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Impact of appliance therapy on orofacial muscle activity in mouth breathers: an electromyographic study. 器械治疗对口腔呼吸者口面肌活动的影响:肌电图研究。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-21 DOI: 10.3290/j.qi.b6496142
Madhulika Srivastava, Priyanka, Subash Singh, Rashika Singhania

Objectives: Mouth breathing is a condition that alters normal skeletal and dental development while also affecting the surrounding orofacial muscles. Electromyography (EMG) provides an objective method to assess these muscular changes. This study aimed to evaluate the activity of the buccinator, orbicularis oris, mentalis, sternocleidomastoid, and trapezius muscles in mouth breathers before and after interceptive therapy and compare these findings with those of nasal breathers.

Method and materials: Children aged 6 to 12 years were selected based on inclusion/exclusion criteria and categorized into two groups: group I (mouth breathers, n = 18) and group II (nasal breathers, n = 18). The electromyographic activity of all the five selected muscles were recorded at rest and during maximal contraction using an EMG Retrainer (Chattanooga Group, DJO), an intraoral device used to measure muscle activity, particularly in the orofacial region. Statistical analysis was performed using SPSS version 22.0 (IBM), with significance set at P < .05. The Mann-Whitney U test was used for intergroup and intragroup comparisons.

Results: Results showed significant differences in muscle activity before and after appliance therapy, particularly in the buccinator, mentalis, orbicularis oris, trapezius, and sternocleidomastoid muscles. Post-therapy, the orbicularis oris and buccinator muscles exhibited notable differences in mouth breathers.

Conclusion: Surface EMG can be a valuable diagnostic and biofeedback tool in pediatric interceptive orthodontics, aiding in treatment assessment and relapse prevention.

目的:口腔呼吸是一种改变正常骨骼和牙齿发育的情况,同时也影响周围的口面部肌肉。肌电图(EMG)提供了一种客观的方法来评估这些肌肉变化。本研究旨在评估口腔呼吸者在阻断治疗前后的颊肌、口轮匝肌、颏肌、胸锁乳突肌和斜方肌的活动,并将这些结果与鼻腔呼吸者的结果进行比较。方法与材料:根据纳入/排除标准选取6 ~ 12岁的儿童,将其分为两组:I组(口腔呼吸者,n=18)和II组(鼻腔呼吸者,n=18)。使用EMG Retrainer (Chattanooga Group Inc, DJO UK Ltd, Guildford Surrey, gu28xg United Kingdom)记录所有选定的五块肌肉在休息和最大收缩时的肌电图活动,EMG Retrainer是一种用于测量肌肉活动的口内装置,特别是在口腔面部区域。应用SPSS 22.0进行统计分析,结果显示矫治前后肌肉活动差异显著,尤其是颊肌、颏肌、口轮匝肌、斜方肌和胸锁乳突肌。治疗后,口轮匝肌和颊肌在口腔呼吸方面表现出显著差异。结论:体表肌电图是一种有价值的诊断和生物反馈工具,有助于儿童拦截正畸治疗评估和预防复发。
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引用次数: 0
Parental knowledge of oral prophylaxis and recommended fluoride concentration in toothpastes for children in Israel. 以色列父母对口腔预防的知识和儿童牙膏中建议的氟化物浓度。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-18 DOI: 10.3290/j.qi.b6287918
Ieva Avidana, Aaya Shahin, Jomana Hassan, Samer Srouji, Mervat Khoury Absawi

Objective: To evaluate parents' knowledge of the Israeli Ministry of Health guidelines on basic oral health practices and appropriate toothpaste usage for different pediatric age groups.

Method and materials: Anonymous questionnaires were distributed to parents attending the Pedodontics Department. The questionnaire included two sections: general questions and questions that were completed for all children in the family, categorizing them into three age groups: under 2 years, 2 to 6 years, and over 6 years.

