Pub Date : 2022-10-09DOI: 10.1109/ESGCO55423.2022.9931382
T. Bojić, Zoran Matić, Mirjana M. Platiša, Aleksandar Kalauzi
We explored influence of slow breathing and orthostasis on angular indices that correspond to slopes of regression lines of detrended fluctuation analysis (DFA) of RR intervals and respiration signal. The tool for our exploration was probability density estimation (PDE). By applying it, we got insights about body posture and breathing regime induced group behavioral patterns of these DFA angles and that these patterns have certain physiological meaning. Mainly, obtained PDE patterns (unimodality, bimodality etc) reflect ergo/tropho-tropic character of sympathetic and parasympathetic adaptive modulation with respect to changes of physical and physiological conditions of diverse physiological states.
{"title":"Fractal angle modality patterns in RRI and respiration signal of healthy subjects responding to orthostasis and slow breathing","authors":"T. Bojić, Zoran Matić, Mirjana M. Platiša, Aleksandar Kalauzi","doi":"10.1109/ESGCO55423.2022.9931382","DOIUrl":"https://doi.org/10.1109/ESGCO55423.2022.9931382","url":null,"abstract":"We explored influence of slow breathing and orthostasis on angular indices that correspond to slopes of regression lines of detrended fluctuation analysis (DFA) of RR intervals and respiration signal. The tool for our exploration was probability density estimation (PDE). By applying it, we got insights about body posture and breathing regime induced group behavioral patterns of these DFA angles and that these patterns have certain physiological meaning. Mainly, obtained PDE patterns (unimodality, bimodality etc) reflect ergo/tropho-tropic character of sympathetic and parasympathetic adaptive modulation with respect to changes of physical and physiological conditions of diverse physiological states.","PeriodicalId":199691,"journal":{"name":"2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130412935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-09DOI: 10.1109/ESGCO55423.2022.9931366
Anna Crispino, A. Loppini, I. Uzelac, F. Fenton, A. Gizzi, S. Filippi
Dual voltage-calcium fluorescence optical recordings are increasingly appealing to characterize complex spa-tiotemporal cardiac dynamics within ex-vivo whole-heart ex-perimental preparations. Synchrony among voltage and calcium signals allows us to unveil novel multi-scale and multi-physics couplings at the ventricular scale and quantify features that define the intrinsic nonlinearities of the observed phenom-ena. Within such a complex scenario, we propose a rigorous methodological analysis comparing and contrasting multiple cardiac alternans onset and evolution indicators for rabbit pacing-down restitution protocols. We introduce a novel integral index quantified upon voltage and calcium signals, validated against well-accepted post-processing analyses, and generalized in terms of statistical restitution curves obtained under four different thermal states. Our study suggests that such a novel indicator can further advance our predictability on alternans onset, linking the concurrent evolution to an innovative quan-tification of the characteristic length obtained for both voltage and calcium at different thermal states.
{"title":"Methodological analysis of dual voltage-calcium whole-heart optical signals during restitution pacing under different thermal states","authors":"Anna Crispino, A. Loppini, I. Uzelac, F. Fenton, A. Gizzi, S. Filippi","doi":"10.1109/ESGCO55423.2022.9931366","DOIUrl":"https://doi.org/10.1109/ESGCO55423.2022.9931366","url":null,"abstract":"Dual voltage-calcium fluorescence optical recordings are increasingly appealing to characterize complex spa-tiotemporal cardiac dynamics within ex-vivo whole-heart ex-perimental preparations. Synchrony among voltage and calcium signals allows us to unveil novel multi-scale and multi-physics couplings at the ventricular scale and quantify features that define the intrinsic nonlinearities of the observed phenom-ena. Within such a complex scenario, we propose a rigorous methodological analysis comparing and contrasting multiple cardiac alternans onset and evolution indicators for rabbit pacing-down restitution protocols. We introduce a novel integral index quantified upon voltage and calcium signals, validated against well-accepted post-processing analyses, and generalized in terms of statistical restitution curves obtained under four different thermal states. Our study suggests that such a novel indicator can further advance our predictability on alternans onset, linking the concurrent evolution to an innovative quan-tification of the characteristic length obtained for both voltage and calcium at different thermal states.","PeriodicalId":199691,"journal":{"name":"2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133275997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-09DOI: 10.1109/ESGCO55423.2022.9931383
Beatrice De Maria, L. D. Dalla Vecchia, V. Bari, B. Cairo, F. Gelpi, F. Perego, Anielle Cristhine Medeiros Takahashi, J. Milan-Mattos, V. Minatel, P. Rehder-Santos, A. Catai, A. Porta
The sequence (SEQ) method can be exploited to differentiate the patterns of cardiac baroreflex origin according to the sign of systolic arterial pressure (SAP) variations. Indeed, this method distinguishes between patterns featuring heart period (HP) lengthening in response to SAP increase (SEQ++) from those featuring HP shortening in response to SAP decrease (SEQ–). The aim of the study was to compare the proportion between SEQ++ and SEQ– in healthy subjects at rest in supine condition (REST) and during active standing (STAND). One-hundred healthy subjects, divided into five groups based on age (21-30,31-40,41-50,51-60,61-70 yrs), were studied at REST and during STAND. The percentages of SEQ++ (%SEQ++) and SEQ– (%SEQ–) were calculated. Results showed that: i) %SEQ++ and %SEQ– were balanced regardless of age bin; ii) this conclusion held both at REST and during STAND; iii) %SEQ++ and %SEQ– increased from REST to STAND regardless of age bin; iv) the ageing process decreased %SEQ++ and %SEQ– during STAND, while the percentages were more preserved at REST. This finding might have relevant implications in understanding postural disturbances in advanced age.
