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Quality and Safety in Health Care最新文献

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Authors' response 作者的回应
Pub Date : 2011-07-21 DOI: 10.1136/bmjqs-2011-000196
J. Callen, A. Georgiou, Julie Li, J. Westbrook
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引用次数: 0
Authors' response 作者的回应
Pub Date : 2011-06-04 DOI: 10.1136/bmjqs-2011-000140
A. Angelow, N. Black
mammography justifiable? Lancet 2000;355:129–34. 4 Olsen O, Gotzsche PC. Cochrane review on screening for breast cancer with mammography. Lancet 2001;358:1340–42. 5 Kerlikowske K, Grady D, Rubin SM et al. Efficacy of screening mammography. A meta-analysis. JAMA 1995;273:149–54. 6 Duffy SW, Tabar L, Chen HH et al. The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish counties. Cancer 2002;95:458–69. 7 Bulliard J-L, De Landtsheer J-P, Levi F. Results from the Swiss mammography screening pilot programme. Eur J Cancer 2003;38:1760–68. 8 Thornton H, Edwards A, Baum M. Women need better information about routine mammography. BMJ 2003;327:101–03. 9 Paling J. Strategies to help patients understand risks. BMJ 2003;327:745–48.
乳房x光检查的吗?《柳叶刀》杂志2000;355:129-34。4奥尔森O, Gotzsche PC。用乳房x光检查筛查乳腺癌的Cochrane综述。《柳叶刀》杂志2001;358:1340-42。[5]刘建军,刘建军,刘建军,等。筛查性乳房x光检查的效果。一个荟萃分析。《美国医学会杂志》1995;273:149-54。[6]陈洪波,陈洪波,李建平,等。有组织的乳房x光检查对瑞典7个县乳腺癌死亡率的影响。癌症2002;95:458 - 69。7 Bulliard J-L, De Landtsheer J-P, Levi F.瑞士乳房x光检查试点项目的结果。[J]中华医学杂志2003;38(1):1 - 6。8桑顿H,爱德华A,鲍姆m。妇女需要更多关于常规乳房x光检查的信息。BMJ 2003; 327:101-03。9 Paling J.帮助患者了解风险的策略。BMJ 2003; 327:745-48。
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引用次数: 0
BMJ Quality & Safety: new opportunities for better, safer healthcare BMJ质量与安全:更好,更安全的医疗保健的新机会
Pub Date : 2011-03-28 DOI: 10.1136/BMJQS.2011.052233
K. Shojania
Quality and Safety in Health Care has established itself in recent years as the premier journal in the fields of quality improvement and patient safety. We now receive approximately 800 manuscripts a year, and the journal has an impact factor of 2.8, making it the highest impact journal in the field. A number of changes have occurred at the Journal in 2011, changes which will hopefully continue and enhance the trajectory of excellence established by the previous Editor, Dr David Stevens.1First, consistent with the large number of submissions, the Journal increased in publication from bimonthly to monthly as of January 2011. Second, the Journal's name changed to BMJ Quality & Safety to reflect not just the ownership, but also the BMJ Group's interest in highlighting healthcare improvement as part of its mandate. All of the major general medical journals have published articles related to healthcare quality or patient safety in the past 10 years. But, one could argue that the BMJ publishes the widest range of original research, reviews, commentaries, and debates on issues related to these topics. Most notably, the BMJ has published robust qualitative and mixed methods research,2 3 which are often poorly received at major general journals but represent crucial approaches to evaluating healthcare improvement initiatives. Given this sustained attention to healthcare quality in the BMJ , the new name for our journal seems particularly fitting.A third change at the Journal is its co-ownership by the Health Foundation and the BMJ Group. As readers in the UK probably know already, the Health Foundation (http://www.health.org.uk/) is an independent charity committed to improving healthcare systems. It pursues this mission by identifying important quality and safety challenges, collaborating with others to design innovative solutions to those challenges, and implementing …
近年来,《卫生保健质量与安全》已成为质量改进和患者安全领域的主要期刊。我们现在每年收到大约800份手稿,该期刊的影响因子为2.8,是该领域影响力最高的期刊。2011年,《期刊》发生了一些变化,这些变化有望继续并加强前任编辑David stevens博士所建立的卓越轨迹。首先,与大量投稿相一致,《期刊》从2011年1月起从双月出版增加到每月出版。其次,杂志更名为《BMJ质量与安全》,不仅反映了所有权,还反映了BMJ集团对强调医疗保健改善的兴趣,这是其使命的一部分。在过去的十年里,所有主要的综合医学期刊都发表了与医疗质量或患者安全相关的文章。但是,有人可能会说,BMJ发表了最广泛的原创研究,评论,评论,以及与这些主题相关的问题的辩论。最值得注意的是,BMJ发表了强有力的定性和混合方法研究,这些研究通常在主要的综合期刊上反响不佳,但却代表了评估医疗保健改善举措的关键方法。鉴于BMJ对医疗保健质量的持续关注,我们杂志的新名称似乎特别合适。《华尔街日报》的第三个变化是由健康基金会和英国医学杂志集团共同拥有。英国读者可能已经知道,健康基金会(http://www.health.org.uk/)是一家致力于改善医疗体系的独立慈善机构。它通过识别重要的质量和安全挑战,与其他机构合作设计应对这些挑战的创新解决方案,并实施…
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引用次数: 1
Quality lines 质量行
Pub Date : 2010-10-01 DOI: 10.1136/qshc.2010.048298
D. Stevens
