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Thrombotic Microangiopathy Following Snake Envenomation in Pregnancy. 妊娠期蛇咬伤后的血栓性微血管病。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae213
Sayan Mazumder, Suresh Selvam, P J Karthikashri, Pradeeth Sundar Reddy Gollamudi, Anashwara Merin Jacob, Ripudaman Sharma, Ankur Gupta, Ashok Kumar Pannu
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引用次数: 0
Black pleural effusion. 黑色胸腔积液
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-10-30 DOI: 10.1093/qjmed/hcae210
Shintaro Kakimoto, Yukinori Harada, Taro Shimizu
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引用次数: 0
The 'Chokubi' Phenomenon: Young Physicians' Exodus from State Service to Private Medicine in Japan. Chokubi "现象：日本年轻医生从国立医院流向私立医院。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-10-30 DOI: 10.1093/qjmed/hcae201
Momoka Yamamura, Akihiko Ozaki, Yudai Kaneda, Masaharu Tsubokura, Tetsuya Tanimoto
{"title":"The 'Chokubi' Phenomenon: Young Physicians' Exodus from State Service to Private Medicine in Japan.","authors":"Momoka Yamamura, Akihiko Ozaki, Yudai Kaneda, Masaharu Tsubokura, Tetsuya Tanimoto","doi":"10.1093/qjmed/hcae201","DOIUrl":"https://doi.org/10.1093/qjmed/hcae201","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the genetic etiology of CDH23 gene variation in a child with hearing loss. 听力损失儿童 CDH23 基因变异的遗传病因分析。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-10-30 DOI: 10.1093/qjmed/hcae212
Xue Zhong, Yingzi Wang, Yaning Jia, Fengqi Wang, Shiguo Liu
{"title":"Analysis of the genetic etiology of CDH23 gene variation in a child with hearing loss.","authors":"Xue Zhong, Yingzi Wang, Yaning Jia, Fengqi Wang, Shiguo Liu","doi":"10.1093/qjmed/hcae212","DOIUrl":"https://doi.org/10.1093/qjmed/hcae212","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Erdheim-Chester disease: an unusual presentation of a rare disorder. 乳腺 Erdheim-Chester 病：一种罕见疾病的不寻常表现。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-10-29 DOI: 10.1093/qjmed/hcae211
Jielin Jia, Tengwei Deng, Tao Zhang
{"title":"Breast Erdheim-Chester disease: an unusual presentation of a rare disorder.","authors":"Jielin Jia, Tengwei Deng, Tao Zhang","doi":"10.1093/qjmed/hcae211","DOIUrl":"https://doi.org/10.1093/qjmed/hcae211","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hymenolepsis Nana: The Dwarf Tape Worm. 侏儒带绦虫矮胶带虫
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-10-28 DOI: 10.1093/qjmed/hcae193
Sanjeev Sachdeva, Ravi Teja Reddy, Venkatesh Vaithiyam
{"title":"Hymenolepsis Nana: The Dwarf Tape Worm.","authors":"Sanjeev Sachdeva, Ravi Teja Reddy, Venkatesh Vaithiyam","doi":"10.1093/qjmed/hcae193","DOIUrl":"https://doi.org/10.1093/qjmed/hcae193","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Human Papillomavirus Infection and Offspring Neurodevelopmental Disorders. 母体人类乳头瘤病毒感染与后代神经发育障碍
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-10-24 DOI: 10.1093/qjmed/hcae207
Dian-Jeng Li, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen, Chih-Sung Liang

Background: Human papillomavirus (HPV) infection can lead to multiple comorbidities in women, including mental health problems. However, few studies have examined the association between maternal HPV infection and risk of neurodevelopmental disorders in their offspring.

Aim: We aimed to investigate the association between maternal HPV infection and risk of attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) among their offspring.

Design and methods: Data from the Taiwan National Health Insurance Research Database were used for analysis. Offspring of mothers with HPV infection were identified as the index group, and a demographic-matched group (offspring of mothers without HPV infection) was selected as the controls. The primary outcome was risk of ADHD or ASD. Cox regression models with multiple adjustments were used to estimate hazard ratios (HRs) with 95% of confidence intervals (CIs).

Results: We included 7,762 individuals in the index group and 31,048 in the control group. After adjusting for potential confounding factors, the index group had a higher risk of ADHD (HR: 1.39, 95% CI: 1.15-1.67) than the controls. Importantly, the risk remained significance when HPV infection was diagnosed either before (HR: 1.29, 95% CI: 1.05-1.59) or during pregnancy (HR: 1.79, 95% CI: 1.28-2.51). No increased risk of ASD was identified in the index group compared to the control group.

Conclusions: This study highlights the importance of preventing and treating HPV infection during and before pregnancy. Clinicians should be aware of the association between maternal HPV infection and ADHD in their offspring.

