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QJM: An International Journal of Medicine最新文献

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An immunological perspective in the treatment strategy of allergic bronchopulmonary aspergillosis. 过敏性支气管肺曲霉病治疗策略的免疫学观点。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-08 DOI: 10.1093/qjmed/hcaf005
Oscar M P Jolobe
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引用次数: 0
Post-kidney transplantation EBV-related brainstem encephalitis. 肾移植后ebv相关脑干脑炎。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-07 DOI: 10.1093/qjmed/hcaf003
Jianzhao Zhai, Huiyu Zhong, Minjin Wang
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引用次数: 0
Global and regional burden of cardiovascular diseases due to non-optimal temperature exposure: a systematic analysis with forecasts to 2050. 非最佳温度暴露导致的全球和区域心血管疾病负担：到2050年预测的系统分析。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-07 DOI: 10.1093/qjmed/hcaf002
Diptismita Jena, Bijaya Kumar Padhi

Background: Cardiovascular diseases (CVD) are leading contributors to global morbidity and mortality, significantly influenced by non-optimal temperatures. This study projects the impact of temperature fluctuations on CVD through 2050, considering environmental and climate changes.

Methods: Using Global Burden of Disease (GBD) study data, we analysed age-standardized death rates (ASDR) and disability-adjusted life years (ASR DALYs) related to non-optimal temperatures. We applied Estimated Annual Percentage Change (EAPC) for trend analysis and Auto-Regressive Integrated Moving Average (ARIMA) models for forecasting CVD mortality and DALYs from 2022 to 2050.

Results: EAPC analysis revealed a decline in CVD mortality rates, with a decrease of -0.32% for males (95% CI: -0.39% to -0.24%) and -0.42% for females (95% CI: -0.48% to -0.36%), indicating reduced mortality from non-optimal temperatures. Regions with higher Socio-Demographic Index (SDI) showed more significant declines. ARIMA forecasts predict a substantial increase in CVD burden with deaths projected to rise from 1.2 million in 2022 to 1.9 million by 2050, and DALYs expected to increase from 2.4 million to over 3 million during the same period.

Conclusion: The projected rise in CVD due to temperature variability highlights the need for robust health systems integrated with climate action to mitigate risks. This research underscores the importance of advancing SDG 3.4 to reduce non-communicable disease mortality and emphasizes climate considerations in health planning per SDG 13.

背景：心血管疾病（CVD）是全球发病率和死亡率的主要原因，受非最佳温度的显著影响。考虑到环境和气候变化，本研究预测了到2050年温度波动对心血管疾病的影响。方法：利用全球疾病负担（GBD）研究数据，分析与非最佳温度相关的年龄标准化死亡率（ASDR）和残疾调整生命年（ASR DALYs）。我们应用估计年百分比变化（EAPC）进行趋势分析，并应用自回归综合移动平均（ARIMA）模型预测2022年至2050年的心血管疾病死亡率和DALYs。结果：EAPC分析显示心血管疾病死亡率下降，男性下降-0.32% (95% CI: -0.39%至-0.24%)，女性下降-0.42% (95% CI: -0.48%至-0.36%)，表明非最佳温度导致的死亡率降低。社会人口指数（SDI）越高的地区下降越明显。ARIMA预测，心血管疾病负担将大幅增加，死亡人数预计将从2022年的120万增加到2050年的190万，伤残调整生命年预计将从240万增加到300多万。结论：由于温度变化，CVD预计会上升，这突出表明需要建立健全的卫生系统，并结合气候行动来降低风险。这项研究强调了推进可持续发展目标3.4以降低非传染性疾病死亡率的重要性，并强调了根据可持续发展目标13在卫生规划中考虑气候因素。
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引用次数: 0
Malignant Acanthosis Nigricans as a Dermatological Indicator of Gastric Adenocarcinoma: A Case Report. 恶性黑棘皮病作为胃腺癌的皮肤病指标：1例报告。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-03 DOI: 10.1093/qjmed/hcae252
Yihao Peng, Chengzhi Lv, Kai Huang, Shuang Zhao, Mingxin Li
{"title":"Malignant Acanthosis Nigricans as a Dermatological Indicator of Gastric Adenocarcinoma: A Case Report.","authors":"Yihao Peng, Chengzhi Lv, Kai Huang, Shuang Zhao, Mingxin Li","doi":"10.1093/qjmed/hcae252","DOIUrl":"https://doi.org/10.1093/qjmed/hcae252","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Presentation of Combined Oxidative Phosphorylation Deficiency 30 (COXPD30) & mutations in the TRMT10C gene. 氧化磷酸化缺陷30 （oxpd30）与TRMT10C基因突变的临床表现
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-02 DOI: 10.1093/qjmed/hcae251
Lin Wang, Li He, Bo Zhou, Kexing Li, Xiaoliang Liu
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引用次数: 0
Poikilodermatomyositis with anti-TIF1-γ antibodies overlap Sjogren's syndrome. 带有抗 TIF1-γ 抗体的 Poikilodermatomyositis 与 sjogren's 综合征重叠。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae173
X Wang, L Xie, Z Bu
{"title":"Poikilodermatomyositis with anti-TIF1-γ antibodies overlap Sjogren's syndrome.","authors":"X Wang, L Xie, Z Bu","doi":"10.1093/qjmed/hcae173","DOIUrl":"10.1093/qjmed/hcae173","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"51-52"},"PeriodicalIF":7.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of 25-OH vitamin D in Alzheimer's disease through Mendelian randomization and MRI. 通过孟德尔随机化和核磁共振成像研究 25-OH 维生素 D 在阿尔茨海默病中的作用。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae166
Ling-Ling Fu, Tobias Vollkommer, Sandra Fuest, Martin Gosau, Hongchao Feng, Ming Yan, Ralf Smeets, Simon Burg, Reinhard E Friedrich

