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Psychometric properties of self-reported measures of psychological birth trauma in puerperae: A COSMIN systematic review. 产褥期心理创伤自我报告测量的心理计量特性:COSMIN 系统回顾。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-30 DOI: 10.1007/s11136-024-03811-z
Pingping Chen, Chao Zhang, Guangjian Liu, Hongxia Zuo, Menghe Wang, Xiaoyan Shi, Longti Li

Purpose: To identify and evaluate the psychometric properties of available patient-reported outcome measures (PROMs) of psychological birth trauma (PBT) in postpartum women.

Methods: A literature search was carried out across eight databases-PubMed, Embase, Web of Science, CINAHL, PsycINFO, China National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP Database for Chinese Technical Periodicals-covering studies published from the inception of each database up to 21 May 2024. English and Chinese language studies employing any research design and reporting at least one psychometric property of PBT in puerperae were included. Independent reviewers extracted data and followed the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines to evaluate three aspects of the included instruments: methodological quality, psychometric properties, and level of evidence assessed using the modified Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework.

Results: Thirty-one studies with twelve PROMs were included, measurement error, cross-cultural validity, and responsiveness were not reported for most PROMs. Nine PROMs received a Class B recommendation, based on their measurement attribute ratings and overall evidence quality. In contrast, the CTI, IES-R, and PBTAS with high-quality evidence for insufficient measurement properties, so received a Class C recommendation.

Conclusions: This systematic review provisionally recommends the City BiTS as credible tool for assessing PBT in both clinical practice and research involving puerperae. However, further comprehensive studies are needed to conduct more comprehensive validations of the psychometric properties of existing PROMs.

目的:确定并评估现有患者报告的产后妇女分娩心理创伤(PBT)结局测量指标(PROMs)的心理测量特性:方法:我们在八个数据库(PubMed、Embase、Web of Science、CINAHL、PsycINFO、中国国家知识基础设施(CNKI)、万方数据库和中国科技期刊要目数据库)中进行了文献检索,涵盖了从每个数据库建立之初到 2024 年 5 月 21 日发表的研究。纳入的中英文研究均采用任何研究设计,并至少报告了一项产褥期 PBT 的心理测量学特性。独立审稿人提取数据,并遵循基于共识的健康测量工具选择标准(COSMIN)指南,对纳入工具的三个方面进行评估:方法学质量、心理测量学特性,以及使用修改后的建议评估、发展和评价分级(GRADE)框架评估的证据水平:结果:共纳入了 31 项研究和 12 个 PROM,大多数 PROM 均未报告测量误差、跨文化有效性和响应性。根据测量属性评级和总体证据质量,九项 PROM 获得了 B 级推荐。相比之下,CTI、IES-R 和 PBTAS 具有高质量证据,但测量属性不足,因此获得了 C 级推荐:本系统综述暂时推荐城市生物测量系统作为评估 PBT 的可靠工具,用于涉及产褥期妇女的临床实践和研究。不过,还需要进一步开展综合研究,对现有 PROM 的心理测量特性进行更全面的验证。
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引用次数: 0
Uncovering the story within the story: a scoping review of response shift in qualitative research. 发掘故事中的故事:定性研究中反应转变的范围审查。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-29 DOI: 10.1007/s11136-024-03803-z
Carolyn E Schwartz, I-Chan Huang, Gudrun Rohde, Richard L Skolasky

Purpose: The role of qualitative research in response-shift research has not been well characterized. This scoping review summarizes the status of qualitative studies on response shift.

Methods: A scoping review of the medical literature was done using the keywords "response shift" and "qualitative" or "interview." After excluding ineligible works, each retained article was rated by two independent raters according to the modified Critical Appraisal Skill Program (CASP) criteria. A synthesis of adjudicated review results further characterized the articles.

Results: The search yielded 50 unique articles published from 1991 to 2023, 39 of which were retained after applying exclusion criteria. Most (69%) had the highest possible CASP score. Studies involved a broad range of patients by diagnosis or therapeutic context, caregivers, and healthcare professionals. While studies were often purely descriptive, many addressed components of response-shift theory or assumptions of response-shift methods. Study goals varied by design, time-focus (i.e., retrospective, present-focus or prospective), and by whether response-shift hypotheses were planned or post-hoc. The theoretical value added by the qualitative process involved examining the cognitive/emotional processes underlying quality-of-life ratings and response shifts. The methodological value added by the qualitative process facilitates understanding measurement error and non-responsiveness, and whether the methods used reflect the researchers' presumptions.

Conclusion: The use of qualitative methods in response-shift research yields a nuanced understanding of what response-shift "looks like" in different patient populations, thereby helping to translate results more directly to clinical experience. Studies contributed to response-shift theory or methods in ways not easily captured by purely quantitative research.

目的:定性研究在反应转换研究中的作用尚未得到很好的描述。本范围综述总结了有关反应转变的定性研究现状:方法:使用关键词 "应答转换 "和 "定性 "或 "访谈 "对医学文献进行了范围界定。在排除了不符合条件的作品后,每篇保留下来的文章都由两名独立评审员根据修改后的 "批判性评价技能计划"(CASP)标准进行评分。对评审结果的综合分析进一步确定了文章的特点:搜索结果显示,1991 年至 2023 年间共发表了 50 篇文章,其中 39 篇在应用排除标准后被保留下来。大多数文章(69%)的CASP评分最高。研究涉及的患者范围广泛,包括诊断或治疗背景、护理人员和医疗保健专业人员。虽然研究通常纯粹是描述性的,但许多研究都涉及了反应转变理论的组成部分或反应转变方法的假设。研究目标因设计、时间重点(即回顾性、当前重点或前瞻性)以及反应转变假设是计划性还是事后性而有所不同。定性过程的理论附加值包括研究生活质量评分和反应转变背后的认知/情感过程。定性过程的方法论附加值有助于了解测量误差和非反应性,以及所使用的方法是否反映了研究人员的假设:结论:在反应转变研究中使用定性方法,可以细致入微地了解反应转变在不同患者群体中的 "表现",从而有助于将结果更直接地转化为临床经验。这些研究以纯定量研究难以捕捉的方式对反应偏移理论或方法做出了贡献。
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引用次数: 0
Quality of life of inflammatory bowel diseases patients in france with EQ-5D-5 L: the QALY-MICI study. 法国炎症性肠病患者的 EQ-5D-5 L 生活质量:QALY-MICI 研究。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-29 DOI: 10.1007/s11136-024-03821-x
H Sarter, J Kirschgesner, L Beaugerie, A Buisson, C Gower-Rousseau, Gérard de Pouvourville