Turning administrative data into real-time clinically useful information The delivery of clinical care in isolation of data and information is no longer prudent or acceptable. Cardiothoracic surgical programs face increasingly more complex procedures performed on evermore challenging patients. Public and private stakeholders are demanding these programs report process-level and clinical outcomes as a mechanism for enabling informed clinical decision-making. Increasingly these measures are tied to reimbursement and institutional accreditation. This report describes the development of a system for linking administrative and clinical registries, in real-time, to track performance to satisfy both the needs of patients and stakeholders. Institutional performance is displayed over time using process control charts, and compared to both internal and regional benchmarks. Quarterly reports are automated for five surgical cohorts and are displayed externally on a dedicated website, and internally in the cardiothoracic surgical office suites, operating theatre, and nursing units. Monthly discussions are held with the clinical staff. Expanded applications are serving to integrate these data further into clinical care to drive process improvement. (See page 399)
将管理数据转化为实时的临床有用信息孤立地提供临床护理不再是谨慎或可接受的做法。心胸外科项目面临着越来越复杂的程序,在越来越有挑战性的病人身上进行。公共和私人利益相关者要求这些项目报告过程水平和临床结果,作为一种促进知情临床决策的机制。这些措施越来越多地与报销和机构认证联系在一起。本报告描述了一个系统的开发,用于实时连接行政和临床登记,以跟踪绩效,以满足患者和利益相关者的需求。利用过程控制图表显示机构绩效,并与内部和区域基准进行比较。五个手术队列的季度报告是自动化的,并在一个专门的网站上对外显示,在心胸外科办公室套房、手术室和护理单位内部显示。每月与临床工作人员进行讨论。扩展的应用程序将这些数据进一步集成到临床护理中,以推动流程改进。(见399页)
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引用次数: 0
Quality lines 质量行
Pub Date : 2010-06-01 DOI: 10.1136/qshc.2010.043679
D. Stevens
Adverse events between visits for patients with diabetes mellitus Adverse events between ambulatory patient visits are increasingly the focus of study. By means of an automated telephone self-management tool, 111 patients with diabetes mellitus were monitored for adverse events between visits in the course of their home management. Of note, the study population was ethnically and linguistically diverse, and most had longstanding and poorly controlled diabetes. Among these patients, 86% had at least one event detected over a 9-month study period totalling 111 adverse events and an additional 153 potential adverse events. Medication management was implicated as the dominant adverse event and constituted 63% of events. Of note inadequate clinician-patient communication was implicated in 59%. In fully 80% of all events, a combination of system, clinician and patient factors contributed to the adverse event. The authors suggest that patient-level self-management support and patient-centred communication offer the greatest opportunities for prevention of adverse events in this setting. See page 223
糖尿病患者门诊间不良事件日益成为研究的热点。采用自动电话自我管理工具,对111例糖尿病患者在家庭管理过程中随访期间的不良事件进行监测。值得注意的是,研究人群在种族和语言上是多样化的,而且大多数人长期患有糖尿病,控制不佳。在这些患者中,86%的患者在9个月的研究期间至少检测到一次不良事件,总共有111例不良事件和153例潜在不良事件。药物管理是主要的不良事件,占事件的63%。值得注意的是,59%的患者与临床沟通不足。在80%的不良事件中,系统、临床医生和患者因素共同导致了不良事件。作者建议,在这种情况下,患者层面的自我管理支持和以患者为中心的沟通为预防不良事件提供了最大的机会。见第223页
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引用次数: 0
195 Impact of a multidisciplinary approach of invasive fungal infections from diagnosis to treatment 侵袭性真菌感染从诊断到治疗的多学科方法的影响
Pub Date : 2010-04-01 DOI: 10.1136/qshc.2010.041624.8
L. Florence, Mondain Véronique, Gari-Toussaint Martine, H. Lilia, S. Anne, Poirée Maryline, D. Thomas, Lucas-Daver Stéphanie, Berrouane Yasmina, Mousnier Aline
Invasive fungal infections (IFI) are severe diseases affecting immuno-compromised patients. In France, since 2007, the cost of expensive recommended antifungal treatments (AFT) is not included in the normal per-case payment and each suspected IFI must be systematically documented during interdisciplinary team meetings (ITM) including an infectious disease specialist, a haematologist, a mycologist and a pharmacist. Objective To evaluate the impact of our ITM. Methods In 2008, 179 advices were provided in real time to prescribing doctors concerning 109 patients receiving AFT. This was done during 31 ITM. From January to September 2009, 192 advices were provided during 27 ITM, Each patient's condition was documented according to clinical presentation including emergency high resolution CT of the chest and abdomen, microbiological data as Aspergillus galactomannan antigen assay twice a week, pan-fungal PCR, and mycological analysis of various samples (bronchoalveolar fluid, blood culture…). Results In 2008, eight cases of probable and two of possible invasive aspergillosis (IA) were diagnosed (all in a haematology department, with one paediatric case). Four patients died: in one case IA may have been a causative factor. Incidence rate for IA was 4.7% among patients with acute leukaemia and stem-cell transplantation, which seems low compared to the literature. Advices were followed in 90% of cases. In 2008 and 2009 (until September), 95% of treatments involving added costs, were in line with provisions for marketing authorisation. Number of empirical AFT First half the year 2003 19/41(46%) First half the year 2008 7/23(30%) First half the year 2009 9/39(23%) To conclude, currently, 100% of patients benefit from a radiological and