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Overnight or Short Stay Joint Replacements in the Public and Private settings: An Australian Experience. 夜间或短期停留关节置换在公共和私人设置:澳大利亚的经验。
Pub Date : 2021-01-01 DOI: 10.15438/rr.11.1.283
Sol Qurashi, Supreet Bajwa, Sam Aktas, W. B. Bestic, Jason Chinnappa
Introduction: In today’s post COVID 19 world, many healthcare systems have been pushed past the brink of economic sustainability. With Total Hip (THR) and Knee Replacements (TKR) being a few of the biggest ticket items, the need to adopt methods that improve quality of care & reduce unnecessary costs, is imperative. In this context, we report our experience with a Short Stay / Overnight joint replacement model using an ERAS (Enhanced Recovery After Surgery) Protocol which promotes rapid post-operative recovery and a decreased LOS without an increase in complications or readmission rates.   Method: Retrospective collection of clinical & demographic data was undertaken for 114 consecutive patients undergoing primary THR or TKR by a single surgeon between 1 January 2018 and 19 March 2020 at 2 hospitals (1 public, 1 private). The data was analyzed for LOS, complications & readmission rates within 90 days after surgery.   Results: In THR (n=93) and TKR (n=21), mean LOS was1.54 nights (range 0 - 4). 8 patients were discharged to a rehabilitation facility, the remaining 106 were discharged home. 2 patients were readmitted within 90 days of surgery - one with a periprosthetic fracture and the other for an unrelated respiratory illness.   Conclusion: The implementation of a Short Stay model and associated ERAS protocols in both the public and private hospital settings reduced LOS without a concomitant increase in postoperative complications or readmission rates.
导言:在2019冠状病毒病后的今天,许多医疗保健系统已被推到了经济可持续性的边缘。由于全髋关节置换术(THR)和膝关节置换术(TKR)是最昂贵的项目,因此采取提高护理质量和减少不必要成本的方法势在必行。在这种情况下,我们报告了我们使用ERAS(术后增强恢复)方案的短期住院/过夜关节置换模型的经验,该方案可促进术后快速恢复和降低LOS,而不会增加并发症或再入院率。方法:回顾性收集2018年1月1日至2020年3月19日在2家医院(1家公立医院,1家私立医院)由一名外科医生连续接受原发性THR或TKR的114例患者的临床和人口统计资料。分析术后90天内LOS、并发症和再入院率的数据。结果:在THR (n=93)和TKR (n=21)中,平均LOS为1.54夜(范围0 - 4)。8例患者出院至康复机构,其余106例出院回家。2例患者在手术后90天内再次入院,其中1例为假体周围骨折,另1例为无关的呼吸系统疾病。结论:短期住院模式和相关ERAS方案在公立和私立医院的实施降低了LOS,同时没有增加术后并发症或再入院率。
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引用次数: 3
Range of Motion Comparison Following Total Knee Arthroplasty with and without Patella Resurfacing 全膝关节置换术前后髌骨置换的活动范围比较
Pub Date : 2021-01-01 DOI: 10.15438/rr.11.1.286
Melissa Jackels, Samantha N. Andrews, Maya Y. Matsumoto, Kristin A Mathews, Cass K. Nakasone
Background: Despite significant evaluation, no consensus has been reach for best clinical practice for resurfacing the patella during total knee arthroplasty. Further complicating the ability to reach a conclusion is the inclusion of several different implant types used in previous research. Questions/Purpose: The purpose of this study was to compare post-TKA outcomes between two cruciate retaining implants with or without patella resurfacing. Methods: This retrospective review included 289 patients (380 knees) with a minimum six-month follow-up. All patients received a CR implant, with either a symmetric or an asymmetric tibial baseplate. Post-TKA knee flexion was categorized as <120° and ≥120° and knee extension classified as 0° or >0° and required knee manipulations were noted. Descriptive, nonparametric statistics were performed and a multivariate logistic regression was performed to determine risk of poor range of motion and manipulations. Results: Age was significantly lower in the resurfaced group (p=0.001) and the resurfaced group had longer tourniquet time (p=0.003). The symmetric-resurfaced group had ≥120° of flexion and full extension in 72% and 98.7% of patients, respectively. Compared to symmetric-resurfaced, all other groups had a significantly greater risk of not reaching 120° of knee flexion (p<0.05). There were no significant differences in the risk of requiring a MUA between groups (p>0.06). Conclusions: The effect of resurfacing the patella on post-TKA outcomes may be influenced by tibial implant design. Compared to all other combinations, a symmetric tibial baseplate and resurfaced patella resulted in the highest percentage of patients reaching ≥120°, with a low incidence of manipulations.
