Snezhana D. Timoshkova, M. Fedoseenko, D. Rusinova, G. Glazkova, L. S. Namazova-Baranova
Background. The commitment to vaccination of outpatient doctors is one of the factors that affects patients’ confidence in preventive vaccinations and, as a result, the incidence of controlled infections. Unfortunately, emotionally colored information is currently spreading among the population faster than scientifically proven facts all over the world.The aim of this study is the examine of the level of knowledge and attitude to vaccination of doctors in one of the children’s polyclinics in Moscow.Methods. An anonymous questionnaire survey was conducted among medical doctors of different specialties who expressed their attitude to various aspects of immunoprophylaxis and demonstrated knowledge in this field. Results. The survey demonstrated a positive attitude of respondents towards immunization, while some of them showed a cautious attitude towards the effectiveness and safety of vaccines, misconceptions (erroneous assumptions), increased susceptibility to “myths” about preventive vaccinations.Conclusion. The level of knowledge of medical doctors on vaccine prevention within a single health care institution range from insufficient training, including misconceptions, to a high level of knowledge and commitment regarding immunization. It is necessary to regularly maintain current theoretical knowledge of doctors and consolidate it in practice.
{"title":"Assessment of the commitment to vaccination of outpatient doctors","authors":"Snezhana D. Timoshkova, M. Fedoseenko, D. Rusinova, G. Glazkova, L. S. Namazova-Baranova","doi":"10.15690/pf.v21i1.2719","DOIUrl":"https://doi.org/10.15690/pf.v21i1.2719","url":null,"abstract":"Background. The commitment to vaccination of outpatient doctors is one of the factors that affects patients’ confidence in preventive vaccinations and, as a result, the incidence of controlled infections. Unfortunately, emotionally colored information is currently spreading among the population faster than scientifically proven facts all over the world.The aim of this study is the examine of the level of knowledge and attitude to vaccination of doctors in one of the children’s polyclinics in Moscow.Methods. An anonymous questionnaire survey was conducted among medical doctors of different specialties who expressed their attitude to various aspects of immunoprophylaxis and demonstrated knowledge in this field. Results. The survey demonstrated a positive attitude of respondents towards immunization, while some of them showed a cautious attitude towards the effectiveness and safety of vaccines, misconceptions (erroneous assumptions), increased susceptibility to “myths” about preventive vaccinations.Conclusion. The level of knowledge of medical doctors on vaccine prevention within a single health care institution range from insufficient training, including misconceptions, to a high level of knowledge and commitment regarding immunization. It is necessary to regularly maintain current theoretical knowledge of doctors and consolidate it in practice.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"86 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140433821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Gordeeva, Albina V. Dobrotok, Mariia V. Volkova, N. L. Aleshenko, Vladimir S. Kargin, Irine Dzharkava, Nadezhda F. Zhdanovskaia
Background. Early diagnosis of thrombocytopathies in children is a relevant objective of pediatrics. Diagnostics helps prevent the development of bleeding, chronic posthemorrhagic anemia, reduces the risk of thrombosis.The aim of the study is an assessment of the incidence of platelet aggregation disorders in children with manifestations of hemorrhagic syndrome against the background of chronic pathology.Methods. The study was conducted on the basis of the Research Institute of Pediatrics and Children’s Health, Scientific Center No. 2, Petrovsky National Research Centre of Surgery in the period from January — until December 2022. 62 children were included in the study, of which 50 children were selected (21 boys and 29 girls) aged 2 years 3 months to 17 years 11 months. The median age was 9.4 (7.2; 13.4). Aggregometry was performed using an impedance semiautomatic aggregometer in whole blood.Results. Depending on the diagnosis, the children were divided into the following groups: cardiovascular diseases (CVD), lysosomal storage disorders (LSD), monogenic hereditary diseases (MHD), children with dysplastic syndrome (DS), children with pathology of the nervous system (NS). Hypoaggregation with thrombin-activating peptide (TRAP test) was detected in 28% of cases (n = 14), more often in children from the group with MHD — 10% (n = 5) and with the presenceof DS — 10% (n = 5). Hypoaggregation with adenosine diphosphate (ADP test) was detected in 20% of cases (n = 10), with arachidonic acid (ASPI test) was detected in 14% (n = 7). Hyperaggregation with the TRAP test was detected in 12% (n = 6), with the ADP test detected in 8% of cases (n = 4). Hyperaggregation with ASPI test was detected in 18% of cases (n = 9).Conclusion. The analyzed results of laboratory tests of platelet aggregation function, hypoaggregation with inducers was observed in more than half of the children, hyperaggregation was observed was present in almost half of the patients.