Purpose: This study aimed to document utility values and the Visual Analog Scale (VAS) with the 5-level version of the EQ-5D questionnaire in a large sample of patients with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).

Methods: QALY-MICI was a cross-sectional survey across three sources in France. Data were collected between 2019 and 2022 for patients 18 and over. The EQ-5D-5 L, the EQ-VAS, the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), the Harvey-Bradshaw Index (HBI) for CD, and the Walmsley Index for UC (SCCAI) were collected.

Results: A total of 2,841 patients aged over 18 were recruited (1785 with CD, 1056 with UC). The mean age was 40.2 (SD 14.3). The time since diagnosis was 6 years and over for 61.9% of patients. The most impacted dimensions were usual activities, anxiety/ depression, and pain/ discomfort. The mean utility value was 0.863 (SD 0.172) versus 0.905 (SD 0.158) in the French population (p = 0.007). The mean VAS value was 68 (SD 19.2) versus 73.4 (SD 22.2) in the general population (p = 0.016). Utility values and VAS were similar for CD and UC and higher for men. There was a strong positive correlation between utility values, the VAS, and the SIBDQ score, and a negative correlation between the HBI and the SCCAI. The SIBDQ score and disease activity were the main predictors of utility and VAS.

Conclusion: The QALY-MICI is, to our knowledge, the first study documenting utility values and VAS using the EQ-5D-5 L questionnaire on a large sample, with a comparison to the general population.

目的:本研究旨在记录包括克罗恩病(CD)和溃疡性结肠炎(UC)在内的炎症性肠病(IBD)大样本患者的效用值和五级版 EQ-5D 问卷的视觉模拟量表(VAS):QALY-MICI 是一项横断面调查,涉及法国的三个来源。数据收集时间为 2019 年至 2022 年,对象为 18 岁及以上的患者。调查收集了 EQ-5D-5 L、EQ-VAS、炎症性肠病简短问卷(SIBDQ)、CD 的哈维-布拉德肖指数(HBI)和 UC 的沃姆斯利指数(SCCAI):共招募了 2841 名 18 岁以上的患者(其中 CD 患者 1785 名,UC 患者 1056 名)。平均年龄为 40.2 岁(SD 14.3)。61.9%的患者确诊时间超过 6 年。影响最大的方面是日常活动、焦虑/抑郁和疼痛/不适。平均效用值为 0.863(标清 0.172),而法国人群的效用值为 0.905(标清 0.158)(P = 0.007)。VAS 平均值为 68(标准差 19.2),而普通人群为 73.4(标准差 22.2)(p = 0.016)。CD 和 UC 的效用值和 VAS 值相似,男性的效用值更高。效用值、VAS 和 SIBDQ 评分之间存在很强的正相关性,而 HBI 和 SCCAI 之间存在负相关。SIBDQ评分和疾病活动是预测效用值和VAS的主要因素:据我们所知,QALY-MICI 是第一项使用 EQ-5D-5 L 问卷对大样本进行效用值和 VAS 记录的研究,并与普通人群进行了比较。
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引用次数: 0
The humanistic burden of immunoglobulin A nephropathy on patients and care-partners in the United States. 免疫球蛋白 A 肾病给美国患者和护理伙伴带来的人文负担。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-26 DOI: 10.1007/s11136-024-03813-x
Justyna Szklarzewicz, Ute Floege, Daniel Gallego, Keisha Gibson, Kamyar Kalantar-Zadeh, Kelly Helm, Dale Robinson, Bonnie Schneider, Philip Smith, Kjell Tullus, Ali Poyan-Mehr, Bruce Hendry, Bridget L Balkaran, Adam K Jauregui, Aolin Wang, Ian Nason, Nisha C Hazra, Chunyi Xu, Jingyi Liu, Zheng-Yi Zhou, Mark Bensink

Purpose: This cross-sectional survey study quantified the humanistic burden of immunoglobulin A nephropathy (IgAN), in terms of physical and mental health-related quality of life (HRQoL) and work productivity, among adults with primary IgAN and their care-partners.

Methods: HRQoL was assessed (01/31/22 - 05/31/23) with validated tools including the KDQoL-36 (with SF-12), GAD-7 (anxiety), PHQ-9 (depression), and WPAI: SHP (work productivity). Participant characteristics and total/domain scores were summarized; selected outcomes were compared to an external, kidney disease-free cohort.

Results: 117 adults with IgAN and their care-partner pairs, and one adult without a care-partner, were included. The mean ages of patients and care-partners were 38.0 (SD: 8.6) and 40.2 (11.8) years, respectively; 55.9% and 43.6% were female. Mean physical and mental SF-12 scores for patients were 46.7 (SD: 8.0) and 41.9 (9.2), respectively, and 50.7 (7.3) and 43.7 (10.24) for care-partners. Both SF-12 components for patients, and the mental component for care-givers, were significantly worse compared to the US general population. Among patients, 27.1% had moderate/severe anxiety and 49.2% reported at least moderate depression. Compared to external controls, patients experienced significantly higher severity of anxiety (6.6 vs. 5.4) and depression (8.1 vs. 6.6; both p < 0.0001). Among care-partners, 13.7% experienced moderate anxiety and 37.8% experienced moderate/moderately-severe depression. Among employed individuals, both groups reported IgAN-related absenteeism (8.8-9.4%), presenteeism (25.1-25.9%), and overall work impairment (30.4-30.5%).