背景:尽管有重要的评估,但在全膝关节置换术中髌骨表面置换的最佳临床实践尚未达成共识。进一步使得出结论的能力变得复杂的是,在以前的研究中包括了几种不同的植入物类型。问题/目的:本研究的目的是比较有或没有髌骨表面置换的两种交叉保留植入物在tka后的结果。方法:回顾性分析289例患者(380个膝关节),随访至少6个月。所有患者都接受了CR植入,有对称的或不对称的胫骨底板。tka后膝关节屈曲为0°,并记录了所需的膝关节操作。进行了描述性、非参数统计,并进行了多变量逻辑回归,以确定不良活动范围和操作的风险。结果:表面修复组患者年龄明显降低(p=0.001),止血带时间明显延长(p=0.003)。对称表面修复组患者屈曲≥120°的比例分别为72%和98.7%。与对称表面修复组相比,所有其他组的膝关节屈曲度达不到120°的风险显著增加(p0.06)。结论:髌骨表面置换对tka术后预后的影响可能受胫骨植入物设计的影响。与所有其他组合相比,对称胫骨基板和髌骨表面置换导致≥120°的患者比例最高,手法发生率低。
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引用次数: 0
Metal-on-Metal Total Hip Arthroplasty: Current Recommendations and Lessons Learned 金属对金属全髋关节置换术:目前的建议和经验教训
Pub Date : 2021-01-01 DOI: 10.15438/rr.11.1.282
Jonathan Liu, Alister Hart, Brendan M. Holderread, T. Clyburn
Metal-on-metal (MoM) hip arthroplasty was re-popularized in the 1990s to resolve osteolysis and wear associated with metal-on-polyethylene products. Despite early success, registries began reporting high failure rates due to adverse reactions to metal debris (ARMD), manifesting as pseudotumors, hip effusions and osteolysis. Evaluation includes clinical exam, advanced imaging, and blood metal ions and infectious markers. This review provides physicians with an evidence-based update on the 1) clinical workup and management of patients with existing MoM implants, 2) risk and prognostic factors associated with suboptimal results and 3) the precipitating events and lessons learned applicable to future orthopedic prosthesis.
金属对金属(MoM)髋关节置换术在20世纪90年代重新普及,以解决与金属对聚乙烯制品相关的骨溶解和磨损。尽管早期取得了成功,但由于金属碎片(ARMD)的不良反应(表现为假性肿瘤、髋关节积液和骨溶解),登记开始报告失败率很高。评估包括临床检查,高级影像学检查,血液金属离子和感染标志物。本综述为医生提供了以下方面的循证更新:1)现有MoM植入物患者的临床检查和管理;2)与次优结果相关的风险和预后因素;3)适用于未来骨科假体的突发事件和经验教训。
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引用次数: 1
Addressing a Complex Proximal Femoral Deformity With Custom Cutting Guides Using 3D-Computer Design Software: A Case Report and 2-year Follow-Up 使用3d计算机设计软件处理复杂的股骨近端畸形与定制切割指南:一个病例报告和2年随访
Pub Date : 2021-01-01 DOI: 10.15438/rr.11.1.281
Zachary C. Hanson, Donald Davis, J. Robison, J. Minter
We report a case of a 23-year-old female with a history of congenital proximal femoral deformity and malunion of a prior proximal femoral corrective osteotomy, who presented seeking treatment for debilitating end-stage arthritis of her hip. Consideration for total hip arthroplasty (THA) for this patient was complicated by her young age and the complexity of her proximal femoral deformity. A 3-dimensional bone model of the patient’s femur was created using digital reconstructive software based on preoperative CT-imaging and used to plan our corrective osteotomy and arthroplasty component specifications. Using the detailed characterization of the femoral morphology, custom cutting guides were designed to fit uniquely into the correct position and ensure a high degree of accuracy with our osteotomy cuts. This unique case highlights the use of 3D-modeling software and printing technology for detailed surgical planning and precise execution in patients with complex deformities or otherwise abnormal anatomy.
