Pub Date : 2025-12-18DOI: 10.1016/j.phytol.2025.104097
Kun-Ching Cheng , Chia-Hung Wu , Hao-Ze Li , Tsong-Long Hwang , Ping-Chung Kuo , Tian-Shung Wu
One undescribed coumarin, (2′S)-isomurralonginol 1′-O-(2′′R)-methylbutyrate (1), together with thirteen known coumarins, were isolated successively from the dried leaves of Murraya paniculata var. omphalocarpa Hayata (Rutaceae). In addition, two alkaloids, two coumarin-naphthoquinones, three coumarins, and one alkyl phenylpropanoate were also identified from the stem bark of the same plant. The undescribed coumarin 1 was characterized by the spectroscopic and spectrometric analytical methods, and the known compounds were identified by comparison of their physical and spectral data with those reported. Some isolated compounds were examined for their inhibitory effects on superoxide anion generation and elastase release. The results indicated that some isolates 4, 6, 16, and 18 exhibited significant anti-inflammatory potential, with IC50 values for the inhibition of superoxide anion generation ranging from 0.002 to 5.1 µg/mL.
从芦花科的香树（Murraya paniculata var. omphalocarpa Hayata）的干叶中，先后分离得到1个未被描述的香豆素(2s)-isomurralonginol 1 ' - o -(2 ' R)-甲基丁酸酯(1)和13个已知的香豆素。此外，从该植物的茎皮中还鉴定出两种生物碱、两种香豆素-萘醌、三种香豆素和一种烷基苯丙酸酯。用光谱和光谱分析方法对所描述的香豆素1进行了表征，并将已知化合物的物理和光谱数据与已报道的化合物进行了比较。研究了部分分离化合物对超氧阴离子生成和弹性蛋白酶释放的抑制作用。结果表明，部分分离菌株4、6、16和18表现出明显的抗炎潜能，其抑制超氧阴离子生成的IC50值在0.002 ~ 5.1 µg/mL之间。
{"title":"Anti-inflammatory constituents from Murraya paniculata var. omphalocarpa","authors":"Kun-Ching Cheng , Chia-Hung Wu , Hao-Ze Li , Tsong-Long Hwang , Ping-Chung Kuo , Tian-Shung Wu","doi":"10.1016/j.phytol.2025.104097","DOIUrl":"10.1016/j.phytol.2025.104097","url":null,"abstract":"<div><div>One undescribed coumarin, (2′<em>S</em>)-isomurralonginol 1′-<em>O</em>-(2′′<em>R</em>)-methylbutyrate (<strong>1</strong>), together with thirteen known coumarins, were isolated successively from the dried leaves of <em>Murraya paniculata</em> var. <em>omphalocarpa</em> Hayata (Rutaceae). In addition, two alkaloids, two coumarin-naphthoquinones, three coumarins, and one alkyl phenylpropanoate were also identified from the stem bark of the same plant. The undescribed coumarin <strong>1</strong> was characterized by the spectroscopic and spectrometric analytical methods, and the known compounds were identified by comparison of their physical and spectral data with those reported. Some isolated compounds were examined for their inhibitory effects on superoxide anion generation and elastase release. The results indicated that some isolates <strong>4</strong>, <strong>6</strong>, <strong>16</strong>, and <strong>18</strong> exhibited significant anti-inflammatory potential, with IC<sub>50</sub> values for the inhibition of superoxide anion generation ranging from 0.002 to 5.1 µg/mL.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104097"},"PeriodicalIF":1.4,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.phytol.2025.104098
Ying Niu , Yan-Gang Cao , Meng-Die Luo , Yan-Ling Liu , Xu Chen , Xiao-Ke Zheng , Wei-Sheng Feng
Two previously undescribed monoterpenoids, (6 R)-ephteroid (1) and ephteroid A (2), together with nine known terpenoids were isolated from the stems of Ephedra intermedia. The structures of these terpenoids were determined by analysing various spectroscopic data and comparing literature data. The absolute configuration of compound 1 was determined by combining its aglycone with Rh2(OCOCF3)4 reagent, then observing the Cotton effect at 350 nm on ECD spectrum. The MTT assay was used to evaluate the effect of compounds 1–11 on Poly (I:C)-induced damage to BEAS-2B cells. The results showed that compounds 5–8 mitigated the damage caused by Poly(I:C) in BEAS-2B cells at a concentration of 10 μM, indicating that they exhibited cytoprotective activity.
