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RETRACTION: Melatonin Inhibits the Expression of the Inducible Isoform of Nitric Oxide Synthase and Nuclear Factor Kappa B Activation in Rat Skeletal Muscle 回归:褪黑素抑制大鼠骨骼肌中一氧化氮合成酶诱导型异构体的表达和核因子 Kappa B 的激活。
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-17 DOI: 10.1111/jpi.12972

RETRACTION: Alonso M, Collado PS, González-Gallego J. Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle. J Pineal Res 2006;41:8-14. https://doi.org/10.1111/j.1600-079X.2006.00323.x

The above article, published online on 28 June 2006 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 1. The authors could not provide the original data for this figure, and were unable to provide a satisfactory explanation to resolve the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:Alonso M, Collado PS, González-Gallego J. 褪黑激素抑制大鼠骨骼肌一氧化氮合酶诱导型同工酶的表达和核因子卡巴B的激活。J Pineal Res 2006;41:8-14。https://doi.org/10.1111/j.1600-079X.2006.00323.x 上述文章于 2006 年 6 月 28 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经期刊主编 Gianluca Tosini 和 John Wiley and Sons Ltd.(约翰-威利父子有限公司)协商,该文章已被撤回。文章发表后,第三方对图 1 提出了质疑。作者无法提供该图的原始数据,也无法提供令人满意的解释来消除疑虑。由于该图的部分内容被重复,影响了对数据和结果的解释,因此作者同意撤回该图。作者不同意这一决定。
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引用次数: 0
RETRACTION: Melatonin Prevents Deregulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Signaling Pathway in a Mouse Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma 回放:褪黑素可防止二乙亚硝胺诱发肝细胞癌小鼠模型中鞘氨醇激酶/鞘氨醇 1-磷酸信号通路的失调。
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-17 DOI: 10.1111/jpi.12980

RETRACTION: Sánchez DI, González-Fernández B, San-Miguel B, de Urbina JO, Crespo I, González-Gallego J, Tuñón MJ. Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. J Pineal Res 2017;62:e12369. https://doi.org/10.1111/jpi.12369

The above article, published online on 1 October 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 4C. The authors could not provide the original data for this figure. The authors provided an updated image, but this was not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:Sánchez DI, González-Fernández B, San-Miguel B, de Urbina JO, Crespo I, González-Gallego J, Tuñón MJ.褪黑素可防止鞘氨醇激酶/1-磷酸鞘氨醇信号通路在二乙基亚硝胺诱导的肝细胞癌小鼠模型中的失调。J Pineal Res 2017;62:e12369。https://doi.org/10.1111/jpi.12369 上述文章于2016年10月1日在线发表于《Wiley Online Library》(wileyonlinelibrary.com),经期刊主编Gianluca Tosini和John Wiley and Sons Ltd.协议,该文章已被撤回。文章发表后,第三方对图 4C 提出了质疑。作者无法提供该图的原始数据。作者提供了一张更新的图片,但这并不足以消除疑虑,作者也无法对疑虑做出令人满意的解释。同意撤稿的原因是担心该图的部分内容重复,影响了对所提供数据和结果的解释。作者不同意这一决定。
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引用次数: 0
RETRACTION: Melatonin Attenuates Inflammation and Promotes Regeneration in Rabbits With Fulminant Hepatitis of Viral Origin 回放:褪黑素可减轻病毒性暴发性肝炎家兔的炎症反应并促进再生。
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-17 DOI: 10.1111/jpi.12977

RETRACTION: Laliena A, Miguel BS, Crespo I, Alvarez M, González-Gallego J, Tuñón MJ. Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin. J Pineal Res 2012;53:270-278. https://doi.org/10.1111/j.1600-079X.2012.00995.x

The above article, published online on 19 March 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties that portions of Figure 1B are duplicated in Figures 4, 2A, and 4, respectively, of two other articles by the same author group.1-3 The authors provided some of the original data, but these were not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figure overlap with the authors' previous articles, affecting the interpretation of the data and results presented. The authors disagree with this decision.