我们报告一例23岁的女性,有先天性股骨近端畸形和股骨近端矫正截骨术不愈合的病史,她提出寻求治疗衰弱的终末期髋关节关节炎。由于患者年龄小,股骨近端畸形复杂,因此考虑进行全髋关节置换术(THA)。使用基于术前ct成像的数字重建软件创建患者股骨的三维骨模型,并用于计划我们的纠正截骨和关节置换术组件规格。利用股骨形态的详细特征,定制的切割导具被设计成独特地适合于正确的位置,并确保我们的截骨切割的高度准确性。这个独特的案例强调了3d建模软件和打印技术在复杂畸形或其他异常解剖患者中详细手术计划和精确执行的使用。
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引用次数: 0
Intrapelvic Pseudotumor Causing Neuropathy and Vascular Obstruction After Revision Total Hip Arthroplasty: A Case Report 改良全髋关节置换术后盆腔内假瘤引起神经病变和血管阻塞1例
Pub Date : 2021-01-01 DOI: 10.15438/rr.11.1.285
Matthew C. Sweet, T. Snoap, B. Roehr, Jason Roberts
Background: There is a growing body of recent literature regarding the occurrence of pseudotumors associated with modular junctions and various bearing surfaces after total hip arthroplasty (THA). Revision surgery is often technically challenging and high complication rates have been reported. The optimal management of these patients and outcomes after operative treatment remain poorly understood. Methods: We report the case of a 77-year-old male with progressive unilateral lower extremity swelling, pain, and neuropathy 9 years after revision THA for polyethylene liner wear. Imaging and biopsy confirmed a massive intrapelvic pseudotumor exerting compressive effects. Radiographs demonstrated extensive femoral and pelvic osteolysis without evidence of component loosening. Debulking of the intrapelvic portion of the pseudotumor was performed via the lateral window of the ilioinguinal approach with component retention. Results: Debulking of the intrapelvic mass resulted in resolution of symptoms. One year postoperatively the patient reported pain free ambulation using a walker and no recurrence of symptoms. Radiographs demonstrated stable THA components in comparison with preoperative films. Discussion and Conclusion: This case demonstrates a rare finding of intrapelvic pseudotumor causing neurovascular compression after revision THA. Clinicians should be aware of intrapelvic pseudotumor as a possible cause of limb swelling and neuropathy, and that debulking of the mass is a potential treatment option in the setting of well-fixed implants.
背景:最近有越来越多的文献报道全髋关节置换术(THA)后与模块化连接和各种承载面相关的假肿瘤的发生。翻修手术通常在技术上具有挑战性,并且有高并发症的报道。这些患者的最佳管理和手术治疗后的结果仍然知之甚少。方法:我们报告一例77岁男性患者,在聚乙烯衬垫磨损翻修THA 9年后出现进行性单侧下肢肿胀、疼痛和神经病变。影像学和活检证实一个巨大的盆腔内假瘤施加压缩效应。x线片显示广泛的股骨和骨盆骨溶解,无椎体松动迹象。假肿瘤盆腔内部分的去膨胀是通过髂腹股沟入路的外侧窗进行的,并保留了部分。结果:盆腔内肿块缩小,症状得到缓解。术后1年,患者使用助行器行走无疼痛,无症状复发。与术前片相比,x线片显示THA组成稳定。讨论与结论:本病例是一例罕见的髋关节置换术后盆腔内假性肿瘤引起神经血管压迫的病例。临床医生应该意识到盆腔内假瘤是肢体肿胀和神经病变的可能原因,并且在固定良好的植入物的情况下,肿块的减容是一种潜在的治疗选择。
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引用次数: 0
Early Post-operative Rises in Serum Metal Ion Levels in Total Hip Arthroplasty 全髋关节置换术后早期血清金属离子水平升高
Pub Date : 2020-12-04 DOI: 10.15438/rr.10.1.238
Michael Le, D. Maestri, Bob Jang, Jason Chinnappa, Sol Qurashi
