler flowmetry. Methods: Fifty-four patients undergoing lumbar laminectomy were randomly assigned to one of three groups. Each group received intravenously one of three test solutions; 10 ml of saline in group A (N = 18), 10 ml of saline containing PGE1, 20 μg, in group B (N = 18), and 10 ml of saline containing PGE1, 50 μg, in group C (N = 18). After lumbar laminectomy, a probe of laser Doppler flowmetry was placed directly on the lumbar nerve root. Nerve root blood flow (RBF) velocity was measured before the injection of test solution (T1), at 5 min (T2) and 10 min (T3) after starting injection, and 10 min after the end of injection (T4). A visual analogue scale (VAS) and the walking distance were measured for assessment of neurologic symptoms before and after surgery. Resu...","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"17 1","pages":"287-295"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74844309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-10-01DOI: 10.1163/156856906778704632
S. M. Ozbek, M. S. Evcil, A. Ozbek, A. Erdoğan, M. Köseoğlu
Abstract Objective: The periapical abscess is a collection of pus in the pulp or around the root of teeth. Many odontogenic infections can be managed without antimicrobial therapy or bacteriologic investigation. However, when an acute bacterial infection has progressed or antimicrobial therapy might be of benefit to patients, antibiotics are prescribed. We aimed to identify microorganisms in root canals with periapical abscess and their antimicrobial susceptibility profile in order to revise antimicrobial treatment protocols when antimicrobials are used empirically. Methods: 30 patients (all of whom had pain and swelling) with odontogenic infections were included in this study. The microbiologic investigation was performed under strict aseptic conditions. A standard routine root canal therapy was instituted, and in each case a single root canal was sampled. In multirooted teeth only the largest canal was sampled to preserve the identity of a single endodontic/microbiologic ecosystem. For microbial samplin...
{"title":"Microbiological analysis of root canals associated with periapical abscesses (with pain and swelling) and the antimicrobial susceptibility of isolated bacteria","authors":"S. M. Ozbek, M. S. Evcil, A. Ozbek, A. Erdoğan, M. Köseoğlu","doi":"10.1163/156856906778704632","DOIUrl":"https://doi.org/10.1163/156856906778704632","url":null,"abstract":"Abstract Objective: The periapical abscess is a collection of pus in the pulp or around the root of teeth. Many odontogenic infections can be managed without antimicrobial therapy or bacteriologic investigation. However, when an acute bacterial infection has progressed or antimicrobial therapy might be of benefit to patients, antibiotics are prescribed. We aimed to identify microorganisms in root canals with periapical abscess and their antimicrobial susceptibility profile in order to revise antimicrobial treatment protocols when antimicrobials are used empirically. Methods: 30 patients (all of whom had pain and swelling) with odontogenic infections were included in this study. The microbiologic investigation was performed under strict aseptic conditions. A standard routine root canal therapy was instituted, and in each case a single root canal was sampled. In multirooted teeth only the largest canal was sampled to preserve the identity of a single endodontic/microbiologic ecosystem. For microbial samplin...","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"70 1","pages":"327-337"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86388615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-10-01DOI: 10.1163/156856906778704650
Zhaoxin Ma, Ming Li, Ling Qi
Abstract Objective: To further investigate the ultrastructural features of trigeminal nerve root in patients with trigeminal neuralgia without vascular compression. Methods: Trigeminal nerve root biopsy specimens were excised from 12 patients scheduled to undergo posterior fossa craniotomy and root exploration. In 12 of 106 patients no vascular compression was detected. Partial trigeminal posterior rhizotomy was performed. A biopsy sample was taken from the cut portion of the root, followed by electron microscopic examination. Results: The primary finding was the pronounced involvement of the myelin sheath and Schwann cells. In 10 out of 12 specimens, there were some claviform steroid crystals in the Schwann cell cytoplasm. Myelin filled came to fill the liposomes. In all specimens, dysmyelination and demyelination were the main changes of the myelin sheath. Conclusion: Claviform steroid crystals in Schwann cell cytoplasm and lipid deposition in the inner myelin sheath of trigeminal root were found.