{"title":"Two new monoterpenoids from the stems of Ephedra intermedia and their cytoprotective activity","authors":"Ying Niu , Yan-Gang Cao , Meng-Die Luo , Yan-Ling Liu , Xu Chen , Xiao-Ke Zheng , Wei-Sheng Feng","doi":"10.1016/j.phytol.2025.104098","DOIUrl":"10.1016/j.phytol.2025.104098","url":null,"abstract":"<div><div>Two previously undescribed monoterpenoids, (6 <em>R</em>)-ephteroid (<strong>1</strong>) and ephteroid A (<strong>2</strong>), together with nine known terpenoids were isolated from the stems of <em>Ephedra intermedia</em>. The structures of these terpenoids were determined by analysing various spectroscopic data and comparing literature data. The absolute configuration of compound <strong>1</strong> was determined by combining its aglycone with Rh<sub>2</sub>(OCOCF<sub>3</sub>)<sub>4</sub> reagent, then observing the Cotton effect at 350 nm on ECD spectrum. The MTT assay was used to evaluate the effect of compounds <strong>1</strong>–<strong>11</strong> on Poly (I:C)-induced damage to BEAS-2B cells. The results showed that compounds <strong>5</strong>–<strong>8</strong> mitigated the damage caused by Poly(I:C) in BEAS-2B cells at a concentration of 10 μM, indicating that they exhibited cytoprotective activity.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104098"},"PeriodicalIF":1.4,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A novel norsesquiterpenoid isolated from agarwood, features a rare oxaspiro[4.5]decane structure. It selectively inhibits human liver cancer cell proliferation (SMMC-7721) with an IC50 of 18.82 μM, while showing weaker effects on gastric and ovarian cancer cells. Network pharmacology and molecular docking identified muscarinic acetylcholine receptor M2 (CHRM2) as a target, suggesting compound 1 disrupts the PI3K-Akt pathway. ADMET predictions indicate favorable pharmacokinetics. These findings position compound 1 as a promising CHRM2 antagonist for liver cancer therapy, highlighting the potential of natural product-based drug discovery.
{"title":"Bioinformatics-based discovery of a new norsesquiterpenoid from agarwood targeting CHRM2 and regulating the PI3K-Akt pathway in liver cancer","authors":"Zi-Xiao Jiang, Jian Feng, Wen-Cheng Hou, Mei-Ran Wang, Shu-Nan Zhang, Hao-Jie Liang, Yang-Yang Liu","doi":"10.1016/j.phytol.2025.104101","DOIUrl":"10.1016/j.phytol.2025.104101","url":null,"abstract":"<div><div>A novel norsesquiterpenoid isolated from agarwood, features a rare oxaspiro[4.5]decane structure. It selectively inhibits human liver cancer cell proliferation (SMMC-7721) with an IC<sub>50</sub> of 18.82 μM, while showing weaker effects on gastric and ovarian cancer cells. Network pharmacology and molecular docking identified muscarinic acetylcholine receptor M2 (CHRM2) as a target, suggesting compound 1 disrupts the PI3K-Akt pathway. ADMET predictions indicate favorable pharmacokinetics. These findings position compound 1 as a promising CHRM2 antagonist for liver cancer therapy, highlighting the potential of natural product-based drug discovery.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104101"},"PeriodicalIF":1.4,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.phytol.2025.104096
Dhananjay Sharma , Luxita Sharma
Background
Traditional ethnomedicine has long recognized numerous plants as natural therapeutic remedies, and approximately 25 % of modern pharmaceutical drugs are derived from plant-based phytochemicals. Ficus religiosa, a prominent species of the Moraceae family and widely known as the Peepal tree in India, holds a significant place in traditional medicinal systems such as Ayurveda, Unani, and Siddha. Various parts of the plant, including the stem, bark, roots, fruits, and latex, have been extensively explored for their medicinal potential.
Objectives
This review aims to provide a comprehensive and updated overview of the traditional uses, phytochemical composition, nutritional values, phytopharmacological activities, and contemporary therapeutic applications of Ficus religiosa.
