{"title":"RESOLUTION OF THE XXV CONGRESS OF PEDIATRICIANS OF RUSSIA WITH INTERNATIONAL PARTICIPATION \"ACTUAL PROBLEMS OF PEDIATRICS\" MARCH 1–3, 2024, MOSCOW","authors":"A. Editorial","doi":"10.15690/pf.v21i3.2753","DOIUrl":"https://doi.org/10.15690/pf.v21i3.2753","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Sibirskaya, I. Karachentsova, Viktoriya V. Naumova, M. Chernysheva, Maksim A. Naumov, Akim V. Karelin, Daria V. Fadeeva, Ilia I. Bikhert
This review presents an analysis of the literature data for the last 10 years (2012–2022) investigating the effect of eating disorders on the health of adolescent girl, its diagnosis, and possible tactics of gynecologist. The most common predictor of restoring menstrual function in girls with this pathology is body mass index change, however normalization of weight does not lead to remission in all cases. Thus, estimation of fat percentage, insulin-like growth factor, and leptin is more effective. We suggest directing further research on the study of more effective methods of reproductive disorders correction and the development of multidisciplinary clinical guidelines for the effective diagnosis and management of eating disorders and any gynecological complications.
{"title":"Eating Disorders in Adolescent Girls. Gynecologist’s Point of View","authors":"E. Sibirskaya, I. Karachentsova, Viktoriya V. Naumova, M. Chernysheva, Maksim A. Naumov, Akim V. Karelin, Daria V. Fadeeva, Ilia I. Bikhert","doi":"10.15690/pf.v21i3.2760","DOIUrl":"https://doi.org/10.15690/pf.v21i3.2760","url":null,"abstract":"This review presents an analysis of the literature data for the last 10 years (2012–2022) investigating the effect of eating disorders on the health of adolescent girl, its diagnosis, and possible tactics of gynecologist. The most common predictor of restoring menstrual function in girls with this pathology is body mass index change, however normalization of weight does not lead to remission in all cases. Thus, estimation of fat percentage, insulin-like growth factor, and leptin is more effective. We suggest directing further research on the study of more effective methods of reproductive disorders correction and the development of multidisciplinary clinical guidelines for the effective diagnosis and management of eating disorders and any gynecological complications.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"94 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalia A. Averkina, M. Bagaeva, A. A. Baranov, N. Vashakmadze, E. A. Vishneva, O. Gundobina, N. V. Zhurkova, Elena V. Kaitukova, Elena V. Komarova, T. Margieva, L. S. Namazova-Baranova, Valeria P. Novikova, E. Petryaykina, M. M. Platonova, Aleksander S. Potapov, O. Smirnova, Tatiana V. Strokova, Andrej N. Surkov, Nataliya N. Taran, M. Fedoseenko, Nataliya A. Semenova, I. V. Anisimova, S. Repina, Dmitriy M. Subbotin, Valeria V. Sviridova, A. Havkin, E. Yablokova, G. Volynets, I. V. Sadovnikova, E. Tumanova
Glycogen storage disease refers to hereditary pathologies of carbohydrate metabolism, its cause is mutations of various genes encoding enzymes responsible for the synthesis and breakdown of glycogen. Due to enzyme defects, excessive glycogen deposition occurs in cells of various tissues, mainly in the liver and muscles. The authors present modern epidemiological data and features of the etiopathogenesis of glycogen storage disease, and give clinical characteristics of various types of this nosology. In accordance with the developed clinical guidelines, information is provided on laboratory, instrumental and morphological signs of glycogen storage disease in children, as well as on methods of treatment of glycogen storage disease. Due to the variety of clinical forms of glycogenosis, the article provides up-to-date information on three types of pathology that occur with predominant liver damage.