{"title":"The results of the cross-sectional study of platelet aggregative function in children with hemorrhagic syndrome","authors":"O. Gordeeva, Albina V. Dobrotok, Mariia V. Volkova, N. L. Aleshenko, Vladimir S. Kargin, Irine Dzharkava, Nadezhda F. Zhdanovskaia","doi":"10.15690/pf.v21i1.2658","DOIUrl":"https://doi.org/10.15690/pf.v21i1.2658","url":null,"abstract":"Background. Early diagnosis of thrombocytopathies in children is a relevant objective of pediatrics. Diagnostics helps prevent the development of bleeding, chronic posthemorrhagic anemia, reduces the risk of thrombosis.The aim of the study is an assessment of the incidence of platelet aggregation disorders in children with manifestations of hemorrhagic syndrome against the background of chronic pathology.Methods. The study was conducted on the basis of the Research Institute of Pediatrics and Children’s Health, Scientific Center No. 2, Petrovsky National Research Centre of Surgery in the period from January — until December 2022. 62 children were included in the study, of which 50 children were selected (21 boys and 29 girls) aged 2 years 3 months to 17 years 11 months. The median age was 9.4 (7.2; 13.4). Aggregometry was performed using an impedance semiautomatic aggregometer in whole blood.Results. Depending on the diagnosis, the children were divided into the following groups: cardiovascular diseases (CVD), lysosomal storage disorders (LSD), monogenic hereditary diseases (MHD), children with dysplastic syndrome (DS), children with pathology of the nervous system (NS). Hypoaggregation with thrombin-activating peptide (TRAP test) was detected in 28% of cases (n = 14), more often in children from the group with MHD — 10% (n = 5) and with the presenceof DS — 10% (n = 5). Hypoaggregation with adenosine diphosphate (ADP test) was detected in 20% of cases (n = 10), with arachidonic acid (ASPI test) was detected in 14% (n = 7). Hyperaggregation with the TRAP test was detected in 12% (n = 6), with the ADP test detected in 8% of cases (n = 4). Hyperaggregation with ASPI test was detected in 18% of cases (n = 9).Conclusion. The analyzed results of laboratory tests of platelet aggregation function, hypoaggregation with inducers was observed in more than half of the children, hyperaggregation was observed was present in almost half of the patients.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ulviia Sh. Ashraphova, Olga S. Kupriianova, Elena K. Karmazina, O. Klochkova, Aiaz M. Mamedieiarov, Elena V. Komarova, M. Ivardava, Georgiy A. Karkashadze
{"title":"A personalized approach to application of robotic mechanotherapy methods in children with cerebral palsy of different age groups (review)","authors":"Ulviia Sh. Ashraphova, Olga S. Kupriianova, Elena K. Karmazina, O. Klochkova, Aiaz M. Mamedieiarov, Elena V. Komarova, M. Ivardava, Georgiy A. Karkashadze","doi":"10.15690/pf.v20i6.2668","DOIUrl":"https://doi.org/10.15690/pf.v20i6.2668","url":null,"abstract":"","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"97 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139630436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgiy A. Karkashadze, Marina A. Kurakina, L. S. Namazova-Baranova, Elena V. Vishneva, Elena V. Kaytukova, K. Efendieva, T. Gogberashvili, Tatiana A. Salimgareeva, Safarbegim H. Sadilloeva, T. Konstantinidi, Natalia Е. Sergeeva, Julia E. Kazanceva, Elena S. Zibrova
Dyslexia (disturbance of reading) and dysgraphia (disturbance of writing) are a common problem of teaching children in secondary schools. Information on the prevalence of these conditions is ambiguous, the data presented in the Russian speech therapy literature differ from the results of a few foreign works, and therefore population studies are becoming particularly relevant. The review of the domestic methodological base with the prospect of application in population research and international approaches to population screening are presented.
