Pub Date : 2026-01-05DOI: 10.1016/j.phytol.2025.104109
Jia-Le Chang , Qing-Yun Ma , Li Yang , Qing-Yi Xie , Hai-Tao Li , Jiao-Cen Guo , Hao-Fu Dai , Sha-Sha Liu , You-Xing Zhao
Two new compounds, 1-chloro-decarboxyunguinolic acid (1) and 6-hydroxy-3-methyloctan-4-yl-2,4-dihydroxy-6-methylbenzoate (2), along with seven known ones (3-9), were isolated from a sponge-derived fungus Diaporthe sp. ZYX-Z-582. Five compounds (1–5) exhibited inhibitory activity against agricultural pathogenic fungi Neoscytalidium dimidiatum ZYXPF03, Gilbertella persicaria HLG-T, Fusarium oxysporum f. sp. Passiflorae ZYXPF10 and Colletotrichum musae ZYXPF01, with MIC values ranging from 8 μg/mL to 128 μg/mL.
{"title":"Two new compounds isolated from a sponge-derived fungus Diaporthe sp. ZYX-Z-582","authors":"Jia-Le Chang , Qing-Yun Ma , Li Yang , Qing-Yi Xie , Hai-Tao Li , Jiao-Cen Guo , Hao-Fu Dai , Sha-Sha Liu , You-Xing Zhao","doi":"10.1016/j.phytol.2025.104109","DOIUrl":"10.1016/j.phytol.2025.104109","url":null,"abstract":"<div><div>Two new compounds, 1-chloro-decarboxyunguinolic acid (<strong>1</strong>) and 6-hydroxy-3-methyloctan-4-yl-2,4-dihydroxy-6-methylbenzoate (<strong>2</strong>), along with seven known ones (<strong>3</strong>-<strong>9</strong>), were isolated from a sponge-derived fungus <em>Diaporthe</em> sp. ZYX-Z-582. Five compounds (<strong>1–5</strong>) exhibited inhibitory activity against agricultural pathogenic fungi <em>Neoscytalidium dimidiatum</em> ZYXPF03, <em>Gilbertella persicaria</em> HLG-T, <em>Fusarium oxysporum f. sp. Passiflorae</em> ZYXPF10 and <em>Colletotrichum musae</em> ZYXPF01, with MIC values ranging from 8 μg/mL to 128 μg/mL.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104109"},"PeriodicalIF":1.4,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1016/j.phytol.2025.104107
Yan-Ping Qiu , He Tian , Qian Xie , Shuai Li , Bi-Qian Dong , Guan-Min Su , Ding Luo , Lin-Zhao Ye
Three previously undescribed matrine-type alkaloids, sophaloseedlines U–W (1–3), together with three known analogues, were isolated from the seeds of Sophora alopecuroides L. Their chemical structures, including absolute configurations, were elucidated by comprehensive spectroscopic analyses (HR-ESI-MS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculations. All compounds were evaluated for cytotoxic activities against two human breast cancer cell lines, MCF-7 and MDA-MB-231. Compound 4 exhibited the most potent activity, with IC₅₀ values of 24.8 μM and 26.1 μM, respectively.
