Pharmacology Biochemistry and Behavior最新文献

{"title":"ANXIOLYTICS: Introduction to a special issue celebrating 50 years of Pharmacology, Biochemistry and Behavior","authors":"Jeffrey M. Witkin , James E. Barrett","doi":"10.1016/j.pbb.2024.173905","DOIUrl":"10.1016/j.pbb.2024.173905","url":null,"abstract":"","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173905"},"PeriodicalIF":3.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress","authors":"Lin Zhou ,&nbsp;Zuotian Wu ,&nbsp;Yixin Li ,&nbsp;Ling Xiao ,&nbsp;Huiling Wang ,&nbsp;Gaohua Wang","doi":"10.1016/j.pbb.2024.173898","DOIUrl":"10.1016/j.pbb.2024.173898","url":null,"abstract":"<div><h3>Background</h3><div>Pregnancy is a very complex and highly stressful time in women. Despite the high prevalence of postpartum depression, more than 50 % of mothers are undiagnosed or untreated, showing an urgent need to explore an effective preventive strategy. Regular physical activity has been suggested to be associated with an increased quality of life in pregnant and postpartum women. The purpose of this study was to determine whether perinatal running training can affect maternal care stress-related anxiety, depressive-like behavior, and cognitive changes in postpartum dams and to explore the possible underlying mechanism.</div></div><div><h3>Methods</h3><div>40 female C57BL/6J mice were divided into four groups: prenatal control (NC) and running training (EX) group (NC+EX), prenatal control and nonrunning training (RE) group (NC+RE), prenatal subchronic variable stress (SCVS) and running training group (SCVS+EX) and prenatal SCVS and non-running training group (SCVS+RE). Mice in prenatal stress groups were subjected to SCVS after pregnancy confirmed. Mice in running training groups subjected to running training throughout pregnancy and lactation. Then after the delivery, maternal behavior, cognitive changes, anxiety and depressive-like behaviors were tested. Then we measured the serum prolactin (PRL), hypothalamic–pituitary adrenal (HPA) axis activity, and adult hippocampus neurogenesis (AHN) in dams.</div></div><div><h3>Results</h3><div>Compared to NC+RE, prenatal SCVS caused cognitive impairments, the decrease in maternal behavior, and anxiety and depressive-like behavior in SCVS+RE dams, accompanying increase in HPA axis activity and decreased the PRL levels and AHN in postpartum period. Then compared to SCVS+RE, perinatal running training mitigates cognitive impairments, increased maternal behavior, and alleviates anxiety and depressive-like behavior in SCVS+EX dams, accompanying the decreased HPA axis activity, and the increased PRL levels and AHN in postpartum period.</div></div><div><h3>Conclusion</h3><div>Overall, this study suggests that perinatal running training might improve maternal care and reverse prenatal stress-related cognitive impairment and anxiety and depressive-like behavior in postpartum dams.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173898"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular signature underlying (R)-ketamine rapid antidepressant response on anhedonic-like behavior induced by sustained exposure to stress","authors":"Ellen Scotton ,&nbsp;Paola Rampelotto Ziani ,&nbsp;Renata Luiza Boff Wilges ,&nbsp;Pedro Henrique da Rosa Correa ,&nbsp;Lucas Azambuja Giordano ,&nbsp;Jéferson Ferraz Goularte ,&nbsp;Tainá Schons ,&nbsp;Felipe Borges Almeida ,&nbsp;Dirson João Stein ,&nbsp;Josimar Macedo de Castro ,&nbsp;Marco Antônio de Bastiani ,&nbsp;Eduardo Giovanni de Oliveira Soares ,&nbsp;Douglas Bernardo Paixão ,&nbsp;Caren Daniele Galeano da Silva ,&nbsp;Paulo Henrique Schneider ,&nbsp;Rafael Colombo ,&nbsp;Adriane R. Rosa","doi":"10.1016/j.pbb.2024.173882","DOIUrl":"10.1016/j.pbb.2024.173882","url":null,"abstract":"<div><div>Anhedonia induced by sustained stress exposure is a hallmark symptom of major depressive disorder (MDD) and in rodents, it can be accessed through the sucrose preference test (SPT). (<em>R</em>)-ketamine is a fast-acting antidepressant with less detrimental side effects and abuse liability compared to racemic ketamine. The present study combined high-throughput proteomics and network analysis to identify molecular mechanisms involved