Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-10
A. Zarudsky, E. Perutskaya, D. Perutskiy
{"title":"Cognitive dysfunction in elderly patients with chronic systolic heart failure","authors":"A. Zarudsky, E. Perutskaya, D. Perutskiy","doi":"10.18413/2658-6533-2021-7-2-0-10","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-10","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75250030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-1
A. Ahmed, M. Azova
{"title":"Association of VEGFA, factor V and prothrombin gene polymorphisms with early pregnancy loss","authors":"A. Ahmed, M. Azova","doi":"10.18413/2658-6533-2021-7-2-0-1","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-1","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76627677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-11
Mikhail Yu Sorokin, N. Lutova, V. Wied, M. Khobeysh, O. Makarevich
Background: The expected effects of psychopharmacology in the clinic are mediated by changes in dopamine and serotonin neurotransmission that can determine impaired motivational processes in patients. The aim of the study: To study associations between psychopharmacotherapy and biological, psychological, and social factors of patients` medication adherence. Materials and methods: 83 patients hospitalized due to exacerbation for selection of therapy. Socio-demographic and medical history data were taken from medical records. The original Treatment Motivation Assessment Questionnaire and the Medical Compliance Scale were used. Dispersion analysis with p≤0.05 was performed. Effect sizes (ES) were calculated using Cohen’s d and Cramer’s V. Results: Patients taking atypical antipsychotics were characterized by shorter duration of illness and infrequent hospitalizations (ES=0.68 and 0.47). Only childless and single patients were treated with two antipsychotics (ES=0.32). Past non-compliance varied in subgroups of patients receiving typical and atypical antipsychotics (ES=0.74). The structure of patients' motivation for treatment was objectivized: outpatients treated with typical antipsychotics less often relied on their own knowledge and skills to overcome the disease making a decision about their treatment (ES=0.64) and had lower motivation (ES=0.6). Regardless of their class, the use of antidepressants was associated with better insight. However, unspecific intensification of treatment motivation occurred only when antidepressants were used in combination with mood stabilizers (ES=0.64). Conclusion: Patients' longterm adherence to psychopharmacotherapy is not only a socio-psychological construct, but also a biological process influenced by the neurotropic drugs prescribed in clinical practice. Оригинальная статья Original article Сорокин МЮ, и др. Эффекты психофармакотерапии и ... Sorokin MYu, et al. Effects of psychopharmacotherapy and ... 204
{"title":"Effects of psychopharmacotherapy and patients’ adherence: interdependence within the biopsychosocial paradigm","authors":"Mikhail Yu Sorokin, N. Lutova, V. Wied, M. Khobeysh, O. Makarevich","doi":"10.18413/2658-6533-2021-7-2-0-11","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-11","url":null,"abstract":"Background: The expected effects of psychopharmacology in the clinic are mediated by changes in dopamine and serotonin neurotransmission that can determine impaired motivational processes in patients. The aim of the study: To study associations between psychopharmacotherapy and biological, psychological, and social factors of patients` medication adherence. Materials and methods: 83 patients hospitalized due to exacerbation for selection of therapy. Socio-demographic and medical history data were taken from medical records. The original Treatment Motivation Assessment Questionnaire and the Medical Compliance Scale were used. Dispersion analysis with p≤0.05 was performed. Effect sizes (ES) were calculated using Cohen’s d and Cramer’s V. Results: Patients taking atypical antipsychotics were characterized by shorter duration of illness and infrequent hospitalizations (ES=0.68 and 0.47). Only childless and single patients were treated with two antipsychotics (ES=0.32). Past non-compliance varied in subgroups of patients receiving typical and atypical antipsychotics (ES=0.74). The structure of patients' motivation for treatment was objectivized: outpatients treated with typical antipsychotics less often relied on their own knowledge and skills to overcome the disease making a decision about their treatment (ES=0.64) and had lower motivation (ES=0.6). Regardless of their class, the use of antidepressants was associated with better insight. However, unspecific intensification of treatment motivation occurred only when antidepressants were used in combination with mood stabilizers (ES=0.64). Conclusion: Patients' longterm adherence to psychopharmacotherapy is not only a socio-psychological construct, but also a biological process influenced by the neurotropic drugs prescribed in clinical practice. Оригинальная статья Original article Сорокин МЮ, и др. Эффекты психофармакотерапии и ... Sorokin MYu, et al. Effects of psychopharmacotherapy and ... 204","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82236532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-5
H. N. Thi, Tai Phung Anh, Hien Nguyen Thanh, D. N. Anh, Linh Nguyen Anh, Huyen Nguyen Thi Thuong
{"title":"Study on the antioxidant capacity of Hibiscus rosa-sinensis decoction in vivo in Mus musculus var. albino","authors":"H. N. Thi, Tai Phung Anh, Hien Nguyen Thanh, D. N. Anh, Linh Nguyen Anh, Huyen Nguyen Thi Thuong","doi":"10.18413/2658-6533-2021-7-2-0-5","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-5","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86701088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-8
N. M. Agarkov, Tatyana S. Gorko, I. Lev, Alexey A. Shekaturov, A. A. Shabalin
{"title":"Changes in the blood complement system in the development of diabetic retinopathy in the elderly","authors":"N. M. Agarkov, Tatyana S. Gorko, I. Lev, Alexey A. Shekaturov, A. A. Shabalin","doi":"10.18413/2658-6533-2021-7-2-0-8","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-8","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91402986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-4
T. A. Samgina
{"title":"Influence of some risk factors and rs1799930 polymorphism of the NAT2-590 G>A gene on the development of chronic pancreatitis","authors":"T. A. Samgina","doi":"10.18413/2658-6533-2021-7-2-0-4","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-4","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83383648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-9
Еlena V. Enkova, Еlena V. Kiseleva, O. V. Khoperskaya, S. Shamarin, Ekaterina S. Dukhanina, E.Ya. Sentsova, Voronezh City Clinical Polyclinic No.
