Pediatric dentistry最新文献

Purpose: The purpose of this study was to investigate changes in 25-hydroxyvitamin D (25(OH)D) levels in children with severe early childhood caries (S-ECC) following rehabilitative surgery using general anesthesia (GA). Methods: Children with S-ECC were recruited on the day of surgery for a prospective study investigating changes in nutritional status and well-being before and after surgery. Venipunctures for 25(OH)D were performed while children were in the operating room, and parents completed a questionnaire regarding nutritional intake, oral health, quality of life, and family demographics. Participants returned at a minimum of three months for a follow-up venipuncture, questionnaire, and dental examination. Analyses included descriptive, bivariate, and multivariable regression analyses. A P-value of ≤ 0.05 was significant. Results: Overall, 150 children participated, with a mean age of 47.7±14.1 months. The mean baseline 25(OH)D concentration was 49.8±16.9 nmol/L, with 17 percent having deficient levels. Overall, 106 returned for follow-up. Paired t-tests revealed significant improvements in the mean 25(OH)D levels following rehabilitation (50.1±17.1 nmol/L versus 61.2±18.7, P<0.001). The proportion with optimal and adequate 25(OH)D levels increased from 9.2 percent to 24.1 percent and from 48.3 percent to 67.8 percent, respectively, while those classified as deficient decreased from 17.2 percent to 8.1 percent from baseline to follow-up. Conclusions: Significant improvements in vitamin D concentrations were observed following dental rehabilitation. This provides additional evidence of the association between oral health and nutritional status.

Purpose: The purpose of this study was to evaluate the effect of 38 percent silver diamine fluoride (SDF) application on the shear bond strength (SBS) of three types of bulk-fill restorative materials to dentin. Methods: Eighty recently extracted deidentified, sound, human premolar teeth were sectioned to expose the mid-coronal dentin. A composite restorative material (ACTIVA™), a giomer (Beautifil^®), and a high-viscosity glass ionomer (HVGI) cement (Equia Forte^®) were used. The specimens were randomly assigned into eight groups (N equals 10 per group) according to the type of restorative material (ACTIVA^™, Beautifil ^®, Equia Forte ^® with and without the conditioner) and pretreatment with one drop of 38 percent SDF. Both ACTIVA^™ and Beautifil ^® were bonded to dentin with a universal adhesive (Scotchbond™ Universal). The SBS was measured in a universal testing machine with a 0.5 mm per minute crosshead speed. One-way analysis of variance, Tukey's, and adjusted pairwise comparison tests were used for statistical analysis of data (α equals 0.05). Results: Pretreatment of dentin with SDF did not affect the SBS of the tested bulk-fill materials (P>0.05). The SBS of the ACTIVA^™ and Beautifil^® groups was similar (P>0.05) and significantly higher than all Equia Forte^® groups (P<0.001). Application of conditioner had no significant effect on the SBS values of Equia Forte^® (adjusted P>0.01). Conclusions: The application of silver diamine fluoride did not influence the shear bond strength of tested bulk-fill materials to dentin. Prior conditioning did not affect the SBS of the high-viscosity glass ionomer to dentin. The giomer and composite restorative materials showed significantly higher SBS than high-viscosity glass ionomer.

Purpose: The purpose of this study was to determine the risk of prolonged general anesthesia (GA) for pediatric dental patients and understand factors that contribute to prolonged GA in patients under age three years in an academic hospital. Methods: A retrospective chart review for pediatric dental patients treated using GA collected data for patient age, treatment provided, other services involved in patient management, and case GA length. Further chart analysis was completed by a multidisciplinary team for cases of prolonged general anesthesia. Results: A total of 114 cases were evaluated. The incidence of prolonged GA exposure was 21.9 percent (N equals 25). Cohort data of cases younger than three years show that cases of prolonged GA exposure were more likely to be closer to age three, require longer non-throat pack time, require more restorative procedures, require longer procedure times, and utilize additional surgical services more often (P<0.05). Four common themes for prolonged exposure were identified (significant restorative needs, provider-level training, anesthesia complications, and utilization of other services), with most cases (88 percent) experiencing multiple themes as contributing factors. Few adverse effects were noted, and none had long-lasting effects. Conclusions: Dental rehabilitation cases in very young patients are at risk for prolonged exposure to GA. Providers should be aware of total anesthesia time while completing dental rehabilitation using GA and proactively attempt to reduce the risk of prolonged exposure.