{"title":"Current Clinical Guidelines for the Management of Patients with Glycogen Storage Disease","authors":"Natalia A. Averkina, M. Bagaeva, A. A. Baranov, N. Vashakmadze, E. A. Vishneva, O. Gundobina, N. V. Zhurkova, Elena V. Kaitukova, Elena V. Komarova, T. Margieva, L. S. Namazova-Baranova, Valeria P. Novikova, E. Petryaykina, M. M. Platonova, Aleksander S. Potapov, O. Smirnova, Tatiana V. Strokova, Andrej N. Surkov, Nataliya N. Taran, M. Fedoseenko, Nataliya A. Semenova, I. V. Anisimova, S. Repina, Dmitriy M. Subbotin, Valeria V. Sviridova, A. Havkin, E. Yablokova, G. Volynets, I. V. Sadovnikova, E. Tumanova","doi":"10.15690/pf.v21i3.2765","DOIUrl":"https://doi.org/10.15690/pf.v21i3.2765","url":null,"abstract":"Glycogen storage disease refers to hereditary pathologies of carbohydrate metabolism, its cause is mutations of various genes encoding enzymes responsible for the synthesis and breakdown of glycogen. Due to enzyme defects, excessive glycogen deposition occurs in cells of various tissues, mainly in the liver and muscles. The authors present modern epidemiological data and features of the etiopathogenesis of glycogen storage disease, and give clinical characteristics of various types of this nosology. In accordance with the developed clinical guidelines, information is provided on laboratory, instrumental and morphological signs of glycogen storage disease in children, as well as on methods of treatment of glycogen storage disease. Due to the variety of clinical forms of glycogenosis, the article provides up-to-date information on three types of pathology that occur with predominant liver damage.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Gubanova, E. T. Ambarchyan, L. S. Namazova-Baranova, E. A. Vishneva, I. Zelenkova, Viktor A. Gankovskiy, N. L. Aleshenko, Elena V. Kaytukova, Anastasia D. Kuzminova, V. V. Ivanchikov
Psoriasis is the second most common skin disease after atopic dermatitis in childhood. There are factors affecting both the manifestation and aggravation of this inflammatory skin process. The leading role in the psoriasis pathogenesis is currently associated with key cytokines. However, infectious diseases could be the triggers for psoriasis.Nowadays, the approach to psoriasis management in children has been revised due to emerging of new knowledge about the clinical manifestations and the role of numerous comorbid conditions in psoriasis course. Risk factors assessment, as well as evaluation of potential comorbidities signs and symptoms, is crucial part in patient management to create a prognostic model of the disease progression and the aggravation development (with underlying associated inflammatory processes included).
{"title":"Potential Effects of Some Factors on Psoriasis Course in Children","authors":"S. Gubanova, E. T. Ambarchyan, L. S. Namazova-Baranova, E. A. Vishneva, I. Zelenkova, Viktor A. Gankovskiy, N. L. Aleshenko, Elena V. Kaytukova, Anastasia D. Kuzminova, V. V. Ivanchikov","doi":"10.15690/pf.v21i3.2764","DOIUrl":"https://doi.org/10.15690/pf.v21i3.2764","url":null,"abstract":"Psoriasis is the second most common skin disease after atopic dermatitis in childhood. There are factors affecting both the manifestation and aggravation of this inflammatory skin process. The leading role in the psoriasis pathogenesis is currently associated with key cytokines. However, infectious diseases could be the triggers for psoriasis.Nowadays, the approach to psoriasis management in children has been revised due to emerging of new knowledge about the clinical manifestations and the role of numerous comorbid conditions in psoriasis course. Risk factors assessment, as well as evaluation of potential comorbidities signs and symptoms, is crucial part in patient management to create a prognostic model of the disease progression and the aggravation development (with underlying associated inflammatory processes included).","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In recent years, there has been a significant increase in the prevalence of inflammatory bowel diseases. Despite the significant progress made in the instrumental diagnosis of this group of diseases, their treatment in most cases remains formalized, based on fairly strict schemes. In this context, an urgent area of modern research is to study the effectiveness of the use of diet therapy and certain foods in order to modulate the activity of the inflammatory process, which allows avoiding adverse reactions of immunosuppressive, including immunobiological, therapy. Adherence to the Mediterranean diet has proven its effectiveness in the treatment of chronic non-infectious diseases. Recent studies have also established its benefits in the treatment of inflammatory bowel diseases. Recent studies have also established its benefits in the treatment of inflammatory bowel diseases. This article will present the results of modern research on the effect of the use of olive oil and its components on the course of inflammatory processes in the intestine. A number of studies conducted in vitro and in animal models have revealed the mechanisms by which olive oil and its components have a positive effect on the course of inflammation in the intestinal wall through anti-inflammatory, antioxidant, immunomodulatory and antitumor effects. Few clinical studies conducted on patients with inflammatory bowel diseases have shown the possibility of using diet therapy with the addition of olive oil in this group of patients as an additional treatment.