Conclusion: US adults with IgAN and their care partners experience impairments to mental and physical HRQoL and heightened levels of depression and anxiety, underscoring the need for effective IgAN therapies and care-partner support.

目的:这项横断面调查研究从身心健康相关生活质量(HRQoL)和工作效率的角度量化了免疫球蛋白A肾病(IgAN)给原发性IgAN成人患者及其护理伙伴带来的人文负担。方法:使用经过验证的工具评估 HRQoL(01/31/22 - 05/31/23),包括 KDQoL-36(与 SF-12)、GAD-7(焦虑)、PHQ-9(抑郁)和 WPAI:SHP(工作效率)。对参与者的特征和总分/领域分进行了总结,并将选定的结果与外部无肾脏病队列进行了比较:研究共纳入了 117 名成人 IgAN 患者及其护理伴侣,以及一名无护理伴侣的成人。患者和护理伙伴的平均年龄分别为 38.0 岁(标清:8.6 岁)和 40.2 岁(11.8 岁);女性分别占 55.9% 和 43.6%。患者的身体和心理 SF-12 平均得分分别为 46.7 分(标度:8.0)和 41.9 分(9.2),护理伙伴的身体和心理 SF-12 平均得分分别为 50.7 分(7.3)和 43.7 分(10.24)。与美国普通人群相比,患者的 SF-12 指标和护理人员的精神指标都明显较差。在患者中,27.1%患有中度/重度焦虑症,49.2%至少患有中度抑郁症。与外部对照组相比,患者的焦虑(6.6 对 5.4)和抑郁(8.1 对 6.6;均为 p)严重程度明显更高:美国成人 IgAN 患者及其护理伙伴的身心健康生活质量受到损害,抑郁和焦虑水平升高,这突出表明需要有效的 IgAN 治疗方法和护理伙伴支持。
{"title":"The humanistic burden of immunoglobulin A nephropathy on patients and care-partners in the United States.","authors":"Justyna Szklarzewicz, Ute Floege, Daniel Gallego, Keisha Gibson, Kamyar Kalantar-Zadeh, Kelly Helm, Dale Robinson, Bonnie Schneider, Philip Smith, Kjell Tullus, Ali Poyan-Mehr, Bruce Hendry, Bridget L Balkaran, Adam K Jauregui, Aolin Wang, Ian Nason, Nisha C Hazra, Chunyi Xu, Jingyi Liu, Zheng-Yi Zhou, Mark Bensink","doi":"10.1007/s11136-024-03813-x","DOIUrl":"https://doi.org/10.1007/s11136-024-03813-x","url":null,"abstract":"<p><strong>Purpose: </strong>This cross-sectional survey study quantified the humanistic burden of immunoglobulin A nephropathy (IgAN), in terms of physical and mental health-related quality of life (HRQoL) and work productivity, among adults with primary IgAN and their care-partners.</p><p><strong>Methods: </strong>HRQoL was assessed (01/31/22 - 05/31/23) with validated tools including the KDQoL-36 (with SF-12), GAD-7 (anxiety), PHQ-9 (depression), and WPAI: SHP (work productivity). Participant characteristics and total/domain scores were summarized; selected outcomes were compared to an external, kidney disease-free cohort.</p><p><strong>Results: </strong>117 adults with IgAN and their care-partner pairs, and one adult without a care-partner, were included. The mean ages of patients and care-partners were 38.0 (SD: 8.6) and 40.2 (11.8) years, respectively; 55.9% and 43.6% were female. Mean physical and mental SF-12 scores for patients were 46.7 (SD: 8.0) and 41.9 (9.2), respectively, and 50.7 (7.3) and 43.7 (10.24) for care-partners. Both SF-12 components for patients, and the mental component for care-givers, were significantly worse compared to the US general population. Among patients, 27.1% had moderate/severe anxiety and 49.2% reported at least moderate depression. Compared to external controls, patients experienced significantly higher severity of anxiety (6.6 vs. 5.4) and depression (8.1 vs. 6.6; both p < 0.0001). Among care-partners, 13.7% experienced moderate anxiety and 37.8% experienced moderate/moderately-severe depression. Among employed individuals, both groups reported IgAN-related absenteeism (8.8-9.4%), presenteeism (25.1-25.9%), and overall work impairment (30.4-30.5%).</p><p><strong>Conclusion: </strong>US adults with IgAN and their care partners experience impairments to mental and physical HRQoL and heightened levels of depression and anxiety, underscoring the need for effective IgAN therapies and care-partner support.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of the celiac disease symptom diary version 2.1© (CDSD 2.1©) patient-reported outcome measure. 开发腹腔疾病症状日记 2.1©(CDSD 2.1©)患者报告结果测量方法。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-26 DOI: 10.1007/s11136-024-03799-6
Kellee Howard, Daniel Adelman, Sonal Ghura, Sarah Acaster, Sarah Clifford, Ciaran P Kelly, Susan A Martin, Lisa M Meckley, Daniel A Leffler

Purpose: For patients with celiac disease (CeD), the only current management option is adherence to a strict gluten-free diet (GFD); however, many patients on a GFD continue to experience symptoms with a significant impact on quality of life. Potential new treatments for CeD are under development and a validated patient-reported outcome measure is required to evaluate their utility in clinical trials. The purpose of this article is to provide a history of the development of the Celiac Disease Symptom Diary (CDSD) 2.1© for use in clinical trials.