biological monitoring, in order to optimise the diagnosis and AFT. Thus, the empirical's antifungal (AF) number has been reduced from 46 to 23%. Indeed, we observed a 17% drop in added AF costs and 12% for other systemic AF (2007 vs 2008). A good compliance with the suggested advices shows that prescribing doctors are in favour of the scheme. The consumption of AF expressed in Daily Defined Dose will allow further assessment of practice trends. Les MFI sont des pathologies infectieuses sévères des patients immunodéprimés. Les traitements antifongiques (AF) systémiques recommandés font partie depuis 2005 des médicaments tarifiés en sus de l'activité. Depuis 2005, pour chaque suspicion de MFI une documentation systématique est demandée en cellule antifongiques (RCP hebdomadaire pluridisciplinaire: infectiologue, hématologue, mycologue, pharmacien) et les traitements AF en cours sont discutés. En 2008, 179 avis ont été communiqués en temps réel aux prescripteurs concernant 109 patients traités par AF. Ces avis ont été donnés au cours de 31 RCP au vu des données diagnostiques, microbiologiques et d'imagerie accessibles dans le dossier patient informatisé. Lors du 1er semestre 2009, 192 avis donnés au cours
侵袭性真菌感染(IFI)是影响免疫功能低下患者的严重疾病。在法国,自2007年以来,昂贵的推荐抗真菌治疗(AFT)的费用不包括在正常的每例付款中,并且必须在包括传染病专家、血液病学家、真菌学家和药剂师在内的跨学科小组会议(ITM)期间系统地记录每个疑似抗真菌治疗。目的评价我院ITM的临床效果。方法2008年对109例AFT患者进行31次ITM,实时向处方医师提供179条建议。2009年1月至9月,在27例ITM中提供了192次咨询,根据临床表现记录每位患者的病情,包括胸腹急诊高分辨率CT,微生物学数据如半乳甘露聚糖曲霉抗原检测(每周2次),泛真菌PCR,以及各种样品(支气管肺泡液,血培养…)的真菌学分析。结果2008年,本院共确诊8例疑似侵袭性曲霉病,2例可能侵袭性曲霉病(IA),均发生在血液科,其中1例为儿科。4名患者死亡:其中1例可能是IA的致病因素。急性白血病和干细胞移植患者的IA发生率为4.7%,与文献相比似乎较低。90%的病例遵循了建议。在2008年和2009年(截至9月),95%涉及额外费用的治疗符合上市许可的规定。经验性抗真菌药物数量2003年上半年19/41(46%)2008年上半年7/23(30%)2009年上半年9/39(23%)总而言之,目前,100%的患者受益于放射学和生物学监测,以优化诊断和抗真菌药物。因此,经验性抗真菌药物(AF)数量已从46减少到23%。事实上,我们观察到增加的AF成本下降了17%,其他系统AF成本下降了12%(2007年与2008年相比)。对建议意见的良好遵从表明开处方的医生赞成该方案。在每日限定剂量中表示的房颤消耗量将允许进一步评估实践趋势。MFI是指病理、感染、免疫、免疫等因素。《反欺诈制度》(afms)建议,2005年,《反欺诈制度》(afms)建议,2005年,《反欺诈制度》(afms)建议,2005年,《反欺诈制度》(afms)建议,2005年,《反欺诈制度》。2005年6月,《关于MFI文件系统的怀疑》,《多学科杂志:传染病学、传染病学、霉菌学、药物学》,《关于细胞反变异的研究报告》,以及《关于细胞反变异的研究报告》。2008年,共有179份与患者有关的医疗档案,涉及109名患者的医疗档案,其中包括与患者有关的医疗档案,与患者有关的医疗档案,与患者有关的医疗档案,与患者有关的医疗档案,与患者有关的医疗档案,与患者有关的诊断资料,微生物学资料等。2009年第11学期,192名学生参加了第27届RCP课程。所有的患者都有相同的记录,如:1 .适应症;1 .适应症;1 .适应症;1 .适应症;3 .适应症;2 .适应症;3 .适应症;2008年,8例诊断为aspergillose invasive (AI),可能为3例,可能为2例(10例为1例,1例为1例)。4例患者均为单纯的抑郁,4例患者为单纯的抑郁,4例患者为单纯的抑郁。CSH患者的发病率为4.7%,其中有1例为纯纯的CSH患者,1例为纯纯的CSH患者;这似乎是一种可靠的人际关系,但不是很正常。90%的人被诊断为患有抑郁症,而不是被诊断为患有抑郁症。从2008年到2009年第11学期,有95%的病例符合AMM标准。Nb de traitements expeririques par antifongiques:2003年第19/41学期总理(46%)2008年第7/23学期总理(30%)2009年第9/39学期总理(23%)乐观地认为,所有的患者都有可能患有由微生物和其他因素决定的疾病,所有的患者都有可能患有由其他因素决定的疾病,所有的患者都有可能患有由其他因素决定的疾病,所有的患者都有可能患有由其他因素决定的疾病。与2007年相比,2008年平均有17%的可调制器和12%的可调制器被调制器调制器所调制器。遵守《关于规定者的薪金和薪金的规定》。在过去的几个月里,所有的薪金薪金都是由薪金薪金和薪金薪金组成的。
{"title":"195 Impact of a multidisciplinary approach of invasive fungal infections from diagnosis to treatment","authors":"L. Florence, Mondain Véronique, Gari-Toussaint Martine, H. Lilia, S. Anne, Poirée Maryline, D. Thomas, Lucas-Daver Stéphanie, Berrouane Yasmina, Mousnier Aline","doi":"10.1136/qshc.2010.041624.8","DOIUrl":"https://doi.org/10.1136/qshc.2010.041624.8","url":null,"abstract":"Invasive fungal infections (IFI) are severe diseases affecting immuno-compromised patients. In France, since 2007, the cost of expensive recommended antifungal treatments (AFT) is not included in the normal per-case payment and each suspected IFI must be systematically documented during interdisciplinary team meetings (ITM) including an infectious disease specialist, a haematologist, a mycologist and a pharmacist. Objective To evaluate the impact of our ITM. Methods In 2008, 179 advices were provided in real time to prescribing doctors concerning 109 patients receiving AFT. This was done during 31 ITM. From January to September 2009, 192 advices were provided during 27 ITM, Each patient's condition was documented according to clinical presentation including emergency high resolution CT of the chest and abdomen, microbiological data as Aspergillus galactomannan antigen assay twice a week, pan-fungal PCR, and mycological analysis of various samples (bronchoalveolar fluid, blood culture…). Results In 2008, eight cases of probable and two of possible invasive aspergillosis (IA) were diagnosed (all in a haematology department, with one paediatric case). Four patients died: in one case IA may have been a causative factor. Incidence rate for IA was 4.7% among patients with acute leukaemia and stem-cell transplantation, which seems low compared to the literature. Advices were followed in 90% of cases. In 2008 and 2009 (until September), 95% of treatments involving added costs, were in line with provisions for marketing authorisation. Number of empirical AFT First half