首页 > 最新文献

Pediatric Infectious Disease最新文献

英文 中文
Rotavirus immunization and type 1 diabetes mellitus: A nested case–control study 轮状病毒免疫与1型糖尿病:一项巢式病例对照研究
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2014.12.004
Gabriel Chodick , Moran Almog , Shai Ashkenazi , Tal Sella

The objective of the present nested case–control study was to assess whether rotavirus vaccination is associated with reduced risk of Type 1 diabetes mellitus (T1DM). Using clinical database of a large health organization in Israel, we identified all incident cases of T1DM that were born during the period spanning January 2008 to June 2010, and diagnosed before March 2012. For each case, we selected up to three control individuals without T1DM that were individually matched on the exact date of birth. A total of 16 eligible T1DM cases were detected and 45 matched controls. After adjusting to residence area in Israel, the odds ratio for T1DM associated with full vaccination against rotavirus was 7.38 (95%: 1.19–45.62, P = 0.032). The results of the present study do not support the conclusion that childhood immunization with rotavirus vaccine is associated with reduced risk of T1DM.

本巢式病例对照研究的目的是评估轮状病毒疫苗接种是否与1型糖尿病(T1DM)风险降低相关。利用以色列一家大型卫生组织的临床数据库,我们确定了2008年1月至2010年6月期间出生并在2012年3月之前诊断的所有T1DM病例。对于每个病例,我们选择了多达三个没有T1DM的对照个体,他们分别在确切的出生日期进行了匹配。共检测到16例符合条件的T1DM病例和45例匹配的对照。根据以色列居住地区进行调整后,T1DM与轮状病毒全面接种相关的优势比为7.38 (95%:1.19-45.62,P = 0.032)。本研究的结果不支持儿童接种轮状病毒疫苗与降低T1DM风险相关的结论。
{"title":"Rotavirus immunization and type 1 diabetes mellitus: A nested case–control study","authors":"Gabriel Chodick ,&nbsp;Moran Almog ,&nbsp;Shai Ashkenazi ,&nbsp;Tal Sella","doi":"10.1016/j.pid.2014.12.004","DOIUrl":"10.1016/j.pid.2014.12.004","url":null,"abstract":"<div><p><span><span>The objective of the present nested case–control study was to assess whether rotavirus vaccination is associated with reduced risk of </span>Type 1 diabetes mellitus<span> (T1DM). Using clinical database of a large health organization in Israel, we identified all incident cases of T1DM that were born during the period spanning January 2008 to June 2010, and diagnosed before March 2012. For each case, we selected up to three control individuals without T1DM that were individually matched on the exact date of birth. A total of 16 eligible T1DM cases were detected and 45 matched controls. After adjusting to residence area in Israel, the odds ratio for T1DM associated with full vaccination against rotavirus was 7.38 (95%: 1.19–45.62, P = 0.032). The results of the present study do not support the conclusion that childhood immunization with </span></span>rotavirus vaccine is associated with reduced risk of T1DM.</p></div>","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 147-149"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2014.12.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73499619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
CNS infections – The challenges ahead 中枢神经系统感染——未来的挑战
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2015.01.002
Vrajesh Udani
{"title":"CNS infections – The challenges ahead","authors":"Vrajesh Udani","doi":"10.1016/j.pid.2015.01.002","DOIUrl":"10.1016/j.pid.2015.01.002","url":null,"abstract":"","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 121-123"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2015.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76153449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Borderline Hansen's disease presenting as isolated macrocheilia 边缘性汉森氏病表现为孤立的大鼻窦
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2014.12.001
Maitreyee Panda , Nibedita Patro , Ajaya Kumar Jena , Sarita Pradhan , Mrutunjay Dash

Although oral lesions in leprosy are common, they are mostly described in the late stages of lepromatous pole. As there are very few studies discussing the oral findings in leprosy, involvement of oral mucosa as the only manifestation of leprosy often goes misdiagnosed. Here we are reporting a case of tuberculoid leprosy presenting as chronic lip swelling.

