Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.oa488
D. McCracken, R. Mercer, M. Tsikrika, R. Varatharajah, A. Thayanandan, Lu Qiang, Gillian Shephard, E. Bedawi, R. Asciak, J. Wrightson, N. Rahman
{"title":"Transudative malignant pleural effusions","authors":"D. McCracken, R. Mercer, M. Tsikrika, R. Varatharajah, A. Thayanandan, Lu Qiang, Gillian Shephard, E. Bedawi, R. Asciak, J. Wrightson, N. Rahman","doi":"10.1183/13993003.congress-2019.oa488","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa488","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"167 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72556577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa3082
Alexander Taylor, T. Sathyamoorthy
{"title":"Case Series: Non-resolving pneumothorax – an early presentation of mesothelioma","authors":"Alexander Taylor, T. Sathyamoorthy","doi":"10.1183/13993003.congress-2019.pa3082","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa3082","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89557237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.oa490
R. Varatharajah, G. Shepherd, R. Mercer, Andrew Thanayanandan, Q. Lu, M. Tsikrika, D. McCracken, R. Asciak, E. Bedawi, Maged Hassan, N. Rahman
{"title":"Cytology positive pleural aspirations: sufficient to guide treatment?","authors":"R. Varatharajah, G. Shepherd, R. Mercer, Andrew Thanayanandan, Q. Lu, M. Tsikrika, D. McCracken, R. Asciak, E. Bedawi, Maged Hassan, N. Rahman","doi":"10.1183/13993003.congress-2019.oa490","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa490","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89426576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa3098
Rajesh Gupta, Sharad Joshi, Ankit Bhatia, Nitesh Tayal, P. Pandey
Introduction: The aim of this study was to evaluate the usefulness of EBUS elastography for mediastinal lymph nodes by comparing the elastographic patterns of lymph nodes with the final pathological diagnosis from EBUS-guided transbronchial needle aspiration. Methods: The convex probe EBUS was inserted through the oral route, and images were generated using a dedicated processor to assess elastographic patterns that were classified based on color distribution-Type-1, predominantly non-blue (green, yellow and red);Type-2-less than 50% blue, part non-blue(green, yellow and red);Type-3-predominant blue color. The elastographic patterns were compared with the final pathologic diagnosis results Results: On evaluating the cell blocks,40 were benign and 18 were malignant. Nodes that were assigned as Type-1 were benign in 18/18 (100%); for Type-2 lymph nodes, 16/22 (72.7%) were benign and 6/22 (27.27%) were malignant; Type-3 lymph nodes were benign in 6/18 (33.33%) and malignant in 12/18 (66.66%). On classifying Type 3 as ‘malignant’ and Type 1 as ‘benign,’ the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy rates were 100%, 75%, 66%, 100% and 83.3%, respectively. Conclusion: Endobronchial ultrasound elastography of mediastinal lymph nodes is a relatively new noninvasive technique that may be helpful in the prediction of nodal characteristics and in selecting sites for biospy during EBUS guided transbronchial needle aspiration
{"title":"The qualitative role of Endobronchial Elastography with Endobronchial Ultrasound in differentiating Malignant and Benign lesions-A retrospective single center study","authors":"Rajesh Gupta, Sharad Joshi, Ankit Bhatia, Nitesh Tayal, P. Pandey","doi":"10.1183/13993003.congress-2019.pa3098","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa3098","url":null,"abstract":"Introduction: The aim of this study was to evaluate the usefulness of EBUS elastography for mediastinal lymph nodes by comparing the elastographic patterns of lymph nodes with the final pathological diagnosis from EBUS-guided transbronchial needle aspiration. Methods: The convex probe EBUS was inserted through the oral route, and images were generated using a dedicated processor to assess elastographic patterns that were classified based on color distribution-Type-1, predominantly non-blue (green, yellow and red);Type-2-less than 50% blue, part non-blue(green, yellow and red);Type-3-predominant blue color. The elastographic patterns were compared with the final pathologic diagnosis results Results: On evaluating the cell blocks,40 were benign and 18 were malignant. Nodes that were assigned as Type-1 were benign in 18/18 (100%); for Type-2 lymph nodes, 16/22 (72.7%) were benign and 6/22 (27.27%) were malignant; Type-3 lymph nodes were benign in 6/18 (33.33%) and malignant in 12/18 (66.66%). On classifying Type 3 as ‘malignant’ and Type 1 as ‘benign,’ the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy rates were 100%, 75%, 66%, 100% and 83.3%, respectively. Conclusion: Endobronchial ultrasound elastography of mediastinal lymph nodes is a relatively new noninvasive technique that may be helpful in the prediction of nodal characteristics and in selecting sites for biospy during EBUS guided transbronchial needle aspiration","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"2 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75717629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa3096