in chronic variable stress (CVS)-induced anhedonia and promising targets underlying (<em>R</em>)-ketamine rapid antidepressant response. Male Wistar rats were subjected to CVS for five weeks. Based on the SPT, animals were clustered into resilient or anhedonic-like (ANH) groups. ANH rats received a single dose of saline or (<em>R</em>)-ketamine (20 mg/kg, i.p.), which was proceeded by treatment response evaluation. After prefrontal cortex collection, proteomic analysis was performed to uncover the differentially expressed proteins (DEPs) related to both anhedonic-like behavior and pharmacological response. The behavioral assessment showed that the ANH animals had a significant decrease in SPT, and that (<em>R</em>)-ketamine responders showed a reversal of anhedonic-like behavior. On a molecular level, anhedonia-like behavior was associated with the downregulation of Neuronal Pentraxin Receptor (Nptxr) and Galectin−1 (Gal-1). These data reinforce a disruption in the inflammatory response, neurotransmitter receptor activity, and glutamatergic synapses in chronic stress-induced anhedonia. (<em>R</em>)-ketamine response-associated DEPs included novel potential targets involved in the modulation of oxidative stress, energetic metabolism, synaptogenesis, dendritic arborization, neuroinflammation, gene expression, and telomere length, converging to biological themes extensively documented in MDD physiopathology. Our data provide valuable insights into the molecular mechanisms underlying the response to (<em>R</em>)-ketamine and highlight these pathways as potential therapeutic targets for anhedonia. By addressing proteins involved in oxidative stress, energy metabolism, synaptogenesis, dendritic arborization, neuroinflammation, gene expression, and telomere length, we can target multiple key factors involved in the pathophysiology of MDD. Modulating these proteins could open avenues for novel therapeutic strategies and deepen our understanding of anhedonia, offering hope for improved outcomes in individuals facing this challenging condition. However, additional studies will be essential to validate these findings and further explore their therapeutic implications.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173882"},"PeriodicalIF":3.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute stress induces different changes on the expression of CB1 receptors in the hippocampus of two lines of male rats differing in their response to stressors","authors":"Maria Pina Serra ,&nbsp;Marianna Boi ,&nbsp;Ylenia Lai ,&nbsp;Marcello Trucas ,&nbsp;Alberto Fernández-Teruel ,&nbsp;Maria Giuseppa Corda ,&nbsp;Osvaldo Giorgi ,&nbsp;Marina Quartu","doi":"10.1016/j.pbb.2024.173901","DOIUrl":"10.1016/j.pbb.2024.173901","url":null,"abstract":"<div><div>The stress-induced alterations in cognitive processes and psychiatric disorders can be accelerated when acute stressors challenge the hippocampal functions. To address this issue, we used Western Blot (WB) and immunohistochemistry assays to investigate the impact of acute forced swimming (FS) on the expression of the CB1 cannabinoid receptors (CB1R) in the hippocampus (HC) of the male outbred Roman High- (RHA) and Low-Avoidance (RLA) rat lines, one of the most validated genetic models for the study of behavior related to fear/anxiety and stress-induced depression.</div><div>The distinct responses to FS confirmed the different behavioral strategies displayed by the two phenotypes when exposed to stressors, with RLA and RHA rats displaying reactive vs. proactive coping, respectively. In control rats, the WB analysis showed lower hippocampal CB1R relative levels in RLA rats than in their RHA counterparts. After FS, RLA rats showed increased CB1R levels in the dorsal HC (dHC) vs. no change in the ventral HC (vHC), while RHA rats displayed no change in the dHC vs. a decrease in the vHC. In the tissue sections from dHC, FS elicited an increment over the control level of CB1R-like immunoreactivity (LI) in the CA1 and CA3 sectors of the Ammon's horn of RLA rats, while in RHA rats the density of CB1R-LI increased only in the CA1 sector. In tissue sections from the vHC, FS caused an increase over the control values of CB1R-LI only in the CA1 sector of RLA rats and a decrement of the CB1R-LI in the CA1 sector and dentate gyrus of control RHA rats.