Introduction: The mechanism underlying the relationship between Alzheimer's disease (AD) and minerals (serum calcium, copper, iron, magnesium, zinc), vitamins (25-OH vitamin D, vitamin A1 [retinol], B9 [folic acid], B12, C) is unclear.

Methods: In a two-step Mendelian randomization analysis, the association between positive nutritional elements and 3935 magnetic resonance images (MRI) phenotypes was examined, and the mediation proportion was calculated. Horizontal pleiotropy and heterogeneity of MR were assessed using MR-Egger, Cochran's Q test, MR-PRESSO. RESULTS: 25-OH vitamin D (P = 0.0019, OR = 0.6179, 95% CI = 0.4562-0.8368, inverse weighted variance [IVW]) is negatively associated with AD among 10 nutrients. The mediation proportion of the effect of vitamin D on AD mediated by IDP_dMRI_TBSS_L3_Superior_fronto-occipital_fasciculus_L was ∼7.08%.

Discussion: Our results support 25-OH vitamin D as a causal protective factor for Alzheimer disease. It was found that the Superior_fronto-occipital_fasciculus_L may play a minimal mediating role.

导言：阿尔茨海默病（AD）与矿物质（血清钙、铜、铁、镁、锌）、维生素（25-OH维生素D、维生素A1[视黄醇]、B9[叶酸]、B12、C）之间的关系机制尚不清楚：在两步孟德尔随机分析中，研究了积极营养元素与 3935 种 MRI 表型之间的关联，并计算了中介比例。结果：在 10 种营养素中，25-OH 维生素 D（p = 0.0019，OR = 0.6179，95% CI = 0.4562-0.8368，IVW）与 AD 负相关。IDP_dMRI_TBSS_L3_Superior_fronto-occipital_fasciculus_L介导的维生素D对AD影响的中介比例约为7.08%：我们的研究结果支持 25-OH 维生素 D 是阿尔茨海默病的因果保护因素。研究发现，颞叶上部_前枕叶_筋膜_L可能只发挥了极小的中介作用。
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引用次数: 0
Our circadian rhythms and optimizing when to take our medications.
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcaf031
Seamas C Donnelly
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引用次数: 0
Pityriasis rubra pilaris and underlying malignancy. 红斑狼疮和潜在的恶性肿瘤。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae192
Wang Lin, Wenting Xu, Cheng Tan
{"title":"Pityriasis rubra pilaris and underlying malignancy.","authors":"Wang Lin, Wenting Xu, Cheng Tan","doi":"10.1093/qjmed/hcae192","DOIUrl":"10.1093/qjmed/hcae192","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"53-54"},"PeriodicalIF":7.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycetoma and the dot in circle sign. 霉菌瘤和圆圈中的圆点标志。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae198
Nitin Gupta, Anjely Sebastian, Muralidhar Varma
{"title":"Mycetoma and the dot in circle sign.","authors":"Nitin Gupta, Anjely Sebastian, Muralidhar Varma","doi":"10.1093/qjmed/hcae198","DOIUrl":"10.1093/qjmed/hcae198","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"58-59"},"PeriodicalIF":7.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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