Key Findings
Scientific literature demonstrates that F. religiosa contains a rich diversity of bioactive phytochemicals, including flavonoids, phenolic compounds, dietary fibers, antioxidants, serotonin, vitamins, minerals, and other essential nutrients. These constituents contribute to a broad spectrum of pharmacological activities such as antioxidant, anti-inflammatory, antidiabetic, antimicrobial, neuroprotective, and wound-healing effects. Recent research continues to isolate and characterize new compounds from F. religiosa, further supporting its therapeutic relevance. Compared to synthetic drugs, plant-derived compounds often exhibit lower adverse effects, making them valuable candidates for drug development.
Conclusion
Ficus religiosa exhibits significant pharmacological potential supported by both traditional knowledge and contemporary scientific evidence. Given its diverse phytochemical profile and wide range of therapeutic properties, this plant represents a promising natural resource for future pharmacological research and drug discovery.
{"title":"Phytochemistry and therapeutic applications of Ficus religiosa: A comprehensive review","authors":"Dhananjay Sharma , Luxita Sharma","doi":"10.1016/j.phytol.2025.104096","DOIUrl":"10.1016/j.phytol.2025.104096","url":null,"abstract":"<div><h3>Background</h3><div>Traditional ethnomedicine has long recognized numerous plants as natural therapeutic remedies, and approximately 25 % of modern pharmaceutical drugs are derived from plant-based phytochemicals. <em>Ficus religiosa</em>, a prominent species of the Moraceae family and widely known as the Peepal tree in India, holds a significant place in traditional medicinal systems such as Ayurveda, Unani, and Siddha. Various parts of the plant, including the stem, bark, roots, fruits, and latex, have been extensively explored for their medicinal potential.</div></div><div><h3>Objectives</h3><div>This review aims to provide a comprehensive and updated overview of the traditional uses, phytochemical composition, nutritional values, phytopharmacological activities, and contemporary therapeutic applications of <em>Ficus religiosa</em>.</div></div><div><h3>Key Findings</h3><div>Scientific literature demonstrates that <em>F. religiosa</em> contains a rich diversity of bioactive phytochemicals, including flavonoids, phenolic compounds, dietary fibers, antioxidants, serotonin, vitamins, minerals, and other essential nutrients. These constituents contribute to a broad spectrum of <em>pharmacological</em> activities such as antioxidant, anti-inflammatory, antidiabetic, antimicrobial, neuroprotective, and wound-healing effects. Recent research continues to isolate and characterize new compounds from <em>F. religiosa</em>, further supporting its therapeutic relevance. Compared to synthetic drugs, plant-derived compounds often exhibit lower adverse effects, making them valuable candidates for drug development.</div></div><div><h3>Conclusion</h3><div><em>Ficus religiosa</em> exhibits significant pharmacological potential supported by both traditional knowledge and contemporary scientific evidence. Given its diverse phytochemical profile and wide range of therapeutic properties, this plant represents a promising natural resource for future pharmacological research and drug discovery.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104096"},"PeriodicalIF":1.4,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-13DOI: 10.1016/j.phytol.2025.104095
Bel Youssouf G. Mountessou , Gesquiere Laure M. Tiani , Joseph Tchamgoue , Rukesh Maharjan , Aron Trucksess , Rainer Kalscheuer , Muhammad I. Choudhary , Simeon F. Kouam
This study aimed to investigate the chemical constituents of a Chaetomium strain (CECA 170) isolated from decaying wood and to assess their antimicrobial and cytotoxic activities. One previously unreported macrolide (1), one ketone-derived isoxazolidine (2), and one naturally occurring chromone (3), along with four known metabolites (4 −7), were isolated from the submerged culture of Chaetomium sp. The structures of the new compounds were established by extensive spectroscopic and spectrometric analyses (NMR, MS). The known compounds were identified by comparing their experimental data with previously published literature. Compound 1 exhibited cytotoxic activities against human breast cancer cells (MCF-7) and HeLa cervical cancer cells, with IC50 values of 7.84 µM and 18.7 µM, respectively. In contrast, compound 2 displayed stronger cytotoxicity against HeLa cells (IC50 = 14.3 µM) than MCF-7 cells (IC50 = 18.5 µM). However, none of the tested compounds showed antimicrobial activity on the evaluated microorganisms. These results underscore the potential of fungi from underexplored niches, like decaying wood, for the discovery of new chemotherapeutic leads.