Results: A total of 242 questionnaires and 410 responses across different age groups were collected. Most respondents knew that teeth should be brushed as soon as the first tooth appears and believed that the first dental visit should be at age 2 (60.5% and 26.9%, respectively). However, only 15% of parents answered both questions correctly. Toothpaste selection was primarily based on age (46.6%), with no significant differences across age groups for correct answer (P = .130). Awareness of the recommended fluoride concentration was low (16.1%), though parents of older children showed better knowledge (P = .040). Appropriate toothpaste amounts were used in 30.2% of the cases, with the 2- to 6-year age group demonstrating the highest awareness (P .001). Only 3.7% of parents correctly answered all three toothpaste-related questions. Overall, the knowledge score for toothpaste guidelines was highest in the middle age group (31.2%, SD = 28.66, P .001).

Conclusion: A minority of parents are familiar with recommended early dental care practices and correct toothpaste usage. The findings emphasize the need to improve parental awareness from the very beginning of a child's development. (Quintessence Int 2025;56:644-653; doi: 10.3290/j.qi.b6287918).

目的:评估家长对以色列卫生部关于不同儿童年龄组基本口腔卫生习惯和适当牙膏使用指南的了解程度。方法与材料:采用不记名问卷的方式对就诊的家长进行问卷调查。问卷包括两个部分:一般问题和针对家庭中所有儿童完成的问题,将他们分为三个年龄组:2岁以下,2至6岁和6岁以上。结果:共收集问卷242份,各年龄段回复410份。大多数回答者知道应在长出第一颗牙齿时立即刷牙,并认为应在两岁时进行第一次牙科检查(分别为60.5%和26.9%)。然而,只有15%的家长正确回答了这两个问题。牙膏选择主要基于年龄(46.6%),正确率在不同年龄组间无显著差异(P = 0.130)。对推荐氟化物浓度的了解程度较低(16.1%),但年龄较大儿童的家长对建议氟化物浓度的了解程度较高(P = 0.040)。30.2%的病例使用了适量的牙膏,其中2至6岁年龄组表现出最高的意识(P .001)。只有3.7%的家长正确回答了所有三个与牙膏有关的问题。总体而言,中年人牙膏指南知识得分最高(31.2%,SD = 28.66, P .001)。结论:少数家长熟悉推荐的早期牙齿保健方法和正确使用牙膏。研究结果强调了从孩子成长之初就提高父母意识的必要性。[j] .国精Int 2025;56:644-653; doi: 10.3290/ j.i q .b6287918]。
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引用次数: 0
Management of medication-related osteonecrosis of the jaw through the association of surgical treatment with local and systemic adjuvant therapies: a case series with follow-ups of up to 3 years. 通过手术治疗与局部和全身辅助治疗的关联来管理药物相关性颌骨骨坏死:一个随访长达3年的病例系列。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-18 DOI: 10.3290/j.qi.b6376673
Leonardo Faverani, Stefany Cruz, Leonardo Delanora, Izabela Delamura, Mirela Silva, João Fonseca E Santos, Tiburtino Lima Neto, Edilson Ervolino, Valdir Garcia, Leticia Theodoro, Ana Bassi

The objective of this case series was to report the outcomes of patients diagnosed with medication-related osteonecrosis of the jaw (MRONJ) and seek a remission through surgical management associated with local and systemic adjuvant therapies. A total of 14 patients were followed for up to 3 years, of whom one had MRONJ stage 0; three with stage I; seven with stage II; and four with stage III. Twelve patients underwent conservative sequestrectomy. In seven of these cases, the surgery was guided by fluorescence, using doxycycline preoperatively to remove necrotic bone tissue more accurately. In four participants, platelet-rich fibrin membranes were positioned at the surgical site before suturing. All 14 patients were instructed to perform daily mouthwashes with 0.12% chlorhexidine, and all underwent weekly sessions of antimicrobial photodynamic therapy according to the following protocol: Pre-irradiation with methylene blue (100 μg/mL) for 60 seconds, followed by irradiation with a low-level laser (600 nm; 100 mW; 214 J/cm2; 6 J/point; 60 s/point). Other adjuvant therapies were employed, such as the prescription of a combination of pentoxifylline and tocopherol, in addition to metronidazole paste. The proposed therapies led to remission in most patients, and although some of the patients did not achieve complete remission, they showed a significant reduction in pain complaints. These results demonstrate that the protocols used in this study are promising for the management of MRONJ in different stages. As such, they offer potential for the practice of surgeons and should be the object of further clinical investigations. (Quintessence Int 2025;56:654-666; doi: 10.3290/j.qi.b6376673).

