Fathimath Ina Shareef, Mariyam Luba Abdulla, Aminath Efa Ibrahim, K. Subbaram
{"title":"Resurgence of Monkeypox: Transmission, Clinical Features with Emphasis on Countermeasures and Treatment","authors":"Fathimath Ina Shareef, Mariyam Luba Abdulla, Aminath Efa Ibrahim, K. Subbaram","doi":"10.51847/4ubxvhhdma","DOIUrl":"https://doi.org/10.51847/4ubxvhhdma","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreea Antonescu, A. Antonescu, F. Miere, L. Fritea, A. Teodorescu, L. Vicaș, Ilarie Brihan, M. Domuța, M. Zdrîncă, Marcel Zdrîncă, Luciana Dobjanschi, M. Ganea, S. Cavalu
This study aimed to highlight the importance of phytochemical-based formulations in the treatment of wounds with different etiologies, avoiding the possible side effects generated by conventional treatments. We present the preparation method of novel topical formulations (cream, ointment, and hydrogel) based on mixed extracts of Ocimum basilicum and Tifolium pratense along with evidence of their antimicrobial and antioxidant effect in vitro . The anti-inflammatory and wound healing properties of the new formulations were evaluated against different chronic inflammatory processes by presenting three clinical cases of chronic skin diseases. The clinical cases presented in our study revealed good outcomes of the cream formulation in the case of dyshidrotic eczema, ointment formulation in the case of hypertrophic scar, and hydrogel formulation in the case of psoriasis lesions. The best effect was noticed after 6 days of topical application of hydrogel on psoriatic plaques, resulting in a significant reduction of erythematous plaques. antioxidant and antimicrobial activity of the mixed extract was further exploited to develop novel therapeutic formulations designed for the treatment of acute and chronic wounds susceptible to superinfection and/or antibiotic resistance. Hence, novel formulations (ointment, cream, and hydrogel) were prepared and applied in 3 clinical cases: dyshidrotic palmar eczema, hypertrophic scar, and psoriasis lesions. The clinical cases presented in our study revealed good outcomes of the cream formulation in the case of Dyshidrotic eczema, ointment formulation in the case of Hypertrophic scar, and hydrogel formulation in the case of Psoriasis lesions. The best effect was noticed after 6 days of topical application of hydrogel on psoriatic plaques, resulting in a significant reduction of erythematous plaques, reduction of adherent pearly white scales, and local itching. Our results highlight the importance of phytochemical-based formulations in the treatment of chronic wounds with different etiologies, avoiding the possible side effects generated by conventional treatment with corticosteroids such as allergic skin reactions, secondary skin infections, skin thinning, skin discoloration, itching, or stretch marks.
{"title":"Novel Topical Formulations Based on O. Basilicum and T. Pratense: Antioxidant, Antimicrobial, and Anti-Inflammatory Effect","authors":"Andreea Antonescu, A. Antonescu, F. Miere, L. Fritea, A. Teodorescu, L. Vicaș, Ilarie Brihan, M. Domuța, M. Zdrîncă, Marcel Zdrîncă, Luciana Dobjanschi, M. Ganea, S. Cavalu","doi":"10.51847/c9xdrsvt7w","DOIUrl":"https://doi.org/10.51847/c9xdrsvt7w","url":null,"abstract":"This study aimed to highlight the importance of phytochemical-based formulations in the treatment of wounds with different etiologies, avoiding the possible side effects generated by conventional treatments. We present the preparation method of novel topical formulations (cream, ointment, and hydrogel) based on mixed extracts of Ocimum basilicum and Tifolium pratense along with evidence of their antimicrobial and antioxidant effect in vitro . The anti-inflammatory and wound healing properties of the new formulations were evaluated against different chronic inflammatory processes by presenting three clinical cases of chronic skin diseases. The clinical cases presented in our study revealed good outcomes of the cream formulation in the case of dyshidrotic eczema, ointment formulation in the case of hypertrophic scar, and hydrogel formulation in the case of psoriasis lesions. The best effect was noticed after 6 days of topical application of hydrogel on psoriatic plaques, resulting in a significant reduction of erythematous plaques. antioxidant and antimicrobial activity of the mixed extract was further exploited to develop novel therapeutic formulations designed for the treatment of