R. A. Indriyanti, Eko Fuji Ariyanto, H. Usman, R. R. Effendy, D. Dhianawaty
{"title":"Synergistic Effect of Imperata cylindrica Root Extract and Erlotinib on A549 Lung Cancer Cell Viability","authors":"R. A. Indriyanti, Eko Fuji Ariyanto, H. Usman, R. R. Effendy, D. Dhianawaty","doi":"10.5530/pj.2024.16.103","DOIUrl":"https://doi.org/10.5530/pj.2024.16.103","url":null,"abstract":"","PeriodicalId":19892,"journal":{"name":"Pharmacognosy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of α-SMA, Type 1 Collagen, and Myofibroblasts in Cicatrizing Conjunctivitis by Alkali Chemical Trauma","authors":"Henu Hadiyantama, Lukisiari Agustini, Sutjipto Sutjipto, Evelyn Komaratih, Ismi Zuhria, Pudji Lestari, Ridholia Ridholia","doi":"10.5530/pj.2024.16.92","DOIUrl":"https://doi.org/10.5530/pj.2024.16.92","url":null,"abstract":"","PeriodicalId":19892,"journal":{"name":"Pharmacognosy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neni Wahyu Hastuti, D. Munir, R. Kamarlis, Bintang Yinke Magdalena Sinaga, Adang Bachtiar, Farhat Farhat, Amira Permatasari Tarigan, Delyuzar Delyuzar
Cell and Mass Appearance in Atypical Mycobacterium Infection of Lymphadenitis
淋巴结炎非典型分枝杆菌感染的细胞和肿块表现
{"title":"Eosinophil Cell and Mass Appearance in Atypical Mycobacterium Infection of Lymphadenitis","authors":"Neni Wahyu Hastuti, D. Munir, R. Kamarlis, Bintang Yinke Magdalena Sinaga, Adang Bachtiar, Farhat Farhat, Amira Permatasari Tarigan, Delyuzar Delyuzar","doi":"10.5530/pj.2024.16.105","DOIUrl":"https://doi.org/10.5530/pj.2024.16.105","url":null,"abstract":"Cell and Mass Appearance in Atypical Mycobacterium Infection of Lymphadenitis","PeriodicalId":19892,"journal":{"name":"Pharmacognosy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Novi Fajar Utami, B. Elya, Hayun Hayun, K. Kusmardi
Background: The utilization of coffee cascara, a byproduct of coffee cultivation, in cancer therapy research. This research begins with the rationale of exploring medicinal plants, especially coffee, to obtain compounds that can target cancer cells with fewer side effects. Objectivity: This research aims to extract and evaluate the secondary metabolites from robusta coffee cascara, such as friedelin, lupeol, stigmasterol, ursolic acid, caffeine, chlorogenic acid, caffeic acid
{"title":"Quantification of Active Compounds from Coffea canephora Pierre ex A.Froehner cascara and their Potential Against MCF-7 and HeLa","authors":"Novi Fajar Utami, B. Elya, Hayun Hayun, K. Kusmardi","doi":"10.5530/pj.2024.16.82","DOIUrl":"https://doi.org/10.5530/pj.2024.16.82","url":null,"abstract":"Background: The utilization of coffee cascara, a byproduct of coffee cultivation, in cancer therapy research. This research begins with the rationale of exploring medicinal plants, especially coffee, to obtain compounds that can target cancer cells with fewer side effects. Objectivity: This research aims to extract and evaluate the secondary metabolites from robusta coffee cascara, such as friedelin, lupeol, stigmasterol, ursolic acid, caffeine, chlorogenic acid, caffeic acid","PeriodicalId":19892,"journal":{"name":"Pharmacognosy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intanri Kurniati, Agustyas Tjiptaningrum, Raja Iqbal Mulya Harahap, Bayu Putra Danan Jaya
{"title":"Serum Trace Element Levels in Type 2 DM Patients and its Correlation with Glycemic Control","authors":"Intanri Kurniati, Agustyas Tjiptaningrum, Raja Iqbal Mulya Harahap, Bayu Putra Danan Jaya","doi":"10.5530/pj.2024.16.104","DOIUrl":"https://doi.org/10.5530/pj.2024.16.104","url":null,"abstract":"","PeriodicalId":19892,"journal":{"name":"Pharmacognosy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AD is the most common form of dementia. Extracellular senile (amyloid) plaques and intracellular neurofibrillary tangles (NFTs) are hallmarks of the disease. Vigna radiata and Vigna pilosa are plants used in many Ayurvedic formulations used in the management of dementia and related conditions. The present study was aimed to evaluate the neuroprotective effect of these plants on an amyloid-β (A β ) 1-42 model of Alzheimer’s disease in rats. Duration of the study was 21 days. After the recovery period post A β 1-42 ICV administration, from the 8 th day, the ethyl acetate extract of Vigna radiata and ethanolic extract of Vigna pilosa (200mg/kg, 400mg/kg), Donepezil (3mg/kg) treatments were made once daily p.o till the 21 st day. Cognitive behavioural studies were conducted using radial maze test, Step-through Passive Avoidance Test. The animals were further subjected to euthanasia and the brain were collected and evaluated