{"title":"The percentage of cardiac baroreflex sequences is independent from the sign of arterial pressure variations in healthy subjects","authors":"Beatrice De Maria, L. D. Dalla Vecchia, V. Bari, B. Cairo, F. Gelpi, F. Perego, Anielle Cristhine Medeiros Takahashi, J. Milan-Mattos, V. Minatel, P. Rehder-Santos, A. Catai, A. Porta","doi":"10.1109/ESGCO55423.2022.9931383","DOIUrl":"https://doi.org/10.1109/ESGCO55423.2022.9931383","url":null,"abstract":"The sequence (SEQ) method can be exploited to differentiate the patterns of cardiac baroreflex origin according to the sign of systolic arterial pressure (SAP) variations. Indeed, this method distinguishes between patterns featuring heart period (HP) lengthening in response to SAP increase (SEQ++) from those featuring HP shortening in response to SAP decrease (SEQ–). The aim of the study was to compare the proportion between SEQ++ and SEQ– in healthy subjects at rest in supine condition (REST) and during active standing (STAND). One-hundred healthy subjects, divided into five groups based on age (21-30,31-40,41-50,51-60,61-70 yrs), were studied at REST and during STAND. The percentages of SEQ++ (%SEQ++) and SEQ– (%SEQ–) were calculated. Results showed that: i) %SEQ++ and %SEQ– were balanced regardless of age bin; ii) this conclusion held both at REST and during STAND; iii) %SEQ++ and %SEQ– increased from REST to STAND regardless of age bin; iv) the ageing process decreased %SEQ++ and %SEQ– during STAND, while the percentages were more preserved at REST. This finding might have relevant implications in understanding postural disturbances in advanced age.","PeriodicalId":199691,"journal":{"name":"2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131977508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-09DOI: 10.1109/ESGCO55423.2022.9931369
M. Hörning, A. Loppini, Julia Erhardt, F. Fenton, S. Filippi, A. Gizzi
A relevant issue in cardiology is represented by identifying valuable biomarkers of cardiac dysfunctions and by designing reliable computational models to predict transitions into pathological cardiac dynamics. In this context, alternans regimes have been proven to anticipate tachycardia and fibrillation. Still, an open problem is defining accurate and convenient methods to predict the onset and evolution of alternans patterns and formulate reliable models reproducing alternans features as observed in experiments. In this contribution, we present an FFT-based method on voltage mapping data, named FFI (Fast-Fourier-Imaging), which is able to early identify alternating cardiac dynamics and recover tissue structural information. Our results show that FFI identifies alternans patterns with great accuracy, avoiding excessive data preprocessing required by other methods. The extracted optical ultrastructural details of the tissue are used to inform computational parameters by accurate data assimilation, which enables the in-silico recovery of the experimental ex-vivo observations of a canine heart. Clinical Relevance-The application of FFI analysis enables the almost real-time detection of concordant and discordant alternans patterns in cardiac tissue and opens the way to new mathematical approaches with significant impacts on personalized modeling and whole organ simulations.