{"title":"Three new matrine-type alkaloids from Sophora alopecuroides with cytotoxic activity","authors":"Yan-Ping Qiu , He Tian , Qian Xie , Shuai Li , Bi-Qian Dong , Guan-Min Su , Ding Luo , Lin-Zhao Ye","doi":"10.1016/j.phytol.2025.104107","DOIUrl":"10.1016/j.phytol.2025.104107","url":null,"abstract":"<div><div>Three previously undescribed matrine-type alkaloids, sophaloseedlines U–W (<strong>1–3</strong>), together with three known analogues, were isolated from the seeds of <em>Sophora alopecuroides</em> L. Their chemical structures, including absolute configurations, were elucidated by comprehensive spectroscopic analyses (HR-ESI-MS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculations. All compounds were evaluated for cytotoxic activities against two human breast cancer cell lines, MCF-7 and MDA-MB-231. Compound <strong>4</strong> exhibited the most potent activity, with IC₅₀ values of 24.8 μM and 26.1 μM, respectively.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104107"},"PeriodicalIF":1.4,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1016/j.phytol.2026.104111
Ling Li , Lin Feng , Lihua Peng , Weilin Qiao , Wei Li , De-an Guo
Two new naphthopyrones, berchelineatones A and B (1 and 2), together with a new prenylisoflavone (3), were isolated from Berchemia lineata. Their structures were primarily determined by high-resolution mass spectrometry, NMR spectroscopy, and X-ray crystallographic data analysis. Notably, compounds 1 and 2 exhibited potent inhibition on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophages, with IC50 values of 2.52 and 2.06 μM, respectively.
{"title":"Two new naphthopyrones and a new prenylisoflavone from Berchemia lineata","authors":"Ling Li , Lin Feng , Lihua Peng , Weilin Qiao , Wei Li , De-an Guo","doi":"10.1016/j.phytol.2026.104111","DOIUrl":"10.1016/j.phytol.2026.104111","url":null,"abstract":"<div><div>Two new naphthopyrones, berchelineatones A and B (<strong>1</strong> and <strong>2</strong>), together with a new prenylisoflavone (<strong>3</strong>), were isolated from <em>Berchemia lineata</em>. Their structures were primarily determined by high-resolution mass spectrometry, NMR spectroscopy, and X-ray crystallographic data analysis. Notably, compounds <strong>1</strong> and <strong>2</strong> exhibited potent inhibition on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophages, with IC<sub>50</sub> values of 2.52 and 2.06 <em>μ</em>M, respectively.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104111"},"PeriodicalIF":1.4,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.phytol.2025.104110
Natalia de Andrade Teixeira Fernandes , Luara Simões , Keelin Hunt , Nicole Nelson , Ricardo San Martin
Quillaja saponaria Molina is an endemic Chilean tree valued for its saponin-rich bark and biomass. However, overexploitation and drought have endangered natural populations, highlighting the need for sustainable alternatives such as the use of leaves. In this study, we analyzed the polyphenolic profile of water extracts obtained from fresh and dried Q. saponaria leaves using UHPLC/MS. Although the extraction was optimized for saponin recovery, several polyphenolic compounds remained detectable. The analysis revealed a diverse composition, including phenolic acids and flavonoids, with piscidic acid dominating (82.65–82.96 % of total quantified polyphenols), followed by p-coumaric acid derivatives identified as Quillajasides A and B and their isomers (4.81–5.34 %), and quercetin derivatives (3.7–4.15 %). These findings suggest that polyphenols, though secondary in saponin-rich water extracts, may influence extract properties relevant to industrial and food applications. This comprehensive analysis contributes to sustainable plant resource management and provides insights into Q. saponaria leaves as a source of bioactive compounds.