{"title":"Vaccination against human papillomavirus is a fundamental factor in the prevention of cervical cancer (review)","authors":"Еlena V. Enkova, Еlena V. Kiseleva, O. V. Khoperskaya, S. Shamarin, Ekaterina S. Dukhanina, E.Ya. Sentsova, Voronezh City Clinical Polyclinic No.","doi":"10.18413/2658-6533-2021-7-2-0-9","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-9","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72583638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-6
Hadeel N. AlSudairi, Alanoud T. Alrasheed, V. Dvornyk
Background: Uterine fibroids or uterine leiomyomata (UL) are common benign tu-mors of the uterine myometrium affecting a significant proportion of women at reproductive age. UL is a disease with complex etiology determined by many genetic and environmental factors. Estrogen is widely acknowledged as one of the main factors contributing to the risk and pathogenesis of UL. The aim of the study: To summarize available literature data about the estrogen-related environmental factors, genes and metabolic pathways, which may play a role in the disease. Materials and methods: The PubMed, Scopus, and Web of Science literature databases were searched for relevant articles using such keywords as ―uterine fibroids‖, ―uterine leiomyoma‖, ―estrogen‖, ―gene‖, ―association‖, ―expression‖, ―epigenetic‖ in various combinations. Results: Estrogen contributes to the risk and pathophysiology of UL in multiple ways. Apart from the well-known effect of estrogen on expression of many genes mediated by estrogen receptors, it increases sensitivity of myometrium to progesterone and thus influences expression of the progesterone-controlled genes. On the other hand, the data about association of various estrogen-related genes with UL are largely inconsistent and inconclusive. Conclusion: The observed heterogene-ity of UL apparently results from the diversity of mechanisms contributing to the disease. This makes identification of the causative genetic variants challenging and prompts for further studies of this problem.
背景:子宫肌瘤或子宫平滑肌瘤(UL)是子宫肌层常见的良性肿瘤，影响相当大比例的育龄妇女。UL是一种病因复杂的疾病，由多种遗传和环境因素决定。雌激素被广泛认为是导致UL发病的主要因素之一。本研究的目的:总结现有文献资料，探讨雌激素相关的环境因素、基因和代谢途径可能在该疾病中起作用。材料与方法:以关键词-子宫肌瘤‖、-子宫平滑肌瘤‖、-雌激素‖、-基因‖、-关联‖、-表达‖、-表观遗传‖等不同组合，在PubMed、Scopus、Web of Science数据库中检索相关文章。结果:雌激素多途径参与UL的发病和病理生理。除了众所周知的雌激素对雌激素受体介导的许多基因表达的影响外，它还增加了肌层对黄体酮的敏感性，从而影响黄体酮控制基因的表达。另一方面，各种雌激素相关基因与UL的关联数据在很大程度上是不一致和不确定的。结论:观察到的UL的异质性显然是由疾病机制的多样性引起的。这使得鉴定致病的遗传变异具有挑战性，并提示进一步研究这个问题。
{"title":"Estrogens and uterine fibroids: an integrated view","authors":"Hadeel N. AlSudairi, Alanoud T. Alrasheed, V. Dvornyk","doi":"10.18413/2658-6533-2021-7-2-0-6","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-6","url":null,"abstract":"Background: Uterine fibroids or uterine leiomyomata (UL) are common benign tu-mors of the uterine myometrium affecting a significant proportion of women at reproductive age. UL is a disease with complex etiology determined by many genetic and environmental factors. Estrogen is widely acknowledged as one of the main factors contributing to the risk and pathogenesis of UL. The aim of the study: To summarize available literature data about the estrogen-related environmental factors, genes and metabolic pathways, which may play a role in the disease. Materials and methods: The PubMed, Scopus, and Web of Science literature databases were searched for relevant articles using such keywords as ―uterine fibroids‖, ―uterine leiomyoma‖, ―estrogen‖, ―gene‖, ―association‖, ―expression‖, ―epigenetic‖ in various combinations. Results: Estrogen contributes to the risk and pathophysiology of UL in multiple ways. Apart from the well-known effect of estrogen on expression of many genes mediated by estrogen receptors, it increases sensitivity of myometrium to progesterone and thus influences expression of the progesterone-controlled genes. On the other hand, the data about association of various estrogen-related genes with UL are largely inconsistent and inconclusive. Conclusion: The observed heterogene-ity of UL apparently results from the diversity of mechanisms contributing to the disease. This makes identification of the causative genetic variants challenging and prompts for further studies of this problem.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86890896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-3
E. Reshetnikov
{"title":"Polymorphism of genes associated with the age at menarche and the risk of complications of pregnancy in women in the Central Black Earth Region of Russia","authors":"E. Reshetnikov","doi":"10.18413/2658-6533-2021-7-2-0-3","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-3","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78502236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.18413/2658-6533-2021-7-2-0-2
A. H. Albosale
{"title":"Association of polymorphism of genes STAT3, IL10 and IL12B with a viral load in women with human papillomavirus","authors":"A. H. Albosale","doi":"10.18413/2658-6533-2021-7-2-0-2","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-2","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81894849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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