{"title":"Anti-inflammatory Effects of Olive Oil and Its Components. Prospects of Application in the Treatment of Inflammatory Bowel Diseases","authors":"A. I. Khavkin, A. V. Nalyotov, M. A. Matsynina","doi":"10.15690/pf.v21i3.2754","DOIUrl":"https://doi.org/10.15690/pf.v21i3.2754","url":null,"abstract":"In recent years, there has been a significant increase in the prevalence of inflammatory bowel diseases. Despite the significant progress made in the instrumental diagnosis of this group of diseases, their treatment in most cases remains formalized, based on fairly strict schemes. In this context, an urgent area of modern research is to study the effectiveness of the use of diet therapy and certain foods in order to modulate the activity of the inflammatory process, which allows avoiding adverse reactions of immunosuppressive, including immunobiological, therapy. Adherence to the Mediterranean diet has proven its effectiveness in the treatment of chronic non-infectious diseases. Recent studies have also established its benefits in the treatment of inflammatory bowel diseases. Recent studies have also established its benefits in the treatment of inflammatory bowel diseases. This article will present the results of modern research on the effect of the use of olive oil and its components on the course of inflammatory processes in the intestine. A number of studies conducted in vitro and in animal models have revealed the mechanisms by which olive oil and its components have a positive effect on the course of inflammation in the intestinal wall through anti-inflammatory, antioxidant, immunomodulatory and antitumor effects. Few clinical studies conducted on patients with inflammatory bowel diseases have shown the possibility of using diet therapy with the addition of olive oil in this group of patients as an additional treatment.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"73 s312","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Ustinova, Georgiy A. Karkashadze, L. S. Namazova-Baranova
The publication is devoted to the review of accumulated data on the relationship of respiratory allergopathology with neuropsychiatric disorders in childhood. The immediacy of the problem is due to the mutual influence of allergic and neuropsychiatric conditions combined in a child on the course of these diseases. According to research, the connection of respiratory allergic diseases with disorders of neurodevelopment, in particular with attention deficit and hyperactivity disorder and autism spectrum disorders, is clearly manifested, and the first publications on the connection with speech and other mild cognitive impairments have appeared. At the same time, the formation of depression, suicidal behavior, and anxiety disorders in respiratory allergopathology is being actively studied. It is assumed that the close relationship between nervous and immune regulation provides a high correlation of allergic and neuropsychiatric pathological conditions, although cause-and-effect relationships have not yet been precisely established. In this regard, it becomes relevant to introduce into clinical practice monitoring of cognitive status, neuropsychic development and possible symptoms of anxiety, depression and suicidal thoughts in the treatment of children with respiratory allergic diseases. Timely detection of violations will make it possible to provide specialized interventions at an early stage in order to achieve a favorable treatment result in the long term.
{"title":"Cognitive, Emotional, and Behavioral Disorders in Children with Respiratory Allergic Diseases: Causes and Solutions","authors":"N. Ustinova, Georgiy A. Karkashadze, L. S. Namazova-Baranova","doi":"10.15690/pf.v21i3.2757","DOIUrl":"https://doi.org/10.15690/pf.v21i3.2757","url":null,"abstract":"The publication is devoted to the review of accumulated data on the relationship of respiratory allergopathology with neuropsychiatric disorders in childhood. The immediacy of the problem is due to the mutual influence of allergic and neuropsychiatric conditions combined in a child on the course of these diseases. According to research, the connection of respiratory allergic diseases with disorders of neurodevelopment, in particular with attention deficit and hyperactivity disorder and autism spectrum disorders, is clearly manifested, and the first publications on the connection with speech and other mild cognitive impairments have appeared. At the same time, the formation of depression, suicidal behavior, and anxiety disorders in respiratory allergopathology is being actively studied. It is assumed that the close relationship between nervous and immune regulation provides a high correlation of allergic and neuropsychiatric pathological conditions, although cause-and-effect relationships have not yet been precisely established. In this regard, it becomes relevant to introduce into clinical practice monitoring of cognitive status, neuropsychic development and possible symptoms of anxiety, depression and suicidal thoughts in the treatment of children with respiratory allergic diseases. Timely detection of violations will make it possible to provide specialized interventions at an early stage in order to achieve a favorable treatment result in the long term.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The discovery of immune checkpoints (IC) has become a landmark event in immuno-oncolog y, improving the understanding of the mechanisms of tumor cells evading immune sur veillance. Based on this, a group of drugs such as immune checkpoint inhibitors (ICIs) were developed, the ef fect of which is due to the rupture of the immunological synapse and recognition by tumor T cells. Currently, ICIs are successfully used in the treatment of a number of malignant neoplasms, improving the indicators of diseasefree and overall sur vival. However, determining the role of these drugs in the treatment of children with tumors of the blood system is the subject of active research. This article presents a review of the literature on topical aspects of the administration of PD-1 and PD-L1 inhibitors in pediatric hematolog y. Their mechanisms of action, ef fectiveness and potential complications of therapy are presented.