Methods: Qualitative and quantitative studies were conducted from 2010 to 2021, including concept elicitation and cognitive debriefing interviews with adult and adolescent participants with CeD (N = 93) diagnosed via biopsy and/or serology and input from eight interviews with CeD clinical experts. During these studies, different iterations of the CDSD were presented to the US Food and Drug Administration and the European Medicines Agency, and modifications were made in line with their feedback.

Results: These studies ultimately led to the development of CDSD 2.1©, a daily diary which focuses on key symptoms of CeD (abdominal pain, bloating, diarrhea, nausea and tiredness). This patient-reported outcome measure was readily understood by adult and adolescent participants with CeD and content validity was demonstrated in both populations.

Conclusion: CDSD 2.1© is a content-valid patient-reported outcome measure developed in accordance with best practices and regulatory guidance. A thorough exploration of the psychometric properties of CDSD 2.1© for both adult and adolescent participants with CeD is ongoing to support utilization in clinical trials.

目的:对于乳糜泻(CeD)患者来说,目前唯一的治疗方法是坚持严格的无麸质饮食(GFD);然而,许多患者在坚持无麸质饮食后仍会出现症状,严重影响生活质量。潜在的 CeD 新疗法正在开发中,需要一种经过验证的患者报告结果测量方法来评估其在临床试验中的效用。本文旨在介绍用于临床试验的乳糜泻症状日记(CSD)2.1© 的开发历史:方法:2010年至2021年期间进行了定性和定量研究,包括对通过活检和/或血清学确诊患有乳糜泻的成人和青少年参与者(N = 93)进行概念诱导和认知汇报访谈,以及对8名乳糜泻临床专家进行访谈。在这些研究过程中,我们向美国食品药品管理局和欧洲药品管理局提交了 CDSD 的不同迭代版本,并根据他们的反馈意见进行了修改:这些研究最终促成了 CDSD 2.1©的开发,它是一种侧重于 CeD 主要症状(腹痛、腹胀、腹泻、恶心和疲倦)的每日日记。成人和青少年 CeD 参与者很容易理解这种由患者报告的结果测量方法,而且这两种人群都证明了其内容的有效性:CDSD 2.1©是根据最佳实践和法规指南开发的一种内容效度良好的患者报告结果测量方法。目前正在对 CDSD 2.1©针对成人和青少年 CeD 参与者的心理测量特性进行深入探讨,以支持在临床试验中的应用。
{"title":"Development of the celiac disease symptom diary version 2.1<sup>©</sup> (CDSD 2.1<sup>©</sup>) patient-reported outcome measure.","authors":"Kellee Howard, Daniel Adelman, Sonal Ghura, Sarah Acaster, Sarah Clifford, Ciaran P Kelly, Susan A Martin, Lisa M Meckley, Daniel A Leffler","doi":"10.1007/s11136-024-03799-6","DOIUrl":"https://doi.org/10.1007/s11136-024-03799-6","url":null,"abstract":"<p><strong>Purpose: </strong>For patients with celiac disease (CeD), the only current management option is adherence to a strict gluten-free diet (GFD); however, many patients on a GFD continue to experience symptoms with a significant impact on quality of life. Potential new treatments for CeD are under development and a validated patient-reported outcome measure is required to evaluate their utility in clinical trials. The purpose of this article is to provide a history of the development of the Celiac Disease Symptom Diary (CDSD) 2.1<sup>©</sup> for use in clinical trials.</p><p><strong>Methods: </strong>Qualitative and quantitative studies were conducted from 2010 to 2021, including concept elicitation and cognitive debriefing interviews with adult and adolescent participants with CeD (N = 93) diagnosed via biopsy and/or serology and input from eight interviews with CeD clinical experts. During these studies, different iterations of the CDSD were presented to the US Food and Drug Administration and the European Medicines Agency, and modifications were made in line with their feedback.</p><p><strong>Results: </strong>These studies ultimately led to the development of CDSD 2.1<sup>©</sup>, a daily diary which focuses on key symptoms of CeD (abdominal pain, bloating, diarrhea, nausea and tiredness). This patient-reported outcome measure was readily understood by adult and adolescent participants with CeD and content validity was demonstrated in both populations.</p><p><strong>Conclusion: </strong>CDSD 2.1<sup>©</sup> is a content-valid patient-reported outcome measure developed in accordance with best practices and regulatory guidance. A thorough exploration of the psychometric properties of CDSD 2.1<sup>©</sup> for both adult and adolescent participants with CeD is ongoing to support utilization in clinical trials.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testing the psychometric characteristics of EQ-5D-5L and respiratory bolt-ons using a sample of the Australian population. 使用澳大利亚人口样本测试 EQ-5D-5L 和呼吸系统附加功能的心理测量特性。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-26 DOI: 10.1007/s11136-024-03817-7
Mina Bahrampour, Slavica Kochovska, David C Currow, Rosalie Viney, Brendan Mulhern

Purpose: The EQ-5D has been used to assess health related quality of life (HRQoL) in respiratory conditions. However, the core descriptive system may not be sensitive to all the HRQoL impacts of these conditions. To increase the sensitivity of the descriptive system, two respiratory specific bolt-ons, have been developed. Psychometric assessment of the bolt-ons in comparison to other validated instruments is required to facilitate their use. Therefore, the aim of this study is to test the psychometric characteristics of the EQ-5D-5L + R using a large dataset collected in Australia.

Methods: A cross-sectional online survey was used to recruit adult respondents (≥ 18 years) representative of the Australian population. Descriptive and psychometric analyses were used to understand the performance of the EQ-5D-5L and bolt-ons in comparison to other validated instruments. The construct validity was estimated using correlations. Known-group validity was tested to determine the sensitivity of the instruments to differences across different severity groups.