{"title":"Ultrastructural findings of idiopathic trigeminal neuralgia","authors":"Zhaoxin Ma, Ming Li, Ling Qi","doi":"10.1163/156856906778704650","DOIUrl":"https://doi.org/10.1163/156856906778704650","url":null,"abstract":"Abstract Objective: To further investigate the ultrastructural features of trigeminal nerve root in patients with trigeminal neuralgia without vascular compression. Methods: Trigeminal nerve root biopsy specimens were excised from 12 patients scheduled to undergo posterior fossa craniotomy and root exploration. In 12 of 106 patients no vascular compression was detected. Partial trigeminal posterior rhizotomy was performed. A biopsy sample was taken from the cut portion of the root, followed by electron microscopic examination. Results: The primary finding was the pronounced involvement of the myelin sheath and Schwann cells. In 10 out of 12 specimens, there were some claviform steroid crystals in the Schwann cell cytoplasm. Myelin filled came to fill the liposomes. In all specimens, dysmyelination and demyelination were the main changes of the myelin sheath. Conclusion: Claviform steroid crystals in Schwann cell cytoplasm and lipid deposition in the inner myelin sheath of trigeminal root were found.","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"7 1","pages":"339-344"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76723313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-10-01DOI: 10.1179/016911106779499055
A. O. Bayrak, H. Türker, M. Onar
AbstractNeuropathic pain is by definition a chronic pain initiated or caused by a primary lesion or dysfunction of the peripheral or central nervous system. Since multiple complex pathophysiological mechanisms are supposed to be the cause for neuropathic pain, therapeutic approaches vary among physicians. In this article we report three cases with neuropathic pain and discuss therapeutic approaches with current trends while pointing out some important problems arising in everyday practice.
{"title":"Neuropathic pain with case examples and current therapeutic approaches","authors":"A. O. Bayrak, H. Türker, M. Onar","doi":"10.1179/016911106779499055","DOIUrl":"https://doi.org/10.1179/016911106779499055","url":null,"abstract":"AbstractNeuropathic pain is by definition a chronic pain initiated or caused by a primary lesion or dysfunction of the peripheral or central nervous system. Since multiple complex pathophysiological mechanisms are supposed to be the cause for neuropathic pain, therapeutic approaches vary among physicians. In this article we report three cases with neuropathic pain and discuss therapeutic approaches with current trends while pointing out some important problems arising in everyday practice.","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"41 1","pages":"387-393"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85752723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-10-01DOI: 10.1179/016911106779498966
M. Komori, A. Fukuuchi, Tomoko Mae, K. Nishiyama, M. Kawamata, M. Ozaki
AbstractWe studied the effect of milnacipran hydrochloride, a newly developed serotonin-noradrenaline-reuptake-inhibitor antidepressant with minimal side effects, in 12 patients with postherpetic neuralgia. All patients had a pain score of at least 40 on a visual-analogue scale (VAS) ranging from 0 (no pain) to 100 (worst pain possible), 3 months after the resolution of herpes zoster. Their pain did not respond to nerve blocks and could not be adequately controlled by currently used drugs. Milnacipran was given at an initial dose of 15 mg/day. The dose was then adjusted according to symptoms. The mean VAS score after 8 weeks of treatment with milnacipran (28.0 ± 17.5) significantly decreased, as compared with the baseline value (68.0 ± 16.9, p < 0.05). The mean daily dose of milnacipran was 52.0 ± 35.1 mg. No relevant side effects were observed. We conclude that milnacipran is useful in patients with postherpetic neuralgia refractory to conventional treatment.