1. Kretzmann NA, Fillmann H, Mauriz JL, Marroni, CA, Marroni N, González-Gallego J, Tuñón MJ. Effects of glutamine on pro-inflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. Inflamm Bowel Dis 2008;14:1504-1513. https://doi.org/10.1002/ibd.20543

2. Crespo I, García-Mediavilla MV, Gutiérrez B, Sánchez-Campos S, Tuñón MJ, González-Gallego J. A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells. Br J Nutr 2008;100(5):968-976. https://doi.org/10.1017/S0007114508966083

3. Tuñón MJ, Miguel BS, Crespo I, Jorquera F, Santamaría E, Alvarez M, Prieto J, González-Gallego J. Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus. J Pineal Res 2011;50:38-45. https://doi.org/10.1111/j.1600-079X.2010.00807.x

撤回:Laliena A、Miguel BS、Crespo I、Alvarez M、González-Gallego J、Tuñón MJ。褪黑激素可减轻病毒性暴发性肝炎兔的炎症反应并促进再生。J Pineal Res 2012; 53:270-278。https://doi.org/10.1111/j.1600-079X.2012.00995.x 上述文章于 2012 年 3 月 19 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经杂志主编 Gianluca Tosini 和 John Wiley and Sons Ltd.(约翰-威利父子有限公司)协商,该文章已被撤回。图 1B 的部分内容在同一作者组的另外两篇文章的图 4、图 2A 和图 4 中分别出现了重复。之所以同意撤稿,是因为有人担心该图的部分内容与作者以前的文章重叠,影响了对所提供数据和结果的解释。作者不同意这一决定。1.Kretzmann NA, Fillmann H, Mauriz JL, Marroni, CA, Marroni N, González-Gallego J, Tuñón MJ.谷氨酰胺对 TNBS 诱导的结肠炎中促炎症基因表达以及核因子卡巴 B 和信号转导及转录激活因子激活的影响。Inflamm Bowel Dis 2008; 14:1504-1513. https://doi.org/10.1002/ibd.20543 2.Crespo I, García-Mediavilla MV, Gutiérrez B, Sánchez-Campos S, Tuñón MJ, González-Gallego J. 比较山奈酚和槲皮素对细胞因子诱导的培养人内皮细胞促炎状态的影响。Br J Nutr 2008;100(5):968-976. https://doi.org/10.1017/S0007114508966083 3.Tuñón MJ, Miguel BS, Crespo I, Jorquera F, Santamaría E, Alvarez M, Prieto J, González-Gallego J. Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus.J Pineal Res 2011;50:38-45. https://doi.org/10.1111/j.1600-079X.2010.00807.x.
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引用次数: 0
RETRACTION: Melatonin Inhibits Autophagy and Endoplasmic Reticulum Stress in Mice With Carbon Tetrachloride-Induced Fibrosis 回放:褪黑素可抑制四氯化碳诱发纤维化小鼠的自噬和内质网应激。
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-17 DOI: 10.1111/jpi.12978

RETRACTION: San-Miguel B, Crespo I, Sánchez, DI, González-Fernández B, Ortiz de Urbina JJ, Tuñón MJ, González-Gallego J. Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis. J Pineal Res 2015;59:151-162. https://doi.org/10.1111/jpi.12247

The above article, published online on 8 May 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figures 3 A and 6 A. The authors could not provide the original data for these figures. The authors provided some updated images, but these were not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figures were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:San-Miguel B, Crespo I, Sánchez, DI, González-Fernández B, Ortiz de Urbina JJ, Tuñón MJ, González-Gallego J. Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis.J Pineal Res 2015;59:151-162。https://doi.org/10.1111/jpi.12247 上述文章于2015年5月8日在线发表于Wiley Online Library (wileyonlinelibrary.com),经期刊主编Gianluca Tosini和John Wiley and Sons Ltd.协议,该文章已被撤回。文章发表后,第三方对图 3 A 和图 6 A 提出了质疑。作者无法提供这些图的原始数据。作者提供了一些更新的图片,但这些图片不足以解决这些问题,作者也无法对这些问题做出令人满意的解释。同意撤稿的原因是担心部分图表重复,影响对数据和结果的解释。作者不同意这一决定。
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引用次数: 0
RETRACTION: Melatonin Modulates Dysregulated Circadian Clocks in Mice With Diethylnitrosamine-Induced Hepatocellular Carcinoma 回放:褪黑素可调节二乙基亚硝胺诱发肝细胞癌小鼠体内失调的昼夜节律。
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-17 DOI: 10.1111/jpi.12981

