首页 > 最新文献

QJM: An International Journal of Medicine最新文献

英文 中文
Raccoon eyes and macroglossia in AL amyloidosis. AL淀粉样变的浣熊眼和大舌。
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-30 DOI: 10.1093/qjmed/hcag036
Ankur Jain
{"title":"Raccoon eyes and macroglossia in AL amyloidosis.","authors":"Ankur Jain","doi":"10.1093/qjmed/hcag036","DOIUrl":"https://doi.org/10.1093/qjmed/hcag036","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 修正。
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-29 DOI: 10.1093/qjmed/hcaf301
{"title":"Correction.","authors":"","doi":"10.1093/qjmed/hcaf301","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf301","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do megakaryocytes contribute to organ fibrosis? 巨核细胞是否导致器官纤维化?
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-28 DOI: 10.1093/qjmed/hcag031
Gerard Gurumurthy, Jecko Thachil

Megakaryocytes, the platelet precursors, have been known to populate tissues other than the bone marrow, most prominently the lung, but also the liver and spleen. Work in myeloproliferative neoplasms has established that dysplastic megakaryocytes are central organisers of the fibrosis in the bone marrow. In this commentary, we frame a hypothesis-gathering question as to whether megakaryocytes might analogously act as context-dependent contributors to organ fibrosis outside the marrow. In the lung, studies have identified resident/trafficking megakaryocytes with inflammatory properties, while in the liver, megakaryocytes-rich extramedullary foci often co-localise with periportal and perisinusoidal fibrosis. Approved agents for idiopathic pulmonary fibrosis act on broad growth-factor pathways across multiple cell types that may overlapwith the megakaryocytes/platelet secretome. It is thus possible that megakaryocytes may play a contributory role in organ fibrosis. We acknowledge that these observations are associative and preclinical, and that established epithelial-mesenchymal mechanisms remain central in organ fibrosis. We therefore do not assert that megakaryocytes are contributors of organ fibrosis. Rather, we pose this as a testable question prompted by converging yet incomplete evidence.