{"title":"Cytotoxic secondary metabolites from submerged cultures of Chaetomium sp. isolated from decaying wood","authors":"Bel Youssouf G. Mountessou , Gesquiere Laure M. Tiani , Joseph Tchamgoue , Rukesh Maharjan , Aron Trucksess , Rainer Kalscheuer , Muhammad I. Choudhary , Simeon F. Kouam","doi":"10.1016/j.phytol.2025.104095","DOIUrl":"10.1016/j.phytol.2025.104095","url":null,"abstract":"<div><div>This study aimed to investigate the chemical constituents of a <em>Chaetomium</em> strain (CECA 170) isolated from decaying wood and to assess their antimicrobial and cytotoxic activities. One previously unreported macrolide (<strong>1</strong>), one ketone-derived isoxazolidine (<strong>2</strong>), and one naturally occurring chromone (<strong>3</strong>), along with four known metabolites (<strong>4 −7</strong>), were isolated from the submerged culture of <em>Chaetomium</em> sp. The structures of the new compounds were established by extensive spectroscopic and spectrometric analyses (NMR, MS). The known compounds were identified by comparing their experimental data with previously published literature. Compound <strong>1</strong> exhibited cytotoxic activities against human breast cancer cells (MCF-7) and HeLa cervical cancer cells, with IC<sub>50</sub> values of 7.84 µM and 18.7 µM, respectively. In contrast, compound <strong>2</strong> displayed stronger cytotoxicity against HeLa cells (IC<sub>50</sub> = 14.3 µM) than MCF-7 cells (IC<sub>50</sub> = 18.5 µM). However, none of the tested compounds showed antimicrobial activity on the evaluated microorganisms. These results underscore the potential of fungi from underexplored niches, like decaying wood, for the discovery of new chemotherapeutic leads.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104095"},"PeriodicalIF":1.4,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.phytol.2025.104094
Yan Huang , Hao Wang , Wen-Li Mei , Hui-Qin Chen , Fei Wu , Yan-Mei Wei , Wen-Ming Cheng , Hao-Fu Dai
Two unprecedented 2-(2-phenylethyl)chromone dimers, namely aquicrassones V and W (1−2), and a known compound (3) were isolated from ethanol extract of agarwood originating from Aquilaria crassna in Cambodia by the UHPLC-MS guided method. Their structures were unambiguously elucidated by the analysis of HR-ESI-MS, 1D and 2D NMR, and CD data. All compounds were evaluated for their inhibitory effect on nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells and anti-Helicobacter pylori activity. Compounds 1 and 3 displayed anti-inflammatory activity with IC50 values of 14.37 ± 2.36 and 14.18 ± 1.39 μM. Compounds 1–3 exhibited anti-H. pylori activity with MIC values of 80, 80, and 40 µM, respectively.