the year 2003 19/41(46%) First half the year 2008 7/23(30%) First half the year 2009 9/39(23%) To conclude, currently, 100% of patients benefit from a radiological and biological monitoring, in order to optimise the diagnosis and AFT. Thus, the empirical's antifungal (AF) number has been reduced from 46 to 23%. Indeed, we observed a 17% drop in added AF costs and 12% for other systemic AF (2007 vs 2008). A good compliance with the suggested advices shows that prescribing doctors are in favour of the scheme. The consumption of AF expressed in Daily Defined Dose will allow further assessment of practice trends. Les MFI sont des pathologies infectieuses sévères des patients immunodéprimés. Les traitements antifongiques (AF) systémiques recommandés font partie depuis 2005 des médicaments tarifiés en sus de l'activité. Depuis 2005, pour chaque suspicion de MFI une documentation systématique est demandée en cellule antifongiques (RCP hebdomadaire pluridisciplinaire: infectiologue, hématologue, mycologue, pharmacien) et les traitements AF en cours sont discutés. En 2008, 179 avis ont été communiqués en temps réel aux prescripteurs concernant 109 patients traités par AF. Ces avis ont été donnés au cours de 31 RCP au vu des données diagnostiques, microbiologiques et d'imagerie accessibles dans le dossier patient informatisé. Lors du 1er semestre 2009, 192 avis donnés au cours","PeriodicalId":20849,"journal":{"name":"Quality and Safety in Health Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73998158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
251 OMAGE: OPTIMAL DRUG MANAGEMENT OF THE ELDERLY 251图像:老年人最佳药物管理
Pub Date : 2010-04-01 DOI: 10.1136/QSHC.2010.041616.13
S. Legrain, D. Bonnet
Context The elderly are at high risk of repeated hospitalisations, which are potentially hazardous and costly. Clinical experience and literature support the evidence that a high percentage of these unplanned hospitalisations are avoidable. The purpose of our study was to implement a new multi-component patient-centred intervention suited to elderly admitted in acute geriatric units (AGU) and to assess its impact 3- and 6-month- post-discharge on survival without unplanned readmission or emergency visit. Program A prospective multicentric randomised controlled trial conducted in six AGU. Participants were consecutive patients aged 70 years and over. Intervention was patient-centred, with no intervention after discharge. It had three components: prescription optimisation, a specific patient and/or carer's educative program and an enhanced coordination, with a focus on three topics: drug-related problems, depression and malnutrition. It was formalised to be implemented by four geriatrician investigators. Primary outcome was survival for 90 and 180 days without unplanned readmission or emergency visit (Kaplan–Meier analysis). Secondary outcomes were mortality, rate of readmitted patients, rate of patient with at least one emergency visits (Log rank test) and the number of readmissions and the number of days of readmission (Wilcoxon test). Results 665 patients were included (348 in usual care group (UC) and 317 in intervention group (IG)), with a mean age of 86.1 years. 66% were women, 47.4% lived alone; they had a mean of three chronic diseases and took a mean of seven daily chronic medications. The mean duration to perform the intervention was 3 h 30 min. Survival for 90 days without unplanned readmission or emergency visit was significantly higher in the IG than in the UC (p=0.0173). This trend persisted at 180 days but not significantly (p=0.06). At 90 days, the rate of patients readmitted in IG was decreased by 25% vs UC (21% vs 29.4%, p=0.0012). The number of readmissions and the number of days spent in acute care were significantly lower in IG vs UC (p=0.0218 and p=0.0472 respectively). The mortality in IG was lower but it was not statistically significant (p=0.055). At 180 days, the same trend was observed for the rate of readmitted patients, the number of readmissions and the mortality, but it was not statistically significant. Limits Only 665 patients were included instead of the planned 800 that could have induced a lack of potency and hindered to demonstrate the efficiency of the intervention at 6 months. Discussion This intervention could be proposed in other settings of geriatric care (rehabilitation, ambulatory care). Conclusion A complex but one-shot and geriatrician-directed intervention increases significantly survival without readmission at 3 months in unselected elderly inpatients. Contexte Les réhospitalisations sont fréquentes, potentiellement délétères et coûteuses chez les malades âgés. Mais, la fréquence des réhospi
