Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p176
Shi Guo, Cindy Huang, C. Begley, Michael J. Bishop, Ping Cao
{"title":"Abstract P176: Discovery and development of novel covalent inhibitors of the YAP-TEAD transcription activity","authors":"Shi Guo, Cindy Huang, C. Begley, Michael J. Bishop, Ping Cao","doi":"10.1158/1535-7163.targ-21-p176","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p176","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83275758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p127
Y. Greer, L. Hernandez, D. Voeller, R. Chari, Binwu Tang, C. Annunziata, Samuel F Gilbert, L. Wakefield, E. Iwanowicz, L. Graves, S. Lipkowitz
{"title":"Abstract P127: Mitochondrial matrix protease ClpP agonists suppress breast cancer stem cell function by downregulating multiple stem cell regulatory mechanisms","authors":"Y. Greer, L. Hernandez, D. Voeller, R. Chari, Binwu Tang, C. Annunziata, Samuel F Gilbert, L. Wakefield, E. Iwanowicz, L. Graves, S. Lipkowitz","doi":"10.1158/1535-7163.targ-21-p127","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p127","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76793741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p226
M. McKean, S. Kato, A. Spira, Yan Xing, Hao Xie, E. Buchbinder, Ken Kobayashi, Richard Williams
{"title":"Abstract P226: Design and rationale of a first in human (FIH) phase 1/1b study evaluating KIN-2787, a potent and highly selective pan-RAF inhibitor, in adult patients with BRAF mutation positive solid tumors","authors":"M. McKean, S. Kato, A. Spira, Yan Xing, Hao Xie, E. Buchbinder, Ken Kobayashi, Richard Williams","doi":"10.1158/1535-7163.targ-21-p226","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p226","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"90 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85930037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p209
Douglas D Fang, Q. Tang, Qixin Wang, Y. Kong, Na Li, F. Zhou, R. Tao, Dajun Yang, Y. Zhai
{"title":"Abstract P209: Collaborative crosstalk between two apoptosis pathways drives synergy of dual inhibition of BCL-2/MDM2 in preclinical models of neuroblastoma","authors":"Douglas D Fang, Q. Tang, Qixin Wang, Y. Kong, Na Li, F. Zhou, R. Tao, Dajun Yang, Y. Zhai","doi":"10.1158/1535-7163.targ-21-p209","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p209","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88692060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p230
D. Spigel, K. Goto, D. Camidge, Y. Elamin, A. D. de Langen, N. Leighl, A. Minchom, Z. Piotrowska, D. Planchard, K. Reckamp, F. Albayya, Jennifer Green, Sean H. J. Kim, M. Louie-Gao, R. Sawtell, A. Zalutskaya, Byoung Chul Co
{"title":"Abstract P230: A phase 1/2 study of BLU-945, a highly potent and selective inhibitor of epidermal growth factor receptor (EGFR) resistance mutations, in patients with EGFR-mutant non-small cell lung cancer (NSCLC)","authors":"D. Spigel, K. Goto, D. Camidge, Y. Elamin, A. D. de Langen, N. Leighl, A. Minchom, Z. Piotrowska, D. Planchard, K. Reckamp, F. Albayya, Jennifer Green, Sean H. J. Kim, M. Louie-Gao, R. Sawtell, A. Zalutskaya, Byoung Chul Co","doi":"10.1158/1535-7163.targ-21-p230","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p230","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85232415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p045
B. Inman, M. Milowsky, R. Pruthi, M. Posner, Melissa J. Polasek, S. Morris, L. Mixson, K. Orr, Elizabeth M. H. Woodson, A. Kelly, W. Nichols, A. Balar
{"title":"Abstract P045: LUMINOS-103: A basket trial evaluating the safety and efficacy of PVSRIPO and PVSRIPO in combination with anti-PD-1/L1 checkpoint inhibitors in patients with advanced solid tumors","authors":"B. Inman, M. Milowsky, R. Pruthi, M. Posner, Melissa J. Polasek, S. Morris, L. Mixson, K. Orr, Elizabeth M. H. Woodson, A. Kelly, W. Nichols, A. Balar","doi":"10.1158/1535-7163.targ-21-p045","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p045","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87373838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p233
I. Odintsov, R. Kurth, Kota Ishizawa, L. Delasos, A. Lui, I. Khodos, Connor J. Hagen, Q. Chang, M. Mattar, M. Vojnic, S. Kunte, A. Bonifacio, C. Giuliano, E. de Stanchina, Emily Cheng, E. Lovati, M. Ladanyi, R. Somwar
{"title":"Abstract P233: TAS0953/HM06 is effective in preclinical models of diverse tumor types driven by RET alterations","authors":"I. Odintsov, R. Kurth, Kota Ishizawa, L. Delasos, A. Lui, I. Khodos, Connor J. Hagen, Q. Chang, M. Mattar, M. Vojnic, S. Kunte, A. Bonifacio, C. Giuliano, E. de Stanchina, Emily Cheng, E. Lovati, M. Ladanyi, R. Somwar","doi":"10.1158/1535-7163.targ-21-p233","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p233","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82727489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p115
N. Beztsinna, F. Grillet, Niels Meesters, D. van der Meer, L. Daszkiewicz, K. Yan, E. Spanjaard, W. Vader, L. Price
{"title":"Abstract P115: Novel patient avatar platform for oncology drug testing using 3D ex vivo models derived from fresh patient tumor tissues","authors":"N. Beztsinna, F. Grillet, Niels Meesters, D. van der Meer, L. Daszkiewicz, K. Yan, E. Spanjaard, W. Vader, L. Price","doi":"10.1158/1535-7163.targ-21-p115","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p115","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87798536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p033
T. Lesimple, M. D. de Miguel, Cristophe Le Tourneau, M. Ponz-Sarvisé, M. Sablin, D. Benito, B. Hanna, Henry Chang, Xin Wei, Marta Ocejo Garcia, P. Lardelli, Tania Sánchez, J. Palau, Z. Nikolova, E. Calvo
{"title":"Abstract P033: CC-95775, a reversible, oral bromodomain and extra-terminal (BET) inhibitor in patients with advanced solid tumors (STs): Results of a phase 1 study","authors":"T. Lesimple, M. D. de Miguel, Cristophe Le Tourneau, M. Ponz-Sarvisé, M. Sablin, D. Benito, B. Hanna, Henry Chang, Xin Wei, Marta Ocejo Garcia, P. Lardelli, Tania Sánchez, J. Palau, Z. Nikolova, E. Calvo","doi":"10.1158/1535-7163.targ-21-p033","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p033","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"23 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91447518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p021
Brittany A. Borden, A. D. De Souza, D. Mahalingam, S. Powell, P. Munster, K. Huntington, A. Mazar, Ludmila Calvacante, F. Giles, W. El-Deiry, H. Safran, B. Carneiro
{"title":"Abstract P021: Genomic biomarkers for response to 9-ING-41, a small molecule selective glycogen synthase kinase-3 (GSK-3) inhibitor, in pancreas cancer: Preliminary results","authors":"Brittany A. Borden, A. D. De Souza, D. Mahalingam, S. Powell, P. Munster, K. Huntington, A. Mazar, Ludmila Calvacante, F. Giles, W. El-Deiry, H. Safran, B. Carneiro","doi":"10.1158/1535-7163.targ-21-p021","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p021","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90953355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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