R. Mercer, G. Shepherd, N. Rahman
Introduction: Patients with a malignant pleural effusion (MPE) usually require a definitive intervention to prevent fluid reaccumulation after an initial therapeutic aspiration, often in the form of chest drain and pleurodesis or indwelling pleural catheter insertion. Autopleurodesis can occur in patients who have a chest drain inserted or thoracoscopy without poudrage. At times, oncological treatments may prevent further fluid build-up, but it is unclear what proportion of patients this applies to. Methods: All patients with a new diagnosis of MPE, in our hospital, between 2015-2017 were included. They were catagorised into having one aspiration only, compared to multiple or definitive procedures. Cancer type and treatment information was collected. Results: 309 patients had a newly diagnosed MPE, 6 of whom did not have follow up data. 63 patients did not survive longer than 30 days after the aspiration and 9 patients had a small effusion for a diagnostic aspiration only. 24/232 (10.3%) of patients required only one therapeutic aspiration for management of their MPE. Of these patients 13 had initiation or change of their oncological treatment, the majority were breast or lung cancer. The remaining 11 patients did not have any new treatments but only 4 survived longer than 3 months. A further 86 patients had a change in treatment but required further interventions. Conclusion: Oncological treatment may have prevented the need for further pleural interventions in around 15% of patients. A single aspiration was only sufficient 3.6% of patients who did not have a change in oncological treatment who survived for more than 3 months. Oncological treatment only prevents the need for further interventions in a minority of patients.
{"title":"How often is a single therapeutic aspiration sufficient to manage a malignant pleural effusion and does oncological treatment have an impact on this?","authors":"R. Mercer, G. Shepherd, N. Rahman","doi":"10.1183/13993003.congress-2019.pa3096","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa3096","url":null,"abstract":"Introduction: Patients with a malignant pleural effusion (MPE) usually require a definitive intervention to prevent fluid reaccumulation after an initial therapeutic aspiration, often in the form of chest drain and pleurodesis or indwelling pleural catheter insertion. Autopleurodesis can occur in patients who have a chest drain inserted or thoracoscopy without poudrage. At times, oncological treatments may prevent further fluid build-up, but it is unclear what proportion of patients this applies to. Methods: All patients with a new diagnosis of MPE, in our hospital, between 2015-2017 were included. They were catagorised into having one aspiration only, compared to multiple or definitive procedures. Cancer type and treatment information was collected. Results: 309 patients had a newly diagnosed MPE, 6 of whom did not have follow up data. 63 patients did not survive longer than 30 days after the aspiration and 9 patients had a small effusion for a diagnostic aspiration only. 24/232 (10.3%) of patients required only one therapeutic aspiration for management of their MPE. Of these patients 13 had initiation or change of their oncological treatment, the majority were breast or lung cancer. The remaining 11 patients did not have any new treatments but only 4 survived longer than 3 months. A further 86 patients had a change in treatment but required further interventions. Conclusion: Oncological treatment may have prevented the need for further pleural interventions in around 15% of patients. A single aspiration was only sufficient 3.6% of patients who did not have a change in oncological treatment who survived for more than 3 months. Oncological treatment only prevents the need for further interventions in a minority of patients.","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82287570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa3099
