Nicolae Dumitru Nicoară, Paula Marian, Alin Ovidiu Petriș, Cristian Delcea, Felicia Manole
{"title":"A Review of the Role of Cognitive-Behavioral Therapy on Anxiety Disorders of Children and Adolescents","authors":"Nicolae Dumitru Nicoară, Paula Marian, Alin Ovidiu Petriș, Cristian Delcea, Felicia Manole","doi":"10.51847/lkulo5pb1t","DOIUrl":"https://doi.org/10.51847/lkulo5pb1t","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135181738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katarzyna Szklener, Karolina Nieoczym, Katarzyna Niedziela, Łukasz Światłowski, Sławomir Mańdziuk
Genetic abnormalities in the anaplastic lymphoma (ALK) kinase gene are present in 3-5% of Non-squamous Cell Lung Cancer (NSCLC) cases. ALK gene rearrangement plays a crucial role in determining the sensitivity of neoplastic cells to small molecule ALK tyrosine kinase inhibitors. However, some patients may develop resistance to ALK inhibitors over time, leading to disease progression. In such cases, it is important to perform genetic testing to identify any emerging mutations that may be responsible for resistance and to select the appropriate subsequent treatment. We provide a case of a 56-year-old patient with advanced NSCLC. The patient achieved an overall progression-free survival of 71 months, which highlights the potential benefits of using a sequence of ALK inhibitors in treating advanced ALK-rearranged lung adenocarcinoma. Overall, this case study highlights the importance of genetic profiling and personalized treatment in managing advanced NSCLC, and it offers hope for improved outcomes in patients
{"title":"Exceptionally Long Survival with Lorlatinib in a Patient with Alk-Rearranged Lung","authors":"Katarzyna Szklener, Karolina Nieoczym, Katarzyna Niedziela, Łukasz Światłowski, Sławomir Mańdziuk","doi":"10.51847/n1yjzejnbd","DOIUrl":"https://doi.org/10.51847/n1yjzejnbd","url":null,"abstract":"Genetic abnormalities in the anaplastic lymphoma (ALK) kinase gene are present in 3-5% of Non-squamous Cell Lung Cancer (NSCLC) cases. ALK gene rearrangement plays a crucial role in determining the sensitivity of neoplastic cells to small molecule ALK tyrosine kinase inhibitors. However, some patients may develop resistance to ALK inhibitors over time, leading to disease progression. In such cases, it is important to perform genetic testing to identify any emerging mutations that may be responsible for resistance and to select the appropriate subsequent treatment. We provide a case of a 56-year-old patient with advanced NSCLC. The patient achieved an overall progression-free survival of 71 months, which highlights the potential benefits of using a sequence of ALK inhibitors in treating advanced ALK-rearranged lung adenocarcinoma. Overall, this case study highlights the importance of genetic profiling and personalized treatment in managing advanced NSCLC, and it offers hope for improved outcomes in patients","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135002033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Wanjari, B. Rathi, Dinesh Santoshrao Wanjari, Rohit Ajit Gokarn
{"title":"Interdisciplinary Perspective of Laghumalini Vasant an Ayurvedic Formulation Towards Therapeutic Potential in Antenatal Care","authors":"A. Wanjari, B. Rathi, Dinesh Santoshrao Wanjari, Rohit Ajit Gokarn","doi":"10.51847/5fppjrfii5","DOIUrl":"https://doi.org/10.51847/5fppjrfii5","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. M. A. El-Mawgod, A. Agarwal, Bishri Fawzan Almesned, M. M. Alruwaili, Shuruq Alshammari, Rehab Madallah Sulaiman Almatrafi
{"title":"Knowledge, Attitudes, and Practices Associated with Vitamin D Misuse among General Population during COVID-19","authors":"M. M. A. El-Mawgod, A. Agarwal, Bishri Fawzan Almesned, M. M. Alruwaili, Shuruq Alshammari, Rehab Madallah Sulaiman Almatrafi","doi":"10.51847/cmnejaqtlr","DOIUrl":"https://doi.org/10.51847/cmnejaqtlr","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Q. Alshammari, Awatif Radhy Alshammari, Amjad R. Alyahyawi, Alaa Sharef Alhmshe, Alanoud Saad Alshammari, Mai Fhaid Alshammari, S. Cg, M. Alshammari, M. A. Alghamdi, Asma Saud Alanazi
{"title":"MRI Assessment of Rotator Cuff Tear in Patients with Shoulder Pain","authors":"Q. Alshammari, Awatif Radhy Alshammari, Amjad R. Alyahyawi, Alaa Sharef Alhmshe, Alanoud Saad Alshammari, Mai Fhaid Alshammari, S. Cg, M. Alshammari, M. A. Alghamdi, Asma Saud Alanazi","doi":"10.51847/q4teobtciz","DOIUrl":"https://doi.org/10.51847/q4teobtciz","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacokinetics of Amikacin in Eye Media Using Various Drugs","authors":"Markha Khozh-Akhmedovna Bersanova, Lina Magomedovna Batkhieva, Tamar Elbrusovna Baramiya, Daniela Georgievna Birkaya, Elena Vladimirovna Belokobylskaya, Zulmira Temirsoltanovna Saidova","doi":"10.51847/qzs08gqjvc","DOIUrl":"https://doi.org/10.51847/qzs08gqjvc","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70832090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radu Fodor, Florica Voiță-Mekereș, C. Cheregi, M. Indrieș, Hassan Noor, N. Pop, Paula Marian, Rita Ioana Platona, Camelia Florentina Lascu, O. Marcu
{"title":"Epidemiological Study on Spinal Cord Injuries in a Hospital from North-West of Romania","authors":"Radu Fodor, Florica Voiță-Mekereș, C. Cheregi, M. Indrieș, Hassan Noor, N. Pop, Paula Marian, Rita Ioana Platona, Camelia Florentina Lascu, O. Marcu","doi":"10.51847/ht5jip60uc","DOIUrl":"https://doi.org/10.51847/ht5jip60uc","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70823114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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