{"title":"Polyphenol composition of fresh and dried Quillaja saponaria leaf extracts by UHPLC/MS","authors":"Natalia de Andrade Teixeira Fernandes , Luara Simões , Keelin Hunt , Nicole Nelson , Ricardo San Martin","doi":"10.1016/j.phytol.2025.104110","DOIUrl":"10.1016/j.phytol.2025.104110","url":null,"abstract":"<div><div><em>Quillaja saponaria</em> Molina is an endemic Chilean tree valued for its saponin-rich bark and biomass. However, overexploitation and drought have endangered natural populations, highlighting the need for sustainable alternatives such as the use of leaves. In this study, we analyzed the polyphenolic profile of water extracts obtained from fresh and dried <em>Q. saponaria</em> leaves using UHPLC/MS. Although the extraction was optimized for saponin recovery, several polyphenolic compounds remained detectable. The analysis revealed a diverse composition, including phenolic acids and flavonoids, with piscidic acid dominating (82.65–82.96 % of total quantified polyphenols), followed by <em>p</em>-coumaric acid derivatives identified as Quillajasides A and B and their isomers (4.81–5.34 %), and quercetin derivatives (3.7–4.15 %). These findings suggest that polyphenols, though secondary in saponin-rich water extracts, may influence extract properties relevant to industrial and food applications. This comprehensive analysis contributes to sustainable plant resource management and provides insights into <em>Q. saponaria</em> leaves as a source of bioactive compounds.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104110"},"PeriodicalIF":1.4,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.phytol.2025.104106
Quoc-Vu Pham , Hsin-Wei Wang , Yu-Cheng Chen , Yu-Chia Chang , You-Song Cheng , Yun-Shiuan Chen , Mei-Hsien Lee , Jui-Hsin Su , Bo-Rong Peng , Kuei-Hung Lai
A new C₂₂ furanoterpenoid, lendenfurone A (1), was isolated from the Formosan marine sponge Lendenfeldia sp. C₂₂ furanoterpenoids are rare among sponge-derived natural products, with only two compounds (furodendin and dehydrofurodendin) reported to date. The structure of 1 was elucidated by NMR spectroscopy and HRESIMS, and the absolute configuration was established by specific optical rotation (SOR) prediction and confirmed through DFT-based NMR calculations with DP4⁺ analysis. Although compound 1 showed no significant anti-osteoclastogenic activity in PMA/RANKL-induced THP-1 cells, it exhibited no cytotoxicity. The unique scaffold of lendenfurone A may serve as a promising lead for future pharmacological studies.
{"title":"New C22-related terpenoid from Formosan marine sponge Lendenfeldia sp.","authors":"Quoc-Vu Pham , Hsin-Wei Wang , Yu-Cheng Chen , Yu-Chia Chang , You-Song Cheng , Yun-Shiuan Chen , Mei-Hsien Lee , Jui-Hsin Su , Bo-Rong Peng , Kuei-Hung Lai","doi":"10.1016/j.phytol.2025.104106","DOIUrl":"10.1016/j.phytol.2025.104106","url":null,"abstract":"<div><div>A new C₂₂ furanoterpenoid, lendenfurone A (<strong>1</strong>), was isolated from the Formosan marine sponge <em>Lendenfeldia</em> sp. C₂₂ furanoterpenoids are rare among sponge-derived natural products, with only two compounds (furodendin and dehydrofurodendin) reported to date. The structure of <strong>1</strong> was elucidated by NMR spectroscopy and HRESIMS, and the absolute configuration was established by specific optical rotation (SOR) prediction and confirmed through DFT-based NMR calculations with DP4⁺ analysis. Although compound <strong>1</strong> showed no significant anti-osteoclastogenic activity in PMA/RANKL-induced THP-1 cells, it exhibited no cytotoxicity. The unique scaffold of lendenfurone A may serve as a promising lead for future pharmacological studies.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104106"},"PeriodicalIF":1.4,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.phytol.2025.104099
Payar Hossain , Md. Hossain Rasel , Md. Jahirul Islam Mamun , Md. Abdul Alim , S.M. Naim Uddin
Bischofia javanica (Euphorbiaceae) has been used for a long time to manage ulcers, bone fractures, dislocations, inflammation, and tuberculosis. This study evaluated the analgesic, antidiarrheal, and hypoglycemic effects of the methanolic fruit extract (MFBJ) and n-hexane fraction (NHF) of the plant. At 400 mg/kg, both reduced pain in the writhing test (56.74 % and 51.63 %; p < 0.001) and prolonged hot plate response times. MFBJ also showed stronger antidiarrheal (68.65 %) and hypoglycemic (5.92 ± 0.03 mmol/L; p < 0.001) effects. Findings suggest therapeutic potential, warranting further characterisation of bioactive compounds.
