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Prediction of the healing efficiency of episiotomy wounds using hydrogel dressings with lidocaine 使用含利多卡因的水凝胶敷料预测外阴切开术伤口的愈合效率
Pub Date : 2024-04-02 DOI: 10.30841/2708-8731.1.2024.300855
M. Liashko, D. Govsieiev
The objective: to study the factors affecting the healing process of an episiotomy wound and the effectiveness of using hydrogel dressings with lidocaine for its healing.Materials and methods. The prospective randomized study includes the analysis of anamnestic data from the medical cards of 123 primiparous women with episiotomy wounds who gave birth in the Kyiv City Maternity Hospital No. 5 during 2021–2022. The women were divided into two groups: a comparison group – 63 patients who received standard treatment, and a research group – 60 patients who additionally used hydrogel dressings with lidocaine on the wound.The healing of episiotomy wounds was evaluated according to the REEDA scale. Factors that may influence episiotomy wound healing were studied in patients of both groups: anthropometric indicators (age, height, body mass index), interventions during childbirth, and indicators of obstetric and gynecological history (term of gestation, volume of blood loss during childbirth, body weight of the newborn, etc.). Statistical analysis was performed using the Fisher, Mann–Whitney, Student and chi-square tests of the statistical package EZR v. 1.54.Results. Age (p=0.689) and body mass index (p=0.974) of patients in both groups did not show statistically significant differences. The duration of the second period of labor on average was 72 min (57.6–86.4) in the comparison group versus 43.2 min (28.8–57.6) in the research group with a statistically significant difference (p<0.001). No statistically significant differences were found between the two groups regarding the term of delivery, the volume of blood loss, the weight of the newborn, the risk of pregnancy loss, the frequency of labor induction, the weakness of labor activity, manual revision of the uterine cavity, and vacuum extraction of the fetus. The frequency of use of different types of anesthesia during childbirth also did not differ (р=0.396).REEDA scale assessment revealed a reduced risk of high sum scores in the research group (odds ratio (OR) = 0.16, 95% confidence interval (CI): 0.07–0.38), that supports the efficacy of hydrogel dressings with lidocaine. Analysis of the duration of the second labor period and gestational term also revealed an association with the risk of a high sum of points on the REEDA scale (OR = 1.22, 95% CI: 1.02–1.45 per 0.01 days; OR = 1.65, 95% CI: 1.16–2.35 per week of pregnancy).A multivariate model which included research group, body mass index, duration of the second labor period, gestational term confirmed a reduced risk according to the REEDA scale in this group (OR = 0.19, 95% CI: 0.08–0.47). The four-factor model had a high accuracy (AUC = 0.81, 95% CI: 0.73–0.88), indicating a strong relationship between the selected factors and the risk of complications after episiotomy.Conclusions. The use of hydrogel dressings with lidocaine and taking into account some aspects of childbirth, namely, the duration of childbirth and gestational period, can contrib