</div><div>This study shows for the first time that, in baseline conditions, the CB1Rs are present in the dHC and the vHC of the Roman rat lines with a different distribution along the septo-temporal extension of the HC and that the FS induces rapid and distinct changes in the hippocampal expression of CB1R of RLA vs. RLA rats, in keeping with the view that endocannabinoid signaling may contribute to the molecular mechanisms that regulate the different responses of the dHC vs. the vHC to aversive situations in male Roman rats. Our results also provide evidence supporting the involvement of CB1R in the molecular underpinnings of the susceptibility of RLA rats and the resistance of RHA rats to stress-induced depression-like behavior.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173901"},"PeriodicalIF":3.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting retrieval of methamphetamine reward memory in the context of REM sleep deprivation: Age-dependent role of GABAB receptors","authors":"Mehdi Khodamoradi ,&nbsp;Christian P. Müller ,&nbsp;Hamed Ghazvini ,&nbsp;Abolhassan Ghaderi ,&nbsp;Nasrin Abdoli ,&nbsp;Shahab Aldin Zarei","doi":"10.1016/j.pbb.2024.173900","DOIUrl":"10.1016/j.pbb.2024.173900","url":null,"abstract":"<div><div>GABA_B receptors play a modulatory role in the mechanisms underlying drug addiction, sleep problems, and aging; however, there are few studies addressing their relationships to each other. Therefore, this study aimed to examine whether blockade of these receptors affects methamphetamine (METH) reward memory in adult and adolescent rapid-eye movement sleep-deprived (RSD) rats. Adolescent and adult male Wistar rats were subjected to RSD for seven days. They were then conditioned to receive methamphetamine (METH; 2 mg/kg, ip) during an eight-day conditioning period. METH reward memory was then reactivated during a retrieval trial and the GABA_B receptor agonist baclofen (2.5 or 5 mg/kg, ip) was injected prior to the retrieval trial. Afterward, animals were retested for the expression of conditioned place preference (CPP) and hippocampal expression of GABA_B receptors. Baclofen dose-dependently decreased the retrieval of METH reward memory in control and RSD adult and adolescent rats, but its effects were stronger at the higher dose. Moreover, we found stronger effects of baclofen in adolescent animals than in adult ones. In addition, baclofen at its higher dose decreased GABA_B overexpression in the hippocampus of adolescent rats, but not in adult rats. These findings shed new light on the mechanisms underlying the role of GABA_B receptors in the retrieval of METH reward memory and highlight the importance of considering age and sleep problems in understanding addiction. Further research could potentially lead to the development of therapeutics for individuals struggling with METH addiction.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173900"},"PeriodicalIF":3.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonsedating anxiolytics","authors":"Rok Cerne ,&nbsp;Jodi L. Smith ,&nbsp;Aleksandra Chrzanowska ,&nbsp;Arnold Lippa","doi":"10.1016/j.pbb.2024.173895","DOIUrl":"10.1016/j.pbb.2024.173895","url":null,"abstract":"<div><div>Anxiety disorders are the most prevalent psychiatric pathology with substantial cost to society, but the existing treatments are often inadequate. This has rekindled the interest in the GABA_A-receptor (GABA_AR) positive allosteric modulator (PAM) compounds, which have a long history in treatment of anxiety beginning with diazepam, chlordiazepoxide, and alprazolam. While the GABA_AR PAMs possess remarkable anxiolytic efficacy, they have fallen out of favor due to a host of adverse effects including sedation, motor impairment, addictive potential and tolerance development. A substantial effort was thus devoted to the design of GABA_AR PAMs as anxiolytics with reduced sedative liabilities. Several non-benzodiazepine (BZD) GABA_APAMs progressed to clinical trials (bretazenil, abecarnil, alpidem, and ocinaplon) with alpidem obtaining regulatory approval as anxiolytic, but