Pub Date : 2018-09-15DOI: 10.1183/13993003.CONGRESS-2018.PA2881
R. Mercer, N. Speck, H. Jeffries, J. Macready, N. Kanellakis, N. Maskell, J. Pepperell, T. Saba, A. West, N. Ali, Robert F. Miller, J. Corcoran, R. Asciak, Maged Hassan, R. Hallifax, I. Psallidas, N. Rahman
Introduction: Patients with malignant pleural effusions (MPE) have a poor life expectancy and a high symptom burden. Definitive management strategies include chest drain and pleurodesis or placement of an indwelling pleural catheter. A meta analysis showed that 76% - 82% of patients had a successful pleurodesis with sterile talc. It has been postulated that patients who experience a greater inflammatory response or experience more pain are more likely to have a successful pleurodesis. Trapped lung is associated with a lower rate of pleurodesis success and it is thought that the number of previous interventions may be related to the development of trapped lung. Methods: A post hoc analysis from the TIME 1 trial was undertaken to establish the accuracy of these hypotheses. 320 patients were included who had a diagnosis of MPE. Results: There was a correlation between the number of previous ipsilateral aspirations and the incidence of trapped lung (p=0.015). Conclusion: Inflammation may play a factor in pleurodesis success as patients with a greater rise in CRP were more likely to have a successful pleurodesis. There is no evidence to support the hypothesis that patients who have more pain are more likely to have a successful pleurodesis. The correlation between the incidence of trapped lung and previous pleural interventions needs further study into whether or not there is a causal relationship.
{"title":"Predictors of pleurodesis success","authors":"R. Mercer, N. Speck, H. Jeffries, J. Macready, N. Kanellakis, N. Maskell, J. Pepperell, T. Saba, A. West, N. Ali, Robert F. Miller, J. Corcoran, R. Asciak, Maged Hassan, R. Hallifax, I. Psallidas, N. Rahman","doi":"10.1183/13993003.CONGRESS-2018.PA2881","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA2881","url":null,"abstract":"Introduction: Patients with malignant pleural effusions (MPE) have a poor life expectancy and a high symptom burden. Definitive management strategies include chest drain and pleurodesis or placement of an indwelling pleural catheter. A meta analysis showed that 76% - 82% of patients had a successful pleurodesis with sterile talc. It has been postulated that patients who experience a greater inflammatory response or experience more pain are more likely to have a successful pleurodesis. Trapped lung is associated with a lower rate of pleurodesis success and it is thought that the number of previous interventions may be related to the development of trapped lung. Methods: A post hoc analysis from the TIME 1 trial was undertaken to establish the accuracy of these hypotheses. 320 patients were included who had a diagnosis of MPE. Results: There was a correlation between the number of previous ipsilateral aspirations and the incidence of trapped lung (p=0.015). Conclusion: Inflammation may play a factor in pleurodesis success as patients with a greater rise in CRP were more likely to have a successful pleurodesis. There is no evidence to support the hypothesis that patients who have more pain are more likely to have a successful pleurodesis. The correlation between the incidence of trapped lung and previous pleural interventions needs further study into whether or not there is a causal relationship.","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89392005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.1183/13993003.congress-2018.pa2884
Nicola Pferdmenges, V. Krieg, A. Schulze, H. Kajueter, G. Evers, M. Mohr, L. Schmidt, H. Hense, O. Heidinger, R. Wiewrodt
Background: The cancer registry Northrhine-Westphalia (CR NRW) is state-law based, prospective cancer registry, including all state residents with the diagnosis of cancer (NRW counts approx. 18 million residents). Methods: All MM cases diagnosed and collected between 2010 and 2012 in CR NRW were included (n=1199). 232 cases contained incomplete datasets. In 755 of 967 valid cases (78.1%) the original pathology report was visible, in 468 cases (48.4%) including immunohistochemistry. Results: Of 967 patients with MM 796 were male (82.3%) and 171 female (17.7%), 81.8% were already diseased upon last validation date. Based on ICD-codes 885 patients (91.5%) suffered from pleural MM (C45.0), 72 (7.4%) had peritoneal MM, 2 (0.2%) pericardial MM and 8 (0.8%) had various MM locations. Histology showed predominantly epithelioid growing pattern (60.4%), followed by biphasic growth (13.4%) and sarcomatoid growth (9.4%); in 16.8% the growing pattern was not defined. Median overall survival (OS) of pleural MM was 12.4 months (95%KI 11.3-13.4; all histologies), OS of peritoneal MM was 15.1 months (95%KI 4.5-25.7; all histologies). Multivariate analysis revealed gender, age, histological subtype, cell specific growing features (spindle cell type; papillary type), necrosis, hyaline plaques and proliferation marker Ki67 as independent prognostic factors (p Conclusion: The comprehensive, state-law embedded cancer registry NRW ensures the complete area-wide identification and collection of cancer patients’ course out of 18 million residents. In this very large study MM cell specific growing features and proliferation index could be identified as new independent markers of MM outcome.