本病例系列的目的是报告诊断为MRONJ的患者的结果,并通过局部和全身辅助治疗的手术治疗寻求缓解。共有14例患者随访长达3年,其中1例为MRONJ零期;第1阶段3个;7个为第二阶段;4例为第三阶段。12例患者行保守隔离切除术。在这些病例中,有7例手术在荧光引导下进行,术前使用强力霉素更准确地去除坏死骨组织。在四名参与者中,在缝合前将富血小板纤维蛋白(PRF)膜放置在手术部位。所有14例患者每天使用0.12%氯己定漱口,并根据以下方案每周进行抗菌光动力治疗(aPDT):亚甲蓝(100 μg/ml)预照射60 s,然后进行低强度激光(600 nm;100兆瓦;214 J / cm2;6 J /点;60年代/点)。其他辅助治疗被采用,如联合处方己酮茶碱和生育酚,除了甲硝唑膏。建议的治疗方法导致大多数患者缓解,尽管一些患者没有达到完全缓解,但他们的疼痛投诉显着减少。这些结果表明,本研究中使用的方案对于不同阶段的MRONJ的管理是有希望的。因此,它们为外科医生的实践提供了潜力,并应成为进一步临床研究的对象。
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引用次数: 0
Periodontitis and Mediterranean fever: a systematic review and metaanalysis. 牙周炎和地中海热:一项系统综述和荟萃分析。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-18 DOI: 10.3290/j.qi.b6353965
Iman Elahi Vahed, Mahtab Mottaghi, Nima Khamisi, Taymaz Shirinzadeh, Kimia Mosadeghi, Elina Almadi, Sepehr Salehi Omran, Rozhin Hedayatpour, Marieh Aalizadeh, Zohre Masoumi Shahr-E Babak, Mahta Malek, Mohammad Rahmanian

Background: Periodontitis is a severe oral health condition that damages the supporting bone and soft tissues surrounding the teeth. In recent years, it has become evident that periodontitis could increase systemic inflammatory markers. Some studies showed a potential link between periodontitis and autoinflammatory diseases, including Familial Mediterranean fever (FMF), which is a hereditary autoinflammatory condition. The current study aimed to comprehensively evaluate the association between FMF and periodontitis by analyzing clinical periodontal parameters-Plaque Index (PI), Gingival Index (GI), and Clinical Attachment Loss (CAL)-through a meta-analysis.

Methods: A thorough search was conducted across different databases, including PubMed, Scopus, Web of Science, and Google Scholar, covering publications up to July 2024. Eleven studies were included, consisting of one cohort and ten case controls. Following established methods, we performed data extraction and quality assessment of the selected publications. We conducted a meta-analysis to gather the effect sizes obtained from the eligible publications.

Results: The meta-analysis highlighted a statistically significant increase in PI among FMF patients compared to controls, with a pooled mean difference of 0.1833 (95% CI: 0.0012, 0.3655; p=0.0485), indicating higher plaque accumulation in FMF patients. On the other hand, CAL exhibited a non-significant mean difference of -0.0933 (95% CI: -0.2928 to 0.1062; p = 0.3596), and the GI similarly did not reach statistical significance, presenting a mean difference of 0.3223 (95% CI: -0.0713 to 0.7158; p = 0.1085).

Conclusion: Our investigation underscores a potential association between FMF and periodontitis, as seen by elevated levels of PI in FMF patients. These results suggest that FMF patients experience higher levels of periodontal inflammation, emphasizing the importance of periodontal care in this population.

