{"title":"Abstract of the Scientific Literature.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19863,"journal":{"name":"Pediatric dentistry","volume":" ","pages":"166"},"PeriodicalIF":1.6,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40570582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The American Academy of Pediatric Dentistry (AAPD) is dedicated to the advancement of research related to improving children's oral health and the specialty of pediatric dentistry. To fulfill part of this mission, AAPD supports many research awards, grants, and fellowships. The following research abstracts have been chosen by a subcommittee of the AAPD Council on Scientific Affairs. Note: These research abstracts have not been edited by the AAPD editorial staff. The abstracts are published as received from the authors, except for changes in style. Any errors in content are the responsibility of the contributors, not of Pediatric Dentistry, the journal of the American Academy of Pediatric Dentistry.
{"title":"2022 GSRA Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The American Academy of Pediatric Dentistry (AAPD) is dedicated to the advancement of research related to improving children's oral health and the specialty of pediatric dentistry. To fulfill part of this mission, AAPD supports many research awards, grants, and fellowships. The following research abstracts have been chosen by a subcommittee of the AAPD Council on Scientific Affairs. <i>Note: These research abstracts have not been edited by the AAPD editorial staff. The abstracts are published as received from the authors, except for changes in style. Any errors in content are the responsibility of the contributors, not of Pediatric Dentistry, the journal of the American Academy of Pediatric Dentistry.</i></p>","PeriodicalId":19863,"journal":{"name":"Pediatric dentistry","volume":" ","pages":"215-219"},"PeriodicalIF":1.6,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40592750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hellene Ellenikiotis, Kuan-Fu Chen, David N Soleimani-Meigooni, Marilynn L Rothen, Brice Thompson, Yvonne S Lin, Peter Milgrom
Purpose: The purpose of this study was to measure serum levels and characterize the pharmacokinetics of silver and fluoride in healthy children receiving silver diamine fluoride (SDF) treatment for dental caries lesions.
Methods: Children (three to 13 years old with at least one caries lesion) were recruited at the University of California, San Francisco Pediatric Dental Clinic from August 2019 through March 2020. Blood was obtained at one randomly selected timepoint up to 168 hours after SDF application. Serum fluoride and silver were measured, and population pharmacokinetic modeling was used to estimate pharmacokinetic parameters and simulate silver concentration versus time profiles in cohorts of children (15 to 50 kg).
Results: Fifty-five children completed the study. Serum fluoride had no discernable temporal pattern. Silver concentra- tions were best described by a one-compartment model with first-order absorption and elimination, and weight as a covariate. Simulated 15 kg children had higher predicted peak silver concentrations than simulated 50 kg children (22.0 ng/mL [95 percent confidence interval {95 percent CI} equals 19.4 to 24.6] versus 12.8 ng/mL [95 percent CI equals 11.3 to 14.3]), and a longer predicted silver half-life (15.5 days [95 percent CI equals 12.5 to 18.5] versus 4.0 days [95 percent CI equals 2.7 to 5.3]).
Conclusions: Evidence presented indicate that topical silver diamine fluoride application in children is safe, and serum concentrations of fluoride and silver pose little risk of toxicity.