acute and chronic wounds susceptible to superinfection and/or antibiotic resistance. Hence, novel formulations (ointment, cream, and hydrogel) were prepared and applied in 3 clinical cases: dyshidrotic palmar eczema, hypertrophic scar, and psoriasis lesions. The clinical cases presented in our study revealed good outcomes of the cream formulation in the case of Dyshidrotic eczema, ointment formulation in the case of Hypertrophic scar, and hydrogel formulation in the case of Psoriasis lesions. The best effect was noticed after 6 days of topical application of hydrogel on psoriatic plaques, resulting in a significant reduction of erythematous plaques, reduction of adherent pearly white scales, and local itching. Our results highlight the importance of phytochemical-based formulations in the treatment of chronic wounds with different etiologies, avoiding the possible side effects generated by conventional treatment with corticosteroids such as allergic skin reactions, secondary skin infections, skin thinning, skin discoloration, itching, or stretch marks.","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sneha Kashid, A. Suttee, P. Kadam, Gopal L. Khatik, Ramesh Kasarla
are synthetic standards. All the phytoconstituents showed good binding affinities with 1M48 (IL-2) protein in the range of -4.3 to - 7.3 kcal/mol, while on 1P9M (IL-6) protein, the binding affinities observed to be in the range of - 5.2 to -9.8 kcal/mol. The in-silico ADME studies showed that these phytoconstituents have better druggability and no cytotoxicity. The current study showed that the immunomodulatory properties of N. Sativa are from Nigellamine C.
{"title":"An In- Silico Studies for Immunomodulatory Potential of Phytoconstituents from a Naturally Occurring Herb Nigella Sativa","authors":"Sneha Kashid, A. Suttee, P. Kadam, Gopal L. Khatik, Ramesh Kasarla","doi":"10.51847/e6ckqdrhe4","DOIUrl":"https://doi.org/10.51847/e6ckqdrhe4","url":null,"abstract":"are synthetic standards. All the phytoconstituents showed good binding affinities with 1M48 (IL-2) protein in the range of -4.3 to - 7.3 kcal/mol, while on 1P9M (IL-6) protein, the binding affinities observed to be in the range of - 5.2 to -9.8 kcal/mol. The in-silico ADME studies showed that these phytoconstituents have better druggability and no cytotoxicity. The current study showed that the immunomodulatory properties of N. Sativa are from Nigellamine C.","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"50 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Badr Soliman Al Hussian, M. Al Hammad, N. Al Amri, Faisal Al Markhan, A. Asiri, Zeyad Al Deraibi, A. Alarnous
{"title":"Application of Lasers in Various Procedures Performed in Prosthodontics; A Systemic Review","authors":"Badr Soliman Al Hussian, M. Al Hammad, N. Al Amri, Faisal Al Markhan, A. Asiri, Zeyad Al Deraibi, A. Alarnous","doi":"10.51847/ssjjrkhxhr","DOIUrl":"https://doi.org/10.51847/ssjjrkhxhr","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eating Disorders in Accordance with the International Classification of Diseases","authors":"Imani Hamzatovna Salgirieva, Tamara Olegovna Stepanyan, Rassita Hizirovna Voitleva, Vladislav Ikromzhonovich Achilov, Mikail Alihanovich Albakov, Aminat Aslanovna Ahmarova","doi":"10.51847/stuvhqrlyk","DOIUrl":"https://doi.org/10.51847/stuvhqrlyk","url":null,"abstract":"Received: 10 Jul 2022 Received in revised form: 14 Oct 2022 Accepted: 17 Oct 2022 Available online: 28 Oct 2022","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"45 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva Kleszken, A. Timar, A. Memete, F. Miere, S. Vicaș
{"title":"On Overview Of Bioactive Compounds, Biological And Pharmacological Effects Of Mistletoe (Viscum Album L)","authors":"Eva Kleszken, A. Timar, A. Memete, F. Miere, S. Vicaș","doi":"10.51847/tmo2sxgqrs","DOIUrl":"https://doi.org/10.51847/tmo2sxgqrs","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70835204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formulation and Evaluation of Dolutegravir Sodium Nanoemulsion for the Treatment of HIV","authors":"Paul Rodriques, B. Prajapati","doi":"10.51847/gnvuquucif","DOIUrl":"https://doi.org/10.51847/gnvuquucif","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enwa Felix Oghenemaro, Jemikalajah Daniel Johnson, A. Collins, Oghenejobo Micheal, Aviye Hosanna Aruoriwoghene