背景:牙周炎是一种严重的口腔健康状况,损害牙齿周围的支撑骨和软组织。近年来,牙周炎明显可以增加全身炎症标志物。一些研究表明牙周炎与自身炎症性疾病之间存在潜在联系,包括家族性地中海热(FMF),这是一种遗传性自身炎症。本研究旨在通过荟萃分析,分析临床牙周参数-菌斑指数(PI)、牙龈指数(GI)和临床附着丧失(CAL),全面评估FMF与牙周炎之间的关系。方法:对PubMed、Scopus、Web of Science、b谷歌Scholar等数据库进行全面检索,检索截止到2024年7月的出版物。纳入了11项研究,包括1个队列和10个病例对照。按照既定的方法,我们对选定的出版物进行数据提取和质量评估。我们进行了荟萃分析,以收集从符合条件的出版物中获得的效应量。结果:荟萃分析显示,与对照组相比,FMF患者的PI有统计学意义的增加,合并平均差异为0.1833 (95% CI: 0.0012, 0.3655;p=0.0485),表明FMF患者斑块积累较高。另一方面,CAL的平均差异为-0.0933 (95% CI: -0.2928 ~ 0.1062;p = 0.3596), GI同样没有达到统计学意义,平均差异为0.3223 (95% CI: -0.0713 ~ 0.7158;P = 0.1085)。结论:我们的研究强调了FMF和牙周炎之间的潜在关联,正如FMF患者PI水平升高所见。这些结果表明,FMF患者牙周炎症水平较高,强调了牙周护理在这一人群中的重要性。
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引用次数: 0
Hybrid implant-supported restorations bonded to nitride-coated titanium bases: a clinical method to address biologic, functional, and esthetic challenges in the esthetic zone. 结合氮化涂层钛基的混合种植体支持修复体:一种解决美学领域生物、功能和美学挑战的临床方法。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-18 DOI: 10.3290/j.qi.b6353957
Rafael Del Castillo, Carlo Ercoli, Rafael Valera, José Díaz Fernández, Miguel Padial-Molina, Javier Ata-Ali

Objective: To describe how advancements in digital technologies and materials science provide additional restorative alternatives and material combinations for single- and multiple-unit implant-supported restorations, such as those incorporating the clinical use of nitride-coated titanium bases in combination with the two-piece, CAD/CAM, screw-retained, zirconia-ceramic, hybrid implant-supported restoration concept.

Case presentation: Two partially edentulous patients with missing teeth in the maxillary esthetic zone were treated with a novel technical and restorative concept using the two-piece CAD/CAM screw-retained zirconia-ceramic hybrid-abutment crown concept bonded to nitride-coated titanium bases. Biologic outcomes showed that tissues were maintained healthy with the patients showing an adequate oral hygiene level, no detectable plaque present upon probing, and no bleeding on probing. Esthetic evaluation demonstrated an excellent esthetic outcome and peri-implant soft-tissue integration with adjacent natural teeth and pontic tissue areas, together with posttreatment stability of the gingival zenith position. Neither of the two patients showed technical complications such as screw loosening or porcelain chipping/fracture. Radiographic evaluation revealed a precise fit between nitride-coated titanium bases and the implant connecting interfaces, no marginal bone loss, and stable implant osseointegration. The principal advantages of incorporating nitride-coated titanium bases in implant-supported restorations rely on the favorable esthetic outcomes, improved technical, mechanical, and biologic aspects, as well as the physicochemical characteristics of nitride-coated titanium bases' hard thin film coatings and their positive impact on titanium biocompatibility.

Conclusions: The short-term promising clinical outcomes of the two-piece CAD/CAM screw-retained, zirconia-ceramic hybrid-abutment crown concept bonded to nitride-coated titanium bases, indicate the potential clinical benefits of the described restorative alternative. However, additional in vitro investigations and randomized clinical trials are needed to validate these initial observations, especially those evaluating the two-piece CAD/CAM screw-retained, zirconia-ceramic hybrid-abutment crown bonded to nitride-coated titanium bases when compared to the conventional two-piece hybrid design as well as stock/custom, metal/zirconia/lithium disilicate, screw/cemented implant-supported restorations.