{"title":"Milnacipran hydrochloride for the treatment of postherpetic neuralgia","authors":"M. Komori, A. Fukuuchi, Tomoko Mae, K. Nishiyama, M. Kawamata, M. Ozaki","doi":"10.1179/016911106779498966","DOIUrl":"https://doi.org/10.1179/016911106779498966","url":null,"abstract":"AbstractWe studied the effect of milnacipran hydrochloride, a newly developed serotonin-noradrenaline-reuptake-inhibitor antidepressant with minimal side effects, in 12 patients with postherpetic neuralgia. All patients had a pain score of at least 40 on a visual-analogue scale (VAS) ranging from 0 (no pain) to 100 (worst pain possible), 3 months after the resolution of herpes zoster. Their pain did not respond to nerve blocks and could not be adequately controlled by currently used drugs. Milnacipran was given at an initial dose of 15 mg/day. The dose was then adjusted according to symptoms. The mean VAS score after 8 weeks of treatment with milnacipran (28.0 ± 17.5) significantly decreased, as compared with the baseline value (68.0 ± 16.9, p < 0.05). The mean daily dose of milnacipran was 52.0 ± 35.1 mg. No relevant side effects were observed. We conclude that milnacipran is useful in patients with postherpetic neuralgia refractory to conventional treatment.","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"19 1","pages":"421-423"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85956242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-07-01DOI: 10.1163/156856906778026220
B. Balaban, M. Taşkaynatan, Serhat Gencdogan, A. Özgül, A. Tan, T. Kalyon
AbstractEwing's sarcoma is one of the most common malignant tumors of the musculoskeletal system in children, adolescents and young adults. Early recognition of this sarcoma and early treatment improves outcome. In the event of pelvic involvement, patients may have spinal symptoms and radiographic findings similar to discogenic pain or sacroiliitis. In this report. a 21-year-old male, who had clinical features mimicking unilateral sacroiliitis and lumbar disc syndrome, is described. His advanced radiographic evaluation and biopsy demonstrated Ewing's sarcoma of the pelvic girdle. Pelvic tumors in the differential diagnosis of low back pain are discussed.
{"title":"Ewing's sarcoma of the pelvic girdle mimicking the unilateral sacroiliitis and lumbar disc syndrome: Case report","authors":"B. Balaban, M. Taşkaynatan, Serhat Gencdogan, A. Özgül, A. Tan, T. Kalyon","doi":"10.1163/156856906778026220","DOIUrl":"https://doi.org/10.1163/156856906778026220","url":null,"abstract":"AbstractEwing's sarcoma is one of the most common malignant tumors of the musculoskeletal system in children, adolescents and young adults. Early recognition of this sarcoma and early treatment improves outcome. In the event of pelvic involvement, patients may have spinal symptoms and radiographic findings similar to discogenic pain or sacroiliitis. In this report. a 21-year-old male, who had clinical features mimicking unilateral sacroiliitis and lumbar disc syndrome, is described. His advanced radiographic evaluation and biopsy demonstrated Ewing's sarcoma of the pelvic girdle. Pelvic tumors in the differential diagnosis of low back pain are discussed.","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"92 1","pages":"259-262"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80421155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-07-01DOI: 10.1163/156856906778026176
P. Kirdemi̇r, A. Marsan, V. Kırdemir
Abstract Purpose: To compare post-operative analgesic effects of intra-articular (i.a.) drugs. Methods: After the approval of ethic committee, a randomized study on 68 patients undergoing knee arthroscopy was performed. In Group I (n = 16) 0.5 mg of neostigmine, in Group II (n = 14) 100 mg of tradamol, in Group III (n = 20) 20 mg of tenoxicam in 20 ml 0.9% NaCl solution and Group P (n = 18) 20 ml of 0.9% NaCl were injected i.a. at the end of the arthroscopy. The visual analogue scale, heart rate (HR), mean arterial pressure (MAP) values and side effects were recorded at intervals of 1, 2, 6 and 24 hours after the operation. Patient's satisfaction was also recorded. Results: The duration of analgesia in Group I was significantly longer than in the other groups. In Group III patients' satisfaction was excellent. One patient in Group I and Group II had nausea, one patient in Group II had somnolence. Conclusion: All drugs provided acceptable post-operative analgesia with excellent satisfaction in Group III. A...