目的:研究影响外阴切开术伤口愈合过程的因素,以及使用含利多卡因的水凝胶敷料促进伤口愈合的效果。该前瞻性随机研究分析了 2021-2022 年间在基辅市第五妇产医院分娩的 123 名有外阴切开术伤口的初产妇的医疗卡数据。这些产妇被分为两组:对比组--63 名接受标准治疗的患者;研究组--60 名在伤口上额外使用含利多卡因的水凝胶敷料的患者。对两组患者中可能影响外阴切开术伤口愈合的因素进行了研究:人体测量指标(年龄、身高、体重指数)、分娩时的干预措施、妇产科病史指标(妊娠期、分娩时失血量、新生儿体重等)。统计分析采用 EZR v.1.54 统计软件包中的费雪检验、曼-惠特尼检验、学生检验和卡方检验。两组患者的年龄(P=0.689)和体重指数(P=0.974)在统计学上没有显著差异。对比组第二产程的平均持续时间为 72 分钟(57.6-86.4),而研究组为 43.2 分钟(28.8-57.6),差异有统计学意义(P<0.001)。两组在产程、失血量、新生儿体重、妊娠失败风险、引产频率、产程活动强度、人工修补宫腔和真空取胎等方面的差异无统计学意义。REEDA量表评估显示,研究组出现高总分的风险降低(几率比(OR)=0.16,95%置信区间(CI):0.07-0.38),这支持了利多卡因水凝胶敷料的功效。对第二产程持续时间和妊娠期的分析也显示出与 REEDA 量表高分总和的风险有关(OR = 1.22,95% CI:每 0.01 天 1.02-1.45;OR = 1.65,95% CI:每妊娠周 1.16-2.35)。多变量模型包括研究组、体重指数、第二产程持续时间、妊娠足月,根据 REEDA 量表,证实该组风险降低(OR = 0.19,95% CI:0.08-0.47)。四因素模型具有很高的准确性(AUC = 0.81,95% CI:0.73-0.88),表明所选因素与外阴切开术后并发症风险之间存在密切关系。使用含利多卡因的水凝胶敷料并考虑到分娩的一些因素,即分娩时间和妊娠期,有助于改善外阴切开术伤口的愈合过程。这种综合方法支持了在现代产科实践中使用含利多卡因的水凝胶敷料改善外阴切开术伤口患者治疗效果的有效性和意义。
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引用次数: 0
Age fertility rates in Transcarpathian region of Ukraine and analysis of birth rates by women who are not in registered marriage 乌克兰外喀尔巴阡地区的年龄生育率以及未登记结婚妇女的出生率分析
Pub Date : 2023-10-31 DOI: 10.30841/2708-8731.7.2023.292597
G.О. Slabkiy, О.S. Shcherbinska, V.J. Bilak-Lukianchuk, L. Rusyn
Ukraine is going through difficult times of a prolonged demographic crisis.The objective: to study and analyze the age-related birth rates in the Transcarpathian region of Ukraine and analyze the birth rates among women who are not in a registered marriage.Materials and methods. In the course of the study, official data from sectoral statistical reporting for 2000–2021 were used in the cross-section of the administrative territories of Transcarpathian region. The research was conducted in four stages. Bibliosemantic and medical-statistical methods and the method of structural logical analysis are used.Results. It was established that the total birth rate in Transcarpathian region during the study period decreased by 16.4% and in 2021 it was 1.534. At the same time, a decrease in the birth rate was registered in the age groups of women from 15 to 39 years, and among women in the age category 40–49 years, a tendency to increase the birth rate was revealed.In the age group of 15–19 years the birth rate decreased by 1.31 times and amounted to 39.6; in the age group of 20–24 years, the birth rate decreased by 1.33 times and amounted to 133.3; in the age group of 25–29 years the birth rate decreased by 1.34 times and amounted to 88.9; in the age group of 30–34 years the birth rate decreased by 1.09 times and amounted to 51.3; in the age group of 35–39 years the birth rate decreased by 1.08 times and amounted to 21.0; in the age group of 40–44 years the birth rate increased by 1.13 times and was 5.2; in the age group of 45–49 years, the birth rate increased by 3.0 times and was 0.3.The rate of children who were born in mothers who were not in a registered marriage increased by 1.8 times in 2021 and accounted for 24.3% of the total number of live births. A uniform growth of the specified indicator was registered both in cities and in rural areas.Conclusions. The results of the study provide a basis for ascertaining the negative dynamics of the birth rate in Transcarpathian region, which will further intensify due to the consequences of the war against Russian aggression.