目的:描述数字技术和材料科学的进步如何为单个和多个单元种植体支持修复提供额外的修复选择和材料组合,例如将临床使用的氮化涂层钛基(TiN)与2片式、CAD/CAM、螺钉保留、氧化锆-陶瓷混合种植体支持修复概念相结合。材料与方法:对2例上颌美观区部分无牙缺失患者采用CAD/CAM螺钉保留氧化锆-陶瓷混合基冠概念结合氮化涂层钛基冠进行修复。临床结果:生物学结果显示,组织保持健康,患者表现出适当的口腔卫生水平,在探针时没有检测到菌斑,探针时没有出血。美学评估显示了良好的美学结果,种植体周围软组织与邻近天然牙和桥状组织区域的整合,以及治疗后牙龈顶位的稳定性。两例患者均未出现螺钉松动或瓷屑/骨折等技术并发症。x线评估显示TiN基基与种植体连接界面之间的精确配合,无边缘骨丢失和稳定的种植体骨整合。氮化涂层钛基(TiN)在种植体支撑修复体中的主要优势在于其良好的美学效果、技术、机械和生物学方面的改进,以及TiN硬薄膜涂层的物理化学特性及其对钛生物相容性的积极影响。结论:2片CAD/CAM螺钉保留,氧化锆陶瓷混合基冠概念结合氮化涂层钛基的短期临床结果表明,所述的修复替代方案具有潜在的临床益处。然而,需要额外的体外研究和随机临床试验来验证这些初步观察结果,特别是那些评估2片CAD/CAM螺钉保留、氧化锆陶瓷混合基冠结合TiN基冠与传统的2片混合设计以及库存/定制、金属/氧化锆/二硅酸锂、螺钉/骨水泥种植体支撑修复体的研究。
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引用次数: 0
Classification of postoperative bleeding severity by general dental practitioners in the National Dental Practice-Based Research Network: a survey-based assessment. 在全国牙科实践为基础的研究网络中,普通牙科医生术后出血严重程度的分类:一项基于调查的评估。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-18 DOI: 10.3290/j.qi.b6376527
Sharon Elad, Greg Connolly, Rita Cacciato, Rebekah Boy, Michael C Leo, William Calnon, Suzanne Gillespie, Denis Nyongesa, Gregg H Gilbert, Cyril Meyerowitz

Objective: The objectives of this study were to: (1) describe how general dental practitioners (GDPs) in the National Dental Practice-Based Research Network ('Network') classify the severity of postoperative bleeding; and (2) examine the association between bleeding severity classification and whether the GDP had residency training.

Method and materials: An electronic questionnaire was developed to assess GDPs' classification of bleeding severity for various scenarios following scaling or a single-tooth simple extraction, and to collect information about respondents' experience with bleeding scenarios. A total of 1,815 GDP members of the Network were invited to participate.

Results: A total of 866 GDPs responded. Strong agreement (low variability) was observed for scenarios that were classified as 'severe bleeding' (94.7% to 96.8%), and lower agreement (higher variability) was observed for scenarios classified as 'moderate bleeding' (53.2% to 65.2%). The GDP's classification of bleeding severity was not correlated with training in a General Practice Residency (GPR) or Advanced Education in General Dentistry (AEGD). A minority of respondents had experience with 'major bleeding' that may lead to hemodynamic emergency (15.5%) or a referral to an emergency department (4.8%).

Conclusion: This study identified scenarios for which there is high agreement and low agreement regarding bleeding severity classification among GDPs in the US. A small percentage of respondents had actual experience with major bleeding in their patients. Based on these results, a new tool is proposed to assess the severity of oral bleeding, intended to foster better communication between dental professionals. The new tool may assist GDPs to standardize documentation and communication with other health care professionals. (Quintessence Int 2025;56:668-679; doi: 10.3290/j.qi.b6376527).