Background: Serum Cobalt (Co) and Chromium (Cr) forms part of the diagnostic process for metallosis following Total Hip Arthroplasty (THA). While knowledge exists on longer term metal ion levels, expected early post-operative rises in serum Co and Cr in Metal-on-Polyethylene (MoP) THAs are currently unknown. This study aims to describe early rises in serum Co and Cr at 6 months postoperatively. Methods: A prospective cohort study of 84 consecutive patients with an uncemented titanium stem from a single THA manufacturer was performed. Patients had either a metal (n=43) or ceramic (n=41) head articulating with a highly cross-linked polyethylene. Serum Co and Cr levels were measured six months post-operatively. Analysis compared mean values between groups and to determined baseline levels. Subgroup analysis investigated the effect of femoral head size and offset on metal ion levels. Results: A mean difference of 0.002259 ppb (95% CI 0.000449-0.004069 ppb; p=0.015) was found when comparing 6-month serum Co in the metal head group compared to baseline. No significant differences were found in serum Cr (p=0.943) at six months post-surgery compared to baseline. Mean serum Co levels were higher in the MoP group compared to the CoP (Ceramic-on-Polyethylene) and auxiliary control group (p=0.012). There were no differences in serum Cr (p=0.976) between the MoP and CoP groups at 6 months post-surgery. Variations in femoral head size and offset did not impact metal ion levels. Conclusion: At six months post-surgery, a higher magnitude of serum Co exists in metal heads when compared to baseline (p=0.015) and to ceramic heads (p=0.012). Further study is required to determine whether serum concentrations of metal ions will continue to increase over time which might leads to implant failure and revision.
背景:血清钴(Co)和铬(Cr)是全髋关节置换术(THA)后金属中毒诊断过程的一部分。虽然对长期金属离子水平有了解,但术后早期在金属对聚乙烯(MoP) tha中血清Co和Cr的预期升高目前尚不清楚。本研究旨在描述术后6个月血清Co和Cr的早期升高。方法:一项前瞻性队列研究,对84例连续使用来自单一THA制造商的未胶结钛干的患者进行了研究。患者采用金属头(n=43)或陶瓷头(n=41)与高度交联聚乙烯连接。术后6个月测定血清Co和Cr水平。分析比较各组之间的平均值和确定的基线水平。亚组分析探讨股骨头大小和偏移量对金属离子水平的影响。结果:平均差值为0.002259 ppb (95% CI 0.000449-0.004069 ppb;p=0.015),比较金属头组6个月血清Co与基线的差异。术后6个月血清Cr与基线比较无显著差异(p=0.943)。MoP组的平均血清Co水平高于CoP (ceramic -on-聚乙烯)组和辅助对照组(p=0.012)。术后6个月MoP组与CoP组血清Cr差异无统计学意义(p=0.976)。股骨头大小和偏移量的变化对金属离子水平没有影响。结论:术后6个月,金属头的血清Co浓度高于基线(p=0.015)和陶瓷头(p=0.012)。需要进一步的研究来确定血清金属离子浓度是否会随着时间的推移而继续增加,这可能导致种植体失败和翻修。
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引用次数: 0
Impact of Anterior Cruciate Ligament Status on Early Satisfaction and Clinical Outcomes Following Total Knee Arthroplasty 前交叉韧带状态对全膝关节置换术后早期满意度和临床结果的影响
Pub Date : 2020-07-22 DOI: 10.15438/rr.10.1.236
Ali Etemad-Rezaie, Tori A. Edmiston, S. Kearns, Philip H. Locker, D. Bohl, Andrew C Sexton, R. Frank, B. Levine
Background: While total knee arthroplasty (TKA) is a successful treatment for debilitating arthritis, up to 20% of patients may be dissatisfied with their outcome. One hypothesis for dissatisfaction is the distortion of native knee kinematics following sacrifice of the anterior cruciate ligament (ACL) during TKA. The purpose of this study was to determine the impact of ACL status at the time of surgery in patients undergoing Posterior Stabilized (PS) TKA for osteoarthritis (OA). Methods: A consecutive prospective