{"title":"Clinical and histological analysis of malignant mesothelioma - a comprehensive state-wide study","authors":"Nicola Pferdmenges, V. Krieg, A. Schulze, H. Kajueter, G. Evers, M. Mohr, L. Schmidt, H. Hense, O. Heidinger, R. Wiewrodt","doi":"10.1183/13993003.congress-2018.pa2884","DOIUrl":"https://doi.org/10.1183/13993003.congress-2018.pa2884","url":null,"abstract":"Background: The cancer registry Northrhine-Westphalia (CR NRW) is state-law based, prospective cancer registry, including all state residents with the diagnosis of cancer (NRW counts approx. 18 million residents). Methods: All MM cases diagnosed and collected between 2010 and 2012 in CR NRW were included (n=1199). 232 cases contained incomplete datasets. In 755 of 967 valid cases (78.1%) the original pathology report was visible, in 468 cases (48.4%) including immunohistochemistry. Results: Of 967 patients with MM 796 were male (82.3%) and 171 female (17.7%), 81.8% were already diseased upon last validation date. Based on ICD-codes 885 patients (91.5%) suffered from pleural MM (C45.0), 72 (7.4%) had peritoneal MM, 2 (0.2%) pericardial MM and 8 (0.8%) had various MM locations. Histology showed predominantly epithelioid growing pattern (60.4%), followed by biphasic growth (13.4%) and sarcomatoid growth (9.4%); in 16.8% the growing pattern was not defined. Median overall survival (OS) of pleural MM was 12.4 months (95%KI 11.3-13.4; all histologies), OS of peritoneal MM was 15.1 months (95%KI 4.5-25.7; all histologies). Multivariate analysis revealed gender, age, histological subtype, cell specific growing features (spindle cell type; papillary type), necrosis, hyaline plaques and proliferation marker Ki67 as independent prognostic factors (p Conclusion: The comprehensive, state-law embedded cancer registry NRW ensures the complete area-wide identification and collection of cancer patients’ course out of 18 million residents. In this very large study MM cell specific growing features and proliferation index could be identified as new independent markers of MM outcome.","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81534344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.1183/13993003.CONGRESS-2018.PA2889
Maryam Ahmed, J. Lyons, S. Jackson, A. Sharman, M. Dixon, P. Taylor, J. Holme, M. Evison
Background: Malignant mesothelioma (MM) is an incurable malignancy with a poor prognosis. In 2014, 43% of patients survived to one year following diagnosis in the UK. There is evidence of patient benefit from regional mesothelioma multidisciplinary team meetings1. The 2016 NLCA Pleural Mesothelioma report defined key recommendations for patients diagnosed with MM in England in 2014. Aims: To evaluate and compare outcomes of patients managed through the Greater Manchester Regional Mesothelioma MDT against the 2016 NLCA findings. Methods: Retrospective review of MM cases discussed at our MDT meeting between April 2016 and February 2018 using data from electronic MDT proformas. Results: Conclusions: Outcomes from our MDT are encouraging and may help build evidence in favour of regional mesothelioma MDTs. In particular, active treatment rates and ensuring equity of access to clinical research appears higher than national figures within this specialist service. References: 1. Bibby, Anna C et al. “What Is the Role of a Specialist Regional Mesothelioma Multidisciplinary Team Meeting? A Service Evaluation of One Tertiary Referral Centre in the UK.” BMJ Open 6.9 (2016): e012092.