虽然麻风患者的口腔病变很常见,但它们大多发生在麻风极点的晚期。由于很少有研究讨论麻风病的口腔表现,作为麻风病唯一表现的口腔黏膜受累经常被误诊。这里我们报告一例结核样麻风病表现为慢性嘴唇肿胀。
{"title":"Borderline Hansen's disease presenting as isolated macrocheilia","authors":"Maitreyee Panda ,&nbsp;Nibedita Patro ,&nbsp;Ajaya Kumar Jena ,&nbsp;Sarita Pradhan ,&nbsp;Mrutunjay Dash","doi":"10.1016/j.pid.2014.12.001","DOIUrl":"10.1016/j.pid.2014.12.001","url":null,"abstract":"<div><p><span><span>Although oral lesions in leprosy are common, they are mostly described in the late stages of lepromatous pole. As there are very few studies discussing the oral findings in leprosy, involvement of </span>oral mucosa as the only manifestation of leprosy often goes misdiagnosed. Here we are reporting a case of </span>tuberculoid leprosy presenting as chronic lip swelling.</p></div>","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 139-141"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2014.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117901426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What's in 是什么
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2014.12.002
Anita Shet
{"title":"What's in","authors":"Anita Shet","doi":"10.1016/j.pid.2014.12.002","DOIUrl":"https://doi.org/10.1016/j.pid.2014.12.002","url":null,"abstract":"","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 159-161"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2014.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134669313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anthrax meningo-encephalitis in a neonate 新生儿炭疽脑膜炎脑炎
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2014.09.001
Promila Mohan Raj , Indira Agarwal , Winsley Rose

Anthrax is primarily a disease of herbivorous animals; humans acquire the infection by handling infected dead animals or animal by-products. We report a 28 day old male infant, youngest of all reported Indian anthrax patients with Cutaneous anthrax which disseminated and lead to fatal anthrax meningo-encephalitis. The child's parents or siblings did not report contact with dead animals or animal by-products. Mechanical transmission through insect bite was the likely route for acquisition of this infection by the infant.

炭疽主要是食草动物的一种疾病;人类通过处理受感染的死亡动物或动物副产品而获得感染。我们报告一个28天大的男婴,年龄最小的所有报告的印度炭疽患者皮肤炭疽传播并导致致命的炭疽脑膜炎脑炎。该儿童的父母或兄弟姐妹未报告接触过死亡动物或动物副产品。通过昆虫叮咬的机械传播是婴儿获得这种感染的可能途径。
{"title":"Anthrax meningo-encephalitis in a neonate","authors":"Promila Mohan Raj ,&nbsp;Indira Agarwal ,&nbsp;Winsley Rose","doi":"10.1016/j.pid.2014.09.001","DOIUrl":"10.1016/j.pid.2014.09.001","url":null,"abstract":"<div><p>Anthrax is primarily a disease of herbivorous animals; humans acquire the infection by handling infected dead animals or animal by-products. We report a 28 day old male infant, youngest of all reported Indian anthrax patients with Cutaneous anthrax which disseminated and lead to fatal anthrax meningo-encephalitis. The child's parents or siblings did not report contact with dead animals or animal by-products. Mechanical transmission through insect bite was the likely route for acquisition of this infection by the infant.</p></div>","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 130-131"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2014.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73525754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Infantile botulism: Forgotten etiology of acute hypotonia in infancy” 婴儿肉毒杆菌中毒:被遗忘的婴儿急性肌张力低下的病因
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2014.07.004
K. Kamrani , M. Habibi , N. Khosroshahi

In Asian countries infantile botulism is a rare and often under diagnosed disease. With the intent to spread the awareness of this potentially life threatening disease we report two confirmed cases of infantile botulism and describe the way we could make our final diagnosis. Additionally since the treatment of choice of infantile botulism is Baby BIG and it is not available in our country and because of financial problems we could not afford it, we treated our patients with equine botulinum antitoxin (EqBA). We report here the effectiveness and safety of equine botulinum antitoxin (EqBA) as an alternative treatment of infantile botulism.