目的:研究和分析乌克兰外喀尔巴阡地区与年龄相关的出生率,并分析未登记结婚妇女的出生率。在研究过程中使用了外喀尔巴阡州行政区域内 2000-2021 年部门统计报告的官方数据。研究分四个阶段进行。研究采用了文献学和医学统计方法以及结构逻辑分析方法。研究表明,外喀尔巴阡地区的总出生率在研究期间下降了 16.4%,2021 年为 1.534。与此同时,15 至 39 岁年龄组妇女的出生率有所下降,而 40 至 49 岁年龄组妇女的出生率呈上升趋势。9 人;30-34 岁年龄组的出生率下降了 1.09 倍,为 51.3 人;35-39 岁年龄组的出生率下降了 1.08 倍,为 21.0 人;40-44 岁年龄组的出生率上升了 1.13 倍,为 5.2 人;45 岁年龄组的出生率下降了 1.33 倍,为 133.3 人;25-29 岁年龄组的出生率下降了 1.34 倍,为 88.9 人;30-34 岁年龄组的出生率下降了 1.09 倍,为 51.3 人。2021 年,未登记结婚的母亲所生子女的比率增加了 1.8 倍,占活产婴儿总数的 24.3%。无论是在城市还是在农村地区,该指标的增长都是一致的。研究结果为确定外喀尔巴阡地区出生率的负面动态提供了依据。
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引用次数: 0
What is in common between preeclampsia, HPS70 and medieval headwear? Part I. Serum HPS70 in preeclampsia: systematic review and meta-analysis 子痫前期、HPS70 和中世纪头饰之间有何共同之处?第一部分:子痫前期血清 HPS70:系统回顾和荟萃分析
Pub Date : 2023-10-31 DOI: 10.30841/2708-8731.7.2023.292599
O.K. Popel, D. Govsieiev
The objective: to investigate the relationship between HSP70 concentrations in maternal serum and preeclampsia and assess the prospects of using HSP70 as a preeclampsia predictor.Materials and methods. The original publications, which study HSP70 in maternal serum of preeclamptic women, were searched and analyzed. Papers were identified with Scopus, PubMed Central, Virtual Health Library databases, published before January 2023, the keywords were «HSP70», «preeclampsia», «heat shock protein 70», «pregnant». Statistical analysis was performed via software EZR 1.55.Results. 16 case-control studies were included, making a total of 751 pregnant women with preeclampsia and 719 healthy pregnant women. The analysis found the statistically significant difference between HSP70 concentrations in maternal serum of preeclamptic and healthy pregnant patients. Cochrane Q-test showed high heterogeneity among studies (p<0.01), the value of the І2 statistic was 97%. Dividing the studies into groups made it possible to reduce or remove heterogeneity completely. This high level of heterogeneity for publications together, but low within most groups, suggests that there are certain factors that significantly influence some studies.Conclusions. The conducted systematic review and meta-analysis confidently indicate an increased average serum concentration of HSP70 in pregnant women with preeclampsia compared to healthy pregnant women at the corresponding gestational age.No statistically significant relationship was found between increased HSP70 concentration in preeclampsia and pregnant women’s age, gestational age, systolic and diastolic blood pressure. Quantitative assessment of HSP70 levels is complicated by the lack of a single standard for laboratory diagnostics. The case-control design of the presented studies limits their significance.The use of HSP70 as a predictor of preeclampsia is promising, but requires further study and prospective cohort studies.
目的:研究母体血清中HSP70浓度与子痫前期之间的关系,并评估使用HSP70作为子痫前期预测指标的前景。对研究子痫前期妇女母体血清中 HSP70 的原始文献进行了检索和分析。论文通过 Scopus、PubMed Central、Virtual Health Library 数据库查找,发表于 2023 年 1 月之前,关键词为 "HSP70"、"子痫前期"、"热休克蛋白 70"、"妊娠"。统计分析通过 EZR 1.55 软件进行。共纳入 16 项病例对照研究,包括 751 名子痫前期孕妇和 719 名健康孕妇。分析发现,子痫前期孕妇和健康孕妇母体血清中的 HSP70 浓度差异有统计学意义。Cochrane Q 检验显示各研究之间存在高度异质性(P<0.01),І2 统计量值为 97%。将研究分为几组后,异质性得以降低或完全消除。出版物的异质性很高,但大多数研究组内的异质性较低,这表明某些因素对某些研究有重大影响。所进行的系统综述和荟萃分析表明,与相应孕龄的健康孕妇相比,患有子痫前期的孕妇血清中 HSP70 的平均浓度有所增加。由于缺乏单一的实验室诊断标准,HSP70 水平的定量评估变得复杂。将 HSP70 用作子痫前期的预测指标很有希望,但还需要进一步研究和前瞻性队列研究。
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引用次数: 0