series of patients undergoing TKA by a single surgeon underwent prospective intraoperative assessment of their ACL status divided into three different groups:1) intact, 2) attenuated, or 3) deficient. Demographic, preoperative, intraoperative, and postoperative data were collected for each patient by two blinded, independent observers. Outcomes included patient satisfaction and Knee Society Score for Pain (KSS) and Function (KSF), Kellgren and Lawrence (K&L), UCLA Activity Score (UCLA), Short Form-12 (SF12), EuroQol (EQ5D) and patient satisfaction. Results: Of 116 patients, 33 (28.4%) patients had an ACL deficient knee, 40 (34.5%) patients had an attenuated ACL, and 43 (37.1%) patients had an intact ACL. Those with absent ACL were significantly more likely to have a higher BMI (p=.007) and be male (p=.003). Patient with a deficient ACL had significantly lower preoperative KSF and higher K&L scores (p=.009, p=1.26 x 10-7). Attenuated and deficient groups had the greatest change in SF12PCS scores at their one-year follow-up with increases of 9.9 (±10.0) and 10.8 (±8.0), respectively (p=.037). No significant differences in overall postoperative KSS, KSF and satisfaction scores based on ACL status (p=.574 and p=.529, respectively) were found. Conclusion: In a relatively large series, patient with ACL deficiency were more likely to have worse pre-operative outcome scores and similar or better post-operative outcome scores. This suggests that those with ACL insufficiency may experience more subjective improvement from TKA. ACL status can be used as an additional surgical marker to help orthopaedic surgeons identify which patients would most benefit from TKA.
背景:虽然全膝关节置换术(TKA)是一种治疗衰弱性关节炎的成功方法,但高达20%的患者可能对其结果不满意。不满意的一种假设是在TKA期间牺牲前交叉韧带(ACL)后,膝关节本身的运动学扭曲。本研究的目的是确定在骨性关节炎(OA)患者接受后路稳定(PS) TKA手术时ACL状态的影响。方法:对一名外科医生进行TKA的连续前瞻性患者进行前瞻性术中ACL状态评估,分为三组:1)完整,2)减弱或3)缺陷。每位患者的人口学、术前、术中和术后数据由两名独立的盲法观察者收集。结果包括患者满意度、膝关节疼痛评分(KSS)和功能评分(KSF)、Kellgren和Lawrence评分(K&L)、UCLA活动评分(UCLA)、短表12 (SF12)、EuroQol (EQ5D)和患者满意度。结果:116例患者中,33例(28.4%)患者为ACL缺陷膝,40例(34.5%)患者为ACL减弱,43例(37.1%)患者为ACL完整。前交叉韧带缺失的患者更有可能有更高的BMI (p= 0.007),并且是男性(p= 0.003)。前交叉韧带缺陷患者术前KSF明显降低,K&L评分明显升高(p=。009, p=1.26 × 10-7)。1年随访时,减毒组和缺陷组SF12PCS评分变化最大,分别增加9.9(±10.0)和10.8(±8.0),差异有统计学意义(p= 0.037)。术后总体KSS、KSF和基于ACL状态的满意度评分无显著差异(p=。574和p=。分别为529个)。结论:在一个相对较大的系列中,ACL缺陷患者更有可能具有较差的术前预后评分和相似或较好的术后预后评分。这表明那些ACL功能不全的患者可能会从TKA中获得更多的主观改善。ACL状态可以作为一个额外的手术标记,帮助骨科医生确定哪些患者将从TKA中获益最多。
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引用次数: 1
An Overview of Trauma Center Levels and Disparities in Rural Trauma Care 创伤中心水平与农村创伤护理差距综述
Pub Date : 2020-07-22 DOI: 10.15438/rr.10.1.234
Udit Dave, Brandon Gosine, Ashwin Palaniappan
