Pub Date : 2024-09-01Epub Date: 2023-12-13DOI: 10.23736/S0031-0808.23.04964-9
Xuan Lu, Fubi Jin, Shaomei Ni
{"title":"Correlation between blood glucose changes and sleep quality in type 2 diabetes patients with sleep disorders.","authors":"Xuan Lu, Fubi Jin, Shaomei Ni","doi":"10.23736/S0031-0808.23.04964-9","DOIUrl":"10.23736/S0031-0808.23.04964-9","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"349-351"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2021-09-21DOI: 10.23736/S0031-0808.21.04481-5
Zefeng Ren, Rongxiu Huang, Jie Zhang, Xianfeng Zhu, Yan Cai
{"title":"Application of nurse-patient communication in the nursing process of hypertension and its value analysis on the construction of harmonious nurse-patient relationship.","authors":"Zefeng Ren, Rongxiu Huang, Jie Zhang, Xianfeng Zhu, Yan Cai","doi":"10.23736/S0031-0808.21.04481-5","DOIUrl":"10.23736/S0031-0808.21.04481-5","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"355-357"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39435079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-07-11DOI: 10.23736/S0031-0808.24.05112-7
Mustafa Guldan, Lasin Ozbek, Ahmet U Topcu, Adrian Covic, Mehmet Kanbay
Obesity represents a prevalent global health concern with significant implications for various diseases, including chronic kidney disease (CKD). Within this landscape, the phenomenon of metabolically healthy obesity has emerged, challenging traditional notions about the health risks associated with excess weight. While traditional CKD risk factors involve obesity, metabolic syndrome, diabetes, and hypertension, the metabolically healthy obese (MHO) subgroup disrupts these assumptions. Our main objective in this study is to integrate existing literature on CKD in MHO individuals. In this endeavor, we delve into the pathophysiological foundations, the transition between obesity phenotypes and their impact on renal health, examine the implications of their metabolic resilience on mortality within a renal context, and explore potential management strategies specifically designed for MHO individuals. Offering a comprehensive overview of the pathophysiology, we cover various factors contributing to the risk of CKD in the metabolically healthy obese setting, including inflammation, cytokines, hemodynamics, and the renin-angiotensin-aldosterone system, gastrointestinal microbiota, diet, exercise, adipose distribution, and lipotoxicity. Through this synthesis, we aim to provide a comprehensive understanding of the risk of CKD in those classified as MHO.
{"title":"Metabolically healthy obesity and chronic kidney disease risk: exploring the dynamics.","authors":"Mustafa Guldan, Lasin Ozbek, Ahmet U Topcu, Adrian Covic, Mehmet Kanbay","doi":"10.23736/S0031-0808.24.05112-7","DOIUrl":"10.23736/S0031-0808.24.05112-7","url":null,"abstract":"<p><p>Obesity represents a prevalent global health concern with significant implications for various diseases, including chronic kidney disease (CKD). Within this landscape, the phenomenon of metabolically healthy obesity has emerged, challenging traditional notions about the health risks associated with excess weight. While traditional CKD risk factors involve obesity, metabolic syndrome, diabetes, and hypertension, the metabolically healthy obese (MHO) subgroup disrupts these assumptions. Our main objective in this study is to integrate existing literature on CKD in MHO individuals. In this endeavor, we delve into the pathophysiological foundations, the transition between obesity phenotypes and their impact on renal health, examine the implications of their metabolic resilience on mortality within a renal context, and explore potential management strategies specifically designed for MHO individuals. Offering a comprehensive overview of the pathophysiology, we cover various factors contributing to the risk of CKD in the metabolically healthy obese setting, including inflammation, cytokines, hemodynamics, and the renin-angiotensin-aldosterone system, gastrointestinal microbiota, diet, exercise, adipose distribution, and lipotoxicity. Through this synthesis, we aim to provide a comprehensive understanding of the risk of CKD in those classified as MHO.</p>","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"293-308"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-02-02DOI: 10.23736/S0031-0808.23.04912-1