老年人反复住院的风险很高,这是潜在的危险和昂贵的。临床经验和文献支持的证据表明,这些意外住院的很大一部分是可以避免的。本研究的目的是实施一种新的多组分以患者为中心的干预措施,适用于急性老年病房(AGU)住院的老年人,并评估其在出院后3个月和6个月对无计划外再入院或急诊的生存率的影响。一项在6个AGU进行的前瞻性多中心随机对照试验。参与者为70岁及以上的连续患者。干预以患者为中心,出院后不进行干预。它有三个组成部分:处方优化、特定患者和/或护理人员的教育计划和加强协调,重点关注三个主题:与药物有关的问题、抑郁症和营养不良。它正式由四名老年病学调查人员实施。主要终点是90天和180天的生存率,无计划外再入院或急诊(Kaplan-Meier分析)。次要结局是死亡率、再入院患者率、至少一次急诊患者率(Log rank检验)、再入院人数和再入院天数(Wilcoxon检验)。结果纳入665例患者,其中常规护理组(UC) 348例,干预组(IG) 317例,平均年龄86.1岁。66%为女性,47.4%独居;他们平均患有三种慢性疾病,平均每天服用七种慢性药物。进行干预的平均时间为3小时30分钟。IG组90天无意外再入院或急诊的生存率显著高于UC组(p=0.0173)。这种趋势持续到180天,但不显著(p=0.06)。在90天,IG患者再入院率比UC降低25%(21%对29.4%,p=0.0012)。与UC相比,IG组的再入院次数和急症护理天数显著降低(p=0.0218和p=0.0472)。IG组病死率较低,但差异无统计学意义(p=0.055)。在180天,再入院率、再入院人数和死亡率的变化趋势相同,但无统计学意义。只纳入了665名患者,而不是计划的800名患者,这可能会导致缺乏效力,并阻碍在6个月时展示干预的效率。该干预措施可在其他老年护理(康复、门诊护理)中提出。结论对未选择的老年住院患者进行复杂的单次干预,可显著提高其3个月无再入院生存率。综上所述,在住院治疗中,有三个因素分别是:1、<s:1>其他因素:1、<s:1>其他因素:1、<s:1>其他因素:1、<s:1>其他因素:1、<s:2>。主要包括:<s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> (<s:1>)、<s:1> <s:1> <s:1> (<s:1>)、<s:1> (<s:1>)、<s:1> (<s:1>)、<s:1>(()和()。n / n / n / n / n / n / n / n / n / n / n / n / n / n / n / n / n / n / n1 .目标1 .评估1 .影响1 .干预1 .多面性确定不包括<s:1> <s:1> <s:1> <s:1>材料和材料3 .和6 .确定不包括<s:1> <s:1>材料和材料6 .确定不包括<s:1>材料和材料6 .确定不包括材料1 .确定不包括材料1 . (UGA)。方案练习曲多中心(6 UGA d'Ile de France)前瞻性随机取样(selon Zelen) contrôlée。人口:在2007年4月至2008年10月期间,年龄≥70岁的人在UGA平均年龄≥3岁,年龄≥5岁的人。干预:由个人组成的、由个人组成的、由目标确定的、优先事项确定的、由问题确定的、由个人组成的、由个人组成的(未充分利用、遵守、健康的)、由个人组成的、由个人组成的、由个人组成的、由个人组成的、由个人组成的。Elle综合了3个方面:处方优化、患者康复、患者康复、患者康复、患者康复。a 'intervention a samest standardissame pour pouvoir être mensame par 4 . samriza表示高级的不同的samriza。6个地点的<s:1>筛选系统- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -3 .对<s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1>···························································
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引用次数: 0
025 Impact of a quality procedure on the survival of patients with malignant hyperthermia 025质量程序对恶性高热患者生存的影响
Pub Date : 2010-04-01 DOI: 10.1136/QSHC.2010.041608.3
R. Krivosic, B. Marciniak, L. Mazzoli, T. Depret, J. Salleron
Background and Objectives The mortality rate of malignant hyperthermia (MH) was 64% before the US Food and Drug Administration approved intravenous dantrolene in 1980. In France, a national formal quality procedure relative to the treatment of MH was issued in 1989 and updated in November 1999. It made the availability of an adequate stock of dantrolene compulsory and provided guidelines for MH management. Our objective was to analyse trends in mortality in proven MH cases in France. Programme We retrospectively reviewed the database of the MH unit at Lille hospital. The inclusion criteria for our review were the following: at least one positive halothane test (in vitro contracture test (IVCT)) in the surviving subject or a close relative and/or a MH causative mutation in the RyR1 gene. Informed consent was obtained from all patients and/or relatives. Statistical analysis was performed using SAS 9.1.3 Service Pack 4. Results There were a total of 115 MH cases between 1969 and 2007 (see Abstract 25 Table 1). Abstract 25 Table 1 Period MH N (%) Mortality N (%) Median age (IQ) Succinylcholine (%) Dantrolene (%) 1969–2007 115 35 (31) 16 (7–21) 50 46 1969–1979 22 (19) 13 (59) 14 (11–20) 76 0 1980–1989 37 (32) 14 (38) 13 (6–22) 64 42 1990–1999 41 (35) 7 (18) 15 (10–28) 39 68 2000–2007 15 (13) 1 (7) 20 (13–28) 8 60 p<0.002 NS p<0.007 p<0.001 Overall mortality was 31%. Mortality decreased significantly over time from 59% to 7%. The last two deaths occurred in 1995 and 2004. We observed no serious sequelae in survivors. Neither median age nor sex ratio (64% male) varied significantly over the four time periods; neither influenced mortality. Patients received a halogenated anaesthetic (≥90%) and/or succinylcholine (50%). Succinylcholine use decreased over time and was higher in the deceased (74%) than in survivors (43%). Discussion A strength of our study was that MH diagnosis was proven by IVCT and/or genetic analysis. The most striking observation was the trend towards zero mortality. This result does not support the recent report from the North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association1 which concluded that modern US anaesthetic practice did not prevent MH-associated cardiac arrest and death in predominantly young, healthy patients undergoing low - to intermediate-risk surgical procedures. We conclude that the positive impact on survival in our study was probably related to the national formal quality procedure for MH instigated by the French health authorities. Introduction La mortalité de l'hyperthermie maligne anesthésique (HM) était chiffrée à 64% avant le dantrolène injectable (1980). La France a rédigé une procédure qualité sous forme de circulaire, en 1989, modifiée en 1999 (Circulaire DGS/DH du 18 novembre 1999 relative au traitement de l'hyperthermie maligne (HM) peranesthésique). Le but de ce travail est d'étudier l'évolution de la mortalité au décours d'une crise HM prouvée par des tes