Coconut oil has been claimed to have some beneficial health effects on the heamatological and biochemical indices, which is adjudged to the presence of medium-chain triglycerides. It was thus, intriguing to investigate its benefits in alleviating the prothrombotic tendency. This study was to investigate the effect of fresh coconut oil on the gastrointestinal tract (GIT) microbiota and hematological and biochemical indices of Wistar rats. Ten adult Wistar rats of comparable age weighing 94 -125g were used for the study (n-5). The animals were divided into two groups, Group one served as the control, and Group two was the test group which was given 0.5 ml/kg of coconut oil. Colony count was done on both the fecal and GIT content while the biochemical and hematological parameters were evaluated via whole blood samples following standard procedures. This study showed a decrease in hemoglobin, red blood cell count, white blood cell count, granulocyte, mean corpuscular hemoglobin concentration, platelet count, and mean platelet volume when compared to the Control Group. Coconut oil (0.5ml/kg body weight) had higher haematinic potency without posing a threat to the hepatocytes. There was no significant change in Na+, K+, Cl-, Cr, and HCO3 and a significant decrease in CHO, HDL, and LDL when compared to the control. However, the K+ concentration in the test Wistar rats showed a significant increase. The study shows that coconut oil has a vasodilator action on the aorta and the lipid profile was not affected. Hence, coconut oil could serve as an alternative haematinic agent.
{"title":"The Effect of Fresh Coconut Oil on Gastrointestinal Tract Microbiome, Heamatological /Biochemical indices of Wistar Rats","authors":"Enwa Felix Oghenemaro, Jemikalajah Daniel Johnson, A. Collins, Oghenejobo Micheal, Aviye Hosanna Aruoriwoghene","doi":"10.51847/rbipc8oiwy","DOIUrl":"https://doi.org/10.51847/rbipc8oiwy","url":null,"abstract":"Coconut oil has been claimed to have some beneficial health effects on the heamatological and biochemical indices, which is adjudged to the presence of medium-chain triglycerides. It was thus, intriguing to investigate its benefits in alleviating the prothrombotic tendency. This study was to investigate the effect of fresh coconut oil on the gastrointestinal tract (GIT) microbiota and hematological and biochemical indices of Wistar rats. Ten adult Wistar rats of comparable age weighing 94 -125g were used for the study (n-5). The animals were divided into two groups, Group one served as the control, and Group two was the test group which was given 0.5 ml/kg of coconut oil. Colony count was done on both the fecal and GIT content while the biochemical and hematological parameters were evaluated via whole blood samples following standard procedures. This study showed a decrease in hemoglobin, red blood cell count, white blood cell count, granulocyte, mean corpuscular hemoglobin concentration, platelet count, and mean platelet volume when compared to the Control Group. Coconut oil (0.5ml/kg body weight) had higher haematinic potency without posing a threat to the hepatocytes. There was no significant change in Na+, K+, Cl-, Cr, and HCO3 and a significant decrease in CHO, HDL, and LDL when compared to the control. However, the K+ concentration in the test Wistar rats showed a significant increase. The study shows that coconut oil has a vasodilator action on the aorta and the lipid profile was not affected. Hence, coconut oil could serve as an alternative haematinic agent.","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70832044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khalil Salameh Yakoub Al Neimat, Abdulmalek Khaled Suliman Alserhany, M. Alanazi, A. Alanazi, Naif Eid Alanazi, Majed A Alanazi, Fai A. Almulhim, Ibrahim Ahmed Alazmi, A. Q. Alanazi, Abdulrahman Saud Alsharari, Meshal M Alsharari, Daham Aldaham, Noor Hassan A Alazmi
{"title":"Updates in Prevalence, Risk Factors, Management and Outcome of Treatment of Acute Pancreatitis","authors":"Khalil Salameh Yakoub Al Neimat, Abdulmalek Khaled Suliman Alserhany, M. Alanazi, A. Alanazi, Naif Eid Alanazi, Majed A Alanazi, Fai A. Almulhim, Ibrahim Ahmed Alazmi, A. Q. Alanazi, Abdulrahman Saud Alsharari, Meshal M Alsharari, Daham Aldaham, Noor Hassan A Alazmi","doi":"10.51847/tyrk6xbcye","DOIUrl":"https://doi.org/10.51847/tyrk6xbcye","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70835432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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