for antioxidant parameters and brain cytokine levels. The brain tissues were subjected to histopathological examination. The treatment with the extracts significantly improved the cognitive capability of the rats in the Radial arm maze task and step through passive avoidance test. It also reduced oxidative stress, which was evident by the lower levels of lipid peroxide and nitric oxide as well as elevated levels of antioxidant enzymes like catalase, superoxide dismutase and reduced glutathione. The treatment alleviated neuroinflammation in rats by decreasing the concentration of neuroinflammatory markers in a dose-dependent manner. From the results it can be concluded that the plants Vigna radiata and Vigna pilosa has beneficial effects in the improvement of cognitive impairment AD, by reducing oxidative stress and neuroinflammation.
{"title":"Evaluation of In Vivo Anti Alzheimer's Activity of Vigna radiata and Vigna pilosa using Beta Amyloid Induced Neurotoxicity in Rats","authors":"Prasanth Nv, P. Pandian, T. Balasubramanian","doi":"10.5530/pj.2024.16.83","DOIUrl":"https://doi.org/10.5530/pj.2024.16.83","url":null,"abstract":"AD is the most common form of dementia. Extracellular senile (amyloid) plaques and intracellular neurofibrillary tangles (NFTs) are hallmarks of the disease. Vigna radiata and Vigna pilosa are plants used in many Ayurvedic formulations used in the management of dementia and related conditions. The present study was aimed to evaluate the neuroprotective effect of these plants on an amyloid-β (A β ) 1-42 model of Alzheimer’s disease in rats. Duration of the study was 21 days. After the recovery period post A β 1-42 ICV administration, from the 8 th day, the ethyl acetate extract of Vigna radiata and ethanolic extract of Vigna pilosa (200mg/kg, 400mg/kg), Donepezil (3mg/kg) treatments were made once daily p.o till the 21 st day. Cognitive behavioural studies were conducted using radial maze test, Step-through Passive Avoidance Test. The animals were further subjected to euthanasia and the brain were collected and evaluated for antioxidant parameters and brain cytokine levels. The brain tissues were subjected to histopathological examination. The treatment with the extracts significantly improved the cognitive capability of the rats in the Radial arm maze task and step through passive avoidance test. It also reduced oxidative stress, which was evident by the lower levels of lipid peroxide and nitric oxide as well as elevated levels of antioxidant enzymes like catalase, superoxide dismutase and reduced glutathione. The treatment alleviated neuroinflammation in rats by decreasing the concentration of neuroinflammatory markers in a dose-dependent manner. From the results it can be concluded that the plants Vigna radiata and Vigna pilosa has beneficial effects in the improvement of cognitive impairment AD, by reducing oxidative stress and neuroinflammation.","PeriodicalId":19892,"journal":{"name":"Pharmacognosy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Renal resistive index (RRI) and estimated glomerular filtration rate (eGFR) are predictive markers for chronic kidney disease (CKD) progression. Aim: To evaluate RRI value, eGFRcr-cys and renal biomarker in nondiabetic patients with CKD stage 3 in Bangkok, Thailand. Methods: A cross-sectional analytical analysis was conducted involving nondiabetic patients with CKD stage 3, aged 35-85 years. Ultrasound was used to assess the RRI of arteries in both kidneys. Patients underwent assessments of serum and urine 24-hour. Results: Among the 61 participants (67.2% male; mean age 69.03 ± 12.59 years), the mean eGFRcr-cys was 41.63 ± 8.64 mL/min/1.73 m², and the mean RRI was 0.65 ± 0.06. Patients were categorized into three RRI groups: low (<0.65, n=35), intermediate (0.65-0.70, n=14), and high (>0.70, n=12). The high RRI group showed a mean RRI of 0.73 ± 0.05 (p < 0.01). Among those with high RRI group were significant decreased right kidney size (p<0.05) and they had a lower BMI, averaging 22.49 ± 3.48. An increase in PP (59.66 ± 13.84, p=0.04) was also significant in this group. The correlations coefficient of RRI value showed a significant positive correlation with age (p<0.05) and significant negative with BMI (p<0.05). In addition, eGFRcr-cys displayed a significant negative correlation with UAGT and 24hUP (p<0.05) and a significant while eGFRcr-cys positive correlation with both kidney size and urine iNOS(p<0.01). Conclusion: An increase in RRI is inversely linked to age, BMI, and PP. Lower eGFR is correlated with factors that cause CKD progression.