背景与目的在1980年美国食品和药物管理局批准静脉注射丹曲林之前,恶性高热(MH)的死亡率为64%。法国于1989年颁布了一项有关MH治疗的国家正式质量程序,并于1999年11月更新。它规定必须提供足够的丹trolene库存,并为MH管理提供指导方针。我们的目标是分析法国已证实的MH病例的死亡率趋势。我们回顾性地回顾了里尔医院MH部门的数据库。纳入标准如下:存活患者或其近亲至少有一项氟烷试验(体外挛缩试验(IVCT))阳性和/或RyR1基因有MH致病突变。获得了所有患者和/或亲属的知情同意。采用SAS 9.1.3 Service Pack 4进行统计分析。结果有115 MH例1969年和2007年之间抽象25(见表1)。表1文摘25期MH N(%)死亡率(%)平均年龄(智商)琥珀酰胆碱(%)丹曲洛林(%)1969 - 2007 115 35(31)16(7-21)50 46 1969 - 1979 22(19)13(59)14(11日至20日)76 0 1980 - 1989 37(32)14(38)13(第6 - 22)64 42 1990 - 1999 41(35)7(18)15(28)39 68 2000 - 2007 15(13)1(7)20(13-28)8 60 2000页。死亡率全球平均值为31%(图表),平均下降幅度显著(平均值为59%,7%)。1995年和2004年,第2条规定了对欧盟的限制。在纪念日那天,我看到了幸存者的坟墓。 (0.5-70)),不同类型的 - (0.5-70)。Le rapport homme-femme (64% d'hommes)是稳定的职业生涯,对死亡率没有影响。6例患者不重复使用麻醉型、纯纯型、纯纯型、纯纯型、纯纯型、纯纯型和纯纯型。随着时间的推移,使用的时间也在减少。患者、患者、患者和幸存者(占比为74%)与患者和幸存者(占比为43%)之间的差异。讨论L' originalit de L' 与危机> >在过去的10年里,人类的生命周期演变演变是一种令人难以置信的过程。是否将“metrem en parallentile”定义为“metrem en parallentile”,即“metrem en parallentile”,即“metreme me”,即“metreme me”或“metreme me”。这篇文章的结论是:“la pratique US moderne de l' anesthsamciesne pracimente pas les morts HM chez des sujets jeunes et en bonne santoise pour des chirurgies risque has ou intermsamdiaire”。在“生存条件”中,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”,“交换条件”是指“交换条件”。表pembroride危机HM(%)死亡率(%)年龄(IQ) cembroride (%) dantrol(%) 1969-2007 115 35(31) 16(7 - 21) 50 46 1969-1979 22(19) 13(59) 14(11-20) 76 1980-1989 37(32) 14(38) 13(6-22) 64 42 1990-1999 41(35) 7(18) 15(10-28) 39 68 2000-2007 15(13) 1(7) 20(13 - 28) 8 60变异p<0.002 NS p<0.007 p<0.001
{"title":"025 Impact of a quality procedure on the survival of patients with malignant hyperthermia","authors":"R. Krivosic, B. Marciniak, L. Mazzoli, T. Depret, J. Salleron","doi":"10.1136/QSHC.2010.041608.3","DOIUrl":"https://doi.org/10.1136/QSHC.2010.041608.3","url":null,"abstract":"Background and Objectives The mortality rate of malignant hyperthermia (MH) was 64% before the US Food and Drug Administration approved intravenous dantrolene in 1980. In France, a national formal quality procedure relative to the treatment of MH was issued in 1989 and updated in November 1999. It made the availability of an adequate stock of dantrolene compulsory and provided guidelines for MH management. Our objective was to analyse trends in mortality in proven MH cases in France. Programme We retrospectively reviewed the database of the MH unit at Lille hospital. The inclusion criteria for our review were the following: at least one positive halothane test (in vitro contracture test (IVCT)) in the surviving subject or a close relative and/or a MH causative mutation in the RyR1 gene. Informed consent was obtained from all patients and/or relatives. Statistical analysis was performed using SAS 9.1.3 Service Pack 4. Results There were a total of 115 MH cases between 1969 and 2007 (see Abstract 25 Table 1). Abstract 25 Table 1 Period MH N (%) Mortality N (%) Median age (IQ) Succinylcholine (%) Dantrolene (%) 1969–2007 115 35 (31) 16 (7–21) 50 46 1969–1979 22 (19) 13 (59) 14 (11–20) 76 0 1980–1989 37 (32) 14 (38) 13 (6–22) 64 42 1990–1999 41 (35) 7 (18) 15 (10–28) 39 68 2000–2007 15 (13) 1 (7) 20 (13–28) 8 60 p<0.002 NS p<0.007 p<0.001 Overall mortality was 31%. Mortality decreased significantly over time from 59% to 7%. The last two deaths occurred in 1995 and 2004. We observed no serious sequelae in survivors. Neither median age nor sex ratio (64% male) varied significantly over the four time periods; neither influenced mortality. Patients received a halogenated anaesthetic (≥90%) and/or succinylcholine (50%). Succinylcholine use decreased over time and was higher in the deceased (74%) than in survivors (43%). Discussion A strength of our study was that MH diagnosis was proven by IVCT and/or genetic analysis. The most striking observation was the trend towards zero mortality. This result does not support the recent report from the North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association1 which concluded that modern US anaesthetic practice did not prevent MH-associated cardiac arrest and death in predominantly young, healthy patients undergoing low - to intermediate-risk surgical procedures. We conclude that the positive impact on survival in our study was probably related to the national formal quality procedure for MH instigated by the French health authorities. Introduction La mortalité de l'hyperthermie maligne anesthésique (HM) était chiffrée à 64% avant le dantrolène injectable (1980). La France a rédigé une procédure qualité sous forme de circulaire, en 1989, modifiée en 1999 (Circulaire DGS/DH du 18 novembre 1999 relative au traitement de l'hyperthermie maligne (HM) peranesthésique). Le but de ce travail est d'étudier l'évolution de la mortalité au décours d'une crise HM prouvée par des tes","PeriodicalId":20849,"journal":{"name":"Quality and Safety in Health Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76161202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