RETRACTION: Sánchez DI, González-Fernández B, Crespo I, San-Miguel B, Álvarez M, González-Gallego J, Tuñón MJ. Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma. J Pineal Res 2018; 65:e12506. https://doi.org/10.1111/jpi.12506

The above article, published online on 16 May 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figures 1C and 3C. Specifically, concerns were raised that portions of Figure 1C are duplicated in Figure 2C of another article by the same author group.1 Concerns were also raised that portions of Figure 3C were duplicated within the figure. The authors could not provide the original data for these figures. The authors provided some updated images, but these were not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figures were duplicated and overlap with the authors' previous article, affecting the interpretation of the data and results presented. The authors disagree with this decision.

1. González-Fernández B, Sánchez DI, Crespo I, San-Miguel B, de Urbina JO, González-Gallego J, Tuñón MJ. Melatonin attenuates dysregulation of the circadian clock pathway in mice with ccl4-induced fibrosis and human hepatic stellate cells. Front. Pharmacol 2018;9:556. https://doi.org/10.3389/fphar.2018.00556

撤回:Sánchez DI, González-Fernández B, Crespo I, San-Miguel B, Álvarez M, González-Gallego J, Tuñón MJ.褪黑激素调节饮食亚硝胺诱发肝细胞癌小鼠体内失调的昼夜节律。J Pineal Res 2018; 65:e12506。https://doi.org/10.1111/jpi.12506 上述文章于2018年5月16日在线发表于《威利在线图书馆》(wileyonlinelibrary.com),经期刊主编Gianluca Tosini和John Wiley and Sons Ltd.协议,该文章已被撤回。文章发表后,第三方对图 1C 和图 3C 提出了质疑。具体来说,有人担心图 1C 中的部分内容与同一作者组1 的另一篇文章的图 2C 中的内容重复。作者无法提供这些图的原始数据。作者提供了一些更新的图片,但这些图片不足以解决这些问题,作者也无法对这些问题做出令人满意的解释。之所以同意撤稿,是因为有人担心部分图表与作者之前的文章重复和重叠,影响了对数据和结果的解释。作者不同意这一决定。1.González-Fernández B, Sánchez DI, Crespo I, San-Miguel B, de Urbina JO, González-Gallego J, Tuñón MJ.褪黑素可减轻cl4诱导纤维化小鼠和人类肝星状细胞昼夜节律时钟通路的失调。Front.Pharmacol 2018;9:556. https://doi.org/10.3389/fphar.2018.00556.
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引用次数: 0
RETRACTION: Melatonin Prevents Oxidative Stress and Changes in Antioxidant Enzyme Expression and Activity in the Liver of Aging Rats 回放:褪黑素可防止氧化应激以及衰老大鼠肝脏中抗氧化酶表达和活性的变化。
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-17 DOI: 10.1111/jpi.12973

RETRACTION: Mauriz JL, Molpeceres V, García-Mediavilla MV, González P, Barrio JP, González-Gallego J. Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats. J Pineal Res 2007;42:222-230. https://doi.org/10.1111/j.1600-079X.2006.00409.x