Inflammatory status of the birth canal of pregnant women with cervical insufficiency treated with progesterone therapy, cervical cerclage and obstetric pessary 使用黄体酮疗法、宫颈环扎术和产科用雌激素治疗宫颈机能不全孕妇的产道炎症状况
Pub Date : 2023-10-31 DOI: 10.30841/2708-8731.7.2023.292601
V. V. Bila, V.О. Chernega
Preterm birth is a major global health problem. Every year about 15 million babies are born prematurely in the world, of which 1 million newborns die. Spontaneous preterm birth (SPB) accounts for 40–45% of all preterm births. Cervical insufficiency (CI) is a significant risk factor for SPB. The studies have established the influence of the vaginal microbiome on cervical length during pregnancy and the importance of the bacterial composition of the vagina as a factor determining the risk of preterm birth.The objective: to study the vaginal microbiome of pregnant women with CI and various treatment methods (progesterone therapy, cervical suture or obstetric pessary).Materials and methods. During 2020–2023, an observational longitudinal study was conducted in the municipal non-profit enterprise “Perinatal Center of Kyiv”, in which 94 pregnant women participated. Among them 64 women were diagnosed CI (progesterone therapy group – n=22, cervical suture group – n=23 and obstetric pessary group – n=19). The control group included 30 pregnant women without CI.Results. Vaginal progesterone therapy and the use of a cervical suture have less effect on the microbiome than the use of a pessary. Conditionally pathogenic and pathogenic microflora was detected in 27.27% of patients in the progesterone group, 47.82% of patients in the cervical suture group, and 57.89% – in the pessary group.Inflammatory smear grade 3–4 was found in 31.81% of patients in the progesterone group, 47.82% – the cervical suture group, and 57.89% – the pessary group; complaints of discomfort and discharge – in 22.72%, 39.13% and 57.89% of patients, respectively. Compared with the control group, the use of a pessary is associated with an increase in the frequency of identification of opportunistic pathogenic microflora (16.67% vs. 52.63%; p<0.05), unsatisfactory results of bacterioscopic examination (20.00% vs. 57.89%; p<0.05), as well as an increase in complaints of discomfort and significant vaginal discharge (16.67% vs. 57.89%; p<0.05).Conclusions. It has been established that regardless of the type of therapy, inflammatory changes (presence of opportunistic pathogenic and pathogenic microflora, inflammatory type of smear, complaints of discharge and discomfort) of the birth canal are observed in pregnant women with CI.There is a connection between different methods of treatment and unsatisfactory results: bacteriological analysis – the presence of opportunistic pathogenic and pathogenic microflora (p<0.05), bacterioscopic analysis – inflammatory type of smear of the 3-4 grade of purity (p<0.05) and anamnestic analysis – the presence of complaints in female patients (p<0.05).
早产是一个重大的全球性健康问题。全世界每年约有 1500 万婴儿早产,其中 100 万新生儿死亡。自发性早产(SPB)占所有早产儿的 40-45%。宫颈机能不全(CI)是导致 SPB 的一个重要风险因素。研究证实了阴道微生物组对孕期宫颈长度的影响,以及阴道细菌组成作为早产风险决定因素的重要性。目的:研究 CI 孕妇的阴道微生物组和各种治疗方法(黄体酮疗法、宫颈缝合术或产科栓塞术)。2020-2023 年期间,在市级非营利企业 "基辅围产中心 "开展了一项观察性纵向研究,共有 94 名孕妇参与。其中 64 名妇女被诊断为 CI(黄体酮治疗组--22 人,宫颈缝合组--23 人,产科栓剂组--19 人)。对照组包括 30 名无 CI 的孕妇。阴道黄体酮疗法和使用宫颈缝合术对微生物组的影响小于使用栓剂。黄体酮组 27.27% 的患者、宫颈缝合组 47.82% 的患者和雌激素组 57.89% 的患者检测到条件致病性和致病性微生物群。黄体酮组中有 31.81%的患者出现炎性涂片 3-4 级,宫颈缝合组中有 47.82%的患者出现炎性涂片 3-4 级,雌激素组中有 57.89%的患者出现炎性涂片 3-4 级。与对照组相比,使用栓剂与机会性病原微生物菌群鉴定频率增加(16.67% 对 52.63%;P<0.05)、细菌学检查结果不满意(20.00% 对 57.89%;P<0.05)以及不适主诉和明显阴道分泌物增加(16.67% 对 57.89%;P<0.05)有关。无论采用哪种治疗方法,均可观察到 CI 孕妇产道的炎症变化(机会致病菌和病原微生物菌群的存在、涂片的炎症类型、分泌物和不适的主诉)。不同的治疗方法与不满意的结果之间存在联系:细菌学分析--存在机会致病性和致病性微生 物(p<0.05),细菌学分析--纯度为 3-4 级的炎性涂片(p<0.05),肛门分析--女性患者出现主 诉(p<0.05)。
