Huda Sultan Almutairi, Manal Abdulbari Tashkandi, Jehad Mustafa Yousef
{"title":"Therapeutic Effect of Resveratrol and Gamma-GlutamylCysteine in Azathioprine Drug-Induced Hepatotoxicity","authors":"Huda Sultan Almutairi, Manal Abdulbari Tashkandi, Jehad Mustafa Yousef","doi":"10.51847/fzp0igmxlo","DOIUrl":"https://doi.org/10.51847/fzp0igmxlo","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135959807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Gad, Mohamed Elbatanony, H. Mirghani, M. Sheikh, M. Alamri, Abdallah Ali, Hisham Alshadfan, S. Begum, Yara Elbatanony, Abeer Alotaibi, Moneera Alkhrisi, Layan AlHarby
{"title":"Prevalence of Obesity in Female Schoolchildren, Risk Factors, and Relation to Lifestylein Tabuk, Saudi Arabia","authors":"N. Gad, Mohamed Elbatanony, H. Mirghani, M. Sheikh, M. Alamri, Abdallah Ali, Hisham Alshadfan, S. Begum, Yara Elbatanony, Abeer Alotaibi, Moneera Alkhrisi, Layan AlHarby","doi":"10.51847/15zxkypumr","DOIUrl":"https://doi.org/10.51847/15zxkypumr","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Sahu, Neha Dubey, R. Pandey, S. Shukla, B. Gidwani
{"title":"Formulation, Evaluation, and Validation of Microspheres of Cyclophosphamide for Topical Delivery","authors":"M. Sahu, Neha Dubey, R. Pandey, S. Shukla, B. Gidwani","doi":"10.51847/e4gvuon96z","DOIUrl":"https://doi.org/10.51847/e4gvuon96z","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neural Network–Based Search for COX-2 Active Ligands from Coxib-like and Similar Compounds","authors":"L. T. Billones, A. Gonzaga","doi":"10.51847/ezwhoceeec","DOIUrl":"https://doi.org/10.51847/ezwhoceeec","url":null,"abstract":"Received: 09 Feb 2023 Received in revised form: 10 May 2023 Accepted: 14 May 2023 Available online: 28 Jun 2023","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70820196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health-Related Knowledge Attitude Practice and Quality of Life Among Diabetic Hypertensive Patients in Eastern Nepal","authors":"Pratiksha Gautam, P. Dahal, Deevan Paul, K. Alam","doi":"10.51847/kvpxg6nvx5","DOIUrl":"https://doi.org/10.51847/kvpxg6nvx5","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70826888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study of Basic Emotions in the General Population Using the Likert Scale","authors":"N. Nicoară, D. Varga, Florica Voiță-Mekereș, Larisa-Bianca Galea-Holhos, Gineta Andreescu, Lavinia Costas","doi":"10.51847/tjyoah1vwm","DOIUrl":"https://doi.org/10.51847/tjyoah1vwm","url":null,"abstract":"Received: 25 Apr 2023 Received in revised form: 14 Jul 2023 Accepted: 20 Jul 2023 Available online: 28 Aug 2023","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease worldwide. The goal of this study was to examine the effects of dimethyl sulfoxide (DMSO) in a rat model of Parkinson's disease caused by rotenone. Due to its capacity to increase the penetration of potential water-insoluble drugs into the central nervous system, DMSO has been widely used in preclinical and clinical studies. Background and evoked spike activities were recorded in the hippocampus of rats administered DMSO (1 ml/kg i.p. for 3 weeks). We showed that pyramidal cells and Nissl bodies in the hippocampal CA1 and CA3 areas of rats administered rotenone dramatically improved after DMSO treatment. Rotenone enhanced TP and induced a milder TD effect, while DMSO also enhanced TP but induced a stronger TD effect. The analysis revealed inhibitory effects in the hippocampus in response to high-frequency stimulation (HFS; 100 Hz for 1 s) of the ipsilateral entorhinal cortex.
{"title":"Effects of Dimethyl Sulfoxide on Hippocampal Activity in a Rotenone-Induced Rat Model of Parkinson’s Disease","authors":"Lilit Darbinyan, Karen Simonyan, Larisa Manukyan, Lilia Hambardzumyan","doi":"10.51847/vafvsv35cl","DOIUrl":"https://doi.org/10.51847/vafvsv35cl","url":null,"abstract":"Parkinson's disease (PD) is the second most common age-related neurodegenerative disease worldwide. The goal of this study was to examine the effects of dimethyl sulfoxide (DMSO) in a rat model of Parkinson's disease caused by rotenone. Due to its capacity to increase the penetration of potential water-insoluble drugs into the central nervous system, DMSO has been widely used in preclinical and clinical studies. Background and evoked spike activities were recorded in the hippocampus of rats administered DMSO (1 ml/kg i.p. for 3 weeks). We showed that pyramidal cells and Nissl bodies in the hippocampal CA1 and CA3 areas of rats administered rotenone dramatically improved after DMSO treatment. Rotenone enhanced TP and induced a milder TD effect, while DMSO also enhanced TP but induced a stronger TD effect. The analysis revealed inhibitory effects in the hippocampus in response to high-frequency stimulation (HFS; 100 Hz for 1 s) of the ipsilateral entorhinal cortex.","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135262471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viviana Hodoșan, Dana Carmen Zaha, Lucia Georgeta Daina, Alina Manuela Tîrb, Lavinia Florica Mărcuț, Aurel George Mohan, Petru Cotrău, Cristian Marius Daina
{"title":"Financial Evaluation and Pattern of Antibiotic Consumption in Intensive Care Units of a University Hospital.","authors":"Viviana Hodoșan, Dana Carmen Zaha, Lucia Georgeta Daina, Alina Manuela Tîrb, Lavinia Florica Mărcuț, Aurel George Mohan, Petru Cotrău, Cristian Marius Daina","doi":"10.51847/ymw2symqir","DOIUrl":"https://doi.org/10.51847/ymw2symqir","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135312479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulaziz Alhossan, Noha Al Aloola, Manar Basoodan, Munirah Alkathiri, Razan Alshahrani, Wael Mansy, Thamer A Almangour
{"title":"Community Pharmacies Services and Preparedness During Covid-19 Pandemic in Saudi Arabia: A Cross-Sectional Study","authors":"Abdulaziz Alhossan, Noha Al Aloola, Manar Basoodan, Munirah Alkathiri, Razan Alshahrani, Wael Mansy, Thamer A Almangour","doi":"10.51847/iyoaj9kc0c","DOIUrl":"https://doi.org/10.51847/iyoaj9kc0c","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135401100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Flavonoids of Capparis Cartilaginea Fruit Extract Effect on Wound Healing in Human Prostate Cancer Cell Line","authors":"H. S. Sonbol, Maram Maram Bakr Hosawi","doi":"10.51847/0q8tpkdopw","DOIUrl":"https://doi.org/10.51847/0q8tpkdopw","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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