{"title":"The application of diagnostic methods for disturbance of reading and writing in Russian population studies","authors":"Georgiy A. Karkashadze, Marina A. Kurakina, L. S. Namazova-Baranova, Elena V. Vishneva, Elena V. Kaytukova, K. Efendieva, T. Gogberashvili, Tatiana A. Salimgareeva, Safarbegim H. Sadilloeva, T. Konstantinidi, Natalia Е. Sergeeva, Julia E. Kazanceva, Elena S. Zibrova","doi":"10.15690/pf.v20i6.2669","DOIUrl":"https://doi.org/10.15690/pf.v20i6.2669","url":null,"abstract":"Dyslexia (disturbance of reading) and dysgraphia (disturbance of writing) are a common problem of teaching children in secondary schools. Information on the prevalence of these conditions is ambiguous, the data presented in the Russian speech therapy literature differ from the results of a few foreign works, and therefore population studies are becoming particularly relevant. The review of the domestic methodological base with the prospect of application in population research and international approaches to population screening are presented.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"96 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139630441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE FDA HAS APPROVED THE FIRST VACCINE AGAINST THE CHIKUNGUNYA VIRUS","authors":"A. Editorial","doi":"10.15690/pf.v20i6.2662","DOIUrl":"https://doi.org/10.15690/pf.v20i6.2662","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"16 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139536293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ekaterina E. Kopylova, Margarita F. Botsieva, Kristina I. Berezovskaya, Sultan M. Kunakkuzin, Alina D. Mikhailova, Anastasiya V. Konova, Anna O. Dasko, Gul’emesh A. Valeeva, Olga S. Ispiryan, Diana A. Sverchkova, Karina N. Keller, Alisa E. Dovgiy
The obesity prevalence in children has increased dramatically over the past four decades and has epidemic nature. Lifestyle correction in majority of obese children and adolescents leads only to slight success in reducing body weight (that usually restores to initial level). The increasing availability of pharmacotherapeutic agents approved by Food and Drug Administration (FDA) for body weight reduction in children provides physicians with new and effective tools for obesity management. Phentermine/ topiramate is a combination medication (with once-a-day administration, controlled release) that has been recently approved by the FDA for pediatric obesity therapy. Its efficacy is significantly higher compared to orlistat and phentermine (in monotherapy), two other FDA-approved drugs for this age group. The aim of this review is to analyze the literature on the topic of phentermine and topiramate mechanism, as well as these drugs safety and efficacy as monotherapy and in combination in children and adolescents with obesity.
{"title":"Phentermine and Topiramate: Monotherapy and Their Combination Efficacy in the Treatment of Children and Adults with Obesity","authors":"Ekaterina E. Kopylova, Margarita F. Botsieva, Kristina I. Berezovskaya, Sultan M. Kunakkuzin, Alina D. Mikhailova, Anastasiya V. Konova, Anna O. Dasko, Gul’emesh A. Valeeva, Olga S. Ispiryan, Diana A. Sverchkova, Karina N. Keller, Alisa E. Dovgiy","doi":"10.15690/pf.v20i6.2667","DOIUrl":"https://doi.org/10.15690/pf.v20i6.2667","url":null,"abstract":"The obesity prevalence in children has increased dramatically over the past four decades and has epidemic nature. Lifestyle correction in majority of obese children and adolescents leads only to slight success in reducing body weight (that usually restores to initial level). The increasing availability of pharmacotherapeutic agents approved by Food and Drug Administration (FDA) for body weight reduction in children provides physicians with new and effective tools for obesity management. Phentermine/ topiramate is a combination medication (with once-a-day administration, controlled release) that has been recently approved by the FDA for pediatric obesity therapy. Its efficacy is significantly higher compared to orlistat and phentermine (in monotherapy), two other FDA-approved drugs for this age group. The aim of this review is to analyze the literature on the topic of phentermine and topiramate mechanism, as well as these drugs safety and efficacy as monotherapy and in combination in children and adolescents with obesity.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"55 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139536638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. S. Namazova-Baranova, S. Gubanova, I. Zelenkova, V. A. Gankovskii, Marina V. Egorova, J. Levina, Elena V. Kaytukova, K. Efendieva, Elena V. Vishneva
Background. Recurrent upper respiratory diseases in children are an urgent and common issue in pediatrics. Comorbidities often lead to prolonged, complicated, or chronic course of the inflammatory process in the upper airways.Objective. The aim of the study — scientific evidence and complex technology development for the management of children with recurrent upper respiratory diseases according to implemented multidisciplinary personalized approach, complex of modern methods for diagnosing and health monitoring to achieve long-term remission.Materials and methods. The study included 115 children aged from 2 years 6 months to 17 years 11 months with recurrent upper respiratory diseases. Examination included: nasal cavity, nasopharynx and larynx endoscopy, abdomen ultrasound with aqueous-siphon test, tympanometry, and laboratory tests (total and specific IgE levels, antistreptolysin-O, microbiological study of nasopharynx and oropharynx discharge, enzyme-linked immunosorbent assay of feces on Helicobacter pylori.Results. The study has revealed high prevalence of associated allergic pathology in children with recurrent upper respiratory diseases. Allergic rhinitis was the most common (55 (48%) children). There was also a high prevalence of gastroesophageal reflux disease (GERD) (37 (32%) children). Clinical signs of GERD were revealed in patients with chronic diseases significantly more often than in children with acute ENT pathology (27 (38%) and 10 (23%) children, respectively). It confirms the role of this comorbid condition in the development and course of chronic inflammatory process of the upper airways. Obtained data analysis has shown high prevalence of allergic and gastrointestinal pathology in children with recurrent upper respiratory diseases. Diagnostic and management algorithm for patients with recurrent upper respiratory diseases as well as practical guidelines were prepared based on the study data. This algorithm will allow to implement the personalized multidisciplinary approach for the management of prior and comorbid diseases via modern informative diagnostic methods. The complex approach to timely physical examination and pathogenetic treatment will ensure control of the patient’s condition and prevent the development of chronic ENT organ pathology in children.