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引用次数: 0
COVID-19 infection and hypertension disorders during pregnancy COVID-19 感染与妊娠期高血压疾病
Pub Date : 2023-10-31 DOI: 10.30841/2708-8731.7.2023.292596
A. Pylypenko, V. I. Medved
The objective: to determine the impact of COVID-19, which occurred before or during pregnancy, on the frequency of development and features of the course of gestational hypertension and preeclampsia.Materials and methods. An observational retrospective study with parallel control one was conducted. The pregnancy course and its outcomes in 178 women during the period of the COVID-19 pandemic – from March 2020 to January 2022 – who were observed in the women’s consultation of a private medical center, were analyzed. It is important to note that the medical documentation was taken one after the other, without being specially selected according to any principle, that is, the analysis carried out had the character of continuous screening.Out of 178 pregnant women, 125 (70.2%) persons were sick with COVID-19, they were included in the main group; 53 (29.8%) women who were part of the comparison group did not get sick. The groups are comparable by age and body mass index. The age of the women was 19–51 years; in the main group – 30.5±4.9 years, in the comparison group – 30.9±5.6 years. Body mass index (kg/m2) at the beginning of pregnancy in women of the main group was 21.6±4.3; comparison group – 22.9±4.8. There were 104 (58.4%) primigravida, 74 (41.6%) – multigravida. 117 (65.7%) women were primipara, 61 (34.3%) – multipara.All pregnant women were performed with a standard examination in accordance with the Order No. 417 of the Ministry of Health of Ukraine dated 15.07.2011. Clinical and anamnestic risk factors for the development of preeclampsia were assessed in all women without exception, on the basis of which 3 women were assigned to the risk group. In addition, 158 (88.8%) pregnant women as part of the first combined screening had an additional examination to determine the risk of developing preeclampsia, as a result of which additional 23 women were included in the risk group. As a result, 26 (14.6%) pregnant women from 12 weeks of gestation were prescribed prophylaxis using acetylsalicylic acid.Results. In women who have had COVID-19, hypertensive disorders of pregnancy develop statistically significantly less often than in those who have not had the disease. After mildly symptomatic COVID-19 the risks of hypertensive disorders in pregnant women are statistically significantly reduced: gestational hypertension – RR=1.15, 95% CI: 1.0–1.3; preeclampsia – RR=1.1, 95% CI: 1.0–1.2, all hypertensive disorders – BP=1.3, 95% CI: 1.1–1.6.The groups did not differ among themselves in the prevalence of generally accepted risk factors. The frequency of hypertensive disorders depending on the vaccination was analyzed. The risk of gestational hypertension in vaccinees who did not suffer from COVID-19 is reduced by 1.4 times (RR=1.4, 95% CI: 1.0–1.9), the risk of all hypertensive disorders in pregnant women in this same group is reduced 2 times (RR=2.0, 95% CI: 1.2–3.5).The development of preeclampsia also probably depends on the vaccination status (χ2=4.0; p