The above article, published online on 12 December 2006 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 4A. The authors could not provide the original data for this figure, and were unable to provide a satisfactory explanation to resolve the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:Mauriz JL, Molpeceres V, García-Mediavilla MV, González P, Barrio JP, González-Gallego J. 褪黑激素可防止氧化应激以及衰老大鼠肝脏中抗氧化酶表达和活性的变化。J Pineal Res 2007; 42:222-230。https://doi.org/10.1111/j.1600-079X.2006.00409.x 上述文章于 2006 年 12 月 12 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经杂志主编 Gianluca Tosini 和 John Wiley and Sons Ltd.协商,该文章已被撤回。文章发表后,第三方对图 4A 提出了质疑。作者无法提供该图的原始数据,也无法提供令人满意的解释来消除疑虑。由于该图部分内容重复,影响了对数据和结果的解释,因此作者同意撤稿。作者不同意这一决定。
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引用次数: 0
RETRACTION: Melatonin Inhibits the Sphingosine Kinase 1/Sphingosine-1-Phosphate Signaling Pathway in Rabbits With Fulminant Hepatitis of Viral Origin 回放:褪黑素抑制病毒性暴发性肝炎家兔的鞘磷脂激酶 1/鞘磷脂-1-磷酸信号通路。
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-17 DOI: 10.1111/jpi.12979

RETRACTION: Crespo I, San-Miguel B, Sánchez DI, González-Fernández B, Álvarez M, González-Gallego J, Tuñón MJ. Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. J Pineal Res 2016;61: 168-176. https://doi.org/10.1111/jpi.12335

The above article, published online on 22 April 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figure 2A. The authors could not provide the original data for this figure. The authors provided an updated image, but this was not sufficient to resolve the concerns, and the authors were unable to provide a satisfactory explanation for the concerns. The retraction has been agreed because of concerns that portions of the figure were duplicated, affecting the interpretation of the data and results presented. The authors disagree with this decision.

撤回:Crespo I, San-Miguel B, Sánchez DI, González-Fernández B, Álvarez M, González-Gallego J, Tuñón MJ.褪黑激素抑制病毒性暴发性肝炎家兔的鞘磷脂激酶1/鞘磷脂-1-磷酸信号通路。J Pineal Res 2016;61: 168-176. https://doi.org/10.1111/jpi.12335 上述文章于2016年4月22日在线发表于《威利在线图书馆》(wileyonlinelibrary.com),经期刊主编Gianluca Tosini和John Wiley and Sons Ltd.协议,该文章已被撤回。文章发表后,第三方对图 2A 提出了质疑。作者无法提供该图的原始数据。作者提供了一张更新后的图片,但这不足以消除疑虑,作者也无法对疑虑做出令人满意的解释。同意撤稿的原因是担心该图的部分内容重复,影响了对所提供数据和结果的解释。作者不同意这一决定。
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引用次数: 0
Zygotic Exposure to Venlafaxine Disrupts the Circadian Locomotor Activity Behaviour in Zebrafish Larvae 斑马鱼幼体的昼夜节律运动行为受到文拉法辛的影响
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-14 DOI: 10.1111/jpi.12984
W. Andrew Thompson, Mathilakath M. Vijayan

The antidepressant venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, is commonly prescribed to treat major depressive disorder and is found at high concentrations in the aquatic environment. Concerns have been raised related to the health of aquatic organisms in response to this nontargeted pharmaceutical exposure. For instance, we previously demonstrated that exposure to venlafaxine perturbs neurodevelopment, leading to behavioural alterations in zebrafish (Danio rerio). We also observed disruption in serotonin expression in the pineal and raphe, regions critical in regulating circadian rhythms, leading us to hypothesize that zygotic exposure to venlafaxine disrupts the circadian locomotor rhythm in larval zebrafish. To test this, we microinjected zebrafish embryos with venlafaxine (1 or 10 ng) and recorded the locomotor activity in 5-day-old larvae over a 24-h period. Venlafaxine deposition reduced larval locomotor activity during the light phase, but not during the dark phase of the diurnal cycle. The melatonin levels were higher in the dark compared to during the light photoperiod and this was not affected by embryonic venlafaxine deposition. Venlafaxine exposure also did not affect the transcript abundance of clock genes, including clock1a, bmal2, cry1a and per2, which showed a clear day/night rhythmicity. A notable finding was that exposure to luzindole, a melatonin receptor antagonist, decreased the locomotor activity in the control group in light, whereas the activity was higher in larvae raised from the venlafaxine-deposited embryos. Overall, zygotic exposure to venlafaxine disrupts the locomotor activity of larval zebrafish fish during the day, demonstrating the capacity of antidepressants to disrupt the circadian rhythms in behaviour. Our results suggest that disruption in melatonin signalling may be playing a role in the venlafaxine impact on circadian behaviour, but further investigation is required to elucidate the possible mechanisms in larval zebrafish.