目的:本研究的目的是测量接受二胺氟化银(SDF)治疗龋齿损伤的健康儿童的血清银和氟化物水平并表征其药代动力学特征。方法:于2019年8月至2020年3月在加州大学旧金山分校儿童牙科诊所招募儿童(3至13岁，至少有一个龋齿病变)。在SDF应用后的168小时内，在一个随机选择的时间点采血。测量血清氟化物和银，并使用群体药代动力学模型来估计药代动力学参数，并模拟儿童队列(15至50 kg)中银浓度与时间的关系。结果:55名儿童完成了研究。血清氟化物没有明显的时间模式。银浓度最好用一阶吸收和消除的单室模型来描述，重量作为协变量。模拟的15公斤儿童的预测峰值银浓度高于模拟的50公斤儿童(22.0 ng/mL[95%置信区间{95% CI} = 19.4至24.6]对12.8 ng/mL [95% CI = 11.3至14.3])，预测的银半衰期更长(15.5天[95% CI = 12.5至18.5]对4.0天[95% CI = 2.7至5.3])。结论:有证据表明，儿童局部应用氟化银二胺是安全的，血清氟化物和银浓度的毒性风险很小。
{"title":"Pharmacokinetics of 38 Percent Silver Diamine Fluoride in Children.","authors":"Hellene Ellenikiotis, Kuan-Fu Chen, David N Soleimani-Meigooni, Marilynn L Rothen, Brice Thompson, Yvonne S Lin, Peter Milgrom","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to measure serum levels and characterize the pharmacokinetics of silver and fluoride in healthy children receiving silver diamine fluoride (SDF) treatment for dental caries lesions.</p><p><strong>Methods: </strong>Children (three to 13 years old with at least one caries lesion) were recruited at the University of California, San Francisco Pediatric Dental Clinic from August 2019 through March 2020. Blood was obtained at one randomly selected timepoint up to 168 hours after SDF application. Serum fluoride and silver were measured, and population pharmacokinetic modeling was used to estimate pharmacokinetic parameters and simulate silver concentration versus time profiles in cohorts of children (15 to 50 kg).</p><p><strong>Results: </strong>Fifty-five children completed the study. Serum fluoride had no discernable temporal pattern. Silver concentra- tions were best described by a one-compartment model with first-order absorption and elimination, and weight as a covariate. Simulated 15 kg children had higher predicted peak silver concentrations than simulated 50 kg children (22.0 ng/mL [95 percent confidence interval {95 percent CI} equals 19.4 to 24.6] versus 12.8 ng/mL [95 percent CI equals 11.3 to 14.3]), and a longer predicted silver half-life (15.5 days [95 percent CI equals 12.5 to 18.5] versus 4.0 days [95 percent CI equals 2.7 to 5.3]).</p><p><strong>Conclusions: </strong>Evidence presented indicate that topical silver diamine fluoride application in children is safe, and serum concentrations of fluoride and silver pose little risk of toxicity.</p>","PeriodicalId":19863,"journal":{"name":"Pediatric dentistry","volume":"44 2","pages":"114-121"},"PeriodicalIF":1.6,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060293/pdf/nihms-1771042.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-78003-6_12
N. Kotsanos, R. Sulyanto, M. Ng
{"title":"Dental Caries Prevention in Children and Adolescents","authors":"N. Kotsanos, R. Sulyanto, M. Ng","doi":"10.1007/978-3-030-78003-6_12","DOIUrl":"https://doi.org/10.1007/978-3-030-78003-6_12","url":null,"abstract":"","PeriodicalId":19863,"journal":{"name":"Pediatric dentistry","volume":"61 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50978408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-78003-6_17
N. Kotsanos, P. Papagerakis, H. Sarnat, A. Bloch-Zupan
{"title":"Developmental Defects of the Teeth and Their Hard Tissues","authors":"N. Kotsanos, P. Papagerakis, H. Sarnat, A. Bloch-Zupan","doi":"10.1007/978-3-030-78003-6_17","DOIUrl":"https://doi.org/10.1007/978-3-030-78003-6_17","url":null,"abstract":"","PeriodicalId":19863,"journal":{"name":"Pediatric dentistry","volume":"7 11","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50978493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-78003-6_16
C. Bourguignon, A. Arhakis, A. Sigurdsson, N. Kotsanos
{"title":"Dentoalveolar Trauma of Children and Adolescents","authors":"C. Bourguignon, A. Arhakis, A. Sigurdsson, N. Kotsanos","doi":"10.1007/978-3-030-78003-6_16","DOIUrl":"https://doi.org/10.1007/978-3-030-78003-6_16","url":null,"abstract":"","PeriodicalId":19863,"journal":{"name":"Pediatric dentistry","volume":"50 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50978480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-78003-6_19
L. van den Berghe, Louis Simoen
{"title":"Temporomandibular Disorders in Children and Adolescents","authors":"L. van den Berghe, Louis Simoen","doi":"10.1007/978-3-030-78003-6_19","DOIUrl":"https://doi.org/10.1007/978-3-030-78003-6_19","url":null,"abstract":"","PeriodicalId":19863,"journal":{"name":"Pediatric dentistry","volume":"1 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50978520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-78003-6_10
A. Arhakis, O. B. Al-Batayneh, H. V. van Waes
{"title":"Tooth Eruption, Shedding, Extraction and Related Surgical Issues","authors":"A. Arhakis, O. B. Al-Batayneh, H. V. van Waes","doi":"10.1007/978-3-030-78003-6_10","DOIUrl":"https://doi.org/10.1007/978-3-030-78003-6_10","url":null,"abstract":"","PeriodicalId":19863,"journal":{"name":"Pediatric dentistry","volume":"65 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50978820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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