Results: Overall 10,033 respondents (52% female) completed the survey, of which 300 had a respiratory condition. There were moderate to high correlation between bolt-ons with EQ-5D-5L and WHODAS. The EQ-5D-5L + bolt-ons slightly reduced the ceiling effect in comparison to the EQ-5D-5L. The effect size was larger for people with respiratory conditions than people who did not have a respiratory condition.

Conclusion: The results show that adding the respiratory bolt-on to the EQ-5D-5L might slightly improve the instruments descriptive sensitivity. The choice of bolt-on may be driven by whether overall problems or limitations are being measured.

目的:EQ-5D 已被用于评估呼吸系统疾病的健康相关生活质量(HRQoL)。然而,核心描述系统对这些疾病的所有 HRQoL 影响可能并不敏感。为了提高描述系统的灵敏度,我们开发了两个专门针对呼吸系统的附加功能。与其他经过验证的工具相比,需要对这些附加工具进行心理计量学评估,以方便使用。因此,本研究旨在利用在澳大利亚收集的大量数据集测试 EQ-5D-5L + R 的心理测量特性:方法:采用横断面在线调查的方式招募代表澳大利亚人口的成年受访者(≥ 18 岁)。通过描述性分析和心理计量分析,了解 EQ-5D-5L 和附加工具与其他有效工具相比的表现。使用相关性估算了构建效度。对已知群体有效性进行了测试,以确定这些工具对不同严重程度群体之间差异的敏感性:共有 10,033 名受访者(52% 为女性)完成了调查,其中 300 人患有呼吸系统疾病。EQ-5D-5L和WHODAS之间存在中度到高度的相关性。与EQ-5D-5L相比,EQ-5D-5L+栓剂略微降低了上限效应。与没有呼吸系统疾病的人相比,有呼吸系统疾病的人的效应规模更大:结果表明,在 EQ-5D-5L 中添加呼吸系统附加项目可略微提高工具的描述灵敏度。选择何种附加项可能取决于测量的是整体问题还是局限性。
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引用次数: 0
Health-related quality of life in 205 children with arthrogryposis multiplex congenita. 205 名先天性关节发育不良儿童的健康相关生活质量。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-22 DOI: 10.1007/s11136-024-03808-8
Shahrzad Nematollahi, Emmanouil Rampakakis, Michael Amara, Reggie C Hamdy, Frank Rauch, Lauren C Hyer, Michelle A James, Haluk Altiok, Ellen Raney, Jonathan Pellett, Cary Mielke, Sarah B Nossov, Sena Tavukcu, Philip F Giampietro, Noémi Dahan-Oliel

Purpose: Arthrogryposis multiplex congenita (AMC) describes a heterogeneous group of rare congenital conditions. Health-related quality of life (HRQL) may be reduced in AMC due to broadly heterogeneous physical impairments and participation limitations. This study described HRQL in children and youth with AMC, compared HRQL between child self- and parent-proxy reports, and identified factors associated with better/worse HRQL.

Methods: Data on 205 children with AMC (age 8-21 years) from a North American AMC registry across eight hospital sites was used. HRQL was assessed cross-sectionally using the Patient Reported Outcome Measurement Information System (PROMIS) and European Quality of Life-5 Dimensions-Youth-3 Levels (EQ-5D-Y-3 L) by self-report, parent proxy-report or both.

Results: Mean child-reported PROMIS T-scores were significantly lower than the normal mean for the Upper Extremity (mean = 33.0) and Mobility (mean = 37.2) but in the normal range for Pain Interference (mean = 46.6) and Peer Relationships (mean = 51.7). A lot of problems in EQ-5D-Y-3 L was reported by 37% in Feeling Worried/ Sad/ Unhappy, 46% in Having Pain/Discomfort, 50% in Doing Usual Activities, 56% in Mobility, and 57% in Looking After Myself. Compared to child-report, parents reported significantly worse PROMIS T-scores and higher problems in EQ-5D domains. Wheelchair use, being small for gestational age, prolonged hospitalization after birth, increased number of orthopedic surgeries, and caregiver's stress were associated with lower HRQL scores.

Conclusion: Findings indicate the importance of considering both the child's and parents' reports of HRQL, and to provide multimodal interventions that focus on the effect of childhood and parental characteristics to promote HRQL among children with AMC.

目的:先天性多关节炎(AMC)是一种异质性的罕见先天性疾病。AMC患者的健康相关生活质量(HRQL)可能会因广泛的异质性身体损伤和参与限制而降低。这项研究描述了患有AMC的儿童和青少年的HRQL,比较了儿童自我报告和父母代理报告之间的HRQL,并确定了与更好/更差的HRQL相关的因素:研究使用了205名患有AMC的儿童(8-21岁)的数据,这些数据来自北美的一个AMC登记处,分布在8家医院。采用患者报告结果测量信息系统(PROMIS)和欧洲生活质量-5维度-青年-3水平(EQ-5D-Y-3 L),通过自我报告、家长代理报告或两者兼而有之的方式对HRQL进行横截面评估:结果:儿童报告的PROMIS T分平均值在上肢(平均值=33.0)和活动能力(平均值=37.2)方面明显低于正常平均值,但在疼痛干扰(平均值=46.6)和同伴关系(平均值=51.7)方面处于正常范围。在EQ-5D-Y-3 L中,37%的受试者表示在 "感到担忧/悲伤/不开心"、46%的受试者表示在 "疼痛/不适"、50%的受试者表示在 "进行日常活动"、56%的受试者表示在 "行动能力 "和57%的受试者表示在 "照顾自己 "方面存在很多问题。与儿童报告相比,家长报告的 PROMIS T 分数明显较低,EQ-5D 领域的问题较多。使用轮椅、胎龄小、出生后住院时间长、矫形手术次数增加以及护理人员的压力与较低的 HRQL 评分有关:研究结果表明,必须同时考虑儿童和父母对 HRQL 的报告,并提供多模式干预措施,重点关注儿童和父母特征对促进 AMC 儿童 HRQL 的影响。
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引用次数: 0
Determinants of quality of life decrease in family caregivers of care-dependent patients: a longitudinal study. 护理依赖型病人的家庭照顾者生活质量下降的决定因素:一项纵向研究。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-19 DOI: 10.1007/s11136-024-03814-w
Marcus Luciano de Oliveira Tavares, Adriano Marçal Pimenta, Cristina García-Vivar, Mark Anthony Beinner, Lívia Cozer Montenegro

Purpose: Family caregivers of care-dependent patients experience a decline in their Quality of Life (QoL). However, the determinants contributing to this decrease in QoL are still not fully understood. Therefore, this study aimed to estimate prospectively the determinants contributing to decreased QoL among family caregivers of care-dependent patients.