E. Pitaraki, Irene Gerogianni, R. Jagirdar, Olympia A Kouliou, C. Hatzoglou, Konstandinos Gourgouliannis, S. Zarogiannis
Introduction: Metabolic adaptations favor survival of cancer cells with higher glucose uptake. 2-Deoxy-glucose (2DG), a mimetic of glucose cannot undergo further glycolysis and hampers cell growth, essential during tumor metabolism. Chemotherapy with Cisplatin (Cis) and Pemetrexed (Pem) is the main treatment for malignant pleural mesothelioma (MPM). However, there is lack of evidence on the effects of 2DG in MPM. Aim: To assess the synergistic effect of 2DG with Cis+Pem during cell migration in wound scratch assay. Methods: Epithelioid (M14K), biphasic (MSTO) and sarcomatoid (ZL34) MPM cells were used in the study. Cells were grown into confluent monolayers and wounded. Wound widths were measured by microscopic imaging immediately and 8 hours after wound scratch in 10%FBS-RPMI (con), Cis(10μM)+Pem(200μM) or 2DG(3mM)+Cis+Pem. Statistical analyses were performed to assess cell migration. Results: Migration with both treatments (Cis+Pem, 2DG+Cis+Pem) was significantly reduced compared to controls in all cell lines (M14K: con: 0.33±0.02, Cis+Pem: 0.16±0.01, p Conclusions: Combined 2DG and Cis+Pem reduce migration of MPM cells, but the addition of 2DG does not improve further the efficacy of first line chemotherapeutics in inhibiting cell migration rate.
{"title":"2-Deoxy-glucose synergizes with Cisplatin and Pemetrexed chemotherapeutics to reduce cell migration of mesothelioma cells","authors":"E. Pitaraki, Irene Gerogianni, R. Jagirdar, Olympia A Kouliou, C. Hatzoglou, Konstandinos Gourgouliannis, S. Zarogiannis","doi":"10.1183/13993003.congress-2019.pa3099","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa3099","url":null,"abstract":"Introduction: Metabolic adaptations favor survival of cancer cells with higher glucose uptake. 2-Deoxy-glucose (2DG), a mimetic of glucose cannot undergo further glycolysis and hampers cell growth, essential during tumor metabolism. Chemotherapy with Cisplatin (Cis) and Pemetrexed (Pem) is the main treatment for malignant pleural mesothelioma (MPM). However, there is lack of evidence on the effects of 2DG in MPM. Aim: To assess the synergistic effect of 2DG with Cis+Pem during cell migration in wound scratch assay. Methods: Epithelioid (M14K), biphasic (MSTO) and sarcomatoid (ZL34) MPM cells were used in the study. Cells were grown into confluent monolayers and wounded. Wound widths were measured by microscopic imaging immediately and 8 hours after wound scratch in 10%FBS-RPMI (con), Cis(10μM)+Pem(200μM) or 2DG(3mM)+Cis+Pem. Statistical analyses were performed to assess cell migration. Results: Migration with both treatments (Cis+Pem, 2DG+Cis+Pem) was significantly reduced compared to controls in all cell lines (M14K: con: 0.33±0.02, Cis+Pem: 0.16±0.01, p Conclusions: Combined 2DG and Cis+Pem reduce migration of MPM cells, but the addition of 2DG does not improve further the efficacy of first line chemotherapeutics in inhibiting cell migration rate.","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80663098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa3085
Gehan Hassan Ali Abo E-Magd, Ahmad Abouissa, I. Abbass
Introduction: Pleural effusion is considered the most common presentation of pleural diseases; around 50% of cases of pleural effusion remain undiagnosed following thoracentesis. Purpose: To compare between the diagnostic accuracy, safety and complications of medical thoracoscopic (MT) versus CT guided (CTG) tru-cut pleural biopsy. Patients and Methods: The patients with unexplained exudative pleural effusion were classified into two groups for either MT or CTG tru-cut pleural biopsy. The pleural biopsies obtained during both procedures were sent for mycobacterial culture and histopathology. Results: Complications of MT were pain in 6 (20%), prolonged air leak in 2 (6.7%) and subcutaneous emphysema in 2 (6.7%) patients. While the complications of CT guided pleural biopsy were pain in 3 (10%) and pneumothorax in 2 (6.7%) patients with no significant difference. Length of hospital stay was 5.13 ± 1.63 in MT and 2.83 ± 1.23 in CTG group; the difference was highly significant (P Conclusions: Medical thoracoscopy and CT guided pleural biopsy are safe techniques with high diagnostic yield and low complication rate; However, MT was slightly more sensitive than CTG biopsy besides its therapeutic role. On the other hand, CT guided biopsy has a shorter hospital stay than thoracoscopic technique. Proper selection of the procedure will increase the diagnostic value of each procedure.
