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Mouse Models in Circadian Rhythm and Melatonin Research 昼夜节律和褪黑激素研究中的小鼠模型。
IF 8.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-04 DOI: 10.1111/jpi.12986
Horst-Werner Korf, Charlotte von Gall

This contribution reviews the role of inbred and transgenic mouse strains for deciphering the mammalian melatoninergic and circadian system. It focusses on the pineal organ as melatonin factory and two major targets of the melatoninergic system, the suprachiasmatic nuclei (SCN) and the hypophysial pars tuberalis (PT). Mammalian pinealocytes sharing molecular characteristics with true pineal and retinal photoreceptors synthesize and secrete melatonin into the blood and cerebrospinal fluid night by night. Notably, neuron-like connections exist between the deep pinealocytes and the habenular/pretectal region suggesting direct pineal-brain communication. Control of melatonin biosynthesis in rodents involves transcriptional regulation including phosphorylation of CREB and upregulation of mPer1. In the SCN, melatonin acts upon MT1 and MT2 receptors. Melatonin is not necessary to maintain the rhythm of the SCN molecular clockwork, but it has distinct effects on the synchronization of the circadian rhythm by light, facilitates re-entrainment of the circadian system to phase advances in the level of the SCN molecular clockwork by acting upon MT2 receptors and plays a stabilizing role in the circadian system as evidenced from locomotor activity recordings. While the effects in the SCN are subtle, melatonin is essential for PT functions. Via the MT1 receptor it drives the PT-intrinsic molecular clockwork and the retrograde and anterograde output pathways controlling seasonal rhythmicity. Although inbred and transgenic mice do not show seasonal reproduction, the pathways from the PT are fully intact if the animals are melatonin proficient. Thus, only melatonin-proficient strains are suited to investigate the circadian and melatoninergic systems.

这篇论文回顾了近交系和转基因小鼠品系在破译哺乳动物褪黑激素能和昼夜节律系统方面的作用。它重点研究了作为褪黑激素工厂的松果体器官以及褪黑激素能系统的两个主要靶点--上丘脑核(SCN)和下丘脑旁(PT)。哺乳动物的松果体细胞与真正的松果体和视网膜感光细胞具有相同的分子特征,每晚合成并分泌褪黑激素到血液和脑脊液中。值得注意的是,深部松果体细胞与视网膜/网膜区域之间存在神经元样连接,这表明松果体与大脑之间存在直接交流。啮齿类动物褪黑激素生物合成的控制涉及转录调控,包括 CREB 磷酸化和 mPer1 的上调。在SCN中,褪黑激素作用于MT1和MT2受体。褪黑激素并不是维持 SCN 分子时钟节律所必需的,但它对光对昼夜节律的同步有明显的影响,通过作用于 MT2 受体,促进昼夜节律系统重新适应 SCN 分子时钟水平的相位变化,并在昼夜节律系统中发挥稳定作用,运动活动记录证明了这一点。虽然褪黑激素对 SCN 的影响是微妙的,但它对 PT 功能至关重要。它通过 MT1 受体驱动昼夜节律内在分子时钟以及控制季节节律的逆行和顺行输出途径。虽然近亲繁殖和转基因小鼠不表现出季节性繁殖,但如果动物缺乏褪黑激素,来自PT的通路则完全完好无损。因此,只有富含褪黑激素的品系才适合研究昼夜节律和褪黑激素能系统。
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引用次数: 0
RETRACTION: Changes in the Expression of Melatonin Receptors Induced by Melatonin Treatment in Hepatocarcinoma HepG2 Cells 回归:褪黑激素治疗诱导的肝癌 HepG2 细胞中褪黑激素受体表达的变化。
IF 8.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-24 DOI: 10.1111/jpi.12975

RETRACTION: Carbajo-Pescador S, Martín-Renedo J, García-Palomo A, Tuñón MJ, Mauriz JL, González-Gallego J. Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells. Journal of Pineal Research, 2009;47: 330-338. https://doi.org/10.1111/j.1600-079X.2009.00719.x