Methods: This longitudinal study involved 135 family caregivers in Brazil. Data were collected at baseline from October 2016 to August 2017, and at follow-up from December 2021 to July 2022. During both periods, we administered a questionnaire that covered sociodemographic, health, and lifestyle characteristics of the participants; the Barthel Index to assess the dependency level of the patients; and the WHOQOL-bref to assess the caregivers' QoL.

Results: Both caregivers and care-dependent patients were more frequently elderly (44.4% versus 74.6%), female (79.3% versus 61.5%), and had non-communicable disease (60.0% versus 94.3%) at baseline. Most patients experienced a worsening in their level of dependency (59.8%), while over a third of family caregivers (34.8%) reported a decline in their General Quality of Life Index. Eight determinants of decreased QoL were identified: four protective factors (religious faith, physical activity, sharing caregiving responsibilities, and sufficient sleep) and four risk factors (patient hospitalization in the past year, patient increased care dependency, older family caregiver age, and longer caregiving duration).

Conclusion: Many factors influencing caregiver QoL are modifiable through intervention, underscoring the need for public policies to support family caregivers. Healthcare professionals can play a vital role in promoting protective factors and addressing risk factors to enhance caregiver QoL.

目的依赖护理的病人的家庭护理者的生活质量(QoL)会下降。然而,导致生活质量下降的决定因素仍未完全明了。因此,本研究旨在前瞻性地评估导致护理依赖型患者的家庭照顾者生活质量下降的决定因素:这项纵向研究涉及巴西的 135 名家庭照顾者。基线数据收集时间为 2016 年 10 月至 2017 年 8 月,随访数据收集时间为 2021 年 12 月至 2022 年 7 月。在这两个阶段,我们发放了一份调查问卷,内容包括参与者的社会人口学、健康和生活方式特征;评估患者依赖程度的巴特尔指数;以及评估照顾者QoL的WHOQOL-bref:结果:基线时,护理者和依赖护理的患者均多为老年人(44.4% 对 74.6%)、女性(79.3% 对 61.5%)和非传染性疾病患者(60.0% 对 94.3%)。大多数患者的依赖程度恶化(59.8%),而超过三分之一的家庭护理者(34.8%)报告其一般生活质量指数下降。研究发现了导致生活质量下降的八个决定因素:四个保护因素(宗教信仰、体育锻炼、分担护理责任和充足睡眠)和四个风险因素(过去一年患者住院、患者护理依赖性增加、家庭护理者年龄较大和护理时间较长):影响照顾者生活质量的许多因素都可以通过干预加以改变,这说明有必要制定支持家庭照顾者的公共政策。医疗保健专业人员在促进保护性因素和应对风险因素以提高护理人员的生活质量方面可以发挥重要作用。
{"title":"Determinants of quality of life decrease in family caregivers of care-dependent patients: a longitudinal study.","authors":"Marcus Luciano de Oliveira Tavares, Adriano Marçal Pimenta, Cristina García-Vivar, Mark Anthony Beinner, Lívia Cozer Montenegro","doi":"10.1007/s11136-024-03814-w","DOIUrl":"https://doi.org/10.1007/s11136-024-03814-w","url":null,"abstract":"<p><strong>Purpose: </strong>Family caregivers of care-dependent patients experience a decline in their Quality of Life (QoL). However, the determinants contributing to this decrease in QoL are still not fully understood. Therefore, this study aimed to estimate prospectively the determinants contributing to decreased QoL among family caregivers of care-dependent patients.</p><p><strong>Methods: </strong>This longitudinal study involved 135 family caregivers in Brazil. Data were collected at baseline from October 2016 to August 2017, and at follow-up from December 2021 to July 2022. During both periods, we administered a questionnaire that covered sociodemographic, health, and lifestyle characteristics of the participants; the Barthel Index to assess the dependency level of the patients; and the WHOQOL-bref to assess the caregivers' QoL.</p><p><strong>Results: </strong>Both caregivers and care-dependent patients were more frequently elderly (44.4% versus 74.6%), female (79.3% versus 61.5%), and had non-communicable disease (60.0% versus 94.3%) at baseline. Most patients experienced a worsening in their level of dependency (59.8%), while over a third of family caregivers (34.8%) reported a decline in their General Quality of Life Index. Eight determinants of decreased QoL were identified: four protective factors (religious faith, physical activity, sharing caregiving responsibilities, and sufficient sleep) and four risk factors (patient hospitalization in the past year, patient increased care dependency, older family caregiver age, and longer caregiving duration).</p><p><strong>Conclusion: </strong>Many factors influencing caregiver QoL are modifiable through intervention, underscoring the need for public policies to support family caregivers. Healthcare professionals can play a vital role in promoting protective factors and addressing risk factors to enhance caregiver QoL.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-year trajectories of physical and mental health-related quality of life, fatigue and dyspnoea in COVID-19 survivors. COVID-19幸存者与身心健康相关的生活质量、疲劳和呼吸困难的一年轨迹。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-19 DOI: 10.1007/s11136-024-03812-y
Gerko Schaap, John F Davelaar, Peter M Ten Klooster, Carine J M Doggen, Job van der Palen, Christina Bode, Harald E Vonkeman

Purpose: A substantial number of people experience a persisting impact on health-related quality of life (HRQoL) after COVID-19. The current study aims to identify different trajectories of physical and mental HRQoL, fatigue severity, and dyspnoea severity following hospitalisation with COVID-19, and associated factors of these trajectories.