免疫检查点（IC）的发现已成为免疫肿瘤学的标志性事件，加深了人们对肿瘤细胞逃避免疫监视机制的理解。在此基础上，一批药物如免疫检查点抑制剂（ICIs）应运而生，其作用机制是免疫突触的断裂和肿瘤 T 细胞的识别。目前，免疫检查点抑制剂已成功用于多种恶性肿瘤的治疗，改善了无病生存率和总体生存率指标。然而，如何确定这些药物在儿童血液系统肿瘤治疗中的作用是目前正在积极研究的课题。本文综述了在儿科血液病中使用 PD-1 和 PD-L1 抑制剂的相关文献，介绍了它们的作用机制、疗效和潜在并发症。
{"title":"The administration of PD-1 and PD-L1 inhibitors in pediatric hematology: a literature review","authors":"Aleksandra S. Paderina, T. T. Valiev","doi":"10.15690/pf.v21i3.2751","DOIUrl":"https://doi.org/10.15690/pf.v21i3.2751","url":null,"abstract":"The discovery of immune checkpoints (IC) has become a landmark event in immuno-oncolog y, improving the understanding of the mechanisms of tumor cells evading immune sur veillance. Based on this, a group of drugs such as immune checkpoint inhibitors (ICIs) were developed, the ef fect of which is due to the rupture of the immunological synapse and recognition by tumor T cells. Currently, ICIs are successfully used in the treatment of a number of malignant neoplasms, improving the indicators of diseasefree and overall sur vival. However, determining the role of these drugs in the treatment of children with tumors of the blood system is the subject of active research. This article presents a review of the literature on topical aspects of the administration of PD-1 and PD-L1 inhibitors in pediatric hematolog y. Their mechanisms of action, ef fectiveness and potential complications of therapy are presented.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"67 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Systematic reviews are considered the highest evidence of the effectiveness and safety of treatment methods used in clinical practice. The veracity of a results and conclusions of systematic reviews is directly related to their quality. The aim of the study is an assessment of the currency, completeness and methodological quality of published systematic reviews on the evaluation of the effectiveness of ursodeoxycholic acid (UDCA) for the treatment of neonatal hyperbilirubinemia. Materials and methods. A meta-epidemiological methodological study was conducted. The search for evidence sources was performed in November 2023 in the specialized databases MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR), LILACS, CNKI, LENS.ORG, еLibrary.Ru, in registers ClinicalTrials.gov, ICTRP, ISRCTN, PROSPERO, as well as in the Google Academy and Google search engines. Additionally, the lists of references and citations of selected publications have been reviewed. Only systematic reviews and randomized clinical trials are included in the study. The search was carried out to assess the currency and completeness of systematic reviews. A systematic review is considered currency if the most recent studies are included in its analysis. A systematic review is considered complete if its analysis includes all identified studies that meet the inclusion criteria set by the review authors and are published no later than the date of the last search conducted by the review authors. The methodological quality of the systematic reviews was assessed using the AMSTAR-2 tool. Results. As a result of the search, 4 systematic reviews and 23 randomized trials were identified. All reviews evaluated the effect of UDCA in combination with phototherapy on the level of total serum bilirubin, the duration of phototherapy and the frequency of adverse events (for example, loose stools, vomiting, rash) compared with phototherapy alone and/or placebo. All systematic reviews have been published over the past two years, but have already lost their currency. There are missing studies and/or outcomes in each review. The methodological quality of the reviews was found to be extremely low. Conclusion. Given the listed shortcomings of systematic reviews, their results and conclusions should be treated with caution. In order to obtain the most accurate and reliable evidence, a new systematic review is needed.