{"title":"Two unprecedented 2-(2-phenylethyl)chromone dimers from the Cambodian agarwood of Aquilaria crassna","authors":"Yan Huang , Hao Wang , Wen-Li Mei , Hui-Qin Chen , Fei Wu , Yan-Mei Wei , Wen-Ming Cheng , Hao-Fu Dai","doi":"10.1016/j.phytol.2025.104094","DOIUrl":"10.1016/j.phytol.2025.104094","url":null,"abstract":"<div><div>Two unprecedented 2-(2-phenylethyl)chromone dimers, namely aquicrassones V and W (<strong>1</strong>−<strong>2</strong>), and a known compound (<strong>3</strong>) were isolated from ethanol extract of agarwood originating from <em>Aquilaria crassna</em> in Cambodia by the UHPLC-MS guided method. Their structures were unambiguously elucidated by the analysis of HR-ESI-MS, 1D and 2D NMR, and CD data. All compounds were evaluated for their inhibitory effect on nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells and anti-<em>Helicobacter pylori</em> activity. Compounds <strong>1</strong> and <strong>3</strong> displayed anti-inflammatory activity with IC<sub>50</sub> values of 14.37 ± 2.36 and 14.18 ± 1.39 <em>μ</em>M. Compounds <strong>1</strong>–<strong>3</strong> exhibited anti-<em>H. pylori</em> activity with MIC values of 80, 80, and 40 <em>µ</em>M, respectively.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104094"},"PeriodicalIF":1.4,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1016/j.phytol.2025.104083
Hadjer Boubertakh , Assia Khalfallah , Ahmed Kabouche , Zahia Kabouche , Charlotte Sayagh , Anthony Abou Dib , Laurence Voutquenne-Nazabadioko
In continuation of our chemical studies on the secondary metabolites of Algerian Saharan species, we report the isolation of three undescribed cycloartane saponins named astragalarmosides A−C (1–3) together with eleven known compounds that were obtained from the aerial parts of Astragalus armatus subsp. numidicus (Murb.) Emb. & Maire. Among the known compounds, nine cycloartane saponins and one oleanane were isolated for the first time in Astragalus species. Their structures were assigned based on extensive 1D- and 2D NMR experiments (1H, 13C, COSY, ROESY, HSQC, HMBC), mass spectrometry HR-ESI-MS and by comparison of their spectral data with those of literature values. The chemotaxonomic of the genus Astragalus is summarized in this study to show its interesting chemodiversity throughout the world.
{"title":"Triterpenoids from Astragalus armatus subsp. numidicus and their chemotaxonomic significance","authors":"Hadjer Boubertakh , Assia Khalfallah , Ahmed Kabouche , Zahia Kabouche , Charlotte Sayagh , Anthony Abou Dib , Laurence Voutquenne-Nazabadioko","doi":"10.1016/j.phytol.2025.104083","DOIUrl":"10.1016/j.phytol.2025.104083","url":null,"abstract":"<div><div>In continuation of our chemical studies on the secondary metabolites of Algerian Saharan species, we report the isolation of three undescribed cycloartane saponins named astragalarmosides <span><math><mrow><mi>A</mi><mo>-</mo><mi>C</mi></mrow></math></span>A−C (<strong>1–3</strong>) together with eleven known compounds that were obtained from the aerial parts of <em>Astragalus armatus</em> subsp. <em>numidicus</em> (Murb.) Emb. & Maire. Among the known compounds, nine cycloartane saponins and one oleanane were isolated for the first time in <em>Astragalus</em> species. Their structures were assigned based on extensive 1D- and 2D NMR experiments (<sup>1</sup>H, <sup>13</sup>C, COSY, ROESY, HSQC, HMBC), mass spectrometry HR-ESI-MS and by comparison of their spectral data with those of literature values. The chemotaxonomic of the genus <em>Astragalus</em> is summarized in this study to show its interesting chemodiversity throughout the world.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104083"},"PeriodicalIF":1.4,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-06DOI: 10.1016/j.phytol.2025.104093
Bin Wang , Gang Ke , Yue-Ping Lan , En Yuan , Pu-Zhao Zhang
Five previously undescribed tetracyclic cassane-type diterpenoids with an α, β-unsaturated butenolide moiety were isolated from the seeds of Pterolobium macropterum and structurally characterized by a combination of IR, UV, HRESIMS, 1D and 2D NMR spectroscopic data. The cytotoxicity of all isolated compounds was evaluated against human glioma U251 cells and U-87 MG cells. Compound 1 exhibited moderate activity with IC50 values of 22.78 μM in human glioma U251 cells and 73.68 μM in U-87 MG cells, respectively.