{"title":"Comparing analgesic effect of intra-articular neostigmine, tramadol and tenoxicam with placebo","authors":"P. Kirdemi̇r, A. Marsan, V. Kırdemir","doi":"10.1163/156856906778026176","DOIUrl":"https://doi.org/10.1163/156856906778026176","url":null,"abstract":"Abstract Purpose: To compare post-operative analgesic effects of intra-articular (i.a.) drugs. Methods: After the approval of ethic committee, a randomized study on 68 patients undergoing knee arthroscopy was performed. In Group I (n = 16) 0.5 mg of neostigmine, in Group II (n = 14) 100 mg of tradamol, in Group III (n = 20) 20 mg of tenoxicam in 20 ml 0.9% NaCl solution and Group P (n = 18) 20 ml of 0.9% NaCl were injected i.a. at the end of the arthroscopy. The visual analogue scale, heart rate (HR), mean arterial pressure (MAP) values and side effects were recorded at intervals of 1, 2, 6 and 24 hours after the operation. Patient's satisfaction was also recorded. Results: The duration of analgesia in Group I was significantly longer than in the other groups. In Group III patients' satisfaction was excellent. One patient in Group I and Group II had nausea, one patient in Group II had somnolence. Conclusion: All drugs provided acceptable post-operative analgesia with excellent satisfaction in Group III. A...","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"44 1","pages":"231-236"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83039233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-07-01DOI: 10.1163/156856906778026185
E. Ibarra
Over the past fifty years, the subject of pain and its management has gained worldwide recognition, not only as a medical specialty, but also as a subject for both scientific research and philosophical analysis. In keeping with this interest, a number of approaches from a variety of disciplines have been considered, studied and/or developed, in an attempt to further a scientific and humanitarian understanding of the condition and optimize the treatment thereof. These approaches include the bio-psychological approach, multidisciplinary treatment, theories on modulation, the palliative approach, pain behavior methodology, and the use of psychological strategies. In addition, studies on membrane channels and receptors, neuropathic pain states and their changes within the nervous system, disruption using chemical agents on the channels involved in pain transmission, disruption of RNA transcription, the chemical alteration of central processes, the use of implantable neuromodulators, infusion devices, intradiscal interventions, radiofrequency related technologies and many more, bring us closer to understanding the phenomenon of pain and how it can be more effectively prevented, managed or eliminated. Many of the advances made in the area of pain understanding and treatment are due to the invaluable contributions and dedication of such great people as John Bonica,1 Romald Melzack,2 Patrick Wall,2 Prithvi Raj,3 Menno E. Sluijter,4 Gabor Racz5 and Ricardo Plancarte,6 to name just a few. However, let us not forget the humble professional who treats pain with the means available to him or her, and does so without appearing in the forum of the world-renowned. The work of these individuals undoubtedly deserves much admiration, respect and recognition. In addition, many other disciplines have contributed with valuable studies on the subject of pain, which offer the perspective of its broad implications in all aspects of society and on the general quality of human life. Most recently, a humanistic and legal analysis, recognizing pain as the most terrible flagellation of mankind since its origins7 and as a disease in its own right8 brought about worldwide recognition of the related proposition for the recognition of the Treatment of Pain as a Fundamental Human Right. The above brings deserved justice to fathers of the Universal Declaration of Human Rights9 on their awareness and recognition of human suffering due to pain, and the implicit inclusion of the right to its treatment within the right
在过去的五十年中，疼痛及其管理的主题不仅作为医学专业，而且作为科学研究和哲学分析的主题，已经获得了全世界的认可。为了保持这种兴趣，人们考虑、研究和/或开发了来自不同学科的许多方法，试图进一步从科学和人道主义的角度理解这种情况，并优化治疗方法。这些方法包括生物心理学方法、多学科治疗、调节理论、姑息疗法、疼痛行为方法和心理策略的使用。此外，研究膜通道和受体，神经性疼痛状态及其在神经系统内的变化，使用化学剂对参与疼痛传递的通道的破坏，RNA转录的破坏，中枢过程的化学改变，可植入神经调节剂的使用，输注装置，椎间盘内干预，射频相关技术等等。让我们更了解疼痛现象，以及如何更有效地预防、管理或消除疼痛。在疼痛理解和治疗领域取得的许多进步都要归功于诸如John Bonica, Romald Melzack, Patrick Wall, Prithvi Raj, Menno E. Sluijter, Gabor Racz5和Ricardo Plancarte等伟人的宝贵贡献和奉献，仅举几例。然而，让我们不要忘记谦卑的专业人士用他或她可用的手段治疗疼痛，并且没有出现在世界知名的论坛上。这些人的工作无疑值得钦佩、尊重和肯定。此外，许多其他学科也对疼痛这一主题做出了有价值的研究，这些研究为疼痛在社会各个方面和人类生活的总体质量方面的广泛影响提供了视角。最近，一项人道主义和法律分析认为，疼痛是人类自诞生以来遭受的最可怕的折磨，是一种本身就是一种疾病的疾病，这使全世界认识到治疗疼痛是一项基本人权的相关主张。上述情况为《世界人权宣言》的起草者们带来了应有的正义，因为他们意识到并承认了人类因痛苦而遭受的苦难，并将获得治疗的权利含蓄地纳入了权利之中