在亚洲国家,婴儿肉毒杆菌中毒是一种罕见的疾病,而且经常被误诊。为了传播对这种潜在威胁生命的疾病的认识,我们报告了两例婴儿肉毒杆菌中毒确诊病例,并描述了我们做出最终诊断的方法。此外,由于婴儿肉毒杆菌中毒的治疗选择是Baby BIG,而在我国无法获得,由于经济问题,我们无法负担,我们用马肉毒杆菌抗毒素(EqBA)治疗我们的患者。我们在此报告马肉毒杆菌抗毒素(EqBA)作为婴儿肉毒杆菌中毒的替代治疗的有效性和安全性。
{"title":"“Infantile botulism: Forgotten etiology of acute hypotonia in infancy”","authors":"K. Kamrani ,&nbsp;M. Habibi ,&nbsp;N. Khosroshahi","doi":"10.1016/j.pid.2014.07.004","DOIUrl":"10.1016/j.pid.2014.07.004","url":null,"abstract":"<div><p><span>In Asian countries infantile botulism<span> is a rare and often under diagnosed disease. With the intent to spread the awareness of this potentially life threatening disease we report two confirmed cases of infantile botulism and describe the way we could make our final diagnosis. Additionally since the treatment of choice of infantile botulism is Baby BIG and it is not available in our country and because of financial problems we could not afford it, we treated our patients with equine </span></span>botulinum antitoxin (EqBA). We report here the effectiveness and safety of equine botulinum antitoxin (EqBA) as an alternative treatment of infantile botulism.</p></div>","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 132-134"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2014.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72898744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new threat to children: Melioidosis 儿童的新威胁:类鼻疽
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2015.01.001
Uttam Udayan , Sagar Chandrakar , Akshay Dias , Meena Dias

Melioidosis is an infectious disease caused by Burkholderia pseudomallei, usually seen in tropical countries of South East Asia and Northern Australia. Though many cases are reported in adults from western coast of India, the same is not true for children. We report here four cases of Melioidosis; a preterm neonate, two 2 year olds and 9 year old child. While three cases had bacteremic melioidosis with presentation as Respiratory distress syndrome, pneumonia and fever respectively, fourth case presented as bilateral lymphadenitis. All were treated successfully with intensive therapy of Meropenem or ceftazidime followed with eradication therapy of co-trimoxazole. At the end of treatment, all were completely cured. An understanding of the local epidemiology & geographical factors along with awareness and high suspicion of index among microbiologists and paediatricians with laboratory strengthening will aid in early diagnosis and prompt treatment thereby reducing the disease mortality.