later withdrawn from market due to hepatotoxicity. Advances in molecular biology gave birth to a host of subtype selective GABA_AR-PAMs which suffered from signs of sedation and motor impairment and only three compounds progressed to proof-of-concept studies (TPA-023, AZD7325 and PF-06372865). TPA-023 was terminated due to toxicity in preclinical species while AZD7325 and PF-06372865 did not achieve efficacy endpoints in patients. We highlight a new compound, KRM-II-81, that is an imidazodiazepine selective for GABA_AR containing α2/3 and β3 proteins. In preclinical studies KRM-II-81 produced anxiolytic-like effects but with minimal sedation, respiratory depression, and abuse liability. Thus, KRM-II-81 is a newly discovered, non- BZD anxiolytic compound, which targets a selective population of GABA_AR for improved therapeutic gain and reduced side effects.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173895"},"PeriodicalIF":3.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroplasticity-related effects of vitamin D relevant to its neuroprotective effects: A narrative review","authors":"Bruna R. Kouba,&nbsp;Ana Lúcia S. Rodrigues","doi":"10.1016/j.pbb.2024.173899","DOIUrl":"10.1016/j.pbb.2024.173899","url":null,"abstract":"<div><div>The pathophysiology of a wide range of central nervous system (CNS) disorders, such as neurodegenerative and psychiatric diseases, has been associated with impairment of neurogenic and synaptogenic processes. Therefore, pharmacological and/or nutritional strategies based on the stimulation and/or restoration of these processes may have beneficial effects against diseases in which these processes are impaired. In this context, vitamin D has emerged as a promising neuroprotective compound. Due to its pleiotropic properties, it can interact with multiple molecular targets and thereby affect different cell types, including neurons and glial cells. This neurosteroid contributes to CNS homeostasis by non-genomic and genomic mechanisms through its interaction with vitamin D receptors (VDRs). Among several properties of this vitamin, its role in neuronal proliferation and differentiation as well as in synaptic plasticity has received attention. Considering this background, this narrative review aims to highlight the neuroplasticity-related mechanisms of vitamin D that may be associated with its neuroprotective effects.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173899"},"PeriodicalIF":3.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term administration of paroxetine increases cortical EEG beta and gamma band activities in healthy awake rats","authors":"Gökçer Eskikurt ,&nbsp;Bilge Özerman Edis ,&nbsp;Ali Umut Dalanay ,&nbsp;Ilknur Özen ,&nbsp;Asiye Nurten ,&nbsp;Ihsan Kara ,&nbsp;Sacit Karamürsel","doi":"10.1016/j.pbb.2024.173896","DOIUrl":"10.1016/j.pbb.2024.173896","url":null,"abstract":"<div><div>Understanding the electrophysiological properties of antidepressant medications is important to resolve the response heterogeneity of these drugs in clinical practice. Administration of paroxetine, a selective serotonin reuptake inhibitor, has been shown to increase serotonin levels that affect cortical activities in healthy subjects. However, the extent to which cortical oscillations can be altered by ongoing administration of paroxetine is not known. Here, we develop EEG biomarkers showing long-term effects of paroxetine. EEG changes were analyzed using Neuroscan in healthy wakeful rats administered paroxetine (4 mg/kg/day) for six weeks. Subsequent EEG recordings taken at 3 and 6 weeks after treatment showed differences in cortical oscillations obtained from both hemispheres and frontal-central-parietal regions. Chronic paroxetine administration resulted in an increase in gamma band activity. Comparison of EEG frequency bands of paroxetine and saline groups showed an enhancement in higher frequency activities at third weeks after the treatment. Higher activity of alpha oscillations in the temporal cortex was persistent at sixth week of the administration. Overall, our results suggest that chronic paroxetine administration affects cortical oscillations across an expansive network.