Methods: 500 patients with COVID-19 were followed for one year in a longitudinal cohort study. Self-reported outcomes were measured at 3, 6, 9, and 12 months after hospitalisation. Distinct trajectories were characterised using Growth Mixture Modelling. Sociodemographic and clinical correlates of trajectories were investigated using multivariable (multinomial) logistic regression analyses.

Results: Three trajectories ('stable high' (16%), 'improving' (40%), and 'stable low' (44%)) were found for physical HRQoL, and four ('stable high' (43%), 'improving' (14%), 'middle declining' (17%), and 'low' (26%)) for mental HRQoL. Older age, overweight and obesity, lower education, and comorbidities were associated with 'low' physical HRQoL. Younger age was associated with 'low' mental HRQoL. Four fatigue trajectories ('no fatigue' (15%), 'improving' (40%), 'low-severe' (27%), and 'high-severe' (18%)) were found. Participants either experienced almost never ('no dyspnoea', 75%) or almost always ('severe', 25%) dyspnoea. High co-occurrences between low HRQoL and severe fatigue and dyspnoea symptom trajectories were found.

Conclusion: A substantial number of COVID-19 survivors continue to struggle with reduced HRQoL over time. However, large variations in these physical and mental HRQoL trajectories exist, and trajectories are associated with persisting COVID-19-related symptoms or pre-hospitalised health status. Regular measurement of HRQoL and post-COVID symptoms may help identify those that may benefit from timely interventions.

目的:很多人在感染 COVID-19 后,健康相关生活质量(HRQoL)会持续受到影响。本研究旨在确定 COVID-19 患者住院后身心健康相关生活质量、疲劳严重程度和呼吸困难严重程度的不同轨迹,以及这些轨迹的相关因素。在住院后的 3、6、9 和 12 个月对自我报告的结果进行测量。采用生长混合模型对不同的轨迹进行了描述。使用多变量(多项式)逻辑回归分析研究了轨迹的社会人口学和临床相关性:结果:在身体 HRQoL 方面发现了三种轨迹("稳定偏高"(16%)、"改善"(40%)和 "稳定偏低"(44%)),在心理 HRQoL 方面发现了四种轨迹("稳定偏高"(43%)、"改善"(14%)、"中度下降"(17%)和 "偏低"(26%))。年龄较大、超重和肥胖、教育程度较低以及合并症与身体 HRQoL 的 "低 "有关。年龄较小与 "低 "心理 HRQoL 有关。研究发现了四种疲劳轨迹("无疲劳"(15%)、"有改善"(40%)、"低-严重"(27%)和 "高-严重"(18%))。参与者要么几乎从未出现过呼吸困难("无呼吸困难",75%),要么几乎总是出现呼吸困难("严重",25%)。研究发现,低 HRQoL 与严重疲劳和呼吸困难症状轨迹之间的共同发生率很高:结论:随着时间的推移,大量 COVID-19 幸存者的 HRQoL 继续下降。然而,这些身体和精神的 HRQoL 轨迹存在很大差异,而且这些轨迹与 COVID-19 相关症状的持续存在或入院前的健康状况有关。定期测量 HRQoL 和 COVID 后症状可能有助于识别那些可能受益于及时干预的患者。
{"title":"One-year trajectories of physical and mental health-related quality of life, fatigue and dyspnoea in COVID-19 survivors.","authors":"Gerko Schaap, John F Davelaar, Peter M Ten Klooster, Carine J M Doggen, Job van der Palen, Christina Bode, Harald E Vonkeman","doi":"10.1007/s11136-024-03812-y","DOIUrl":"https://doi.org/10.1007/s11136-024-03812-y","url":null,"abstract":"<p><strong>Purpose: </strong>A substantial number of people experience a persisting impact on health-related quality of life (HRQoL) after COVID-19. The current study aims to identify different trajectories of physical and mental HRQoL, fatigue severity, and dyspnoea severity following hospitalisation with COVID-19, and associated factors of these trajectories.</p><p><strong>Methods: </strong>500 patients with COVID-19 were followed for one year in a longitudinal cohort study. Self-reported outcomes were measured at 3, 6, 9, and 12 months after hospitalisation. Distinct trajectories were characterised using Growth Mixture Modelling. Sociodemographic and clinical correlates of trajectories were investigated using multivariable (multinomial) logistic regression analyses.</p><p><strong>Results: </strong>Three trajectories ('stable high' (16%), 'improving' (40%), and 'stable low' (44%)) were found for physical HRQoL, and four ('stable high' (43%), 'improving' (14%), 'middle declining' (17%), and 'low' (26%)) for mental HRQoL. Older age, overweight and obesity, lower education, and comorbidities were associated with 'low' physical HRQoL. Younger age was associated with 'low' mental HRQoL. Four fatigue trajectories ('no fatigue' (15%), 'improving' (40%), 'low-severe' (27%), and 'high-severe' (18%)) were found. Participants either experienced almost never ('no dyspnoea', 75%) or almost always ('severe', 25%) dyspnoea. High co-occurrences between low HRQoL and severe fatigue and dyspnoea symptom trajectories were found.</p><p><strong>Conclusion: </strong>A substantial number of COVID-19 survivors continue to struggle with reduced HRQoL over time. However, large variations in these physical and mental HRQoL trajectories exist, and trajectories are associated with persisting COVID-19-related symptoms or pre-hospitalised health status. Regular measurement of HRQoL and post-COVID symptoms may help identify those that may benefit from timely interventions.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of rehabilitation with dental implants on the quality of life of patients undergoing maxillofacial reconstruction: a systematic review. 种植牙康复对颌面部重建患者生活质量的影响:系统性综述。
IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-17 DOI: 10.1007/s11136-024-03795-w
Simra Azher, Roisin McGrath, Yasaman Mohammadi Kamalabadi, Georgios Tsakos, Felix Sim, Ankur Singh