{"title":"Exploring the therapeutic potentials of Bischofia javanica: Evidence of analgesic, antidiarrheal, and hypoglycemic activities","authors":"Payar Hossain , Md. Hossain Rasel , Md. Jahirul Islam Mamun , Md. Abdul Alim , S.M. Naim Uddin","doi":"10.1016/j.phytol.2025.104099","DOIUrl":"10.1016/j.phytol.2025.104099","url":null,"abstract":"<div><div><em>Bischofia javanica</em> (Euphorbiaceae) has been used for a long time to manage ulcers, bone fractures, dislocations, inflammation, and tuberculosis. This study evaluated the analgesic, antidiarrheal, and hypoglycemic effects of the methanolic fruit extract (MFBJ) and n-hexane fraction (NHF) of the plant. At 400 mg/kg, both reduced pain in the writhing test (56.74 % and 51.63 %; p < 0.001) and prolonged hot plate response times. MFBJ also showed stronger antidiarrheal (68.65 %) and hypoglycemic (5.92 ± 0.03 mmol/L; p < 0.001) effects. Findings suggest therapeutic potential, warranting further characterisation of bioactive compounds.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104099"},"PeriodicalIF":1.4,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-26DOI: 10.1016/j.phytol.2025.104100
Ali Mai Hassan , Albert Atangana Fouda , Jean Pierre Longue Ekon , Baruch Ateba Amana , Moses Langat Kiprotich , Bruno Lenta Ndjakou , Kevine Johane Jumeta Dongmo , Willifred Dongmo Tekapi Tsopgni , Jean Duplex Wansi
A new aromadendrane sesquiterpene derivative, (alafinol, 1), alongside with fourteen known compounds were isolated from the methanolic extract of the liana of Alafia erythrophthalma (K. Schum.) Leeuwenb. The structures of the compounds were determined by analyses of spectroscopic (1D and 2D NMR, HRMS) data and circular dichroism spectra as well as by comparison with literature records. Compounds 5, 8–12 and 14 are reported here for the first time from the genus Alafia. Compounds 1–2 and crude extract were tested for their antimicrobial activity against the bacterial strains Staphylococcus aureus, Salmonella typhi, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and the fungal strains Candida albicans and Cryptococcus neoformans. The crude extract exhibited weak activity against Pseudomonas aeruginosa with a MIC value of 312.5 μg/mL.
从红眼病（Alafia erythrophthalma， K. Schum）藤属植物的甲醇提取物中分离到一个新的芳香腺嘌呤倍半萜衍生物（alafinol, 1）和14个已知化合物。Leeuwenb。化合物的结构通过波谱（1D和2D NMR， HRMS）数据和圆二色光谱分析以及与文献记录的比较来确定。化合物5、8 ~ 12和14为首次从该属植物中分离得到。测定了化合物1-2和粗提物对金黄色葡萄球菌、伤寒沙门氏菌、肺炎克雷伯菌、大肠杆菌、铜绿假单胞菌、白色念珠菌和新型隐球菌的抑菌活性。粗提物对铜绿假单胞菌的抑制活性较弱，MIC值为312.5 μg/mL。
{"title":"A new aromadendrane sesquiterpene from the liana Alafia erythrophthalma","authors":"Ali Mai Hassan , Albert Atangana Fouda , Jean Pierre Longue Ekon , Baruch Ateba Amana , Moses Langat Kiprotich , Bruno Lenta Ndjakou , Kevine Johane Jumeta Dongmo , Willifred Dongmo Tekapi Tsopgni , Jean Duplex Wansi","doi":"10.1016/j.phytol.2025.104100","DOIUrl":"10.1016/j.phytol.2025.104100","url":null,"abstract":"<div><div>A new aromadendrane sesquiterpene derivative, (alafinol, <strong>1</strong>), alongside with fourteen known compounds were isolated from the methanolic extract of the liana of <em>Alafia erythrophthalma</em> (K. Schum.) Leeuwenb. The structures of the compounds were determined by analyses of spectroscopic (1D and 2D NMR, HRMS) data and circular dichroism spectra as well as by comparison with literature records. Compounds <strong>5</strong>, <strong>8–12</strong> and <strong>14</strong> are reported here for the first time from the genus <em>Alafia.</em> Compounds <strong>1–2</strong> and crude extract were tested for their antimicrobial activity against the bacterial strains <em>Staphylococcus aureus, Salmonella typhi, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa</em> and the fungal strains <em>Candida albicans</em> and <em>Cryptococcus neoformans</em>. The crude extract exhibited weak activity against <em>Pseudomonas aeruginosa</em> with a MIC value of 312.5 μg/mL.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104100"},"PeriodicalIF":1.4,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/j.phytol.2025.104102