类鼻疽病是一种由假玛利伯克氏菌引起的传染病,常见于东南亚和北澳大利亚的热带国家。虽然在印度西海岸的成年人中报告了许多病例,但在儿童中却并非如此。我们在此报告四例类鼻疽;一个早产儿,两个2岁的孩子和9岁的孩子。其中3例以呼吸窘迫综合征、肺炎和发热为表现,4例以双侧淋巴结炎为表现。所有患者均通过美罗培南或头孢他啶的强化治疗和复方新诺明的根除治疗获得成功。治疗结束时,所有患者均完全治愈。对当地流行病学的了解地理因素以及微生物学家和儿科医生对该指数的认识和高度怀疑将有助于早期诊断和及时治疗,从而降低疾病死亡率。
{"title":"A new threat to children: Melioidosis","authors":"Uttam Udayan ,&nbsp;Sagar Chandrakar ,&nbsp;Akshay Dias ,&nbsp;Meena Dias","doi":"10.1016/j.pid.2015.01.001","DOIUrl":"10.1016/j.pid.2015.01.001","url":null,"abstract":"<div><p><span>Melioidosis is an infectious disease caused by </span><span><em>Burkholderia pseudomallei</em><em>,</em></span><span><span><span> usually seen in tropical countries of South East Asia and Northern Australia. Though many cases are reported in adults from western coast of India, the same is not true for children. We report here four cases of Melioidosis; a preterm neonate, two 2 year olds and 9 year old child. While three cases had bacteremic melioidosis with presentation as Respiratory distress syndrome, pneumonia and fever respectively, fourth case presented as bilateral </span>lymphadenitis<span><span>. All were treated successfully with intensive therapy of Meropenem or </span>ceftazidime<span> followed with eradication therapy<span> of co-trimoxazole. At the end of treatment, all were completely cured. An understanding of the local </span></span></span></span>epidemiology &amp; geographical factors along with awareness and high suspicion of index among microbiologists and paediatricians with laboratory strengthening will aid in early diagnosis and prompt treatment thereby reducing the disease mortality.</span></p></div>","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 135-138"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2015.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84851444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Schistosoma haematobium and Plasmodium falciparum single and concomitant infections; any association with hematologic abnormalities? 血血吸虫和恶性疟原虫单发感染和合并感染;是否与血液学异常有关?
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2014.11.001
Olajumoke A. Morenikeji , Omotayo S. Atanda , Ituna E. Eleng , Oyetunde T. Salawu

Aim

To assess the association between single infection and co-infection status of the two parasites with hematologic profiles in school children.

Methods

A cross-sectional epidemiological survey was carried out on a total of 202 school children between ages 6–18 years (mean age 11.5 ± 2.6 years). Urine and blood samples were collected by standard methods for concurrent microscopic diagnosis of Schistosoma haematobium and Plasmodium falciparum infections respectively. The following hematologic parameters; hematocrit, hemoglobin, neutrophils, leukocytes, lymphocytes and eosinophils were determined.

Results

The prevalence of single infection was 52.0% and 59.9% for S. haematobium and P. falciparum respectively, while 28.2% individuals were infected with the two parasites. The prevalence of abnormal hematologic profiles in the subjects was not associated with infection status (single or co-infection) (P > 0.05). There were however higher risk of developing low hemoglobin concentration with P. falciparum (Prevalence = 71.0%, OR = 6.0, CI = 3.2–11.0) with children with S. haematobium infection being weakly predisposed to developing abnormal neutrophils (Prevalence = 53.3%, OR = 1.3, CI = 0.7–2.3). Low hemoglobin associated risk in single infection with S. haematobium (OR = 2.0, CI = 1.1–3.6) was increased with co-infection with P. falciparum (OR = 4.0, CI = 1.8–8.7). There seemed to be no difference in abnormal leukocytes and eosinophils associated risk in the three infection categories.

Conclusions

There were variations in Schistosoma and malaria parasite induced hematologic pathologies and more studies are needed to unravel the underlying mechanisms in such variations.