The above article, published online on 14 October 2009 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 5. The authors could not provide the original data for this figure, and were unable to provide a satisfactory explanation to resolve the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:Carbajo-Pescador S、Martín-Renedo J、García-Palomo A、Tuñón MJ、Mauriz JL、González-Gallego J.褪黑激素治疗诱导的肝癌HepG2细胞中褪黑激素受体表达的变化。松果体研究杂志,2009;47:330-338。https://doi.org/10.1111/j.1600-079X.2009.00719.x 上述文章于 2009 年 10 月 14 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经杂志主编 Gianluca Tosini 和 John Wiley and Sons Ltd.(约翰-威利父子有限公司)协商,该文章已被撤回。文章发表后,第三方对图 5 提出了质疑。作者无法提供该图的原始数据,也无法提供令人满意的解释来消除疑虑。由于担心图中的部分内容被重复,影响对数据和结果的解释,作者同意撤回论文。作者不同意这一决定。
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引用次数: 0
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose−Response Meta-Analysis 优化褪黑素作为促进睡眠药物的使用时间和剂量:随机对照试验的系统回顾与剂量反应元分析》。
IF 10.3 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-18 DOI: 10.1111/jpi.12985
Francy Cruz-Sanabria, Simone Bruno, Alessio Crippa, Paolo Frumento, Marco Scarselli, Debra J. Skene, Ugo Faraguna

Previous studies have reported inconsistent results about exogenous melatonin's sleep-promoting effects. A possible explanation relies on the heterogeneity in administration schedule and dose, which might be accountable for differences in treatment efficacy. In this paper, we undertook a systematic review and meta-analysis of double-blind, randomized controlled trials performed on patients with insomnia and healthy volunteers, evaluating the effect of melatonin administration on sleep-related parameters. The standardized mean difference between treatment and placebo groups in terms of sleep onset latency and total sleep time were used as outcomes. Dose−response and meta-regression models were estimated to explore how time of administration, dose, and other treatment-related parameters might affect exogenous melatonin's efficacy. We included 26 randomized controlled trials published between 1987 and 2020, for a total of 1689 observations. Dose−response meta-analysis showed that melatonin gradually reduces sleep onset latency and increases total sleep time, peaking at 4 mg/day. Meta-regression models showed that insomnia status (β = 0.50, p < 0.001) and time between treatment administration and the sleep episode (β = −0.16, p = 0.023) were significant predictors of sleep onset latency, while the time of day (β = −0.086, p < 0.01) was the only significant predictor of total sleep time. Our results suggest that advancing the timing of administration (3 h before the desired bedtime) and increasing the administered dose (4 mg/day), as compared to the exogenous melatonin schedule most used in clinical practice (2 mg 30 min before the desired bedtime), might optimize the efficacy of exogenous melatonin in promoting sleep.

以往的研究对外源性褪黑素促进睡眠效果的研究结果并不一致。一种可能的解释是,给药时间和剂量的不一致性可能是造成疗效差异的原因。在本文中,我们对针对失眠症患者和健康志愿者进行的双盲随机对照试验进行了系统回顾和荟萃分析,评估了服用褪黑素对睡眠相关参数的影响。结果以治疗组和安慰剂组在睡眠开始潜伏期和总睡眠时间方面的标准化平均差异为依据。我们估算了剂量-反应模型和元回归模型,以探讨给药时间、剂量和其他治疗相关参数如何影响外源性褪黑素的疗效。我们纳入了 1987 年至 2020 年间发表的 26 项随机对照试验,共观察到 1689 条数据。剂量-反应荟萃分析表明,褪黑素可逐渐降低睡眠开始潜伏期并增加总睡眠时间,在每天 4 毫克时达到峰值。元回归模型显示,失眠状态(β = 0.50,p
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引用次数: 0
RETRACTION: Melatonin Attenuates Apoptotic Liver Damage in Fulminant Hepatic Failure Induced by the Rabbit Hemorrhagic Disease Virus 返回:褪黑素可减轻兔出血病病毒诱发的暴发性肝衰竭的肝细胞凋亡损伤
IF 10.3 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-17 DOI: 10.1111/jpi.12976

RETRACTION: Tuñón MJ, Miguel BS, Crespo I, Jorquera F, Santamaría E, Alvarez M, Prieto J, González-Gallego J. Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus. J Pineal Res 2011;50:38-45. https://doi.org/10.1111/j.1600-079X.2010.00807.x

The above article, published online on 22 October 2010 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties that portions of Figure 4 are duplicated in Figures 4, 2A, and 1B, respectively, of three other articles by the same author group.1-3 The authors provided some of the original data, but these were not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figure overlap with the authors' previous articles, affecting the interpretation of the data and results presented. The authors disagree with this decision.