Wei Li , Miaomiao Chai , Longfei Zhang , Mengting Yang , Zhenzhen Zhang , Zhenhui Wang , Xueqian He
Three previously undescribed aniline-containing phthalide derivatives, designated talarophthalides A-C (1-3), along with three known polyketides (4-6) were isolated from the culture of the Yellow River wetland-derived Talaromyces funiculosus HPU-Y01 treated with the histone deacetylase inhibitor SAHA (suberanilohydroxamic acid). The structures of the new compounds were determined by comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS, and further confirmed by X-ray crystallography for talarophthalide A (1). Compound 1 showed α-glucosidase inhibitory activity with an IC50 value of 20.7 μM.
{"title":"Aniline-phthalides from the Yellow River wetland-derived fungus Talaromyces funiculosus HPU-Y01 cultured with the HDAC inhibitor SAHA","authors":"Wei Li , Miaomiao Chai , Longfei Zhang , Mengting Yang , Zhenzhen Zhang , Zhenhui Wang , Xueqian He","doi":"10.1016/j.phytol.2025.104102","DOIUrl":"10.1016/j.phytol.2025.104102","url":null,"abstract":"<div><div>Three previously undescribed aniline-containing phthalide derivatives, designated talarophthalides A-C (<strong>1</strong>-<strong>3</strong>), along with three known polyketides (<strong>4</strong>-<strong>6</strong>) were isolated from the culture of the Yellow River wetland-derived <em>Talaromyces funiculosus</em> HPU-Y01 treated with the histone deacetylase inhibitor SAHA (suberanilohydroxamic acid). The structures of the new compounds were determined by comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS, and further confirmed by X-ray crystallography for talarophthalide A (<strong>1</strong>). Compound <strong>1</strong> showed <em>α</em>-glucosidase inhibitory activity with an IC<sub>50</sub> value of 20.7 <em>μ</em>M.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104102"},"PeriodicalIF":1.4,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-20DOI: 10.1016/j.phytol.2025.104104
Tran Thi Minh , Tran Thi Minh Trang , Duong Hoang Thuc , Vu Dinh Hoang , Le Dang Quang , Hun Kim , Minh Van Nguyen , Gyung Ja Choi
Two new euphane-type triterpenoids, lantapenoids A and B (1–2), a new acyclic monoterpenoid, lantapenoid C (7), and four known triterpenoids (3–6), along with hispidulin (8) and 1,2,3-naphthalenetriol (9), were isolated from the dichloromethane extract of the aerial parts of Lantana camara Linn. Their structures were elucidated through extensive analyses of IR, HRESI-MS, 1D, and 2D NMR data, as well as comparison with the published data. In vivo bioassays showed that the dichloromethane extract suppressed Magnaporthe oryzae by 56 % at 3000 µg mL−1, while fraction LD1108 (from the dichloromethane extract) exhibited 69 % inhibition against Phytophthora infestans at 2000 µg mL−1. Among the nine metabolites, only compound 3 showed in vivo antifungal activity against M. oryzae, with 56 % inhibition at 1000 µg mL−1. These results suggested the use of this plant extract and its metabolites as eco-friendly fungicidal agents for controlling plant fungal diseases.