巨核细胞,血小板的前体,已经知道在骨髓以外的组织中存在,最显著的是肺,但也有肝脏和脾脏。对骨髓增生性肿瘤的研究已经证实,发育不良的巨核细胞是骨髓纤维化的中心组织者。在这篇评论中,我们提出了一个假设收集问题,即巨核细胞是否可能类似地作为骨髓外器官纤维化的环境依赖性贡献者。在肺部,研究发现巨核细胞具有炎症特性,而在肝脏,巨核细胞丰富的髓外灶通常与门静脉周围和脉管炎周围纤维化共定位。经批准的特发性肺纤维化药物作用于多种细胞类型的广泛生长因子通路,这些细胞类型可能与巨核细胞/血小板分泌组重叠。因此,巨核细胞可能在器官纤维化中起促进作用。我们承认这些观察结果是相关的和临床前的,并且已建立的上皮-间质机制仍然是器官纤维化的核心。因此,我们不能断言巨核细胞是器官纤维化的贡献者。相反,我们把它作为一个可测试的问题,由聚合但不完整的证据提示。
{"title":"Do megakaryocytes contribute to organ fibrosis?","authors":"Gerard Gurumurthy, Jecko Thachil","doi":"10.1093/qjmed/hcag031","DOIUrl":"https://doi.org/10.1093/qjmed/hcag031","url":null,"abstract":"<p><p>Megakaryocytes, the platelet precursors, have been known to populate tissues other than the bone marrow, most prominently the lung, but also the liver and spleen. Work in myeloproliferative neoplasms has established that dysplastic megakaryocytes are central organisers of the fibrosis in the bone marrow. In this commentary, we frame a hypothesis-gathering question as to whether megakaryocytes might analogously act as context-dependent contributors to organ fibrosis outside the marrow. In the lung, studies have identified resident/trafficking megakaryocytes with inflammatory properties, while in the liver, megakaryocytes-rich extramedullary foci often co-localise with periportal and perisinusoidal fibrosis. Approved agents for idiopathic pulmonary fibrosis act on broad growth-factor pathways across multiple cell types that may overlapwith the megakaryocytes/platelet secretome. It is thus possible that megakaryocytes may play a contributory role in organ fibrosis. We acknowledge that these observations are associative and preclinical, and that established epithelial-mesenchymal mechanisms remain central in organ fibrosis. We therefore do not assert that megakaryocytes are contributors of organ fibrosis. Rather, we pose this as a testable question prompted by converging yet incomplete evidence.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heerfordt's syndrome with glossopharyngeal and vagus nerve involvement: A rare manifestation of sarcoidosis. 伴有舌咽部和迷走神经受累的Heerfordt综合征:结节病的一种罕见表现。
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-24 DOI: 10.1093/qjmed/hcag019
Rohit Kumar, Shuvrajyothi Mondal, Ranveer Singh Jadon, Ved Prakash Meena, Animesh Ray, Nishikant Dhamle, Piyush Ranjan, Sanjeev Sinha
{"title":"Heerfordt's syndrome with glossopharyngeal and vagus nerve involvement: A rare manifestation of sarcoidosis.","authors":"Rohit Kumar, Shuvrajyothi Mondal, Ranveer Singh Jadon, Ved Prakash Meena, Animesh Ray, Nishikant Dhamle, Piyush Ranjan, Sanjeev Sinha","doi":"10.1093/qjmed/hcag019","DOIUrl":"https://doi.org/10.1093/qjmed/hcag019","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: Persistent Racial Disparities in Lung Cancer Survival and the Overlooked Role of Post-Treatment Care. 回答:持续的种族差异在肺癌生存和治疗后护理被忽视的作用。
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-24 DOI: 10.1093/qjmed/hcag030
Yuze Yin, Yinyan Gao, Hang Yi, Guochao Zhang, Yousheng Mao, Jie Wang
{"title":"Reply: Persistent Racial Disparities in Lung Cancer Survival and the Overlooked Role of Post-Treatment Care.","authors":"Yuze Yin, Yinyan Gao, Hang Yi, Guochao Zhang, Yousheng Mao, Jie Wang","doi":"10.1093/qjmed/hcag030","DOIUrl":"https://doi.org/10.1093/qjmed/hcag030","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent Racial Disparities in Lung Cancer Survival and the Overlooked Role of Post-Treatment Care. 持续的种族差异在肺癌生存和忽视治疗后护理的作用。
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-24 DOI: 10.1093/qjmed/hcag029
Bi-Yu Gao, Chin-Feng Tsai
{"title":"Persistent Racial Disparities in Lung Cancer Survival and the Overlooked Role of Post-Treatment Care.","authors":"Bi-Yu Gao, Chin-Feng Tsai","doi":"10.1093/qjmed/hcag029","DOIUrl":"https://doi.org/10.1093/qjmed/hcag029","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute vs chronic arsenic poisoning. Reply. 急性与慢性砷中毒。回复。
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-22 DOI: 10.1093/qjmed/hcag003
Run Dong, Yang Jiao
{"title":"Acute vs chronic arsenic poisoning. Reply.","authors":"Run Dong, Yang Jiao","doi":"10.1093/qjmed/hcag003","DOIUrl":"https://doi.org/10.1093/qjmed/hcag003","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Title: Mitochondrial Integrity, Telomere Dynamics, and Causal Pathways in Pulmonary Fibrosis: Reappraisal of a Mendelian Analysis. 标题:肺纤维化的线粒体完整性、端粒动力学和因果通路:孟德尔分析的重新评估。
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-21 DOI: 10.1093/qjmed/hcag023
Tsai Ling Ting, Yuan-Ti Lee
{"title":"Title: Mitochondrial Integrity, Telomere Dynamics, and Causal Pathways in Pulmonary Fibrosis: Reappraisal of a Mendelian Analysis.","authors":"Tsai Ling Ting, Yuan-Ti Lee","doi":"10.1093/qjmed/hcag023","DOIUrl":"https://doi.org/10.1093/qjmed/hcag023","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: Comment on "New insights from mendelian randomization and mediation analysis: causal relationships between mitochondrial DNA copy number and telomere length in pulmonary fibrosis". 回复:对“孟德尔随机化和中介分析的新见解:肺纤维化中线粒体DNA拷贝数和端粒长度的因果关系”的评论。
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-21 DOI: 10.1093/qjmed/hcag025
Yan Li, Lin Hou
{"title":"Reply: Comment on \"New insights from mendelian randomization and mediation analysis: causal relationships between mitochondrial DNA copy number and telomere length in pulmonary fibrosis\".","authors":"Yan Li, Lin Hou","doi":"10.1093/qjmed/hcag025","DOIUrl":"https://doi.org/10.1093/qjmed/hcag025","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reassessing Ménétrier's Disease: Diagnostic Variability, Molecular Subtypes, and Implications for Precision Therapy. 重新评估梅氏病:诊断变异性、分子亚型和精确治疗的意义。
IF 6.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-20 DOI: 10.1093/qjmed/hcag027
Shiuan-Chih Chen, Ming-Cheng Lin
{"title":"Reassessing Ménétrier's Disease: Diagnostic Variability, Molecular Subtypes, and Implications for Precision Therapy.","authors":"Shiuan-Chih Chen, Ming-Cheng Lin","doi":"10.1093/qjmed/hcag027","DOIUrl":"https://doi.org/10.1093/qjmed/hcag027","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
QJM: An International Journal of Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1