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QJM: An International Journal of Medicine最新文献

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Ursodeoxycholic acid and COVID-19 infection in people with liver transplantation. 肝移植患者的熊去氧胆酸和 COVID-19 感染。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae145
M-C Ou, C-P Li, R-Y Tsai, H-C Chang, S-Y Gau
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引用次数: 0
Optimizing epilepsy treatment: the impact of circadian rhythms and medication timing on conversion rates and survival. 优化癫痫治疗：昼夜节律和用药时间对转换率和存活率的影响。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae167
N Cheng, J Liu, X Kan, J Wang, Z Hui, J Chen

Background: The progression from isolated seizures to status epilepticus (SE) is a critical clinical issue. This study explores the influence of circadian rhythms on this transition and assesses the impact of medication timing on SE conversion rates and patient survival.

Aim: To determine the circadian patterns in the transition from isolated seizures to SE and to evaluate the efficacy of medication timing in reducing this conversion and improving survival outcomes.

Design and methods: Utilizing the eICU Collaborative Research Database v2.0, a retrospective analysis was performed on patients at risk of SE conversion. The study analyzed the correlation between SE conversion timing and AEDs administration in relation to circadian rhythms, using a Logit model to evaluate the impact of medication timing on SE conversion and survival.

Results: The transition from isolated seizures to SE showed distinct circadian patterns, with a delayed acrophase. Early night-time AEDs administration significantly reduced conversion rates. Medication timing also influenced survival rates, with higher survival during specific periods.

Conclusion: Circadian rhythms significantly affect the transition from isolated seizures to SE. Timely AEDs administration is crucial for reducing conversions and improving survival. A chronotherapeutic approach aligning AEDs administration with individual circadian vulnerabilities could advance epilepsy management in ICU settings. Future research should focus on personalized medication strategies that utilize circadian rhythms to optimize treatment effects.

背景：从孤立性癫痫发作发展为癫痫状态（SE）是一个关键的临床问题。本研究探讨了昼夜节律对这一转变的影响，并评估了用药时机对癫痫状态转变率和患者存活率的影响。目的：确定从孤立性癫痫发作转变为癫痫状态的昼夜节律模式，并评估用药时机对减少癫痫状态转变和改善存活率的效果：利用 eICU 合作研究数据库 v2.0，对有 SE 转换风险的患者进行回顾性分析。该研究分析了 SE 转换时间和 AEDs 给药与昼夜节律之间的相关性，并采用 Logit 模型评估了用药时间对 SE 转换和存活率的影响：结果：从孤立性癫痫发作到SE的转变过程呈现出明显的昼夜节律模式，其前后相延迟。夜间提早使用 AEDs 能显著降低转归率。用药时间也影响存活率，在特定时期存活率更高：结论：昼夜节律对从孤立性癫痫发作到 SE 的转变有重要影响。结论：昼夜节律会明显影响从孤立性癫痫发作到 SE 的转变，及时使用 AEDs 对于降低转归率和提高存活率至关重要。根据个体昼夜节律的易感性调整 AEDs 用药的时间治疗方法可促进 ICU 环境中的癫痫管理。未来的研究应侧重于利用昼夜节律优化治疗效果的个性化用药策略。
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引用次数: 0
Facial dysmorphism and limb abnormalities of fetal valproate syndrome. 胎儿丙戊酸钠综合征的面部畸形和肢体异常。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae165
B Singanamalla, P K Gunasekaran, A G Saini
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引用次数: 0
Histoid leprosy. 组织瘤麻风病
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae170
I Kaushal, A Sharma, T Narang, D Chatterjee, K Vinay
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引用次数: 0
Recurrent pregnancy loss caused by a novel gain-of-function variant in PLS3. 由 PLS3 的新型功能增益变异引起的复发性妊娠丢失。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae204
Xiangyuan Huang, Zhuo Meng, Bei Xu, Rui Zhang, Yong Wu
{"title":"Recurrent pregnancy loss caused by a novel gain-of-function variant in PLS3.","authors":"Xiangyuan Huang, Zhuo Meng, Bei Xu, Rui Zhang, Yong Wu","doi":"10.1093/qjmed/hcae204","DOIUrl":"10.1093/qjmed/hcae204","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"60-62"},"PeriodicalIF":7.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating time to withdrawal of anti-cancer drug indications that received FDA's accelerated approval. 评估获得 FDA 加速批准的抗癌药物适应症的撤药时间。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae115
H Hakariya, A Ozaki, S Mulinari, F Moriarty, T Tanimoto
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引用次数: 0
Double doughnut sign in dengue encephalitis. 登革热脑炎的双甜甜圈征
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae162
N Gupta, V Acharya, Cynthia Amrutha, M Varma
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引用次数: 0
A large number of autofluorescent crystals with hyphae in respiratory samples. 呼吸道样本中有大量带有菌丝的自发荧光晶体。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae194
K Nakagoshi, K Yorita, M Kunishige, H Takahashi, K Sumitomo, A Watanabe, T Shinohara
{"title":"A large number of autofluorescent crystals with hyphae in respiratory samples.","authors":"K Nakagoshi, K Yorita, M Kunishige, H Takahashi, K Sumitomo, A Watanabe, T Shinohara","doi":"10.1093/qjmed/hcae194","DOIUrl":"10.1093/qjmed/hcae194","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"55-57"},"PeriodicalIF":7.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the genetic etiology of CDH23 gene variation in a child with hearing loss. 听力损失儿童 CDH23 基因变异的遗传病因分析。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae212
Zhong Xue, Wang Yingzi, Jia Yaning, Wang Fengqi, Liu Shiguo
{"title":"Analysis of the genetic etiology of CDH23 gene variation in a child with hearing loss.","authors":"Zhong Xue, Wang Yingzi, Jia Yaning, Wang Fengqi, Liu Shiguo","doi":"10.1093/qjmed/hcae212","DOIUrl":"10.1093/qjmed/hcae212","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"65-67"},"PeriodicalIF":7.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Erdheim-Chester disease: an unusual presentation of a rare disorder. 乳腺 Erdheim-Chester 病：一种罕见疾病的不寻常表现。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2025-01-01 DOI: 10.1093/qjmed/hcae211
Jielin Jia, Tengwei Deng, Zhang Tao
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引用次数: 0
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