{"title":"Diagnostic yield and safety of medical thoracoscopic versus CT guided percutaneous tru-cut pleural biopsy","authors":"Gehan Hassan Ali Abo E-Magd, Ahmad Abouissa, I. Abbass","doi":"10.1183/13993003.congress-2019.pa3085","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa3085","url":null,"abstract":"Introduction: Pleural effusion is considered the most common presentation of pleural diseases; around 50% of cases of pleural effusion remain undiagnosed following thoracentesis. Purpose: To compare between the diagnostic accuracy, safety and complications of medical thoracoscopic (MT) versus CT guided (CTG) tru-cut pleural biopsy. Patients and Methods: The patients with unexplained exudative pleural effusion were classified into two groups for either MT or CTG tru-cut pleural biopsy. The pleural biopsies obtained during both procedures were sent for mycobacterial culture and histopathology. Results: Complications of MT were pain in 6 (20%), prolonged air leak in 2 (6.7%) and subcutaneous emphysema in 2 (6.7%) patients. While the complications of CT guided pleural biopsy were pain in 3 (10%) and pneumothorax in 2 (6.7%) patients with no significant difference. Length of hospital stay was 5.13 ± 1.63 in MT and 2.83 ± 1.23 in CTG group; the difference was highly significant (P Conclusions: Medical thoracoscopy and CT guided pleural biopsy are safe techniques with high diagnostic yield and low complication rate; However, MT was slightly more sensitive than CTG biopsy besides its therapeutic role. On the other hand, CT guided biopsy has a shorter hospital stay than thoracoscopic technique. Proper selection of the procedure will increase the diagnostic value of each procedure.","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90206510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.oa492
G. Shepherd, R. Mercer, O. Castro, R. Varatharajah, A. Thayanandan, Q. Lu, Maged Hassan, E. Bedawi, D. McCracken, R. Asciak, M. Tsikrika, R. Hallifax, N. Rahman
{"title":"Outcomes of cytology positive malignant pleural effusions; do certain malignancies predispose patients to trapped lung?","authors":"G. Shepherd, R. Mercer, O. Castro, R. Varatharajah, A. Thayanandan, Q. Lu, Maged Hassan, E. Bedawi, D. McCracken, R. Asciak, M. Tsikrika, R. Hallifax, N. Rahman","doi":"10.1183/13993003.congress-2019.oa492","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa492","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88532832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa3091
Z. Iqbal, M. Khan, Mohammad Yousaf Khan, Z. Ullah
Background: Diagnosis of malignant mesothelioma (MM) remains a challenge, especially in developing countries where resources in pathology are limited. The present study was aimed to evaluate cost-effective biomarkers to predict the probability of MM in biopsy samples in order to accelerate the diagnostic workup of the potential cases. Methods: We conducted a study at Pulmonology unit, Lady Reading Hospital Peshawar, Pakistan. Qualitative data (gender, frequency of biomarkers) was presented as frequency and percentage; while quantitative data (age) was presented as means and standard deviation. Results: Total of 81 cases were enrolled in the study. The median age was 55.04 years (range, 24–75 years) and 46 patients (56.8%) were males. Most of the cases (one fourth) were from age group above 50 years. Out of 81 suspected cases of MM, 53 (65%) were MM and 28(34.6%) were Metastatic Adeno-carcinoma (MA) as diagnosed by Abram’s close pleural biopsy. The most frequent marker present in