抗抑郁药文拉法辛(一种选择性血清素和去甲肾上腺素再摄取抑制剂)是治疗重度抑郁症的常用处方药,在水生环境中的浓度很高。这种非靶向药物接触引起了人们对水生生物健康的关注。例如,我们曾证实,暴露于文拉法辛会扰乱斑马鱼(Danio rerio)的神经发育,导致行为改变。我们还观察到松果体和剑突中的血清素表达受到干扰,而松果体和剑突是调节昼夜节律的关键区域,因此我们推测暴露于文拉法辛的子代会干扰幼体斑马鱼的昼夜节律。为了验证这一假设,我们给斑马鱼胚胎注射了文拉法辛(1 或 10 纳克),并记录了 5 天大幼体在 24 小时内的运动活动。在昼夜周期的光照阶段,文拉法辛的沉积降低了幼体的运动活动,但在黑暗阶段却没有降低。黑暗期的褪黑激素水平高于光照期,但这并不受胚胎期文拉法辛沉积的影响。暴露于文拉法辛也不会影响时钟基因的转录本丰度,包括clock1a、bmal2、cry1a和per2,这些基因表现出明显的昼夜节律性。一个值得注意的发现是,暴露于褪黑激素受体拮抗剂卢吲哚会降低对照组在光照下的运动活性,而文拉法辛沉积胚胎培育的幼虫的运动活性更高。总之,卵子期暴露于文拉法辛会扰乱斑马鱼幼鱼在白天的运动活动,这表明抗抑郁药有能力扰乱行为的昼夜节律。我们的研究结果表明,褪黑激素信号的中断可能是文拉法辛影响昼夜节律行为的原因之一,但要阐明斑马鱼幼体的可能机制还需要进一步的研究。
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引用次数: 0
Melatonin decreases human adipose tissue insulin sensitivity 褪黑素会降低人体脂肪组织对胰岛素的敏感性。
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-11 DOI: 10.1111/jpi.12965
Carolina Zambrano, Mireia Tena Garitaonaindia, Diego Salmerón, Fernando Pérez-Sanz, Cynthia Tchio, María Cecilia Picinato, Fermín Sánchez de Medina, Juan Luján, Frank A. J. L. Scheer, Richa Saxena, Olga Martínez-Augustin, Marta Garaulet

Melatonin is a pineal hormone that modulates the circadian system and exerts soporific and phase-shifting effects. It is also involved in many other physiological processes, such as those implicated in cardiovascular, endocrine, immune, and metabolic functions. However, the role of melatonin in glucose metabolism remains contradictory, and its action on human adipose tissue (AT) explants has not been demonstrated. We aimed to assess whether melatonin (a pharmacological dose) influences insulin sensitivity in human AT. This will help better understand melatonin administration's effect on glucose metabolism. Abdominal AT (subcutaneous and visceral) biopsies were obtained from 19 participants with severe obesity (age: 42.84 ± 12.48 years; body mass index: 43.14 ± 8.26 kg/m2) who underwent a laparoscopic gastric bypass. AT biopsies were exposed to four different treatments: control (C), insulin alone (I) (10 nM), melatonin alone (M) (5000 pg/mL), and insulin plus melatonin combined (I + M). All four conditions were repeated in both subcutaneous and visceral AT, and all were performed in the morning at 8 a.m. (n = 19) and the evening at 8 p.m. (in a subsample of n = 12). We used western blot analysis to determine insulin signaling (using the pAKT/tAKT ratio). Furthermore, RNAseq analyses were performed to better understand the metabolic pathways involved in the effect of melatonin on insulin signaling. As expected, insulin treatment (I) increased the pAKT/tAKT ratio compared with control (p < .0001). Furthermore, the addition of melatonin (I + M) resulted in a decrease in insulin signaling as compared with insulin alone (I); this effect was significant only during the evening time (not in the morning time). Further, RNAseq analyses in visceral AT during the evening condition (at 8 p.m.) showed that melatonin resulted in a prompt transcriptome response (around 1 h after melatonin addition), particularly by downregulating the insulin signaling pathway. Our results show that melatonin reduces insulin sensitivity in human AT during the evening. These results may partly explain the previous studies showing a decrease in glucose tolerance after oral melatonin administration in the evening or when eating late when endogenous melatonin is present.