1. Kretzmann NA, Fillmann H, Mauriz JL, Marroni, CA, Marroni N, González-Gallego J, Tuñón MJ. Effects of glutamine on pro-inflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. Inflamm Bowel Dis 2008;14:1504-1513. doi:10.1002/ibd.20543

2. Crespo I, García-Mediavilla MV, Gutiérrez B, Sánchez-Campos S, Tuñón MJ, González-Gallego J. A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells. Br J Nutr 2008;100(5):968-976. doi:10.1017/S0007114508966083

3. Laliena A, Miguel BS, Crespo I, Alvarez M, González-Gallego J, Tuñón MJ. Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin. J Pineal Res 2012;53:270-278. doi:10.1111/j.1600-079X.2012.00995.x

撤回:Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus.J Pineal Res 2011;50:38-45。https://doi.org/10.1111/j.1600-079X.2010.00807.x 上述文章于 2010 年 10 月 22 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经杂志主编 Gianluca Tosini 和 John Wiley and Sons Ltd.(约翰-威利父子有限公司)协商,该文章已被撤回。文章发表后,第三方提出质疑,认为图 4 的部分内容与同一作者组的另外三篇文章的图 4、图 2A 和图 1B 分别重复。之所以同意撤稿,是因为有人担心该图的部分内容与作者以前的文章重叠,影响了对所提供数据和结果的解释。作者不同意这一决定。1.Kretzmann NA, Fillmann H, Mauriz JL, Marroni, CA, Marroni N, González-Gallego J, Tuñón MJ.谷氨酰胺对 TNBS 诱导的结肠炎中促炎症基因表达以及核因子卡巴 B 和信号转导及转录激活因子激活的影响。Doi:10.1002/ibd.20543 2.Crespo I, García-Mediavilla MV, Gutiérrez B, Sánchez-Campos S, Tuñón MJ, González-Gallego J. 比较山奈酚和槲皮素对细胞因子诱导的培养人内皮细胞促炎状态的影响。doi:10.1017/S0007114508966083 3.Laliena A, Miguel BS, Crespo I, Alvarez M, González-Gallego J, Tuñón MJ.褪黑激素可减轻病毒性暴发性肝炎家兔的炎症反应并促进再生。doi:10.1111/j.1600-079X.2012.00995.x.
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引用次数: 0
RETRACTION: Melatonin Induces Cell Cycle Arrest and Apoptosis in Hepatocarcinoma HepG2 Cell Line 返回:褪黑素诱导肝癌 HepG2 细胞系的细胞周期停滞和细胞凋亡。
IF 10.3 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-17 DOI: 10.1111/jpi.12974

RETRACTION: Martín-Renedo J, Mauriz JL, Jorquera F, Ruiz-Andrés O, González P, González-Gallego J. Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res 2008;45:532-540. https://doi.org/10.1111/j.1600-079X.2008.00641.x

The above article, published online on 9 October 2008 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 5B. The authors could not provide the original data for this figure, and were unable to provide a satisfactory explanation to resolve the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:Martín-Renedo J, Mauriz JL, Jorquera F, Ruiz-Andrés O, González P, González-Gallego J. Melatonin induces cell cycle arrests and apoptosis in hepatocarcinoma HepG2 cell line.J Pineal Res 2008;45:532-540. https://doi.org/10.1111/j.1600-079X.2008.00641.x 上述文章于 2008 年 10 月 9 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经杂志主编 Gianluca Tosini 和 John Wiley and Sons Ltd.(约翰-威利父子有限公司)同意,该文章已被撤回。文章发表后,第三方对图 5B 提出了质疑。作者无法提供该图的原始数据,也无法提供令人满意的解释来消除疑虑。由于该图部分内容重复,影响了对数据和结果的解释,因此同意撤稿。作者不同意这一决定。
{"title":"RETRACTION: Melatonin Induces Cell Cycle Arrest and Apoptosis in Hepatocarcinoma HepG2 Cell Line","authors":"","doi":"10.1111/jpi.12974","DOIUrl":"10.1111/jpi.12974","url":null,"abstract":"<p><b>RETRACTION:</b> Martín-Renedo J, Mauriz JL, Jorquera F, Ruiz-Andrés O, González P, González-Gallego J. Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. <i>J Pineal Res</i> 2008;45:532-540. https://doi.org/10.1111/j.1600-079X.2008.00641.x</p><p>The above article, published online on 9 October 2008 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 5B. The authors could not provide the original data for this figure, and were unable to provide a satisfactory explanation to resolve the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.12974","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Melatonin Inhibits the Expression of the Inducible Isoform of Nitric Oxide Synthase and Nuclear Factor Kappa B Activation in Rat Skeletal Muscle 回归:褪黑素抑制大鼠骨骼肌中一氧化氮合成酶诱导型异构体的表达和核因子 Kappa B 的激活。
IF 10.3 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-17 DOI: 10.1111/jpi.12972