132 Automated analysis of compliance of medical decisions with clinical practice guidelines: use of decision algorithms in the management of patients with common or rare tumours 132 .医疗决策是否符合临床实践指南的自动分析:决策算法在常见或罕见肿瘤患者管理中的应用
Pub Date : 2010-04-01 DOI: 10.1136/QSHC.2010.041632.20
A. Lurkin, F. Ducimetière, C. Cropet, D. Cellier, O. Collard, F. Gilly, P. Biron, D. Salameire, J. Blay, I. Ray-Coquard
Background and Objectives Published studies on medical practice assessment often use clinical audit as method. However, clinical audits require considerable resources, in particular human resources, as each medical file has to be reviewed individually. If the number of files is large, this can take time, with furthermore no guarantee that the results will be reproducible. Our objective was to develop algorithms for the automated analysis of compliance of medical decisions with national or regional clinical practice guidelines. Programme Our work was carried out within a financial and organisational partnership between Merck-Serono, the Cancéropole CLARA (Cancéropôle Lyon Auvergne Rhône-Alpes) and the European network of excellence CONTICANET (Connective Tissue Cancer Network). We based our work on medical practice appraisal studies we had performed on the management of patients with non metastatic breast cancer and of patients with sarcoma. We compared the use of human and automated means of assessing compliance with guidelines in a case that was common and one that was rare and required more complex management. We collected data on both types of case in each institution and compared treatment administered to treatment recommended for each patient. When patient management was in line with guidelines, it was considered to comply. When management deviated from guidelines without any medical justification, it was considered not to comply. We determined compliance with guidelines by an observer and by the algorithm and used the kappa coefficient to obtain a reliable and reproducible measure of concordance between the two methods. We then calculated algorithm sensitivity, specifically, positive predictive value (PPV) and megative predictive value (NPV). Results 586 treatments for breast cancer were assessed. kappa for concordance between observer and algorithm was 0.55, indicating that the algorithm is a partial substitute for the observer. Algorithm sensitivity was 46% and specificity was 99%. This means that if the algorithm states that treatment complies with guidelines, the observer need not review the file but can be certain that the answer is correct. This was confirmed by the PPV which was 95.7%. However, the NPV was lower (84.7%). Thus, when the algorithm indicates noncompliance, the observer has to check the decision in the patient's file. In a study of treatment decisions in patients with sarcoma (gastrointestinal stromal tumour (GIST) or retroperitoneal sarcoma), the kappa coefficient was only 0.27 for GIST and 0.13 for retroperitoneal sarcomas. These preliminary results need to be verified on soft tissue sarcomas which are more common. Discussion and Conclusion Our algorithm for analysing compliance with clinical practice guidelines is a useful tool for optimising medical practice assessment. It can help save time and human resources, improve reproducibility, and guarantee unbiased observer judgement. However, for widespread use of suc
如果在没有医学理由的情况下发现偏离标准的情况,则认为治疗不符合标准。我们得到了一个由观察者和算法确定的参考标准的一致性率。为了获得两种方法之间可靠和可重复的一致性测量,我们计算了Kappa一致性系数。然后我们计算敏感性和特异性。该数据还伴有正预测值(ppv)和负预测值(npv)。结果对586个治疗序列进行了乳腺癌管理评估。似乎算法可以部分替代观察者,因为我们发现Kappa为0.55。敏感性和特异性分别为46%和99%。根据这些结果,可以得出这样的结论:当算法按照程序或处理进行编码时,观察者不需要查看文件,可以肯定这种分析是正确的。这是通过VPN(84.7%)和VPP(95.7%)验证的。另一方面,考虑到较低的VPN,当算法编码不符合时,观察者有必要验证得到的决定。这种方法在肉瘤(GIST和手术后)中重复。结果更加微妙,GIST的Kappa为0.27,术后肉瘤的Kappa为0.13。这些关于这种病理的初步结果应该在软组织肉瘤上得到验证,软组织肉瘤的有效性要高得多。结论在医疗实践评估中使用这种算法遵从性分析技术似乎很有趣。此外,医疗实践评估方法的某些阶段可以被决策算法编程的自动化所取代。这个工具的泛化与几个参数有关。首先,病理必须是频繁的,以获得适当的样本量。病理必须在形态和解剖病理上都是同质的。这种类型的工具可以节省医务人员的时间,并可以很好地控制观察者判断的再现性和公正性。
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引用次数: 0
028 Analysis of the impact of measures for the prevention of post-partum hemorrhages in a large maternity unit 028某大型产房预防产后出血措施效果分析
Pub Date : 2010-04-01 DOI: 10.1136/qshc.2010.041624.39
H. Le Guen, O. Teffaud, O. Kick, G. Langlois, Berthereaux Lidwine, Prima Pierre-Yves, Multon Olivier