背景。系统综述被认为是临床实践中治疗方法有效性和安全性的最高证据。系统综述结果和结论的真实性与其质量直接相关。本研究旨在评估已发表的关于熊去氧胆酸（UDCA）治疗新生儿高胆红素血症有效性评估的系统综述的时效性、完整性和方法学质量。材料与方法。进行了一项荟萃流行病学方法研究。2023 年 11 月，在专业数据库 MEDLINE、Cochrane 对照试验中央登记册 (CENTRAL)、Cochrane 系统性综述数据库 (CDSR)、LILACS、CNKI、LENS.ORG、еLibrary.Ru、ClinicalTrials.gov、ICTRP、ISRCTN、PROSPERO 登记册以及 Google Academy 和 Google 搜索引擎中进行了证据来源检索。此外，还查阅了部分出版物的参考文献和引文列表。本研究只包括系统综述和随机临床试验。搜索的目的是评估系统综述的时效性和完整性。如果一篇系统综述的分析中包含了最新的研究，则该综述被认为是最新的。如果一篇系统综述的分析包括了所有符合综述作者设定的纳入标准的已确定研究，且发表日期不晚于综述作者最后一次检索的日期，则该综述被认为是完整的。系统综述的方法学质量采用 AMSTAR-2 工具进行评估。结果。经过检索，共发现了 4 篇系统综述和 23 项随机试验。所有综述都评估了 UDCA 联合光疗与单独光疗和/或安慰剂相比对血清总胆红素水平、光疗持续时间和不良反应（如便稀、呕吐、皮疹）发生频率的影响。所有系统综述都是在过去两年中发表的，但已经失去了时效性。每篇综述都存在研究和/或结果缺失的情况。综述的方法学质量极低。结论鉴于系统综述存在上述缺点，应谨慎对待其结果和结论。为了获得最准确、最可靠的证据，需要进行新的系统综述。
{"title":"Rationale, completeness and quality of evidence for the use of ursodeoxycholic acid in neonatal hyperbilirubinemia","authors":"O.V. Zakharova","doi":"10.15690/pf.v21i2.2739","DOIUrl":"https://doi.org/10.15690/pf.v21i2.2739","url":null,"abstract":"Background. Systematic reviews are considered the highest evidence of the effectiveness and safety of treatment methods used in clinical practice. The veracity of a results and conclusions of systematic reviews is directly related to their quality. The aim of the study is an assessment of the currency, completeness and methodological quality of published systematic reviews on the evaluation of the effectiveness of ursodeoxycholic acid (UDCA) for the treatment of neonatal hyperbilirubinemia. Materials and methods. A meta-epidemiological methodological study was conducted. The search for evidence sources was performed in November 2023 in the specialized databases MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR), LILACS, CNKI, LENS.ORG, еLibrary.Ru, in registers ClinicalTrials.gov, ICTRP, ISRCTN, PROSPERO, as well as in the Google Academy and Google search engines. Additionally, the lists of references and citations of selected publications have been reviewed. Only systematic reviews and randomized clinical trials are included in the study. The search was carried out to assess the currency and completeness of systematic reviews. A systematic review is considered currency if the most recent studies are included in its analysis. A systematic review is considered complete if its analysis includes all identified studies that meet the inclusion criteria set by the review authors and are published no later than the date of the last search conducted by the review authors. The methodological quality of the systematic reviews was assessed using the AMSTAR-2 tool. Results. As a result of the search, 4 systematic reviews and 23 randomized trials were identified. All reviews evaluated the effect of UDCA in combination with phototherapy on the level of total serum bilirubin, the duration of phototherapy and the frequency of adverse events (for example, loose stools, vomiting, rash) compared with phototherapy alone and/or placebo. All systematic reviews have been published over the past two years, but have already lost their currency. There are missing studies and/or outcomes in each review. The methodological quality of the reviews was found to be extremely low. Conclusion. Given the listed shortcomings of systematic reviews, their results and conclusions should be treated with caution. In order to obtain the most accurate and reliable evidence, a new systematic review is needed.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":" 1286","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140989045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Karachentsova, E. Sibirskaya, Mariya M. Fomina, Tatyana G. Dyadik
Background. Currently, oncological diseases and their possible prevention are being actively studied. Cancer mortality remains high. A national project “Healthcare” has been started in Russia, including the Federal projects “Fighting Cancer” and “Development of Children’s Health Care, including the creation of a modern infrastructure for providing medical care to children”. In a number of regions, girls can be vaccinated against the human papillomavirus (HPV). The main reason for refusing HPV vaccination is an unfounded fear of negatively affecting the fertility and other bad data. The aim of the study is an investigation of the reproductive system of adolescent girls with