目的:本研究的目的是:(1)描述国家牙科实践研究网络(“网络”)中的普通牙医(GDs)如何对术后出血的严重程度进行分类;(2)检验出血严重程度分级与GD是否接受住院医师培训的关系。方法:采用电子问卷的形式,评估受试者在刮除或单牙简单拔牙后不同情况下出血严重程度的分类,并收集受访者在出血情况下的经验信息。共有1815名GD网络成员获邀参与。结果:共有866名GDs回复。对于“严重出血”的情况(94.7% -96.8%),观察到强烈的一致性(低可变性),而对于“中度出血”的情况(53.2-65.2%),观察到较低的一致性(较高的可变性)。GD对出血严重程度的分类与全科住院医师(GPR)或高等牙科教育(AEGD)的培训无关。少数受访者有“大出血”的经历,这可能导致血液动力学紧急情况(15.5%)或转介到急诊室(4.8%)。结论:本研究确定了美国GDs中出血严重程度分级的高一致性和低一致性。一小部分受访者对其患者大出血有实际经验。基于这些结果,我们提出了一种评估口腔出血严重程度的新工具,旨在促进牙科专业人员之间更好的沟通。新工具可以帮助GDs标准化文档和与其他医疗保健专业人员的沟通。
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引用次数: 0
Take a step on the right track. 在正确的轨道上迈出一步。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-18 DOI: 10.3290/j.qi.b6574235
Yehuda Zadik, Shlomo P Zusman
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引用次数: 0
Influence of edentulous span length on complete-arch intraoral scanner accuracy: a comparative in vitro study. 无牙跨长度对全弓口内扫描精度的影响:一项体外比较研究。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-18 DOI: 10.3290/j.qi.b639465
Yaniv Mayer, Yarden Berg, Or Kfir, Alessio Triestino, Zvi Gutmacher, Luigi Canullo

Objectives: To assess the influence of edentulous span length on the accuracy of two intraoral scanner (IOS) devices Primescan (Dentsply Sirona) and Trios 3 (3Shape) in complete-arch scenarios. The hypothesis was that accuracy would decline with increasing span length, with performance differences between scanners.

Method and materials: An in vitro study was conducted using a maxillary complete-arch model with a central incisor implant. Twelve span-length scenarios (FA1 to FA12) were created by sequentially removing adjacent teeth. Each condition was scanned 10 times using both IOS devices (n = 240). A laboratory scanner (Identica blue, Medit) provided reference scans. Trueness (vs reference) and precision (intra-group) were evaluated using root mean square (RMS) error. Scans were aligned via automatic and local best-fit in Medit Design. Statistical analysis included two-way mixed ANOVA, repeated measures ANOVA, and linear regression with Bonferroni correction (α = .004).

Results: Trios 3 demonstrated lower overall RMS values (0.296 ± 0.043 mm) than Primescan (0.338 ± 0.049 mm), with significant differences in 9 of 12 scenarios (P .001). Correlation with span length was stronger for Primescan (R2 = 0.892) than Trios 3 (R2 = 0.674). Both devices showed high reliability.

Conclusions: Increasing edentulous span length negatively impacts scanner accuracy. Devices demonstrating consistent performance are preferable for reliable full-arch digital workflows. (Quintessence Int 2025;56:618-625; doi: 10.3290/j.qi.b639465).