Introduction In order to improve maternal safety and reduce the number of post partum hemorrhages in our obstetric unit, we have implemented a standardized standardised protocol for active risk management of post partum hemorrhage haemorrhage(1) and the establishment of a cross-fonctionnal work group. This work group was made up of the various actors involved in the birthing process including gynecologistsgynaecologists, midwives and anesthesiologistsanaesthesiologists. This study analyses the impact of our protocol on the occurence of post partum hemorrhagehaemorrhage. Materials and methods Following national guidelines, a written protocol for the prevention, early recognition, and management of post partum hemorrhage haemorrhage (PPH) was established in our institution in spring 2007. The primary objective of this protocol was the active management of third stage of labor labour and included the following: the administration of 5 UI oxytocin as the anterior shoulder delivers; a routine 2 h observation period after childbirth in the obstetric unit; in case of PPH, surgical exploration of lower genital tract and intravenous sulprostone within 30  minutes. We analyzed analysed data from 2006 (prior to the implementation of the protocol), 2007 (at the introduction of the protocol) and in 2008. Statistical analysis of the data was performed using the χ2chi-squared test and Fisher's exact test Results Year 2006 2007 2008 Child birth (n) 5126 5139 5055 Hemmorrhage total (n) 190(3.,70%) 157(3.,05%) 78(1.,54%)*** Hemmorrhage <1  l (n) 156(3%) 132(2.,6%) 46 (0.,9%)*** Hemorrhage Haemorrhage >1 l (n) 34(0.,66%) 25(0.,49%) 32 (0.63%) (NS) Transfusions (n) 12(0.,23%) 19(0.,37%) 33 (0.65%)** Active third stage (n) Non available 2102(48%) 3523 (83.3%)*** Cesarean section (n) 729 (14.,2%) 776 (15.,1%) 837 (16.5%)* * p<0.05; ** p<0.01; *** p<0.001. Discussion These results show the implementation of the PPH risk-management protocol significantly reduced the incidence of post partum hemorrhages. However, the results also show that the protocol failed to reduce number of occurrences of more serious PPH(>1  literl), the incidence of which was already low as compared with published data. (2). The presence of a senior obstetrician present with the midwife at delivery facilitated the application of the PPH protocol. The incidence of transfusions, although low, increased throughout the protocol evaluation period at 0.24% of births in 2006 compared to 0.63% in 2008. The increase in the rate of transfusion is may be due to: (1) the increased awareness of doctors leading to more rapid intervention at the occurrence of PPH and (2) a concomitant increase in the rate of caesarean sections performed over the protocol evaluation period. Contexte, objectif Dans le but d'améliorer la sécurité maternelle et de diminuer le nombre d'hémorragie de la délivrance, nous avons mis en place au sein de notre maternité une politique active de gestion du risque hémorragique du post
为了提高产妇安全,减少产科病房的产后出血数量,我们实施了一项标准化的产后出血主动风险管理方案(1),并成立了一个跨职能工作组。这个工作小组由参与分娩过程的各种人员组成,包括妇科医生、助产士和麻醉师。本研究分析了我们的方案对产后出血发生的影响。材料和方法根据国家指导方针,我院于2007年春季制定了预防、早期识别和处理产后出血(PPH)的书面方案。该方案的主要目标是积极管理第三阶段产程,包括以下内容:在前肩分娩时给予5ui催产素;分娩后在产科病房常规观察2小时;如PPH,手术探查下生殖道,30分钟内静脉注射磺胺酮。我们分析了2006年(议定书实施之前)、2007年(议定书引入时)和2008年的分析数据。采用χ2 χ2检验和Fisher精确检验对数据进行统计学分析结果2006年2007年2008年分娩(n) 5126 5139 5055出血总量(n) 190(3.70%) 157(3.05%) 78(1.54%)***出血1 l (n) 34(0.66%) 25(0.49%) 32 (0.63%) (NS)输血(n) 12(0.23%) 19(0.37%) 33(0.65%)**活动第三期(n)不可用2102(48%)3523(83.3%)***剖宫产(n) 729 (14.2%) 776 (15.1%) 837 (16.5%)* * p1升,与已发表的数据相比,其发生率已经很低。(2)在分娩时,有一名高级产科医生陪同助产士,有利于PPH方案的应用。输血的发生率虽然很低,但在整个方案评估期间有所增加,2006年为0.24%,而2008年为0.63%。输血率的增加可能是由于:(1)医生意识的提高导致PPH发生时更迅速的干预;(2)在方案评估期间,剖腹产率随之增加。背景,目的:在妇女和其他妇女中,妇女和其他妇女在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在妇女和其他妇女的生活中,在生物和其他妇女的生活中,在妇女和其他妇女的生活中。Le但de ce阵痛是d 'evaluer评估de la协定在法国巴黎的ce protocole苏尔l 'incidence des hemorragies du产后物资等方法从de文档引用,principalement les RPC du CNGOF苏尔«杜l 'Hemorragie产后»公立依照ainsi en 20041, des referentiels苏尔la输血Le groupe EPP mis在地方联合国protocole写,valide组织et l 'ensemble des扩散de la maternite et des sages-femmes盟总理trimestre 2007。根据协议的原则,将其与系统的,将其与系统的,将其与系统的,将其与注射的,将其与细胞素的,将其与系统的,将其与系统的,将其与系统的,将其与系统的,将其与系统的,将其与系统的,将其与系统的,将其与系统的,将其与系统的,将其与系统的,将其与系统的。这是一种非常重要的测量方法,它可以用来测量人体的健康状况,也可以用来测量人体的健康状况。2007年(规定地点和批准日期)2008年(规定地点和批准日期)(规定地点和批准日期)。测试统计利用率:Test khi2和Test de Fisher对百分比进行了比较。结果2006年2007年2008年Naissances 5126 5139 5055 hcv - 1 / 4 190(3.70%) 157(3.05%) 78(1.54%) hcv - 1 1 / 4 34(0.66%) 25(0.49%) 32 (0.63%) (NS)输血12(0.23%)19(0.37%)33(0.65%)(p<0.001) ccv - 1 / 3 2102(48%) 3523 (83.3%) (p<0.001) ccv - 1 / 3 729 (14.2%) 776 (15.1%) 837 (16.5%) (p<0.05)讨论ccv - 1 / 3 montrent l'impact d'un tel protocole sur la diminution du nombre d' hcv - 1 / 3 moins d'un litl。1 .缔约国将不允许使用更小的名称,例如:“薪金薪金”,“薪金薪金”,“薪金薪金”,“薪金薪金”,“薪金薪金”,“薪金薪金”,“薪金薪金”,“薪金薪金”La prassenence en salle d' unobstsamtricien ssamiens chachaque accaccement associes of sage- me facility l'application du protocol .)输血发生率:2006年为0.24%,2008年为0.63%。
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Quality and Safety in Health Care
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