{"title":"Lantapenoids A–C from the aerial parts of Vietnamese Lantana camara","authors":"Tran Thi Minh , Tran Thi Minh Trang , Duong Hoang Thuc , Vu Dinh Hoang , Le Dang Quang , Hun Kim , Minh Van Nguyen , Gyung Ja Choi","doi":"10.1016/j.phytol.2025.104104","DOIUrl":"10.1016/j.phytol.2025.104104","url":null,"abstract":"<div><div>Two new euphane-type triterpenoids, lantapenoids A and B (<strong>1–2</strong>), a new acyclic monoterpenoid, lantapenoid C (<strong>7</strong>), and four known triterpenoids (<strong>3–6</strong>), along with hispidulin (<strong>8</strong>) and 1,2,3-naphthalenetriol (<strong>9</strong>), were isolated from the dichloromethane extract of the aerial parts of <em>Lantana camara</em> Linn. Their structures were elucidated through extensive analyses of IR, HRESI-MS, 1D, and 2D NMR data, as well as comparison with the published data. <em>In vivo</em> bioassays showed that the dichloromethane extract suppressed <em>Magnaporthe oryzae</em> by 56 % at 3000 µg mL<sup>−1</sup>, while fraction LD1108 (from the dichloromethane extract) exhibited 69 % inhibition against <em>Phytophthora infestans</em> at 2000 µg mL<sup>−1</sup>. Among the nine metabolites, only compound <strong>3</strong> showed <em>in vivo</em> antifungal activity against <em>M. oryzae,</em> with 56 % inhibition at 1000 µg mL<sup>−1</sup>. These results suggested the use of this plant extract and its metabolites as eco-friendly fungicidal agents for controlling plant fungal diseases.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104104"},"PeriodicalIF":1.4,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Two new sesquiterpenoids, ginkgonin A (1) and ginkgonin B (2), together with six known compounds (3 - 8), were isolated from the broth of Streptomyces ginkgonis TH01. Their structures were determined through comprehensive spectroscopic analysis, including HRESIMS and 1D/2D NMR (COSY, HSQC, HMBC, and NOESY). The absolute configurations were solved via electronic circular dichroism (ECD) calculations. Compounds 1 – 8 were evaluated for antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli. Compounds 1, 2, 3, 4, and 7 exhibited moderate inhibitory effects against all tested strains, with MIC values ranging from 12.3 to 49.4 μg/mL.
{"title":"Ginkgonins A and B: Two new sesquiterpenoids from Streptomyces ginkgonis TH01","authors":"Yun-Fei He, Jing Miao, Chao Jian, Rui-Jun Wang, Yong-Sheng Gao, Jie-Hao Jin, Xiao-Yi Chen, Ji-Dong Wang, Shao-Yong Zhang","doi":"10.1016/j.phytol.2025.104103","DOIUrl":"10.1016/j.phytol.2025.104103","url":null,"abstract":"<div><div>Two new sesquiterpenoids, ginkgonin A (<strong>1</strong>) and ginkgonin B (<strong>2</strong>), together with six known compounds (<strong>3</strong> - <strong>8</strong>), were isolated from the broth of <em>Streptomyces ginkgonis</em> TH01. Their structures were determined through comprehensive spectroscopic analysis, including HRESIMS and 1D/2D NMR (COSY, HSQC, HMBC, and NOESY). The absolute configurations were solved via electronic circular dichroism (ECD) calculations. Compounds <strong>1</strong> – <strong>8</strong> were evaluated for antimicrobial activity against <em>Staphylococcus aureus</em>, <em>Bacillus subtilis</em>, and <em>Escherichia coli</em>. Compounds <strong>1</strong>, <strong>2</strong>, <strong>3</strong>, <strong>4</strong>, and <strong>7</strong> exhibited moderate inhibitory effects against all tested strains, with MIC values ranging from 12.3 to 49.4 μg/mL.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104103"},"PeriodicalIF":1.4,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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