Jiangli Lan, Lixia Pan, Yanyan Lu, Wei Hong, Di Zeng, Si Meng, Jifeng Feng, Jianqiu Zheng
{"title":"Safety and efficacy of different doses of oral mucosa midazolam combined with intranasal dexmedetomidine in sedation of infant head MRI examination.","authors":"Jiangli Lan, Lixia Pan, Yanyan Lu, Wei Hong, Di Zeng, Si Meng, Jifeng Feng, Jianqiu Zheng","doi":"10.23736/S0031-0808.23.04912-1","DOIUrl":"10.23736/S0031-0808.23.04912-1","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"331-332"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-11-30DOI: 10.23736/S0031-0808.23.05023-1
Congcong Liu, Lin Xu, Peipei Mou
{"title":"Acquired hemophilia A induced by clopidogrel.","authors":"Congcong Liu, Lin Xu, Peipei Mou","doi":"10.23736/S0031-0808.23.05023-1","DOIUrl":"10.23736/S0031-0808.23.05023-1","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"347-349"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138461530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the relationship between the oral microbiota and fasting blood glucose level based on the analysis of NHANES data.","authors":"Yafen Hu, Jiaqi Luo, Jiaxin Xie, Yihan Wang, Dongmei Bao, Lin Hua","doi":"10.23736/S0031-0808.23.04946-7","DOIUrl":"10.23736/S0031-0808.23.04946-7","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"334-336"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9923981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2021-09-21DOI: 10.23736/S0031-0808.21.04477-3
Guimei Feng, Juanjuan Meng, Mei Zhang
{"title":"Application effect of evidence-based nursing in patients with diabetic foot.","authors":"Guimei Feng, Juanjuan Meng, Mei Zhang","doi":"10.23736/S0031-0808.21.04477-3","DOIUrl":"10.23736/S0031-0808.21.04477-3","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"357-359"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39435078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-09-15DOI: 10.23736/S0031-0808.23.04969-8
Yafen Hu, Lin Hua
{"title":"Exploring the relationship between triglyceride and fasting blood glucose based on the combination of mendelian randomization and NHANES data analysis.","authors":"Yafen Hu, Lin Hua","doi":"10.23736/S0031-0808.23.04969-8","DOIUrl":"10.23736/S0031-0808.23.04969-8","url":null,"abstract":"","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"337-339"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10298686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2020-06-23DOI: 10.23736/S0031-0808.20.03990-7
Linxin Hou, Shasha Li, Mengmeng Zhao
Background: The global hypomethylation of CD4+ T cells in systemic lupus erythematosus (SLE) patients has been previously reported. However, potential influencing factors are unclear. This study aimed to uncover the potential influence of obese on hypomethylated CD4+ T cells in SLE patients.
Methods: Obese SLE patients with Body Mass Index (BMI)>30 (N.=15) and normal weight SLE patients with 18+ T cells isolated from SLE patients was assessed, as well as its correlation to BMI and Systemic Lupus Erythematosus Disease Activity Index (SLEADI) in SLE patients. Subsequently, relative level and catalytic activity of DNA (cytosine-5)-methyltransferase 1 (DNMT1) were examined. New Zealand black/white (NZB/W) mice were fed high-fat diet for generating obesity model or normal diet, followed by detection of antinuclear-ribonuclear-protein (nRNP) immunoglobulin G (IgG), antidouble-stranded (ds) DNA IgG, methylation rate of CD4+ T cells and DNMT1 level.
Results: SLEADI, nRNP and dsDNA levels were higher in obese SLE patients than normal weight cases. SLEADI was positively correlated to BMI in included SLE patients. Compared with normal weight SLE patients, methylation rate of CD4+ T cells was lower in obese patients. DNMT1 was downregulated in obese SLE patients, and its level was negatively correlated to BMI in SLE patients. Consistently, methylation rate of CD4+ T cells and DNMT1 level remained lower in obese SLE mice than those normally fed mice with SLE.
Conclusions: Hypomethylated CD4+ T cells extensively occur in SLE patients, which are much more pronounced in obese cases. DNMT1 level is found to be negatively correlated to the methylation rate of CD4+ T cells in SLE patients.