RETRACTION: Alonso M, Collado PS, González-Gallego J. Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle. J Pineal Res 2006;41:8-14. https://doi.org/10.1111/j.1600-079X.2006.00323.x

The above article, published online on 28 June 2006 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 1. The authors could not provide the original data for this figure, and were unable to provide a satisfactory explanation to resolve the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:Alonso M, Collado PS, González-Gallego J. 褪黑激素抑制大鼠骨骼肌一氧化氮合酶诱导型同工酶的表达和核因子卡巴B的激活。J Pineal Res 2006;41:8-14。https://doi.org/10.1111/j.1600-079X.2006.00323.x 上述文章于 2006 年 6 月 28 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经期刊主编 Gianluca Tosini 和 John Wiley and Sons Ltd.(约翰-威利父子有限公司)协商,该文章已被撤回。文章发表后,第三方对图 1 提出了质疑。作者无法提供该图的原始数据,也无法提供令人满意的解释来消除疑虑。由于该图的部分内容被重复,影响了对数据和结果的解释,因此作者同意撤回该图。作者不同意这一决定。
{"title":"RETRACTION: Melatonin Inhibits the Expression of the Inducible Isoform of Nitric Oxide Synthase and Nuclear Factor Kappa B Activation in Rat Skeletal Muscle","authors":"","doi":"10.1111/jpi.12972","DOIUrl":"10.1111/jpi.12972","url":null,"abstract":"<p><b>RETRACTION:</b> Alonso M, Collado PS, González-Gallego J. Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle. <i>J Pineal Res</i> 2006;41:8-14. https://doi.org/10.1111/j.1600-079X.2006.00323.x</p><p>The above article, published online on 28 June 2006 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 1. The authors could not provide the original data for this figure, and were unable to provide a satisfactory explanation to resolve the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.12972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Melatonin Prevents Deregulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Signaling Pathway in a Mouse Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma 回放:褪黑素可防止二乙亚硝胺诱发肝细胞癌小鼠模型中鞘氨醇激酶/鞘氨醇 1-磷酸信号通路的失调。
IF 10.3 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-17 DOI: 10.1111/jpi.12980

RETRACTION: Sánchez DI, González-Fernández B, San-Miguel B, de Urbina JO, Crespo I, González-Gallego J, Tuñón MJ. Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. J Pineal Res 2017;62:e12369. https://doi.org/10.1111/jpi.12369

The above article, published online on 1 October 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 4C. The authors could not provide the original data for this figure. The authors provided an updated image, but this was not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:Sánchez DI, González-Fernández B, San-Miguel B, de Urbina JO, Crespo I, González-Gallego J, Tuñón MJ.褪黑素可防止鞘氨醇激酶/1-磷酸鞘氨醇信号通路在二乙基亚硝胺诱导的肝细胞癌小鼠模型中的失调。J Pineal Res 2017;62:e12369。https://doi.org/10.1111/jpi.12369 上述文章于2016年10月1日在线发表于《Wiley Online Library》(wileyonlinelibrary.com),经期刊主编Gianluca Tosini和John Wiley and Sons Ltd.协议,该文章已被撤回。文章发表后,第三方对图 4C 提出了质疑。作者无法提供该图的原始数据。作者提供了一张更新的图片,但这并不足以消除疑虑,作者也无法对疑虑做出令人满意的解释。同意撤稿的原因是担心该图的部分内容重复,影响了对所提供数据和结果的解释。作者不同意这一决定。
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引用次数: 0
RETRACTION: Melatonin Attenuates Inflammation and Promotes Regeneration in Rabbits With Fulminant Hepatitis of Viral Origin 回放:褪黑素可减轻病毒性暴发性肝炎家兔的炎症反应并促进再生。
IF 10.3 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-17 DOI: 10.1111/jpi.12977

RETRACTION: Laliena A, Miguel BS, Crespo I, Alvarez M, González-Gallego J, Tuñón MJ. Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin. J Pineal Res 2012;53:270-278. https://doi.org/10.1111/j.1600-079X.2012.00995.x

The above article, published online on 19 March 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties that portions of Figure 1B are duplicated in Figures 4, 2A, and 4, respectively, of two other articles by the same author group.1-3 The authors provided some of the original data, but these were not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figure overlap with the authors' previous articles, affecting the interpretation of the data and results presented. The authors disagree with this decision.