{"title":"Optical Ultrastructure of Cardiac Tissue Helps to Reproduce Discordant Alternans by In Silico Data Assimilation","authors":"M. Hörning, A. Loppini, Julia Erhardt, F. Fenton, S. Filippi, A. Gizzi","doi":"10.1109/ESGCO55423.2022.9931369","DOIUrl":"https://doi.org/10.1109/ESGCO55423.2022.9931369","url":null,"abstract":"A relevant issue in cardiology is represented by identifying valuable biomarkers of cardiac dysfunctions and by designing reliable computational models to predict transitions into pathological cardiac dynamics. In this context, alternans regimes have been proven to anticipate tachycardia and fibrillation. Still, an open problem is defining accurate and convenient methods to predict the onset and evolution of alternans patterns and formulate reliable models reproducing alternans features as observed in experiments. In this contribution, we present an FFT-based method on voltage mapping data, named FFI (Fast-Fourier-Imaging), which is able to early identify alternating cardiac dynamics and recover tissue structural information. Our results show that FFI identifies alternans patterns with great accuracy, avoiding excessive data preprocessing required by other methods. The extracted optical ultrastructural details of the tissue are used to inform computational parameters by accurate data assimilation, which enables the in-silico recovery of the experimental ex-vivo observations of a canine heart. Clinical Relevance-The application of FFI analysis enables the almost real-time detection of concordant and discordant alternans patterns in cardiac tissue and opens the way to new mathematical approaches with significant impacts on personalized modeling and whole organ simulations.","PeriodicalId":199691,"journal":{"name":"2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123535937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-09DOI: 10.1109/ESGCO55423.2022.9931374
A. Porta, B. Cairo, V. Bari, F. Gelpi, Beatrice De Maria, R. Colombo
Frequency domain causality analysis based on multivariate autoregressive (MAR) and multivariate dynamic adjustment (MDA) models were applied to typify directional dynamic interactions between heart period (HP) and systolic arterial pressure (SAP) during the baroreflex loading induced by head-down tilt (HDT). We studied 12 healthy men (age: from 41 to 71 yrs, median: 57 yrs) at rest in supine condition and during HDT with a tilt table inclination equal to −25°. We observed a reduction of the involvement of the baroreflex in governing HP-SAP dynamic interactions during HDT. This finding was evident only in the low frequency (LF, from 0.04 to 0.15 Hz) band. We suggest that frequency domain causality analysis allows the investigation of cardiovascular control mechanisms and HDT can be fruitfully utilized to reduce the relevance of baroreflex control, thus raising the chance of observing different cardiovascular regulatory mechanisms.
{"title":"Frequency Domain Causal Interactions Between Heart Period and Systolic Arterial Pressure During Baroreflex Loading","authors":"A. Porta, B. Cairo, V. Bari, F. Gelpi, Beatrice De Maria, R. Colombo","doi":"10.1109/ESGCO55423.2022.9931374","DOIUrl":"https://doi.org/10.1109/ESGCO55423.2022.9931374","url":null,"abstract":"Frequency domain causality analysis based on multivariate autoregressive (MAR) and multivariate dynamic adjustment (MDA) models were applied to typify directional dynamic interactions between heart period (HP) and systolic arterial pressure (SAP) during the baroreflex loading induced by head-down tilt (HDT). We studied 12 healthy men (age: from 41 to 71 yrs, median: 57 yrs) at rest in supine condition and during HDT with a tilt table inclination equal to −25°. We observed a reduction of the involvement of the baroreflex in governing HP-SAP dynamic interactions during HDT. This finding was evident only in the low frequency (LF, from 0.04 to 0.15 Hz) band. We suggest that frequency domain causality analysis allows the investigation of cardiovascular control mechanisms and HDT can be fruitfully utilized to reduce the relevance of baroreflex control, thus raising the chance of observing different cardiovascular regulatory mechanisms.","PeriodicalId":199691,"journal":{"name":"2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128078381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-09DOI: 10.1109/ESGCO55423.2022.9931385
L. Faes, G. Mijatović, Laura Sparacino, R. Pernice, Y. Antonacci, A. Porta, S. Stramaglia
We present a method to analyze the dynamics of physiological networks beyond the framework of pairwise interactions. Our method defines the so-called O-information rate (OIR) as a measure of the higher-order interaction among several physiological variables. The OIR measure is computed from the vector autoregressive representation of multiple time series, and is applied to the network formed by heart period, systolic and diastolic arterial pressure, respiration and cerebral blood flow variability series measured in healthy subjects at rest and after head-up tilt. Our results document that cardiovascular, cerebrovascular and respiratory interactions are highly redundant, and that redundancy is enhanced by the entrainment of cardiovascular and cerebrovascular oscillations and by sympathetic activation.
{"title":"Quantifying High-Order Interactions in Cardiovascular and Cerebrovascular Networks","authors":"L. Faes, G. Mijatović, Laura Sparacino, R. Pernice, Y. Antonacci, A. Porta, S. Stramaglia","doi":"10.1109/ESGCO55423.2022.9931385","DOIUrl":"https://doi.org/10.1109/ESGCO55423.2022.9931385","url":null,"abstract":"We present a method to analyze the dynamics of physiological networks beyond the framework of pairwise interactions. Our method defines the so-called O-information rate (OIR) as a measure of the higher-order interaction among several physiological variables. The OIR measure is computed from the vector autoregressive representation of multiple time series, and is applied to the network formed by heart period, systolic and diastolic arterial pressure, respiration and cerebral blood flow variability series measured in healthy subjects at rest and after head-up tilt. Our results document that cardiovascular, cerebrovascular and respiratory interactions are highly redundant, and that redundancy is enhanced by the entrainment of cardiovascular and cerebrovascular oscillations and by sympathetic activation.","PeriodicalId":199691,"journal":{"name":"2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132291632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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