{"title":"A new definition of 'pain': an imperative of our times","authors":"E. Ibarra","doi":"10.1163/156856906778026185","DOIUrl":"https://doi.org/10.1163/156856906778026185","url":null,"abstract":"Over the past fifty years, the subject of pain and its management has gained worldwide recognition, not only as a medical specialty, but also as a subject for both scientific research and philosophical analysis. In keeping with this interest, a number of approaches from a variety of disciplines have been considered, studied and/or developed, in an attempt to further a scientific and humanitarian understanding of the condition and optimize the treatment thereof. These approaches include the bio-psychological approach, multidisciplinary treatment, theories on modulation, the palliative approach, pain behavior methodology, and the use of psychological strategies. In addition, studies on membrane channels and receptors, neuropathic pain states and their changes within the nervous system, disruption using chemical agents on the channels involved in pain transmission, disruption of RNA transcription, the chemical alteration of central processes, the use of implantable neuromodulators, infusion devices, intradiscal interventions, radiofrequency related technologies and many more, bring us closer to understanding the phenomenon of pain and how it can be more effectively prevented, managed or eliminated. Many of the advances made in the area of pain understanding and treatment are due to the invaluable contributions and dedication of such great people as John Bonica,1 Romald Melzack,2 Patrick Wall,2 Prithvi Raj,3 Menno E. Sluijter,4 Gabor Racz5 and Ricardo Plancarte,6 to name just a few. However, let us not forget the humble professional who treats pain with the means available to him or her, and does so without appearing in the forum of the world-renowned. The work of these individuals undoubtedly deserves much admiration, respect and recognition. In addition, many other disciplines have contributed with valuable studies on the subject of pain, which offer the perspective of its broad implications in all aspects of society and on the general quality of human life. Most recently, a humanistic and legal analysis, recognizing pain as the most terrible flagellation of mankind since its origins7 and as a disease in its own right8 brought about worldwide recognition of the related proposition for the recognition of the Treatment of Pain as a Fundamental Human Right. The above brings deserved justice to fathers of the Universal Declaration of Human Rights9 on their awareness and recognition of human suffering due to pain, and the implicit inclusion of the right to its treatment within the right","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"19 7 1","pages":"277-282"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86563281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-07-01DOI: 10.1163/156856906778026112
A. Tiwari, A. Singh, R. Verma, V. Rastogi, R. Agrawal
AbstractNeuroma is a painful condition and always a challenging situation for pain clinicians. Botulinum toxin (BoNT) is a neurotoxin and it provides analgesia, possibly by inhibiting acetylcholine release or blocking autonomic pathways. We report two interesting cases of neuroma in which botulinum toxin (BoNT) serotype-A was locally infiltrated (10 units into the trigger point), three times after an interval of one month each. We observed relief of pain after 10 days and a complete remission after 4 months.
{"title":"Botulinum toxin in management of neuroma pain: case report","authors":"A. Tiwari, A. Singh, R. Verma, V. Rastogi, R. Agrawal","doi":"10.1163/156856906778026112","DOIUrl":"https://doi.org/10.1163/156856906778026112","url":null,"abstract":"AbstractNeuroma is a painful condition and always a challenging situation for pain clinicians. Botulinum toxin (BoNT) is a neurotoxin and it provides analgesia, possibly by inhibiting acetylcholine release or blocking autonomic pathways. We report two interesting cases of neuroma in which botulinum toxin (BoNT) serotype-A was locally infiltrated (10 units into the trigger point), three times after an interval of one month each. We observed relief of pain after 10 days and a complete remission after 4 months.","PeriodicalId":19808,"journal":{"name":"Pain Clinic","volume":"68 1","pages":"263-265"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81677267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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