目的探讨两种寄生虫单一感染和合并感染情况与学龄儿童血液学特征的关系。方法对202名6 ~ 18岁学龄儿童(平均11.5±2.6岁)进行横断面流行病学调查。采用标准方法采集尿样和血样,分别用于血血吸虫病和恶性疟原虫感染的同时显微镜诊断。以下血液学参数:测定红细胞比容、血红蛋白、中性粒细胞、白细胞、淋巴细胞和嗜酸性粒细胞。结果血球绦虫和恶性疟原虫的单一感染率分别为52.0%和59.9%,其中28.2%的个体同时感染两种寄生虫。受试者中血液学异常的患病率与感染状态(单一或合并感染)无关(P >0.05)。然而,恶性疟原虫感染儿童发生低血红蛋白浓度的风险较高(患病率= 71.0%,OR = 6.0, CI = 3.2 ~ 11.0),而感染嗜血杆菌的儿童发生中性粒细胞异常的易感性较弱(患病率= 53.3%,OR = 1.3, CI = 0.7 ~ 2.3)。合并恶性疟原虫感染的低血红蛋白相关风险(OR = 2.0, CI = 1.1 ~ 3.6)增加了单一感染血链球菌的患者(OR = 4.0, CI = 1.8 ~ 8.7)。在三种感染类别中,异常白细胞和嗜酸性粒细胞相关风险似乎没有差异。结论血吸虫和疟原虫引起的血液学病变存在差异,其机制有待进一步研究。
{"title":"Schistosoma haematobium and Plasmodium falciparum single and concomitant infections; any association with hematologic abnormalities?","authors":"Olajumoke A. Morenikeji ,&nbsp;Omotayo S. Atanda ,&nbsp;Ituna E. Eleng ,&nbsp;Oyetunde T. Salawu","doi":"10.1016/j.pid.2014.11.001","DOIUrl":"10.1016/j.pid.2014.11.001","url":null,"abstract":"<div><h3>Aim</h3><p>To assess the association between single infection and co-infection status of the two parasites with hematologic profiles in school children.</p></div><div><h3>Methods</h3><p>A cross-sectional epidemiological survey was carried out on a total of 202 school children between ages 6–18 years (mean age 11.5 ± 2.6 years). Urine and blood samples were collected by standard methods for concurrent microscopic diagnosis of <span><span>Schistosoma haematobium</span></span> and <em>Plasmodium falciparum</em><span><span> infections respectively. The following hematologic parameters; hematocrit, hemoglobin, neutrophils, leukocytes, lymphocytes and </span>eosinophils were determined.</span></p></div><div><h3>Results</h3><p>The prevalence of single infection was 52.0% and 59.9% for <em>S. haematobium</em> and <em>P. falciparum</em> respectively, while 28.2% individuals were infected with the two parasites. The prevalence of abnormal hematologic profiles in the subjects was not associated with infection status (single or co-infection) (<em>P</em><span> &gt; 0.05). There were however higher risk of developing low hemoglobin concentration with </span><em>P. falciparum</em> (Prevalence = 71.0%, OR = 6.0, CI = 3.2–11.0) with children with <em>S. haematobium</em> infection being weakly predisposed to developing abnormal neutrophils (Prevalence = 53.3%, OR = 1.3, CI = 0.7–2.3). Low hemoglobin associated risk in single infection with <em>S. haematobium</em> (OR = 2.0, CI = 1.1–3.6) was increased with co-infection with <em>P. falciparum</em> (OR = 4.0, CI = 1.8–8.7). There seemed to be no difference in abnormal leukocytes and eosinophils associated risk in the three infection categories.</p></div><div><h3>Conclusions</h3><p>There were variations in <em>Schistosoma</em> and malaria parasite induced hematologic pathologies and more studies are needed to unravel the underlying mechanisms in such variations.</p></div>","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 124-129"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2014.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85197507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Latex Agglutination Test (LAT) – For rapid diagnosis of acute bacterial meningitis 乳胶凝集试验(LAT) -用于快速诊断急性细菌性脑膜炎
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2014.10.004
Bhaskar Shenoy , Suvarna Biradar

Acute bacterial meningitis (ABM) is one of the most common causes of morbidity and mortality in children. Identifying the organism causing meningitis helps in right choice of antibiotics and determines the duration of treatment. Children who are clinically suspected to have meningitis often receive antibiotics before definitive diagnosis. This renders the CSF sterile, hence yield from culture and gram stain diminishes. Rapid diagnosis of ABM can be done by identification of bacterial antigens in the CSF by immunological test like LAT. Most of the commercially available LAT kits include reagents to test the most common bacteria causing meningitis. A wide range of sensitivity and specificity has been reported in various studies from 60% to 93% for the various organisms. It is not a substitute for bacterial culture. However in partially treated meningitis where culture is usually negative, it is very valuable. During the outbreaks it is more useful for rapid diagnosis while awaiting the culture. It is a simple test where expertise is not required.