{"title":"Renal Resistive Index and Estimated Glomerular Filtration Rate in Nondiabetic Chronic Kidney Disease Stage 3: A Cross-Sectional Analytical Study","authors":"Patnaree Wongmanit, Kusuma Sriyakul, Parunkul Tungsukruthai, O. Supasyndh, Sucharat Tungsukruthai, Pratya Phetkate","doi":"10.5530/pj.2024.16.85","DOIUrl":"https://doi.org/10.5530/pj.2024.16.85","url":null,"abstract":"Background: Renal resistive index (RRI) and estimated glomerular filtration rate (eGFR) are predictive markers for chronic kidney disease (CKD) progression. Aim: To evaluate RRI value, eGFRcr-cys and renal biomarker in nondiabetic patients with CKD stage 3 in Bangkok, Thailand. Methods: A cross-sectional analytical analysis was conducted involving nondiabetic patients with CKD stage 3, aged 35-85 years. Ultrasound was used to assess the RRI of arteries in both kidneys. Patients underwent assessments of serum and urine 24-hour. Results: Among the 61 participants (67.2% male; mean age 69.03 ± 12.59 years), the mean eGFRcr-cys was 41.63 ± 8.64 mL/min/1.73 m², and the mean RRI was 0.65 ± 0.06. Patients were categorized into three RRI groups: low (<0.65, n=35), intermediate (0.65-0.70, n=14), and high (>0.70, n=12). The high RRI group showed a mean RRI of 0.73 ± 0.05 (p < 0.01). Among those with high RRI group were significant decreased right kidney size (p<0.05) and they had a lower BMI, averaging 22.49 ± 3.48. An increase in PP (59.66 ± 13.84, p=0.04) was also significant in this group. The correlations coefficient of RRI value showed a significant positive correlation with age (p<0.05) and significant negative with BMI (p<0.05). In addition, eGFRcr-cys displayed a significant negative correlation with UAGT and 24hUP (p<0.05) and a significant while eGFRcr-cys positive correlation with both kidney size and urine iNOS(p<0.01). Conclusion: An increase in RRI is inversely linked to age, BMI, and PP. Lower eGFR is correlated with factors that cause CKD progression.","PeriodicalId":19892,"journal":{"name":"Pharmacognosy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141706486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Zuraida, Silvia W Lestari, Mulyoto Pangestu, A. Hestiantoro, K. Kusmardi
{"title":"Effect of Glutathione Supplementation in Cryoprotectant Modification on Tyrosine Phosphorylation, Acrosin Expression and Acrosome Reaction of Post-Thawing Spermatozoa Quality","authors":"Z. Zuraida, Silvia W Lestari, Mulyoto Pangestu, A. Hestiantoro, K. Kusmardi","doi":"10.5530/pj.2024.16.87","DOIUrl":"https://doi.org/10.5530/pj.2024.16.87","url":null,"abstract":"","PeriodicalId":19892,"journal":{"name":"Pharmacognosy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. M. S. Harsa, Andiani Andiani, S. Sulistiawati, Lilik Herawati, H. Hidayati, K. Kuntaman
{"title":"Comparative Study of Paracetamol vs Paracetamol Plus Acupressure for Pain Relief in Diabetic Neuropathy Patients","authors":"I. M. S. Harsa, Andiani Andiani, S. Sulistiawati, Lilik Herawati, H. Hidayati, K. Kuntaman","doi":"10.5530/pj.2024.16.94","DOIUrl":"https://doi.org/10.5530/pj.2024.16.94","url":null,"abstract":"","PeriodicalId":19892,"journal":{"name":"Pharmacognosy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141689635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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