{"title":"Multidisciplinary Approach To The Problem Of Managing Children With Frequent Respiratory Infections Of The Upper Respiratory Tract: Key Results","authors":"L. S. Namazova-Baranova, S. Gubanova, I. Zelenkova, V. A. Gankovskii, Marina V. Egorova, J. Levina, Elena V. Kaytukova, K. Efendieva, Elena V. Vishneva","doi":"10.15690/pf.v20i6.2704","DOIUrl":"https://doi.org/10.15690/pf.v20i6.2704","url":null,"abstract":"Background. Recurrent upper respiratory diseases in children are an urgent and common issue in pediatrics. Comorbidities often lead to prolonged, complicated, or chronic course of the inflammatory process in the upper airways.Objective. The aim of the study — scientific evidence and complex technology development for the management of children with recurrent upper respiratory diseases according to implemented multidisciplinary personalized approach, complex of modern methods for diagnosing and health monitoring to achieve long-term remission.Materials and methods. The study included 115 children aged from 2 years 6 months to 17 years 11 months with recurrent upper respiratory diseases. Examination included: nasal cavity, nasopharynx and larynx endoscopy, abdomen ultrasound with aqueous-siphon test, tympanometry, and laboratory tests (total and specific IgE levels, antistreptolysin-O, microbiological study of nasopharynx and oropharynx discharge, enzyme-linked immunosorbent assay of feces on Helicobacter pylori.Results. The study has revealed high prevalence of associated allergic pathology in children with recurrent upper respiratory diseases. Allergic rhinitis was the most common (55 (48%) children). There was also a high prevalence of gastroesophageal reflux disease (GERD) (37 (32%) children). Clinical signs of GERD were revealed in patients with chronic diseases significantly more often than in children with acute ENT pathology (27 (38%) and 10 (23%) children, respectively). It confirms the role of this comorbid condition in the development and course of chronic inflammatory process of the upper airways. Obtained data analysis has shown high prevalence of allergic and gastrointestinal pathology in children with recurrent upper respiratory diseases. Diagnostic and management algorithm for patients with recurrent upper respiratory diseases as well as practical guidelines were prepared based on the study data. This algorithm will allow to implement the personalized multidisciplinary approach for the management of prior and comorbid diseases via modern informative diagnostic methods. The complex approach to timely physical examination and pathogenetic treatment will ensure control of the patient’s condition and prevent the development of chronic ENT organ pathology in children.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"8 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Kofeynikova, Darya Yu. Alexeeva, Evgeniya V. Characterova, A. Kostareva, E. Vasichkina
This article describes the onset of arrhythmogenic cardiomyopathy, left-dominant form, in a pediatric patient that was initially regarded as dilated cardiomyopathy. This clinical case shows issues of the disease differential diagnosis and the need of complex approach to the patient’s examination including heart magnetic resonance imaging and molecular and genetic testing.