completed course of vaccination against HPV using quadrivalent vaccine. Methods. We selected 65 schoolgirls in Moscow by analyzing medical documentation data. All of them were vaccinated against HPV and examined by a gynecologist. The state of their reproductive system was assessed. Results. Most girls received the vaccine at the age of 12–13, according to the regional vaccination calendar of the city of Moscow. They were vaccinated with the quadrivalent vaccine twice with an interval of 6 months; no adverse event was noted. The mean period of time since vaccination was 2.7 ± 1.1 years. The mean age of menarche, mean menstrual cycle length, and mean bleeding time were normal in girls vaccinated against HPV. Among menstrual disorders, dysmenorrhea and oligomenorrhea were most often observed, but the data did not differ from the population average. The incidence of abnormal uterine bleeding and breast pathology was lower. No papillomas were detected. Pubertal development corresponded to age of all girls. Conclusion. It has been established that vaccination against the human papillomavirus does not have a negative impact on the reproductive system of teenage girls. However, additional dynamic studies are needed at different age periods of girls and women vaccinated against HPV to confirm the positive effect on the sexual sphere and formation of strong adherence to vaccination.
{"title":"The state of the reproductive system of adolescent girls after vaccination against human papillomavirus using a quadrivalent vaccine","authors":"I. Karachentsova, E. Sibirskaya, Mariya M. Fomina, Tatyana G. Dyadik","doi":"10.15690/pf.v21i2.2716","DOIUrl":"https://doi.org/10.15690/pf.v21i2.2716","url":null,"abstract":"Background. Currently, oncological diseases and their possible prevention are being actively studied. Cancer mortality remains high. A national project “Healthcare” has been started in Russia, including the Federal projects “Fighting Cancer” and “Development of Children’s Health Care, including the creation of a modern infrastructure for providing medical care to children”. In a number of regions, girls can be vaccinated against the human papillomavirus (HPV). The main reason for refusing HPV vaccination is an unfounded fear of negatively affecting the fertility and other bad data. The aim of the study is an investigation of the reproductive system of adolescent girls with completed course of vaccination against HPV using quadrivalent vaccine. Methods. We selected 65 schoolgirls in Moscow by analyzing medical documentation data. All of them were vaccinated against HPV and examined by a gynecologist. The state of their reproductive system was assessed. Results. Most girls received the vaccine at the age of 12–13, according to the regional vaccination calendar of the city of Moscow. They were vaccinated with the quadrivalent vaccine twice with an interval of 6 months; no adverse event was noted. The mean period of time since vaccination was 2.7 ± 1.1 years. The mean age of menarche, mean menstrual cycle length, and mean bleeding time were normal in girls vaccinated against HPV. Among menstrual disorders, dysmenorrhea and oligomenorrhea were most often observed, but the data did not differ from the population average. The incidence of abnormal uterine bleeding and breast pathology was lower. No papillomas were detected. Pubertal development corresponded to age of all girls. Conclusion. It has been established that vaccination against the human papillomavirus does not have a negative impact on the reproductive system of teenage girls. However, additional dynamic studies are needed at different age periods of girls and women vaccinated against HPV to confirm the positive effect on the sexual sphere and formation of strong adherence to vaccination.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"124 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140987158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SYMPOSIUM “WHAT TO CHOOSE FOR A PEDIATRICIAN: TREAT BY YOURSELF OR SEND TO A SUBSPECIALIST?”","authors":"A. Editorial","doi":"10.15690/pf.v21i2.2723","DOIUrl":"https://doi.org/10.15690/pf.v21i2.2723","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140989033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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