背景：人类乳头瘤病毒（HPV）感染可导致女性多种合并症，包括精神健康问题。目的：我们旨在调查母亲感染人乳头瘤病毒（HPV）与后代患注意缺陷多动障碍（ADHD）或自闭症谱系障碍（ASD）风险之间的关系：分析数据来自台湾国民健康保险研究数据库。将感染 HPV 的母亲的后代作为指标组，并选择人口统计学匹配组（未感染 HPV 的母亲的后代）作为对照组。主要结果是多动症或 ASD 的风险。采用多重调整的 Cox 回归模型来估计危险比（HRs）及 95% 的置信区间（CIs）：我们在指数组中纳入了 7,762 人，在对照组中纳入了 31,048 人。在对潜在的混杂因素进行调整后，指数组患多动症的风险（HR：1.39，95% 置信区间：1.15-1.67）高于对照组。重要的是，在怀孕前（HR：1.29，95% CI：1.05-1.59）或怀孕期间（HR：1.79，95% CI：1.28-2.51）诊断出HPV感染时，风险仍然显著。与对照组相比，未发现指数组发生 ASD 的风险增加：这项研究强调了在孕期和孕前预防和治疗人乳头瘤病毒感染的重要性。临床医生应了解母体HPV感染与后代多动症之间的关系。
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引用次数: 0
Multifunctional role of the tumor associated monocytes/macrophages in the metastatic potential of inflammatory breast cancer. 肿瘤相关单核细胞/巨噬细胞在炎性乳腺癌转移潜能中的多功能作用
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-10-22 DOI: 10.1093/qjmed/hcae195
Mona Mostafa Mohamed, Robert J Schneider

Inflammatory breast cancer (IBC) is the most aggressive and lethal phenotype form of breast cancer, which afflicts young women at high incidence in North Africa compared to other continents of the world. IBC is characterized by highly metastatic behavior and possesses specific pathobiological properties different from non-IBC. IBC disease displays unusual common properties at typical presentation, including positive metastatic lymph-nodes, high infiltration of tumor associated monocytes/macrophages, rapid progression to distant metastasis, and possibly the production of a unique repertoire of growth factors, cytokines and chemokines, as well as a striking association with different polarized macrophages compared to non-IBC. Indeed, tumor associated monocytes/macrophages (TAM/M) play a crucial role in breast cancer development. Previously, we showed that cross talk between IBC cells and patient derived TAMs occurs via secretion of inflammatory mediators from TAMs that act on specific extracellular domain receptors activating down-stream signaling pathways that promote the epithelial-to-mesenchymal transition, cancer cell invasion, IBC stem cell properties, drug resistance, local and metastatic recurrence of residual tumor cells and other key markers of malignancy, including in vitro colony formation capacity. In this mini review, we will discuss the role of TAMs in IBC cancer metastatic potential and molecules involved. The review also discusses the recent discoveries in the field of IBC research.

炎症性乳腺癌（IBC）是乳腺癌中最具侵袭性和致命性的表型，与世界其他大洲相比，北非年轻女性的发病率较高。IBC 的特点是高度转移，具有不同于非 IBC 的特殊病理生物学特性。与非 IBC 相比，IBC 疾病在典型表现上具有不寻常的共同特征，包括转移淋巴结阳性、肿瘤相关单核细胞/巨噬细胞高度浸润、迅速向远处转移、可能产生独特的生长因子、细胞因子和趋化因子，以及与不同极化巨噬细胞的显著关联。事实上，肿瘤相关单核细胞/巨噬细胞（TAM/M）在乳腺癌的发展中起着至关重要的作用。此前，我们研究发现，IBC细胞与患者衍生的TAMs之间通过TAMs分泌的炎症介质发生交叉反应，这些介质作用于特定的细胞外结构域受体，激活下行信号通路，促进上皮细胞向间质转化、癌细胞侵袭、IBC干细胞特性、耐药性、残留肿瘤细胞的局部和转移复发以及其他恶性肿瘤的关键标志物，包括体外集落形成能力。在这篇小型综述中，我们将讨论 TAMs 在 IBC 癌症转移潜能中的作用和相关分子。本综述还将讨论 IBC 研究领域的最新发现。
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引用次数: 0
Osteogenesis imperfecta as a cause of respiratory failure. 导致呼吸衰竭的成骨不全症。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-10-21 DOI: 10.1093/qjmed/hcae205
Masahiro Kashiura, Hiroyuki Tamura, Hideto Yasuda, Takashi Moriya
{"title":"Osteogenesis imperfecta as a cause of respiratory failure.","authors":"Masahiro Kashiura, Hiroyuki Tamura, Hideto Yasuda, Takashi Moriya","doi":"10.1093/qjmed/hcae205","DOIUrl":"https://doi.org/10.1093/qjmed/hcae205","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanded Dengue Syndrome: Dengue-Triggered Acute Chest Syndrome. 扩大的登革热综合征：登革热引发的急性胸部综合征。
IF 7.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
QJM: An International Journal of Medicine
Pub Date : 2024-10-21 DOI: 10.1093/qjmed/hcae184
Sarika Singh, Vivek Nayak M, Vasudev Acharya, Cynthia Amrutha Sukumar
{"title":"Expanded Dengue Syndrome: Dengue-Triggered Acute Chest Syndrome.","authors":"Sarika Singh, Vivek Nayak M, Vasudev Acharya, Cynthia Amrutha Sukumar","doi":"10.1093/qjmed/hcae184","DOIUrl":"https://doi.org/10.1093/qjmed/hcae184","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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