目的:评估无牙跨长度对两种口腔内扫描设备Primescan (Dentsply Sirona)和Trios 3 (3Shape)在全牙弓情况下准确性的影响。他们的假设是,准确率会随着跨度长度的增加而下降,这与扫描仪之间的性能差异有关。方法与材料:采用中切牙种植的上颌全弓模型进行体外研究。依次拔除相邻牙齿,形成12个跨长情景(FA1 ~ FA12)。每种情况使用两种IOS设备扫描10次(n = 240)。实验室扫描仪(Identica blue, Medit)提供参考扫描。使用均方根误差(RMS)评估真度(相对于参考)和精密度(组内)。扫描通过Medit Design中的自动和局部最佳拟合进行对齐。统计分析包括双向混合方差分析、重复测量方差分析和Bonferroni校正线性回归(α = 0.004)。结果:Trios 3的总体RMS值(0.296±0.043 mm)低于Primescan(0.338±0.049 mm), 12个场景中有9个场景的RMS值差异有统计学意义(P .001)。Primescan与跨长的相关性(R2 = 0.892)高于Trios 3 (R2 = 0.674)。两种设备都显示出高可靠性。结论:无牙牙跨长度的增加对扫描精度有负面影响。性能一致的设备更适合可靠的全拱形数字工作流程。(国粹Int 2025;56:618-625; doi: 10.3290/ j.i q .b639465)。
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引用次数: 0
Use of low-dose naltrexone in the management of posttraumatic trigeminal neuropathic pain: a retrospective case series. 使用低剂量纳曲酮治疗创伤后三叉神经性疼痛:回顾性病例系列。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-18 DOI: 10.3290/j.qi.b6335903
Sowmya Ananthan, Gary Heir, Olga Korczeniewska
<p><strong>Objective: </strong>Dental practitioners provide treatment of anatomical structures innervated by the trigeminal system, such as the teeth and gingiva, which can be subject to injury even following routine and well-performed dental procedures. As a result, the dental clinician is often presented with patients with neuropathic pain or unusual sensory distortions. In addition, the dental clinician treats patients following facial and oral trauma which may result in chronic pain. Therefore, recognition of posttraumatic trigeminal neuropathic pain (PTTNP) and its management must be considered essential for the dental clinician. Painful neuropathies, including PTTNP, can present as a debilitating form of neuropathic pain that often defies treatment normally effective for other types of somatic pain disorders. Treatment of PTTNP typically involves the use of various classes of medications including antiseizure medications and tricyclic antidepressants. Many patients suffering with PTTNP may have contraindications for these medications due to comorbidities, occupational responsibilities, or medication side effects. An alternative to antiseizure medications and tricyclic antidepressants is the use of low-dose naltrexone.</p><p><strong>Method and materials: </strong>This study is a retrospective extended case series of patients with PTTNP. The records of 21 patients diagnosed with painful PTTNP at the Center for Temporomandibular Disorders and Orofacial Pain of the Rutgers School of Dental Medicine were analyzed. They met the criteria of PTTNP according to the International Classification of Orofacial Pain and were prescribed low-dose naltrexone. Though a total of 21 patients were included, 12 with all the data present were included in the final analysis. The sex distribution was equal, with six women and six men, with a combined average age of 59.33 ± 13.96 years.</p><p><strong>Results: </strong>Low-dose naltrexone significantly reduced the patients' report of pain using visual analog scale (VAS) 0 to 10 subjective pain ratings at the follow-up visits compared to the initial VAS. Interestingly, the small group of patients who used low-dose naltrexone in combination with serotonin norepinephrine reuptake inhibitors, demonstrated a lower average VAS score at the first follow-up visit, compared to those who took low-dose naltrexone with other medications. There were no significant side effects reported by the patients. No adverse effects of low-dose naltrexone therapy were reported. Side effects of the medication are rare and, as reported the literature, include mild abdominal distress or vivid dreams. None were reported among this group of subjects.</p><p><strong>Conclusion: </strong>Based on this retrospective extended case series, low-dose naltrexone appears to be a safe and effective medication for use in chronic PTTNP. These results highlight the need for future studies to elucidate low-dose naltrexone's analgesic mechanism of action and to
简介:牙医提供治疗由三叉神经系统支配的解剖结构,如牙齿,牙龈等,即使遵循常规和良好的牙科手术,也可能受到伤害。因此,牙科临床医生经常会遇到神经性疼痛或不寻常的感觉扭曲的患者。此外,牙科临床医生治疗可能导致慢性疼痛的面部和口腔创伤患者。因此,识别创伤后三叉神经性疼痛(PTTNP)及其管理必须被认为是必不可少的牙科临床医生。疼痛性神经病,包括PTTNP,可以表现为神经性疼痛的一种衰弱形式,通常对其他类型的躯体疼痛疾病有效的治疗无效。治疗PTTNP通常需要使用各种类型的药物,包括抗癫痫药物(aed)和三环抗抑郁药(TCAs)1。由于合并症、职业责任或药物副作用,许多患有PTTNP的患者可能有这些药物的禁忌症。aed和tca的替代方案是使用低剂量纳曲酮(LDN)。方法:本研究是对PTTNP患者的回顾性扩展病例系列。罗格斯大学牙科医学院颞下颌紊乱和口腔面部疼痛中心21名被诊断为创伤后疼痛的三叉神经性疼痛患者的记录。根据ICOP符合PTTNP标准,并给予LDN。虽然共纳入21例患者,但有12例纳入最终分析。性别分布男女各6名,平均年龄59.33±13.96岁。结果:与最初的视觉模拟评分(VAS)相比,LDN显著减少了患者随访时0-10主观疼痛评分的疼痛报告。有趣的是,一小部分使用LDN联合5 -羟色胺去甲肾上腺素再摄取抑制剂(SNRI)的患者在第一次随访时的平均VAS评分较低,与使用LDN联合其他药物的患者相比。患者未报告有明显的副作用。LDN治疗无不良反应报道。药物的副作用是罕见的,据文献报道,包括轻微的腹部疼痛或生动的梦。在这组受试者中没有报告。基于我们的回顾性扩展病例系列,LDN似乎是一种安全有效的治疗慢性PTTNP的药物。这些结果表明,需要进一步研究阐明LDN的镇痛作用机制,并通过随机、双盲、安慰剂对照的临床研究,在更大的队列中明确证明LDN的镇痛作用。
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引用次数: 0
Influence of edentulous span length on complete-arch intraoral scanner accuracy: a comparative in vitro study. 无牙跨长度对全弓口内扫描精度的影响:一项体外比较研究。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-07-28 DOI: 10.3290/j.qi.b6394659
Yaniv Mayer, Yarden Berg, Or Kfir, Alessio Triestino, Zvi Gutmacher, Luigi Canullo