目的:确定妊娠前或妊娠期间发生的COVID-19对妊娠高血压和子痫前期的发病频率和病程特征的影响。该研究是一项带有平行对照的观察性回顾研究。研究分析了在 COVID-19 大流行期间(2020 年 3 月至 2022 年 1 月)在一家私立医疗中心妇女咨询处接受观察的 178 名妇女的妊娠过程及其结果。在 178 名孕妇中,125 人(70.2%)感染了 COVID-19,她们被列入主要群体;53 名(29.8%)属于对比群体的妇女没有感染。两组在年龄和体重指数方面具有可比性。妇女的年龄为 19-51 岁;主要组为(30.5±4.9)岁,对比组为(30.9±5.6)岁。主要组妇女怀孕初期的体重指数(kg/m2)为 21.6±4.3;对比组为 22.9±4.8。初产妇有 104 人(58.4%),多产妇有 74 人(41.6%)。根据乌克兰卫生部 2011 年 7 月 15 日第 417 号命令,对所有孕妇进行了标准检查。对所有孕妇无一例外地进行了子痫前期临床和产前风险因素评估,并根据评估结果将 3 名孕妇归入风险组。此外,作为首次联合筛查的一部分,158 名(88.8%)孕妇接受了额外的检查,以确定患子痫前期的风险,结果又有 23 名孕妇被纳入风险组。结果,26 名(14.6%)妊娠 12 周以上的孕妇接受了乙酰水杨酸预防治疗。与未患过 COVID-19 的孕妇相比,患过 COVID-19 的孕妇出现妊娠高血压疾病的频率明显降低。经轻度症状的 COVID-19 治疗后,孕妇罹患高血压疾病的风险在统计学上明显降低:妊娠高血压--RR=1.15,95% CI:1.0-1.3;子痫前期--RR=1.1,95% CI:1.0-1.2,所有高血压疾病--BP=1.3,95% CI:1.1-1.6。对接种疫苗后高血压疾病的发生率进行了分析。未接种过 COVID-19 的接种者患妊娠高血压的风险降低了 1.4 倍(RR=1.4,95% CI:1.0-1.9),同组孕妇患所有高血压疾病的风险降低了 2 倍(RR=2.0,95% CI:1.2-3.5)。未接种疫苗者的风险增加 1.1 倍(RR=1.1,95%CI:1.2-1.8)。在疫苗接种呈阴性的人群中,患所有高血压疾病的风险也较高(RR=1.3,95%CI:1.0-1.7),但显著性水平 p=0.06 不等,也就是说,这只是一种趋势。在孕前或孕期接种过COVID-19疫苗的妇女发生与妊娠相关的高血压疾病的可能性较小。由于免疫机制和胎盘-血管机制在子痫前期的发病机制中起着重要作用,因此我们假定,经历过冠状病毒感染或接种过冠状病毒疫苗的孕妇会破坏免疫的某些环节,从而导致孕妇高血压发病率的降低。
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引用次数: 0
The role of clinical and immunological factors in the outcomes of in vitro fertilization procedure in women 临床和免疫学因素在妇女体外受精手术结果中的作用
Pub Date : 2023-10-31 DOI: 10.30841/2708-8731.7.2023.292603
A.F. Safarova
The objective: to determine the features of clinical and immunological factors in women undergoing in vitro fertilization (IVF) procedure and to determine a relationship between these parameters and the procedure outcomes.Materials and methods. In the period from 2020 to 2022, 131 patients were examined at the Reproductive Department of the Caspian International Hospital. Of these, 103 (78.6%) are aged 19-35 years, 28 (21.4%) are aged 36-50. Patients were grouped and analyzed based on: IVF success (presence or absence of fertilization), pregnancy (yes, no), and infertility factors. Markers of peripheral blood mononuclear cells (CD16/56 and HLA-DR) were determined in 50 women. The cytokines – interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interferon-ɣ (IFN-ɣ) were studied in blood serum of 84 patients. All samples were taken at the day of oocyte pick-up. Descriptive statistical methods (mean, standard deviation, median, frequency, percentage, and minimum and maximum), Student-t test and Mann–Whitney U test (for comparisons between two groups) were used while evaluating the study data. Statistical significance was accepted as p<0.05.Results. Female infertility occurred in 49 (37.4%) patients, 82 (62.6%) patients were fertile. There was no significant difference in CD16/56 and HLA-DR levels depending on pregnancy status, IVF outcomes and infertility factors (p>0.05). The levels of IL-1β and IFN-ɣ differed in the blood serum of patients with and without pregnancy (p=0.041 and p=0.037, respectively). Analysis of groups based on infertility factors showed that there were not significant differences (p>0.05) in the levels of CD16/56, HLA-DR, IL-1β, TNF-α and IFN-ɣ between groups. Conclusions. Our study showed that there is an association between serum levels of IL‒1β and IFN-y and successful pregnancy in the IVF procedure. We did not reveal the other relationships between clinical and immunological parameters in women with IVF procedure.