Trauma centers in the United States focus on providing care to patients who have suffered injuries and may require critical care. These trauma centers are classified into five different levels: Level I to Level V. Level V trauma centers are the least comprehensive, providing minimal 24hour care and resuscitation, and Level I trauma centers are the most comprehensive, accepting the most severely injured patients and always delivering care through the use of an attending surgeon. However, there is a major inequity in access to trauma centers across the United States, especially amongst rural residents. Level III to Level V trauma centers tend to be dominantly situated in rural and underserved areas. Furthermore, trauma centers tend to be widely dispersed with respect to rural areas. Therefore, these areas tend to have a greater mortality rate in relation to traumatic injuries. Improvements in access to hightier traumatic care must occur in order to reduce mortality due to traumatic injuries in underserved rural areas. Possible improvements to rural trauma care include bolstering the quality of care in Level III trauma centers, increasing Level II center efficiency through the involvement of orthopedic traumatologists, placing medical helicopter bases in more strategic locations that enable transport teams to reach other trauma centers faster, building more Level I and Level II trauma centers, and converting Level III centers into either Level I or Level II centers. Defining Trauma Center Levels
美国的创伤中心专注于为受伤并可能需要重症监护的患者提供护理。这些创伤中心分为五个不同的级别:一级至五级。五级创伤中心是最不全面的,提供最少的24小时护理和复苏,而一级创伤中心则是最全面的,接受最严重的受伤患者,并始终通过主治医生提供护理。然而,在美国各地,尤其是农村居民进入创伤中心的机会存在严重的不平等。三级至五级创伤中心往往主要位于农村和服务不足的地区。此外,创伤中心往往广泛分布在农村地区。因此,与创伤相比,这些地区的死亡率往往更高。必须改善获得更高创伤护理的机会,以降低服务不足的农村地区因创伤而导致的死亡率。农村创伤护理的可能改进包括提高三级创伤中心的护理质量,通过骨科创伤学家的参与提高二级创伤中心效率,将医疗直升机基地设在更具战略意义的地点,使运输队能够更快地到达其他创伤中心,建造更多的一级和二级创伤医院,以及将三级中心转换为一级或二级中心。定义创伤中心级别
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引用次数: 4
In Memorium Richard D. “Nik” Nikolaev August 24, 1938 – December 19, 2019 纪念Richard D.“Nik”Nikolaev 1938年8月24日至2019年12月19日
Pub Date : 2020-07-22 DOI: 10.15438/rr.10.1.244
G. Cipolletti
The worldwide orthopaedic industry lost one of our true giants, as Nik Nikolaev passed away in December of last year. Nik is survived by Sandy, his wife of nearly 60 years, daughter Kimberly and son Cort, of whom he was immensely proud. He is also survived by all of us who had the privilege of knowing and working with him, and by the millions of patients who received the gift of a new prosthesis that Nik was responsible for commercializing.
Nik Nikolaev于去年12月去世,全球整形外科行业失去了我们真正的巨头之一。尼克在世的是结婚近60年的妻子桑迪、女儿金伯利和儿子科特,他为他们感到无比自豪。我们所有有幸认识他并与他共事的人,以及数百万收到Nik负责商业化的新假肢礼物的患者,都让他活了下来。
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引用次数: 0
Year of the Mask; COVID-19 Challenges for Orthopaedic Surgery 面具年;2019冠状病毒病对骨科手术的挑战
Pub Date : 2020-07-22 DOI: 10.15438/rr.10.1.241
E. Smith
As a response to the viral pneumonias and severe illnesses that were emerging in patients, an ophthalmologist Dr Li Wenliang, working at Wuhan Central Hospital, voiced his concerns only to be severely admonished by the authorities. The accelerated spread of the Severe Acute Respiratory Syndrome (SARS) in Wuhan, and then globally, as a result of the novel coronavirus was acute and pronounced. China alerted the World Health Organisation to several pneumonia cases at the end of December 