背景：以前曾有报道称，系统性红斑狼疮（SLE）患者的 CD4+ T 细胞存在全球性的低甲基化。然而，潜在的影响因素尚不清楚。本研究旨在揭示肥胖对系统性红斑狼疮患者 CD4+ T 细胞低甲基化的潜在影响：方法：纳入体重指数（BMI）大于 30 的肥胖系统性红斑狼疮患者（15 人）和体重指数小于 25 的正常体重系统性红斑狼疮患者（20 人）。检测他们体内的 SLEADI、nRNP 和 dsDNA 水平。评估了从系统性红斑狼疮患者体内分离出的 CD4+ T 细胞的甲基化率及其与系统性红斑狼疮患者体重指数和系统性红斑狼疮疾病活动指数（SLEADI）的相关性。随后，研究人员检测了 DNA（胞嘧啶-5）甲基转移酶 1（DNMT1）的相对水平和催化活性。给新西兰黑/白（NZB/W）小鼠喂食高脂饮食以产生肥胖模型或正常饮食，然后检测抗核-核蛋白（nRNP）免疫球蛋白G（IgG）、抗双链（ds）DNA IgG、CD4+ T细胞甲基化率和DNMT1水平：结果：肥胖系统性红斑狼疮患者的SLEADI、nRNP和dsDNA水平均高于正常体重病例。在纳入的系统性红斑狼疮患者中，SLEADI 与体重指数呈正相关。与体重正常的系统性红斑狼疮患者相比，肥胖患者 CD4+ T 细胞的甲基化率较低。肥胖系统性红斑狼疮患者的 DNMT1 下调，其水平与系统性红斑狼疮患者的体重指数呈负相关。肥胖系统性红斑狼疮小鼠的CD4+ T细胞甲基化率和DNMT1水平始终低于正常喂养的系统性红斑狼疮小鼠：结论：在系统性红斑狼疮患者中广泛存在 CD4+ T 细胞甲基化过高的现象，肥胖病例中更为明显。DNMT1水平与系统性红斑狼疮患者CD4+T细胞的甲基化率呈负相关。
{"title":"Obesity promotes the global hypomethylation of CD4+ T cells in patients with systemic lupus erythematosus via downregulating DNMT1.","authors":"Linxin Hou, Shasha Li, Mengmeng Zhao","doi":"10.23736/S0031-0808.20.03990-7","DOIUrl":"10.23736/S0031-0808.20.03990-7","url":null,"abstract":"<p><strong>Background: </strong>The global hypomethylation of CD4<sup>+</sup> T cells in systemic lupus erythematosus (SLE) patients has been previously reported. However, potential influencing factors are unclear. This study aimed to uncover the potential influence of obese on hypomethylated CD4<sup>+</sup> T cells in SLE patients.</p><p><strong>Methods: </strong>Obese SLE patients with Body Mass Index (BMI)>30 (N.=15) and normal weight SLE patients with 18<BMI<25 (N.=20) were included. SLEADI, antinuclear-ribonuclear-protein (nRNP) and dsDNA levels in them were detected. Methylation rate of CD4<sup>+</sup> T cells isolated from SLE patients was assessed, as well as its correlation to BMI and Systemic Lupus Erythematosus Disease Activity Index (SLEADI) in SLE patients. Subsequently, relative level and catalytic activity of DNA (cytosine-5)-methyltransferase 1 (DNMT1) were examined. New Zealand black/white (NZB/W) mice were fed high-fat diet for generating obesity model or normal diet, followed by detection of antinuclear-ribonuclear-protein (nRNP) immunoglobulin G (IgG), antidouble-stranded (ds) DNA IgG, methylation rate of CD4<sup>+</sup> T cells and DNMT1 level.</p><p><strong>Results: </strong>SLEADI, nRNP and dsDNA levels were higher in obese SLE patients than normal weight cases. SLEADI was positively correlated to BMI in included SLE patients. Compared with normal weight SLE patients, methylation rate of CD4<sup>+</sup> T cells was lower in obese patients. DNMT1 was downregulated in obese SLE patients, and its level was negatively correlated to BMI in SLE patients. Consistently, methylation rate of CD4<sup>+</sup> T cells and DNMT1 level remained lower in obese SLE mice than those normally fed mice with SLE.</p><p><strong>Conclusions: </strong>Hypomethylated CD4<sup>+</sup> T cells extensively occur in SLE patients, which are much more pronounced in obese cases. DNMT1 level is found to be negatively correlated to the methylation rate of CD4<sup>+</sup> T cells in SLE patients.</p>","PeriodicalId":19851,"journal":{"name":"Panminerva medica","volume":" ","pages":"237-241"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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