MM case was Calretinine in 46 (86.8%), followed by WT1 and Cytokeratin in 45 (84.9%) cases each. Similarly the most commonly found marker in cases of MA was TTF1 in 22 (78.5%) cases. On the other hand TTF1 was absent in 100% cases of MM. Similarly Calretinine and HBME was absent in 26 (92.8%) cases of MA. One unresolved issue in this result was the presence of Cytokeratin among 42.8% cases of MA. Conclusion: This study shows that Calretinine, Cytokeratin, HBME and WT1 are useful marker that can enhance the speed and accuracy of diagnostic workup in case of suspected MM. More large scale and robust studies are needed to give guideline recommendations
{"title":"Role of Biomarkers for Predicting suspecting Malignant Mesothelioma in patients with Pleural Effusion presenting to a tertiary care hospital","authors":"Z. Iqbal, M. Khan, Mohammad Yousaf Khan, Z. Ullah","doi":"10.1183/13993003.congress-2019.pa3091","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa3091","url":null,"abstract":"Background: Diagnosis of malignant mesothelioma (MM) remains a challenge, especially in developing countries where resources in pathology are limited. The present study was aimed to evaluate cost-effective biomarkers to predict the probability of MM in biopsy samples in order to accelerate the diagnostic workup of the potential cases. Methods: We conducted a study at Pulmonology unit, Lady Reading Hospital Peshawar, Pakistan. Qualitative data (gender, frequency of biomarkers) was presented as frequency and percentage; while quantitative data (age) was presented as means and standard deviation. Results: Total of 81 cases were enrolled in the study. The median age was 55.04 years (range, 24–75 years) and 46 patients (56.8%) were males. Most of the cases (one fourth) were from age group above 50 years. Out of 81 suspected cases of MM, 53 (65%) were MM and 28(34.6%) were Metastatic Adeno-carcinoma (MA) as diagnosed by Abram’s close pleural biopsy. The most frequent marker present in MM case was Calretinine in 46 (86.8%), followed by WT1 and Cytokeratin in 45 (84.9%) cases each. Similarly the most commonly found marker in cases of MA was TTF1 in 22 (78.5%) cases. On the other hand TTF1 was absent in 100% cases of MM. Similarly Calretinine and HBME was absent in 26 (92.8%) cases of MA. One unresolved issue in this result was the presence of Cytokeratin among 42.8% cases of MA. Conclusion: This study shows that Calretinine, Cytokeratin, HBME and WT1 are useful marker that can enhance the speed and accuracy of diagnostic workup in case of suspected MM. More large scale and robust studies are needed to give guideline recommendations","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89181459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.oa3798
N. Kanellakis, R. Asciak, X. Yao, Yanchun Peng, M. Mccole, S. Mcgowan, R. Mercer, R. Hallifax, T. Sherrill, F. Maldonado, D. Ebner, T. Blackwell, G. Stathopoulos, T. Dong, N. Rahman, L Psallidas
{"title":"Patient derived pleural mesothelioma cell lines, can be used as tools, to guide patient stratification","authors":"N. Kanellakis, R. Asciak, X. Yao, Yanchun Peng, M. Mccole, S. Mcgowan, R. Mercer, R. Hallifax, T. Sherrill, F. Maldonado, D. Ebner, T. Blackwell, G. Stathopoulos, T. Dong, N. Rahman, L Psallidas","doi":"10.1183/13993003.congress-2019.oa3798","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa3798","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89421533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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