背景:恶性间皮瘤(MM)是一种无法治愈的恶性肿瘤，预后不良。2014年，在英国，43%的患者在确诊后存活到一年。有证据表明，区域性间皮瘤多学科小组会议对患者有益。2016年NLCA胸膜间皮瘤报告确定了2014年英国诊断为MM的患者的关键建议。目的:评估和比较通过大曼彻斯特地区间皮瘤MDT治疗的患者的结果与2016年NLCA研究结果。方法:回顾性分析2016年4月至2018年2月MDT会议上讨论的MM病例，使用MDT电子表格的数据。结论:我们的MDT的结果是令人鼓舞的，可能有助于建立支持区域间皮瘤MDT的证据。特别是，在这一专业服务中，积极治疗率和确保公平获得临床研究似乎高于全国数字。引用:1。Bibby, Anna C等人，“区域间皮瘤多学科专家小组会议的作用是什么?”英国一家高等教育转诊中心的服务评估。BMJ Open 6.9 (2016): e012092。
{"title":"A comparison of outcomes from a regional Mesothelioma MDT against the National Lung Cancer Audit (NLCA) Mesothelioma standards","authors":"Maryam Ahmed, J. Lyons, S. Jackson, A. Sharman, M. Dixon, P. Taylor, J. Holme, M. Evison","doi":"10.1183/13993003.CONGRESS-2018.PA2889","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA2889","url":null,"abstract":"Background: Malignant mesothelioma (MM) is an incurable malignancy with a poor prognosis. In 2014, 43% of patients survived to one year following diagnosis in the UK. There is evidence of patient benefit from regional mesothelioma multidisciplinary team meetings1. The 2016 NLCA Pleural Mesothelioma report defined key recommendations for patients diagnosed with MM in England in 2014. Aims: To evaluate and compare outcomes of patients managed through the Greater Manchester Regional Mesothelioma MDT against the 2016 NLCA findings. Methods: Retrospective review of MM cases discussed at our MDT meeting between April 2016 and February 2018 using data from electronic MDT proformas. Results: Conclusions: Outcomes from our MDT are encouraging and may help build evidence in favour of regional mesothelioma MDTs. In particular, active treatment rates and ensuring equity of access to clinical research appears higher than national figures within this specialist service. References: 1. Bibby, Anna C et al. “What Is the Role of a Specialist Regional Mesothelioma Multidisciplinary Team Meeting? A Service Evaluation of One Tertiary Referral Centre in the UK.” BMJ Open 6.9 (2016): e012092.","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88970520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.1183/13993003.congress-2018.pa2867
C. Brun, M. Cottier, G. Karpathiou, F. Barral, J. Vergnon, M. Froudarakis
{"title":"Cytology, chest computed and positron emission tomography correlations in lung cancer malignant pleural effusion.","authors":"C. Brun, M. Cottier, G. Karpathiou, F. Barral, J. Vergnon, M. Froudarakis","doi":"10.1183/13993003.congress-2018.pa2867","DOIUrl":"https://doi.org/10.1183/13993003.congress-2018.pa2867","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80110547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.1183/13993003.congress-2018.pa2880
A. Carletti, L. Benfatto, Vanna Balestracci, P. Canessa
{"title":"Determinants of survival in patients with malignant pleural mesothelioma (MPM) managed at a single institution in Liguria, Italy","authors":"A. Carletti, L. Benfatto, Vanna Balestracci, P. Canessa","doi":"10.1183/13993003.congress-2018.pa2880","DOIUrl":"https://doi.org/10.1183/13993003.congress-2018.pa2880","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86759704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.1183/13993003.CONGRESS-2018.OA496
L. Wijmans, M. Disselhorst, D. M. Bruin, J. Roelofs, O. Mets, P. Bonta, P. Baas, J. Annema
{"title":"Needle Based Confocal Laser Endomicroscopy (nCLE) for Diagnosing Malignant Pleural Mesothelioma","authors":"L. Wijmans, M. Disselhorst, D. M. Bruin, J. Roelofs, O. Mets, P. Bonta, P. Baas, J. Annema","doi":"10.1183/13993003.CONGRESS-2018.OA496","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.OA496","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81722038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.1183/13993003.congress-2018.pa2874
G. Karpathiou, Mousa Mobarki, Sirine Hathroubi, M. Stachowicz, A. Patoir, O. Tiffet, M. Péoc'h, M. Froudarakis
{"title":"Pericardial and pleural metastases: clinical and histological differences","authors":"G. Karpathiou, Mousa Mobarki, Sirine Hathroubi, M. Stachowicz, A. Patoir, O. Tiffet, M. Péoc'h, M. Froudarakis","doi":"10.1183/13993003.congress-2018.pa2874","DOIUrl":"https://doi.org/10.1183/13993003.congress-2018.pa2874","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90721666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.1183/13993003.congress-2018.pa2890
I. Novakov, Filip Sterev
{"title":"Survival of patients with malignant pleural effusions: a three-year prospective self-experience study","authors":"I. Novakov, Filip Sterev","doi":"10.1183/13993003.congress-2018.pa2890","DOIUrl":"https://doi.org/10.1183/13993003.congress-2018.pa2890","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74711061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.1183/13993003.congress-2018.pa2888
Y. Kahya, Ç. Soydal, M. Yenigün, E. Ozkan, N. A. Tutkun, S. Enön, N. O. Kucuk, A. Cangır
{"title":"Relationship between baseline metabolic 18F-FDG parameters and survival in malignant pleural mesothelioma: A single centre experience","authors":"Y. Kahya, Ç. Soydal, M. Yenigün, E. Ozkan, N. A. Tutkun, S. Enön, N. O. Kucuk, A. Cangır","doi":"10.1183/13993003.congress-2018.pa2888","DOIUrl":"https://doi.org/10.1183/13993003.congress-2018.pa2888","url":null,"abstract":"","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77183777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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