褪黑素是一种松果体激素,它能调节昼夜节律系统,并具有催眠和移相作用。它还参与许多其他生理过程,例如与心血管、内分泌、免疫和新陈代谢功能有关的过程。然而,褪黑激素在葡萄糖代谢中的作用仍然存在矛盾,而且它对人体脂肪组织(AT)外植体的作用尚未得到证实。我们的目的是评估褪黑素(药理剂量)是否会影响人体脂肪组织的胰岛素敏感性。这将有助于更好地了解褪黑素对糖代谢的影响。我们从19名接受腹腔镜胃旁路手术的重度肥胖症患者(年龄:42.84 ± 12.48岁;体重指数:43.14 ± 8.26 kg/m2)身上采集了腹部AT(皮下和内脏)活检组织。腹腔镜胃旁路术活检组织接受了四种不同的治疗:对照组(C)、单用胰岛素组(I)(10 nM)、单用褪黑素组(M)(5000 pg/mL)和胰岛素加褪黑素组(I + M)。所有四种情况都在皮下和内脏 AT 中重复进行,并且都在早上 8 点(n = 19)和晚上 8 点(n = 12 的子样本)进行。我们使用 Western 印迹分析来确定胰岛素信号转导(使用 pAKT/tAKT 比值)。此外,我们还进行了 RNAseq 分析,以更好地了解褪黑激素对胰岛素信号转导的影响所涉及的代谢途径。不出所料,与对照组相比,胰岛素处理(I)增加了 pAKT/tAKT 比率(p
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引用次数: 0
Novel melatonin-producing Bacillus safensis EH143 mitigates salt and cadmium stress in soybean 新型褪黑素芽孢杆菌 EH143 可减轻大豆的盐和镉胁迫。
IF 10.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-05-27 DOI: 10.1111/jpi.12957
Eun-Hae Kwon, Arjun Adhikari, Muhammad Imran, Adil Hussain, Ho-Jun Gam, Ji-In Woo, Jin Ryeol Jeon, Da-Sol Lee, Chung-Yeol Lee, Liny Lay, Sang-Mo Kang, Won-Chan Kim, Byung-Wook Yun, In-Jung Lee