1. Kretzmann NA, Fillmann H, Mauriz JL, Marroni, CA, Marroni N, González-Gallego J, Tuñón MJ. Effects of glutamine on pro-inflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. Inflamm Bowel Dis 2008;14:1504-1513. https://doi.org/10.1002/ibd.20543

2. Crespo I, García-Mediavilla MV, Gutiérrez B, Sánchez-Campos S, Tuñón MJ, González-Gallego J. A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells. Br J Nutr 2008;100(5):968-976. https://doi.org/10.1017/S0007114508966083

3. Tuñón MJ, Miguel BS, Crespo I, Jorquera F, Santamaría E, Alvarez M, Prieto J, González-Gallego J. Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus. J Pineal Res 2011;50:38-45. https://doi.org/10.1111/j.1600-079X.2010.00807.x

撤回:Laliena A、Miguel BS、Crespo I、Alvarez M、González-Gallego J、Tuñón MJ。褪黑激素可减轻病毒性暴发性肝炎兔的炎症反应并促进再生。J Pineal Res 2012; 53:270-278。https://doi.org/10.1111/j.1600-079X.2012.00995.x 上述文章于 2012 年 3 月 19 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经杂志主编 Gianluca Tosini 和 John Wiley and Sons Ltd.(约翰-威利父子有限公司)协商,该文章已被撤回。图 1B 的部分内容在同一作者组的另外两篇文章的图 4、图 2A 和图 4 中分别出现了重复。之所以同意撤稿,是因为有人担心该图的部分内容与作者以前的文章重叠,影响了对所提供数据和结果的解释。作者不同意这一决定。1.Kretzmann NA, Fillmann H, Mauriz JL, Marroni, CA, Marroni N, González-Gallego J, Tuñón MJ.谷氨酰胺对 TNBS 诱导的结肠炎中促炎症基因表达以及核因子卡巴 B 和信号转导及转录激活因子激活的影响。Inflamm Bowel Dis 2008; 14:1504-1513. https://doi.org/10.1002/ibd.20543 2.Crespo I, García-Mediavilla MV, Gutiérrez B, Sánchez-Campos S, Tuñón MJ, González-Gallego J. 比较山奈酚和槲皮素对细胞因子诱导的培养人内皮细胞促炎状态的影响。Br J Nutr 2008;100(5):968-976. https://doi.org/10.1017/S0007114508966083 3.Tuñón MJ, Miguel BS, Crespo I, Jorquera F, Santamaría E, Alvarez M, Prieto J, González-Gallego J. Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus.J Pineal Res 2011;50:38-45. https://doi.org/10.1111/j.1600-079X.2010.00807.x.
{"title":"RETRACTION: Melatonin Attenuates Inflammation and Promotes Regeneration in Rabbits With Fulminant Hepatitis of Viral Origin","authors":"","doi":"10.1111/jpi.12977","DOIUrl":"10.1111/jpi.12977","url":null,"abstract":"<p><b>RETRACTION:</b> Laliena A, Miguel BS, Crespo I, Alvarez M, González-Gallego J, Tuñón MJ. Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin. <i>J Pineal Res</i> 2012;53:270-278. https://doi.org/10.1111/j.1600-079X.2012.00995.x</p><p>The above article, published online on 19 March 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties that portions of Figure 1B are duplicated in Figures 4, 2A, and 4, respectively, of two other articles by the same author group.<sup>1-3</sup> The authors provided some of the original data, but these were not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figure overlap with the authors' previous articles, affecting the interpretation of the data and results presented. The authors disagree with this decision.</p><p>1. Kretzmann NA, Fillmann H, Mauriz JL, Marroni, CA, Marroni N, González-Gallego J, Tuñón MJ. Effects of glutamine on pro-inflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. <i>Inflamm Bowel Dis</i> 2008;14:1504-1513. https://doi.org/10.1002/ibd.20543</p><p>2. Crespo I, García-Mediavilla MV, Gutiérrez B, Sánchez-Campos S, Tuñón MJ, González-Gallego J. A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells. <i>Br J Nutr</i> 2008;100(5):968-976. https://doi.org/10.1017/S0007114508966083</p><p>3. Tuñón MJ, Miguel BS, Crespo I, Jorquera F, Santamaría E, Alvarez M, Prieto J, González-Gallego J. Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus. <i>J Pineal Res</i> 2011;50:38-45. https://doi.org/10.1111/j.1600-079X.2010.00807.x</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.12977","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Melatonin Inhibits Autophagy and Endoplasmic Reticulum Stress in Mice With Carbon Tetrachloride-Induced Fibrosis 回放:褪黑素可抑制四氯化碳诱发纤维化小鼠的自噬和内质网应激。
IF 10.3 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-17 DOI: 10.1111/jpi.12978