Purpose: The purpose of this study was to compare the chemical and physical properties of eight contemporary direct pulp capping materials. Methods: Materials included: calcium hydroxide-based (Dycal^®, Lime-Lite^TM, and Ultra-Blend^TM plus), bioceramic-based (MTA Angelus^®, Biodentine^®, TheraCal LC^®, Ceramir^® Protect LC), and resin ionomer-based materials (Bio-Cap^®). Calcium release and pH changes were measured after one, seven, 28, and 90 days in 36.8 degrees Celsius of deionized water. Water sorption and solubility were calculated with weight loss after 90 days. Results: Biodentine^® (965.5 ppm) and MTA Angelus^® (921.2 ppm) released significantly more cumulative calcium ions (P<0.05), followed by Ceramir^® Protect LC (450.8 ppm) and Dycal^® (268.1 ppm); Lime-Lite^TM had the least amount of calcium ions. After 90 days, Biodentine^® and MTA Angelus^® showed significantly higher pH (P<0.05), while Bio-Cap^® and Lime-Lite^TM had limited effects in raising the pH to alkaline. Dycal^® presented the most weight loss (26 percent, P<0.05) after 90 days. Conclusions: Biodentine^® and MTA Angelus^® demonstrated more favorable in vitro characteristics for clinical pulp capping purposes, while Lime-Lite^TM had no effect in releasing calcium ions and limited influence in raising pH value.

Purpose: This study aimed to evaluate the effects of different medicaments (sterile saline [SS]; ferric sulfate [FS]; or sodium hypochlorite [SH]) and pulp capping materials (calcium hydroxide [CH] or mineral trioxide aggregate [MTA]) on the success of direct pulp capping (DPC) in primary molars. Methods: The study was conducted with 55 children aged four to eight years. A total of 118 teeth, in which occlusal caries removal resulted in pulp exposure, were treated with DPC across six groups: SS+CH; FS+CH; SH+CH; SS+MTA; FS+MTA; and SH+MTA. Teeth were restored with Class I composite resin. Results: After two years, the overall clinical and radiographical success for DPC were 94.1 percent (111 out of 118 teeth) and 88.9 percent (105 out of 118 teeth), respectively. The clinical and radiographical success, respectively, for hemorrhage control medicaments were 92.1 percent and 89.5 percent for SS, 92.5 percent and 82.5 percent for FS, 97.5 percent, and 95.0 percent for SH (P>0.05). Internal resorption was significantly higher in the FS+CH group when compared to other groups (P<0.05). MTA had significantly higher success than CH for clinical (98.3 percent versus 89.7 percent) and radiographical success (98.3 percent versus 79.3 percent) (P<0.05, each comparison). Conclusions: For primary molars with occlusal caries and less than one-mm exposure sites, these findings suggest that direct pulp capping with MTA following hemorrhage control with the tested solutions offers a more predictable outcome compared to CH. Further, the findings of this study indicate an increased risk for internal resorption when FS and CH are used for DPC.

Purpose: The purpose of this study was to measure serum levels and characterize the pharmacokinetics of silver and fluoride in healthy children receiving silver diamine fluoride (SDF) treatment for dental caries lesions.

Methods: Children (three to 13 years old with at least one caries lesion) were recruited at the University of California, San Francisco Pediatric Dental Clinic from August 2019 through March 2020. Blood was obtained at one randomly selected timepoint up to 168 hours after SDF application. Serum fluoride and silver were measured, and population pharmacokinetic modeling was used to estimate pharmacokinetic parameters and simulate silver concentration versus time profiles in cohorts of children (15 to 50 kg).

Results: Fifty-five children completed the study. Serum fluoride had no discernable temporal pattern. Silver concentra- tions were best described by a one-compartment model with first-order absorption and elimination, and weight as a covariate. Simulated 15 kg children had higher predicted peak silver concentrations than simulated 50 kg children (22.0 ng/mL [95 percent confidence interval {95 percent CI} equals 19.4 to 24.6] versus 12.8 ng/mL [95 percent CI equals 11.3 to 14.3]), and a longer predicted silver half-life (15.5 days [95 percent CI equals 12.5 to 18.5] versus 4.0 days [95 percent CI equals 2.7 to 5.3]).

Conclusions: Evidence presented indicate that topical silver diamine fluoride application in children is safe, and serum concentrations of fluoride and silver pose little risk of toxicity.