Recently, microorganism and exogenous melatonin application has been recognized as an efficient biological tool for enhancing salt tolerance and heavy metal detoxification in agriculture crops. Thus, the goal of this study was to isolate and evaluate a novel melatonin-producing plant growth promoting bacterium. With high-throughput whole genome sequencing, phytohormone measurements, expression profiling, and biochemical analysis, we can identify a novel PGPB that produces melatonin and unravel how it promotes soybean growth and development and protects against salt and Cd stress. We identify the melatonin synthesis pathway (tryptophan→tryptamine→serotonin melatonin) of the halotolerant (NaCl > 800 mM) and heavy metal-resistant (Cd >3 mM) rhizobacterium Bacillus safensis EH143 and use it to treat soybean plants subjected to Cd and NaCl stresses. Results show that EH143 will highly bioaccumulate heavy metals and significantly improve P and Ca2+ uptake and the K+/Na+ (93%↑under salt stress) ratio while reducing Cd uptake (49% under Cd stress) in shoots. This activity was supported by the expression of the ion regulator HKT1, MYPB67, and the calcium sensors CDPK5 and CaMK1 which ultimately led to increased plant growth. EH143 significantly decreased ABA content in shoots by 13%, 20%, and 34% and increased SA biosynthesis in shoots by 14.8%, 31%, and 48.2% in control, salt, and Cd-treated plants, upregulating CYP707A1 and CYP707A2 and PAL1 and ICS, respectively. The melatonin content significantly decreased along with a reduced expression of ASMT3 following treatment with EH143; moreover, reduced expression of peroxidase (POD) and superoxide dismutase (SOD) by 134.5% and 39% under salt+Cd stress, respectively and increased level of total amino acids were observed. Whole-genome sequencing and annotation of EH143 revealed the presence of the melatonin precursor tryptophan synthase (trpA, trpB, trpS), metal and other ion regulators (Cd: cadA, potassium: KtrA and KtrB, phosphate: glpT, calcium: yloB, the sodium/glucose cotransporter: sgIT, and the magnesium transporter: mgtE), and enzyme activators (including the siderophore transport proteins yfiZ and yfhA, the SOD sodA, the catalase katA1, and the glutathione regulator KefG) that may be involved in programming the plant metabolic system. As a consequence, EH143 treatment significantly reduced the contents of lipid peroxidation (O2-, MDA, and H2O2) up to 69%, 46%, and 29% in plants under salt+Cd stress, respectively. These findings suggest that EH143 could be a potent biofertilizer to alleviate NaCl and Cd toxicity in crops and serve as an alternative substitute for exogenous melatonin application.

最近,微生物和外源褪黑激素的应用被认为是提高农作物耐盐性和重金属解毒能力的有效生物工具。因此,本研究的目标是分离和评估一种新型褪黑激素生产植物生长促进菌。通过高通量全基因组测序、植物激素测定、表达谱分析和生化分析,我们可以鉴定出一种能产生褪黑激素的新型 PGPB,并揭示它是如何促进大豆生长发育并抵御盐和镉胁迫的。我们确定了耐盐(NaCl > 800 mM)和抗重金属(Cd > 3 mM)根瘤菌 Bacillus safensis EH143 的褪黑激素合成途径(色氨酸→色胺→serotonin 褪黑激素),并用它来处理受到 Cd 和 NaCl 胁迫的大豆植株。结果表明,EH143 对重金属有很高的生物积累能力,能显著提高大豆对 P、Ca2+ 的吸收和 K+/Na+(在盐胁迫下为 93%↑)的比率,同时降低大豆嫩芽对 Cd 的吸收(在 Cd 胁迫下为 49%)。离子调节因子 HKT1、MYPB67 以及钙传感器 CDPK5 和 CaMK1 的表达支持了这种活性,最终导致植物生长速度加快。在对照、盐和镉处理的植株中,EH143 可使嫩枝中的 ABA 含量分别明显减少 13%、20% 和 34%,并使嫩枝中的 SA 生物合成量分别增加 14.8%、31% 和 48.2%,同时上调 CYP707A1 和 CYP707A2 以及 PAL1 和 ICS。经 EH143 处理后,褪黑激素含量明显降低,ASMT3 的表达量也有所减少;此外,在盐+镉胁迫下,过氧化物酶(POD)和超氧化物歧化酶(SOD)的表达量分别减少了 134.5% 和 39%,总氨基酸的含量也有所增加。对 EH143 进行的全基因组测序和注释发现了褪黑激素前体色氨酸合成酶(trpA、trpB、trpS)、金属和其他离子调节剂(镉:cadA,钾:KtrA 和 KtrB,镉:cadA,钾:cadA 和 KtrB)的存在:此外,EH143 还提供了可能参与植物代谢系统编程的酶激活剂(包括苷元转运蛋白 yfiZ 和 yfhA、SOD sodA、过氧化氢酶 katA1 和谷胱甘肽调节剂 KefG)。因此,EH143 能显著降低盐+镉胁迫下植物的脂质过氧化物(O2-、MDA 和 H2O2)含量,降幅分别高达 69%、46% 和 29%。这些研究结果表明,EH143 是一种有效的生物肥料,可以减轻作物的氯化钠和镉毒性,并可替代外源褪黑激素的应用。
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Journal of Pineal Research
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