Recenti progressi in medicina最新文献

After the normalization of social media in the Public Administration, they have become crucial to increasing citizen satisfaction. Alexandria Hospital has created a compliant website and an active presence on Facebook, Instagram, LinkedIn, X and YouTube. The main objectives of the "True or False" campaign are to educate the public on health issues, fight misinformation and evaluate knowledge on prevention. It was born from the evolution of the inclusion of polls in Instagram stories to increase streaming engagement. The campaign addressed topics such as breastfeeding and antibiotic resistance with true/false posts, followed by explanations from Aou AL health professionals. In 2023, the format became more interactive: followers were invited to answer true/false questions on topics such as breastfeeding and antibiotic resistance through the sentiments proposed by Facebook posts, awaiting responses from healthcare professionals published the next day. On World Cancer Day, the hospital asked eight questions, receiving 60 to 200 responses per post. Participants answered an average of six questions correctly, with accuracy ranging from 99% on UV exposure to 59% on post-surgery driving. These interactive campaigns foster trust and improve dialogue between PA and citizens.

Advanced triple-negative breast cancer is characterized by a severe prognosis, poor response to conventional therapies and poses multiple challenges for the medical oncologist. However, recent developments in molecular research and targeted therapy are opening up new perspectives with encouraging results for the treatment of this aggressive disease. The shared case wants to be an example: we will discuss the story of a 54 years old woman with extensive metastatic localizations in the skin that has obtained an important clinical response to therapy with sacituzumab govitecan, a conjugate antibody approved for the treatment of adult patients with metastatic triple negative breast cancer.

Cardiac rehabilitation (CR) is Class IA indication in patients after an acute cardiovascular (CV) event, with efficacy confirmed even in elderly or frail CV patients CV and geriatric outcomes. However, rate of referral and admission to CR of elderly CV patients remains very low. CV patients admitted in geriatric wards are often complex, multimorbid and frail. Therefore, the present position paper addressees their possible referral to CR, since many have various forms of CV diseases amenable to improve with CR. The multidisciplinary and comprehensive model of CR is applicable to these patients where evaluation and interventions should be tailored to the patient functional and clinical status, aiming to appropriate targets. Cardiologist, Geriatrician and other professionals, should synergistically integrate their competences, thus outlining also the new paradigm of "Cardiogeriatric Rehabilitation and Prevention", possibly leading to an increased awareness of the beneficial effect of CR and to an increased referral to CR from Geriatric departments. Operative recommendations are given, based on appropriateness and priority of indications, clinical risk and frailty level, integrating different expertise to reach more effective programs of care.

The initiative "Le parole della ricerca," launched in 2021, aims to enhance public understanding of health research through digital communication, using visual storytelling and local influencers. The project simplified complex research terms, linked to the DAIRI's activities, into 20 key concepts, illustrated by Gastini, and shared through social media. This campaign involved professionals explaining their work with the support of art, increasing public engagement. This campaign led to an increase in local knowledge of research-related topics, thanks to the increase in specifically dedicated posts on Facebook and their engagement.

Triple-negative breast cancer (TNBC) continues to be the most aggressive molecular subtype of breast cancer and the optimal therapeutic management is still a challenge. Due to the lack of "traditional" molecular targets, for decades, systemic treatment has been characterized by the use of classic cytotoxic drugs. In recent years, it has been proved that TNBC is not represented by a single pathology lack of specific features, but of different entities with distinct genetic, histological and clinical alterations. This allowed to optimize and improve the therapeutic management of the disease, with the approval of multiple anti-tumor agents, including antibody-drug conjugates (ADC). The clinical case we present illustrates the "journey" of a patient affected by metastatic TNBC, of the therapeutic choices made among the options available over the years, from the standard options to the innovative strategies.

This study evaluated the use of ChatGPT among current and former medical students enrolled at Italian universities. The primary goal was to assess its usage and applications in education. Secondary objectives included gathering opinions and satisfaction levels with ChatGPT for educational purposes. The survey included 208 participants, mainly Italian (95%) and aged 18-23 (76%). Most students were from public universities (62%). Nearly all respondents (99%) knew ChatGPT, and 79% used it for study support. Additionally, 81% consider AI suitable for educational purposes, and 39% positively changed their opinion after using it. While 78% found ChatGPT helpful, limitations like confusion (25%) and accuracy concerns (18%) were noted. Still, 85% found responses accurate, and 89% planned to keep using it, with 81% recommending it to peers. Our findings show ChatGPT is widely used by Italian medical students, despite concerns about accuracy and over-reliance. As we witness the rapid advent and evolution of these tools, it is crucial to consider their attentive and deliberate integration into various aspects of our lives.

For many new oncological drugs, including target therapy and immunotherapy, the treatment should be continued as long as the patient is deriving clinical benefit from therapy or until unacceptable toxicity occurs. Drug survival or Time to treatment discontinuation (Ttd) or persistence have become important intermediate efficacy endpoints, especially in real-world settings due to their strong correlation with endpoints such as Time to treatment failure (Ttf) and Progression free survival (Pfs). Our methodology is based on validated indicators and information technology tools, to develop continuous and updated oncology drug utilization reports in hospital setting which include data about enrolment curves, Ttd, adherence, dose intensity, dose changes and budget impact. We present, as real-world example, the case of anti-EGFR in first line NSCLC. We analysed data of first and second generation drugs (afatinib, gefitinib, erlotinib) and the new third generation drug (osimertinib). Median Ttd and adherence as Proportion of days covered (Pdc) were respectively 11.6 versus 23.4 months and 0.92 versus 0.95.