{"title":"Arrhythmogenic Cardiomyopathy in 8-Year-Old Girl: Clinical Case. Difficult Path to Diagnosis","authors":"O. Kofeynikova, Darya Yu. Alexeeva, Evgeniya V. Characterova, A. Kostareva, E. Vasichkina","doi":"10.15690/pf.v20i6.2664","DOIUrl":"https://doi.org/10.15690/pf.v20i6.2664","url":null,"abstract":"This article describes the onset of arrhythmogenic cardiomyopathy, left-dominant form, in a pediatric patient that was initially regarded as dilated cardiomyopathy. This clinical case shows issues of the disease differential diagnosis and the need of complex approach to the patient’s examination including heart magnetic resonance imaging and molecular and genetic testing.","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"49 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139536550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Loshkova, I. V. Doroshenko, T. S. Liulka, A. I. Khavkin, E. I. Kondratieva, N. D. Odinaeva, Yulia S. Rafikova, V. Zhelev, A. L. Solnyshko, E. V. Mikhalev, Sergey P. Ermolenko, I. R. Grishkevich, N. E. Melnikov, Anton A. Bohunetsky, E. I. Makarevich
Background. The usage of new psychoactive substances (NPAS) is increasing every year among various social groups around the world. According to various authors, the use of abused drugs during pregnancy remains at a high level — from 2.8 to 7% of pregnant women. The usage of NPAS, as well as other groups of abused drugs, during pregnancy is fraught with intrauterine multi-organ damage, however, any organ and tissue specificity for NPAS has not been described. In intervention trials conducted on laboratory animals, negative pathophysiological mechanisms triggered by synthetic cathinones have been demonstrated in the form of increased proapoptotic activity, the formation of autophagolysosomes and reactive oxygen intermediates in cells of nervous tissue, and the pro-inflammatory orientation of cells of the immune system.Case report describes a predominant lesion of the nervous system (developmental brain malformations, damage to the inspiratory center) and the musculoskeletal system (pronounced miotonical syndrome, congenital pathological fractures of the femurs), leading to multiorgan dysfunction, uncontrolled inflammatory response and, as a result, to the development of severe disablement of such children and an increase in the cohort of palliative pediatric patients. In the article, the authors focus on the pathophysiological mechanisms of NPAS for a deeper and more holistic understanding of the pathological process occurring in the body, in order to form and improve the medical judgment of specialist doctors and cite their own clinical observation as an illustration of the consequences of using NPAS during pregnancy. The authors believe that this review describing the case report is valuable from the point of view of practical applicability both for clinicians of various fields and for researchers.Conclusion. In addition, it is necessary to pay attention to the fact that the use of NPAS is of great social and economic significance, the description of such clinical observations, as well as in vitro studies, is relevant, and the expansion of ideas about the short-term and long-term negative consequences of the use of NPAS should serve as an initiating stage for the development of rehabilitation strategies for these patients
{"title":"Pathophysiological mechanisms and clinical consequences of exposure to new psychoactive substances (“salts”) on a newborn","authors":"E. Loshkova, I. V. Doroshenko, T. S. Liulka, A. I. Khavkin, E. I. Kondratieva, N. D. Odinaeva, Yulia S. Rafikova, V. Zhelev, A. L. Solnyshko, E. V. Mikhalev, Sergey P. Ermolenko, I. R. Grishkevich, N. E. Melnikov, Anton A. Bohunetsky, E. I. Makarevich","doi":"10.15690/pf.v20i6.2703","DOIUrl":"https://doi.org/10.15690/pf.v20i6.2703","url":null,"abstract":"Background. The usage of new psychoactive substances (NPAS) is increasing every year among various social groups around the world. According to various authors, the use of abused drugs during pregnancy remains at a high level — from 2.8 to 7% of pregnant women. The usage of NPAS, as well as other groups of abused drugs, during pregnancy is fraught with intrauterine multi-organ damage, however, any organ and tissue specificity for NPAS has not been described. In intervention trials conducted on laboratory animals, negative pathophysiological mechanisms triggered by synthetic cathinones have been demonstrated in the form of increased proapoptotic activity, the formation of autophagolysosomes and reactive oxygen intermediates in cells of nervous tissue, and the pro-inflammatory orientation of cells of the immune system.Case report describes a predominant lesion of the nervous system (developmental brain malformations, damage to the inspiratory center) and the musculoskeletal system (pronounced miotonical syndrome, congenital pathological fractures of the femurs), leading to multiorgan dysfunction, uncontrolled inflammatory response and, as a result, to the development of severe disablement of such children and an increase in the cohort of palliative pediatric patients. In the article, the authors focus on the pathophysiological mechanisms of NPAS for a deeper and more holistic understanding of the pathological process occurring in the body, in order to form and improve the medical judgment of specialist doctors and cite their own clinical observation as an illustration of the consequences of using NPAS during pregnancy. The authors believe that this review describing the case report is valuable from the point of view of practical applicability both for clinicians of various fields and for researchers.Conclusion. In addition, it is necessary to pay attention to the fact that the use of NPAS is of great social and economic significance, the description of such clinical observations, as well as in vitro studies, is relevant, and the expansion of ideas about the short-term and long-term negative consequences of the use of NPAS should serve as an initiating stage for the development of rehabilitation strategies for these patients","PeriodicalId":19997,"journal":{"name":"Pediatric pharmacology","volume":"15 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139630662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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