2019 and the first death was recorded in early January 2020. The respiratory physician Dr Nanshan Zhong, announced human-to-human spread and a few days later on the 23 January 2020, Wuhan was placed under quarantine. The virus spread outside China and the WHO declared the outbreak a global health emergency on 30 January 2020. Tragically Dr Li Wenliang died on 7 February 2020 as a result of exposure to the virus, leaving a five-year-old son and a pregnant wife. On 11 February 2020, WHO named the novel viral pneumonia as Coronavirus disease 2019 (COVID-19). The International Committee on Taxonomy of Viruses suggested the name ‘SARS-CoV-2’ as a result of their phylogenetic and taxonomic analysis of the virus. Coronaviruses belong to the family of Coronaviridae, and comprise of large, single, plus-stranded RNA with a 29,903 nucleotide genome. There are 4 genera (designated α, β, γ, δ) of coronavirus and β-CoV mainly infects the respiratory, gastrointestinal, and central nervous system of humans and mammals. 2019-nCOV is the 7th member of the family of coronaviruses. SARS-CoV and MERS-CoV also belong to β-CoV and the nucleotide sequence similarity between SARS-CoV and 2019-nCoV is about 79%. SARS-CoV-2 possesses the typical coronavirus structure with a spike (S) protein in the membrane envelope. This S protein can bind to the receptors of the host to facilitate viral entry into target cells and can also bind to the human angiotensin converting enzyme 2 (ACE2), but cannot bind to the human cells without ACE2. The high affinity between ACE2 and the S protein also suggests that the population with higher expression of ACE2 might be more susceptible to SARS-CoV-2. [1] It is highly likely that the virus originated in its natural host, the horseshoe bat (Rhinolophus affinis) and spilled out via some wild animals such as pangolins, and from a seafood and meat market into humans. The human to human transmission of the virus is via direct transmission (cough, sneeze, droplet dispersal and droplet inhalation) and contact transmission via oral, nasal and eye mucous
作为对患者出现的病毒性肺炎和严重疾病的回应,武汉市中心医院的眼科医生李文亮医生表达了他的担忧,但遭到了当局的严厉警告。由于新型冠状病毒,严重急性呼吸系统综合征(SARS)在武汉以及随后在全球的加速传播是急性和显著的。2019年12月底,中国向世界卫生组织通报了几例肺炎病例,2020年1月初记录了首例死亡病例。呼吸科医生钟南山博士宣布了人与人之间的传播,几天后的2020年1月23日,武汉被隔离。该病毒在中国境外传播,世界卫生组织于2020年1月30日宣布疫情为全球卫生紧急事件。不幸的是,李文亮医生于2020年2月7日因接触病毒去世,留下一个五岁的儿子和一个怀孕的妻子。2020年2月11日,世界卫生组织将新型病毒性肺炎命名为2019冠状病毒病(新冠肺炎)。国际病毒分类委员会建议将其命名为“严重急性呼吸系统综合征冠状病毒2型”,这是对该病毒进行系统发育和分类分析的结果。冠状病毒属于冠状病毒科,由具有29903个核苷酸基因组的大的单链RNA组成。冠状病毒有4属(命名为α、β、γ、δ),β-CoV主要感染人类和哺乳动物的呼吸、胃肠和中枢神经系统。2019 nCOV是冠状病毒家族的第7个成员。SARS-CoV和MERS-CoV也属于β-CoV,其核苷酸序列与2019-nCoV的相似性约为79%。严重急性呼吸系统综合征冠状病毒2型具有典型的冠状病毒结构,膜包膜中有刺突蛋白。这种S蛋白可以与宿主的受体结合,促进病毒进入靶细胞,也可以与人类血管紧张素转换酶2(ACE2)结合,但不能在没有ACE2的情况下与人类细胞结合。ACE2和S蛋白之间的高亲和力也表明,ACE2表达较高的人群可能更容易感染严重急性呼吸系统综合征冠状病毒2型。[1] 该病毒很可能起源于其自然宿主马蹄蝙蝠(Rhinolophus affinis),并通过穿山甲等野生动物传播,并从海鲜和肉类市场传播给人类。病毒的人传人是通过直接传播(咳嗽、打喷嚏、飞沫传播和飞沫吸入)和通过口腔、鼻腔和眼睛粘膜的接触传播
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Reconstructive Review
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