目的:确定接受体外受精(IVF)手术的妇女的临床和免疫学因素特征,并确定这些参数与手术结果之间的关系。2020年至2022年期间,131名患者在里海国际医院生殖科接受了检查。其中 103 人(78.6%)的年龄在 19-35 岁之间,28 人(21.4%)的年龄在 36-50 岁之间。根据以下因素对患者进行分组和分析:试管婴儿成功率(有无受精)、怀孕率(有、无)和不孕因素。对 50 名妇女的外周血单核细胞标记物(CD16/56 和 HLA-DR)进行了测定。研究了 84 名患者血清中的细胞因子--白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)和干扰素-ɣ(IFN-ɣ)。所有样本均在取卵当天采集。在评估研究数据时使用了描述性统计方法(均值、标准差、中位数、频率、百分比、最小值和最大值)、Student-t 检验和 Mann-Whitney U 检验(用于两组间的比较)。统计学意义以 P0.05 为准。)妊娠和未妊娠患者血清中 IL-1β 和 IFN-ɣ 的水平存在差异(分别为 p=0.041 和 p=0.037)。根据不孕因素进行的分组分析表明,CD16/56、HLA-DR、IL-1β、TNF-α 和 IFN-ɣ 的水平在组间差异不显著(P>0.05)。结论我们的研究表明,IL-1β和IFN-y的血清水平与试管婴儿成功妊娠之间存在关联。我们没有发现试管婴儿过程中妇女的临床和免疫学参数之间的其他关系。
{"title":"The role of clinical and immunological factors in the outcomes of in vitro fertilization procedure in women","authors":"A.F. Safarova","doi":"10.30841/2708-8731.7.2023.292603","DOIUrl":"https://doi.org/10.30841/2708-8731.7.2023.292603","url":null,"abstract":"The objective: to determine the features of clinical and immunological factors in women undergoing in vitro fertilization (IVF) procedure and to determine a relationship between these parameters and the procedure outcomes.Materials and methods. In the period from 2020 to 2022, 131 patients were examined at the Reproductive Department of the Caspian International Hospital. Of these, 103 (78.6%) are aged 19-35 years, 28 (21.4%) are aged 36-50. Patients were grouped and analyzed based on: IVF success (presence or absence of fertilization), pregnancy (yes, no), and infertility factors. Markers of peripheral blood mononuclear cells (CD16/56 and HLA-DR) were determined in 50 women. The cytokines – interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interferon-ɣ (IFN-ɣ) were studied in blood serum of 84 patients. All samples were taken at the day of oocyte pick-up. Descriptive statistical methods (mean, standard deviation, median, frequency, percentage, and minimum and maximum), Student-t test and Mann–Whitney U test (for comparisons between two groups) were used while evaluating the study data. Statistical significance was accepted as p<0.05.Results. Female infertility occurred in 49 (37.4%) patients, 82 (62.6%) patients were fertile. There was no significant difference in CD16/56 and HLA-DR levels depending on pregnancy status, IVF outcomes and infertility factors (p>0.05). The levels of IL-1β and IFN-ɣ differed in the blood serum of patients with and without pregnancy (p=0.041 and p=0.037, respectively). Analysis of groups based on infertility factors showed that there were not significant differences (p>0.05) in the levels of CD16/56, HLA-DR, IL-1β, TNF-α and IFN-ɣ between groups. Conclusions. Our study showed that there is an association between serum levels of IL‒1β and IFN-y and successful pregnancy in the IVF procedure. We did not reveal the other relationships between clinical and immunological parameters in women with IVF procedure.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139307070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Лазерна корекція у поєднанні з перинеопластикою для підвищення сексуального задоволення 激光矫正与会阴成形术相结合,提高性生活满意度
Pub Date : 2023-10-31 DOI: 10.30841/2708-8731.7.2023.292600
T.A. Azeez, D.M. Abdulrahman, H.N. Saeed, M.J. Salim, O.I. Al-Mashhadani, B.A.L. Al-Rubaii
After vaginal delivery and improper episiotomy suturing about 40% of women complaint from wide vagina and defect in pelvic support which will lead to loss of satisfaction in sexual relationship with the partner. In recent years many different methods were used for solve the complaint for many of these ladies of wide vagina and loss of satisfaction in their sexual relationship, which was either surgical or non-surgical ways.The objective: to confirm that the fractional CO2 laser was emergency noninvasive modalities to solve problem with or without simple perineoplasty could be needed to restore pelvic support and improve sexual function of women.Materials and methods: 101 women took part in this prospective study. All women were old from 22 to 45 years. The degree of vaginal laxity severity was evaluated by vaginal examination in each patient. Perineal length, vaginal orifice length were measured and female sexual function index questionnaire was used to assess sexual satisfaction score. The women had different degree of vaginal laxity and underwent fractional CO2 laser from 2 to 3 sessions with or without simple perineoplasty and follow up them for gain vaginal tightness and improvement of their sexual function.Results. There was significant correlation between increase body mass index and parity with decrease sexual function of the women as the P values equal to 0.0001 and 0.029 consequently. Regarding the anatomical variation of the genital tract that occurs to women before and after doing the laser sessions and simple perineoplasty, our study show very significant correlation between partner satisfaction and anatomical variation were P value equal the following consequently 0.003, 0.035 and 0.57. Conclusion. The degree of vaginal laxity should be clinically evaluated and accordingly the use of only fractional CO2 laser with or without simple surgical perineoplasty to achieve vaginal tightness and improve in sexual function.