{"title":"Five new cassane diterpenoids from Pterolobium macropterum","authors":"Bin Wang , Gang Ke , Yue-Ping Lan , En Yuan , Pu-Zhao Zhang","doi":"10.1016/j.phytol.2025.104093","DOIUrl":"10.1016/j.phytol.2025.104093","url":null,"abstract":"<div><div>Five previously undescribed tetracyclic cassane-type diterpenoids with an <em>α</em>, <em>β</em>-unsaturated butenolide moiety were isolated from the seeds of <em>Pterolobium macropterum</em> and structurally characterized by a combination of IR, UV, HRESIMS, 1D and 2D NMR spectroscopic data. The cytotoxicity of all isolated compounds was evaluated against human glioma U251 cells and U-87 MG cells. Compound <strong>1</strong> exhibited moderate activity with IC<sub>50</sub> values of 22.78 <em>μ</em>M in human glioma U251 cells and 73.68 <em>μ</em>M in U-87 MG cells, respectively.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104093"},"PeriodicalIF":1.4,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/S1874-3900(25)02183-4
{"title":"Announcements of the Phytochemical Society of Europe","authors":"","doi":"10.1016/S1874-3900(25)02183-4","DOIUrl":"10.1016/S1874-3900(25)02183-4","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 104091"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-27DOI: 10.1016/j.phytol.2025.104082
Ninh Khac Thanh Tung , Nguyen Thi Tu Oanh , Nguyen Thi Minh Hang , Nguyen Thi Thu Ha , Tran My Linh , Vu Huong Giang , Yohan Seo , SeonJu Park , Nguyen Tien Dat , Nguyen Xuan Nhiem , Hyung Min Kim , Ninh Khac Ban
Ligusticum wallichii Franch. (Apiaceae) is a traditional medicinal plant extensively used in Asia for treating circulatory and neurological disorders. Two new phenolic glycosides, ligusticosides A and B (1 and 2), along with five known compounds, 2-methoxy-4-(3-methoxy-1-propenyl)-phenol (3), ferulic acid (4), coniferin (5), 2-methoxy-2-(4′-hydroxyphenyl)ethanol (6), and falcarindiol (7) were isolated from the roots of L. wallichii. The chemical structures of the isolated compounds were elucidated by comprehensive spectroscopic and chemical analyses, including NMR and HR-ESI-MS. All compounds were evaluated for cytotoxic activity by the MTS assay on PC9 (lung), A2058 (melanoma), and HepG2 (liver) cancer cell lines. Compounds 1, 2, 5, and 7 exhibited significant cytotoxic activity with IC₅₀ values ranging from 3.2 to 9.8 µM against the tested cell lines. Compounds 1, 2, 5, and 7 also significantly increased caspase-3 activity (2.52–3.20-fold) and PARP-1 cleavage (2.41–2.88-fold), indicating apoptosis as a major mechanism of action.
{"title":"Phenolic glycosides from Ligusticum wallichii with cytotoxic activity","authors":"Ninh Khac Thanh Tung , Nguyen Thi Tu Oanh , Nguyen Thi Minh Hang , Nguyen Thi Thu Ha , Tran My Linh , Vu Huong Giang , Yohan Seo , SeonJu Park , Nguyen Tien Dat , Nguyen Xuan Nhiem , Hyung Min Kim , Ninh Khac Ban","doi":"10.1016/j.phytol.2025.104082","DOIUrl":"10.1016/j.phytol.2025.104082","url":null,"abstract":"<div><div><em>Ligusticum wallichii</em> Franch. (Apiaceae) is a traditional medicinal plant extensively used in Asia for treating circulatory and neurological disorders. Two new phenolic glycosides, ligusticosides A and B (<strong>1</strong> and <strong>2</strong>), along with five known compounds, 2-methoxy-4-(3-methoxy-1-propenyl)-phenol (<strong>3</strong>), ferulic acid (<strong>4</strong>), coniferin (<strong>5</strong>), 2-methoxy-2-(4′-hydroxyphenyl)ethanol (<strong>6</strong>), and falcarindiol (<strong>7</strong>) were isolated from the roots of <em>L. wallichii.</em> The chemical structures of the isolated compounds were elucidated by comprehensive spectroscopic and chemical analyses, including NMR and HR-ESI-MS. All compounds were evaluated for cytotoxic activity by the MTS assay on PC9 (lung), A2058 (melanoma), and HepG2 (liver) cancer cell lines. Compounds <strong>1</strong>, <strong>2</strong>, <strong>5</strong>, and <strong>7</strong> exhibited significant cytotoxic activity with IC₅₀ values ranging from 3.2 to 9.8 µM against the tested cell lines. Compounds <strong>1</strong>, <strong>2</strong>, <strong>5</strong>, and <strong>7</strong> also significantly increased caspase-3 activity (2.52–3.20-fold) and PARP-1 cleavage (2.41–2.88-fold), indicating apoptosis as a major mechanism of action.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104082"},"PeriodicalIF":1.4,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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