Purpose: Maxillofacial reconstruction with dental implants in microvascular tissue flaps aims to improve mastication. However, the quality of life (QoL) impact of this intervention is yet to be determined. This systematic review assessed the QoL impact of maxillofacial reconstruction with implant-supported teeth compared to no dental rehabilitation, removable dentures, and obturator (modified denture). Additionally, we examined instruments applied to measure QoL in maxillofacial reconstruction.

Methods: Databases Ovid Medline and Embase, Scopus, Web of Science and Handle on QoL were searched. Cohort, case-control and randomized controlled trials (RCT) were narratively synthesized for QoL captured through validated instruments. Study methodological quality was assessed using Cochrane Risk of Bias 2 and Risk of Bias in Non-randomized studies of Exposure. Instruments underwent COSMIN content validity analysis.

Results: Of a total of 2735 studies screened, the three included studies (two cohort and one RCT) showed improved QoL with maxillofacial reconstruction compared to obturator and no dental rehabilitation. However, these studies have high risk of bias due to confounding. None of the instruments achieved a sufficient relevance rating for maxillofacial reconstruction, having been designed for other target populations and there is no evidence on their content validity for this population, but the EORTC QLQ30 H&N35 satisfied more COSMIN criteria than the UW-QOL and OHIP-14.

Conclusion: Although studies showed favourable QoL with maxillofacial reconstruction involving dental implants, these have high risk of bias and further studies are needed to establish the impact. Existing QoL instruments lack content validity and tailored instruments are needed for QoL evaluation in maxillofacial reconstruction.

目的:在微血管组织瓣内植入牙科植入物进行颌面部重建的目的是改善咀嚼功能。然而,这种干预措施对生活质量(QoL)的影响尚未确定。本系统性综述评估了使用种植体支持的牙齿进行颌面重建与不进行牙齿修复、活动假牙和义齿(改良义齿)相比对生活质量的影响。此外,我们还研究了用于测量颌面部重建QoL的工具:方法:检索了 Ovid Medline 和 Embase、Scopus、Web of Science 和 Handle 等数据库中有关 QoL 的内容。对队列、病例对照和随机对照试验(RCT)进行了叙述性综合,以了解通过有效工具获得的 QoL。使用 Cochrane Risk of Bias 2 和 Risk of Bias in Non-randomized Studies of Exposure 对研究方法质量进行了评估。对工具进行了 COSMIN 内容有效性分析:在总共筛选出的2735项研究中,纳入的三项研究(两项队列研究和一项RCT研究)显示,颌面部重建与闭锁器和无牙科康复相比改善了QoL。然而,由于混杂因素,这些研究存在较高的偏倚风险。由于这些工具是为其他目标人群设计的,因此没有一个工具达到了与颌面部重建充分相关的评级,也没有证据表明其内容对这一人群有效,但 EORTC QLQ30 H&N35 比 UW-QOL 和 OHIP-14 更符合 COSMIN 标准:结论:尽管研究显示颌面部重建涉及牙科植入物时的 QoL 较好,但这些研究存在较高的偏倚风险,需要进一步研究以确定其影响。现有的 QoL 工具缺乏内容有效性,因此需要为颌面重建的 QoL 评估量身定制工具。
{"title":"Impact of rehabilitation with dental implants on the quality of life of patients undergoing maxillofacial reconstruction: a systematic review.","authors":"Simra Azher, Roisin McGrath, Yasaman Mohammadi Kamalabadi, Georgios Tsakos, Felix Sim, Ankur Singh","doi":"10.1007/s11136-024-03795-w","DOIUrl":"https://doi.org/10.1007/s11136-024-03795-w","url":null,"abstract":"<p><strong>Purpose: </strong>Maxillofacial reconstruction with dental implants in microvascular tissue flaps aims to improve mastication. However, the quality of life (QoL) impact of this intervention is yet to be determined. This systematic review assessed the QoL impact of maxillofacial reconstruction with implant-supported teeth compared to no dental rehabilitation, removable dentures, and obturator (modified denture). Additionally, we examined instruments applied to measure QoL in maxillofacial reconstruction.</p><p><strong>Methods: </strong>Databases Ovid Medline and Embase, Scopus, Web of Science and Handle on QoL were searched. Cohort, case-control and randomized controlled trials (RCT) were narratively synthesized for QoL captured through validated instruments. Study methodological quality was assessed using Cochrane Risk of Bias 2 and Risk of Bias in Non-randomized studies of Exposure. Instruments underwent COSMIN content validity analysis.</p><p><strong>Results: </strong>Of a total of 2735 studies screened, the three included studies (two cohort and one RCT) showed improved QoL with maxillofacial reconstruction compared to obturator and no dental rehabilitation. However, these studies have high risk of bias due to confounding. None of the instruments achieved a sufficient relevance rating for maxillofacial reconstruction, having been designed for other target populations and there is no evidence on their content validity for this population, but the EORTC QLQ30 H&N35 satisfied more COSMIN criteria than the UW-QOL and OHIP-14.</p><p><strong>Conclusion: </strong>Although studies showed favourable QoL with maxillofacial reconstruction involving dental implants, these have high risk of bias and further studies are needed to establish the impact. Existing QoL instruments lack content validity and tailored instruments are needed for QoL evaluation in maxillofacial reconstruction.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Quality of Life Research
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