RETRACTION: San-Miguel B, Crespo I, Sánchez, DI, González-Fernández B, Ortiz de Urbina JJ, Tuñón MJ, González-Gallego J. Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis. J Pineal Res 2015;59:151-162. https://doi.org/10.1111/jpi.12247

The above article, published online on 8 May 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figures 3 A and 6 A. The authors could not provide the original data for these figures. The authors provided some updated images, but these were not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figures were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:San-Miguel B, Crespo I, Sánchez, DI, González-Fernández B, Ortiz de Urbina JJ, Tuñón MJ, González-Gallego J. Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis.J Pineal Res 2015;59:151-162。https://doi.org/10.1111/jpi.12247 上述文章于2015年5月8日在线发表于Wiley Online Library (wileyonlinelibrary.com),经期刊主编Gianluca Tosini和John Wiley and Sons Ltd.协议,该文章已被撤回。文章发表后,第三方对图 3 A 和图 6 A 提出了质疑。作者无法提供这些图的原始数据。作者提供了一些更新的图片,但这些图片不足以解决这些问题,作者也无法对这些问题做出令人满意的解释。同意撤稿的原因是担心部分图表重复,影响对数据和结果的解释。作者不同意这一决定。
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引用次数: 0
RETRACTION: Melatonin Modulates Dysregulated Circadian Clocks in Mice With Diethylnitrosamine-Induced Hepatocellular Carcinoma 回放:褪黑素可调节二乙基亚硝胺诱发肝细胞癌小鼠体内失调的昼夜节律。
IF 10.3 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-17 DOI: 10.1111/jpi.12981

RETRACTION: Sánchez DI, González-Fernández B, Crespo I, San-Miguel B, Álvarez M, González-Gallego J, Tuñón MJ. Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma. J Pineal Res 2018; 65:e12506. https://doi.org/10.1111/jpi.12506

The above article, published online on 16 May 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figures 1C and 3C. Specifically, concerns were raised that portions of Figure 1C are duplicated in Figure 2C of another article by the same author group.1 Concerns were also raised that portions of Figure 3C were duplicated within the figure. The authors could not provide the original data for these figures. The authors provided some updated images, but these were not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figures were duplicated and overlap with the authors' previous article, affecting the interpretation of the data and results presented. The authors disagree with this decision.

1. González-Fernández B, Sánchez DI, Crespo I, San-Miguel B, de Urbina JO, González-Gallego J, Tuñón MJ. Melatonin attenuates dysregulation of the circadian clock pathway in mice with ccl4-induced fibrosis and human hepatic stellate cells. Front. Pharmacol 2018;9:556. https://doi.org/10.3389/fphar.2018.00556

撤回:Sánchez DI, González-Fernández B, Crespo I, San-Miguel B, Álvarez M, González-Gallego J, Tuñón MJ.褪黑激素调节饮食亚硝胺诱发肝细胞癌小鼠体内失调的昼夜节律。J Pineal Res 2018; 65:e12506。https://doi.org/10.1111/jpi.12506 上述文章于2018年5月16日在线发表于《威利在线图书馆》(wileyonlinelibrary.com),经期刊主编Gianluca Tosini和John Wiley and Sons Ltd.协议,该文章已被撤回。文章发表后,第三方对图 1C 和图 3C 提出了质疑。具体来说,有人担心图 1C 中的部分内容与同一作者组1 的另一篇文章的图 2C 中的内容重复。作者无法提供这些图的原始数据。作者提供了一些更新的图片,但这些图片不足以解决这些问题,作者也无法对这些问题做出令人满意的解释。之所以同意撤稿,是因为有人担心部分图表与作者之前的文章重复和重叠,影响了对数据和结果的解释。作者不同意这一决定。1.González-Fernández B, Sánchez DI, Crespo I, San-Miguel B, de Urbina JO, González-Gallego J, Tuñón MJ.褪黑素可减轻cl4诱导纤维化小鼠和人类肝星状细胞昼夜节律时钟通路的失调。Front.Pharmacol 2018;9:556. https://doi.org/10.3389/fphar.2018.00556.
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