Statement of problem: While intraoral scanners (IOS) demonstrate high accuracy in single-tooth and partial-arch applications, their reliability in full-arch scans with varying edentulous spans remains uncertain. Increasing span length may compromise scanning accuracy and prosthetic outcomes.

Objectives: To assess the influence of edentulous span length on the accuracy of two IOS devices Primescan (Dentsply Sirona) and Trios 3 (3Shape) in complete-arch scenarios. The hypothesis was that accuracy would decline with increasing span length, with performance differences between scanners.

Material and methods: An in vitro study was conducted using a maxillary complete-arch model with a central incisor implant. Twelve span-length scenarios (FA1-FA12) were created by sequentially removing adjacent teeth. Each condition was scanned 10 times using both IOS devices (n = 240). A laboratory scanner (Identica blue, MEDIT) provided reference scans. Trueness (vs. reference) and precision (intra-group) were evaluated using root mean square (RMS) error. Scans were aligned via automatic and local best-fit in Medit Design. Statistical analysis included two-way mixed ANOVA, repeated measures ANOVA, and linear regression with Bonferroni correction (α = 0.004).

Results: Trios 3 demonstrated lower overall RMS values (0.296 ± 0.043 mm) than Primescan (0.338 ± 0.049 mm), with significant differences in 9 of 12 scenarios (p < 0.001). Correlation with span length was stronger for Primescan (R² = 0.892) than Trios 3 (R² = 0.674). Both devices showed high reliability.

Conclusions: Increasing edentulous span length negatively impacts scanner accuracy. Devices demonstrating consistent performance are preferable for reliable full-arch digital workflows.

问题陈述:虽然口腔内扫描仪(IOS)在单牙和部分牙弓应用中表现出很高的准确性,但它们在不同无牙槽位的全牙弓扫描中的可靠性仍然不确定。增加跨度长度可能会损害扫描精度和假体效果。目的:评价无牙跨长度对全牙弓情况下两种IOS器械Primescan (Dentsply Sirona)和Trios 3 (3Shape)准确性的影响。他们的假设是,准确率会随着跨度长度的增加而下降,这与扫描仪之间的性能差异有关。材料和方法:采用中切牙种植的上颌全弓模型进行体外研究。依次拔除相邻牙齿,形成12个跨长情景(FA1-FA12)。每种情况使用两种IOS设备扫描10次(n = 240)。实验室扫描仪(Identica blue, MEDIT)提供参考扫描。使用均方根误差(RMS)评估真度(相对于参考)和精密度(组内)。扫描通过Medit Design中的自动和局部最佳拟合进行对齐。统计分析包括双向混合方差分析、重复测量方差分析和Bonferroni校正线性回归(α = 0.004)。结果:Trios 3的总体RMS值(0.296±0.043 mm)低于Primescan(0.338±0.049 mm), 12个场景中有9个场景的RMS值差异显著(p < 0.001)。Primescan与跨长的相关性(R²= 0.892)高于Trios 3 (R²= 0.674)。两种设备都显示出高可靠性。结论:无牙牙跨长度的增加对扫描精度有负面影响。性能一致的设备更适合可靠的全拱形数字工作流程。
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Quintessence international
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