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173896"},"PeriodicalIF":3.3,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic-epigenetic-neuropeptide associations in mood and anxiety disorders: Toward personalized medicine","authors":"Maryam Gilani ,&nbsp;Niloofar Abak ,&nbsp;Mostafa Saberian","doi":"10.1016/j.pbb.2024.173897","DOIUrl":"10.1016/j.pbb.2024.173897","url":null,"abstract":"<div><div>Mood and anxiety disorders are complex psychiatric conditions shaped by the multifactorial interplay of genetic, epigenetic, and neuropeptide factors. This review aims to elucidate the intricate interactions among these factors and their potential in advancing personalized medicine. We examine the genetic underpinnings, emphasizing key heritability studies and specific gene associations. The role of epigenetics is discussed, focusing on how environmental factors can modify gene expression and contribute to these disorders. Neuropeptides, including substance P, CRF, AVP, NPY, galanin, and kisspeptin, are evaluated for their involvement in mood regulation and their potential as therapeutic targets. Additionally, we address the emerging role of the gut microbiome in modulating neuropeptide activity and its connection to mood disorders. This review integrates findings from genetic, epigenetic, and neuropeptide research, offering a comprehensive overview of their collective impact on mood and anxiety disorders. By highlighting novel insights and potential clinical applications, we underscore the importance of a multi-omics approach in developing personalized treatment strategies. Future research directions are proposed to address existing knowledge gaps and translate these findings into clinical practice. Our review provides a fresh perspective on the pathophysiology of mood and anxiety disorders, paving the way for more effective and individualized therapies.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173897"},"PeriodicalIF":3.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute exercise performed during the late consolidation phase improves memory persistence by hippocampal protein synthesis and catecholamine modulation","authors":"Karine Ramires Lima,&nbsp;Ana Carolina de Souza da Rosa,&nbsp;Gabriela Cristiane Mendes Gomes,&nbsp;Gabriela Jaques Sigaran,&nbsp;Anna Cecilia Perretto,&nbsp;Pâmela Billig Mello-Carpes","doi":"10.1016/j.pbb.2024.173893","DOIUrl":"10.1016/j.pbb.2024.173893","url":null,"abstract":"<div><div>Memory persistence is a crucial aspect of long-term memory (LTM) and involves late consolidation processes that modulate memory stability over time. Acute physical exercise (PE) has emerged as a potential strategy to modulate memory consolidation and enhance memory persistence. While its effects have been extensively explored in the early consolidation phase, its impact on the late phase remains unexplored. In this study, we investigated the effects and mechanisms of an acute PE on the late consolidation window of novel object recognition (NOR) memory in rats. A 30-minute running session applied 11 h after NOR memory acquisition significantly increased memory persistence for at least 7 days. The inhibition of hippocampal protein synthesis immediately after acute PE using anisomycin (a ribosomal inhibitor) or rapamycin (an mTOR pathway inhibitor) impaired the effect of PE on memory persistence. Animals only presented memory 1 day after acquisition. The same effect was observed with the inhibition of beta-adrenergic receptors by timolol. Although there were no differences between the groups' comparison, blocking D1/D5 receptors after acute PE resulted in a lack of memory persistence in the dichotomous testing (remember/non-remember). Therefore, our exploration of the mechanisms underlying this enhancement revealed the involvement of protein synthesis and the requirement of beta-adrenergic and dopaminergic D1/D5 receptors in the dorsal hippocampus. These findings provide valuable insights into PE as a potential memory modulator, contributing to expanding our understanding of memory consolidation dynamics and acute PE effects.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173893"},"PeriodicalIF":3.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}