急性细菌性脑膜炎(ABM)是儿童发病和死亡的最常见原因之一。确定引起脑膜炎的微生物有助于正确选择抗生素,并决定治疗的持续时间。临床怀疑患有脑膜炎的儿童通常在确诊前接受抗生素治疗。这使得脑脊液无菌,因此从培养和革兰氏染色产量减少。通过免疫试验如LAT检测脑脊液中的细菌抗原,可快速诊断ABM。大多数市售的LAT试剂盒包括检测引起脑膜炎的最常见细菌的试剂。在各种研究中,对各种生物体的敏感性和特异性范围从60%到93%不等。它不能代替细菌培养。然而,在部分治疗的脑膜炎中,培养通常为阴性,这是非常有价值的。在疫情爆发期间,等待培养时进行快速诊断更有用。这是一个简单的测试,不需要专业知识。
{"title":"Latex Agglutination Test (LAT) – For rapid diagnosis of acute bacterial meningitis","authors":"Bhaskar Shenoy ,&nbsp;Suvarna Biradar","doi":"10.1016/j.pid.2014.10.004","DOIUrl":"10.1016/j.pid.2014.10.004","url":null,"abstract":"<div><p>Acute bacterial meningitis<span> (ABM) is one of the most common causes of morbidity and mortality in children. Identifying the organism causing meningitis helps in right choice of antibiotics and determines the duration of treatment. Children who are clinically suspected to have meningitis often receive antibiotics before definitive diagnosis. This renders the CSF sterile, hence yield from culture and gram stain<span> diminishes. Rapid diagnosis of ABM can be done by identification of bacterial antigens<span><span> in the CSF by immunological test like LAT. Most of the commercially available LAT kits include reagents to test the most common bacteria causing meningitis. A wide range of sensitivity and specificity has been reported in various studies from 60% to 93% for the various organisms. It is not a substitute for </span>bacterial culture. However in partially treated meningitis where culture is usually negative, it is very valuable. During the outbreaks it is more useful for rapid diagnosis while awaiting the culture. It is a simple test where expertise is not required.</span></span></span></p></div>","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 150-152"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2014.10.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90016492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Herpes zoster in a six month old infant: A case report 6个月大婴儿带状疱疹1例报告
Pub Date : 2014-10-01 DOI: 10.1016/j.pid.2014.07.005
Emy Abi Thomas , Abhilasha Williams

Herpes zoster occurs due to reactivation of the latent varicella zoster virus and is usually a disease of the elderly. Infantile herpes zoster is believed to be rare, though recent reports suggests an increasing incidence in infants. Here we report a six month old immunocompetent infant with herpes zoster whose mother had varicella during antenatal period.

带状疱疹是由于潜伏的水痘带状疱疹病毒的再激活而发生的,通常是老年人的疾病。婴儿带状疱疹被认为是罕见的,尽管最近的报告表明婴儿的发病率在增加。在这里,我们报告一个六个月大的免疫能力婴儿带状疱疹的母亲有水痘在产前期。
{"title":"Herpes zoster in a six month old infant: A case report","authors":"Emy Abi Thomas ,&nbsp;Abhilasha Williams","doi":"10.1016/j.pid.2014.07.005","DOIUrl":"10.1016/j.pid.2014.07.005","url":null,"abstract":"<div><p><span>Herpes zoster occurs due to reactivation of the latent </span>varicella zoster virus<span> and is usually a disease of the elderly. Infantile herpes zoster is believed to be rare, though recent reports suggests an increasing incidence in infants. Here we report a six month old immunocompetent infant with herpes zoster whose mother had varicella during antenatal period.</span></p></div>","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 145-146"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2014.07.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91348870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Pediatric Infectious Disease
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1