约有 40% 的妇女在阴道分娩和外阴切开术缝合不当后,抱怨阴道过宽和骨盆支撑力不足,导致她们在与伴侣的性关系中失去满足感。目的:证实点阵式 CO2 激光是一种紧急无创方法,无论是否需要进行简单的会阴成形术,都能解决问题,恢复骨盆支撑力并改善妇女的性功能。所有女性的年龄在 22 至 45 岁之间。每位患者的阴道松弛程度均通过阴道检查进行评估。测量会阴长度和阴道口长度,并使用女性性功能指数问卷评估性生活满意度。这些妇女的阴道松弛程度各不相同,她们接受了 2 至 3 次点阵 CO2 激光治疗,同时接受或不接受简单的会阴成形术,并对她们进行随访,以获得阴道紧致度和性功能的改善。结果表明,体重指数和胎次的增加与妇女性功能的下降有明显的相关性,P 值分别为 0.0001 和 0.029。关于女性在接受激光治疗和简单会阴成形术前后生殖道的解剖结构变化,我们的研究显示伴侣满意度与解剖结构变化之间存在非常显著的相关性,P 值分别为 0.003、0.035 和 0.57。结论临床上应评估阴道松弛的程度,并据此使用二氧化碳点阵激光和或不使用简单的会阴整形手术来达到阴道紧致和改善性功能的目的。
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引用次数: 0
Clinical assessment of the placenta function in women at risk and threat of premature delivery 对面临早产风险和威胁的妇女的胎盘功能进行临床评估
Pub Date : 2023-10-31 DOI: 10.30841/2708-8731.7.2023.292602
O. Laba, V. Pyrohova
Premature birth, despite the significant achievements of perinatal medicine in recent decades, remains an urgent global and national medical and social problem, as it is the leading cause of perinatal morbidity and mortality. According to modern views, placental dysfunction can be one of the causes of premature birth, and its frequency, according to randomized studies, can be from 78 to 91%, depending on the gestational age. At the same time, the research conducted to date does not provide a clear understanding of the role of timely diagnosis and prevention of placental dysfunction in preventing premature birth.The objective: to perform clinical evaluation of the prevalence of placental dysfunction in women at risk of preterm birth and with threat of preterm birth.Materials and methods. 180 pregnant women were took part in the study. To achieve the research aim, three research groups were formed. I group – 73 pregnant women with threat of premature birth; II group – 77 pregnant women with risk factors for premature birth. Women with risk factors for premature birth were included in the study at the stage of pregnancy planning (IIA subgroup, 39 women) or from the moment of applying to a women’s outpatient clinic to monitor the course of pregnancy (IIB subgroup, 38 pregnant women). The control group included 30 pregnant women with an uncomplicated course of pregnancy.Transabdominal ultrasound examination with color Doppler mapping, determination of free estriol, progesterone and placental lactogen levels in blood serum were performed at 18–21+6 and 28–30 weeks of gestation.Results. Analysis of the prevalence of risk factors for placental dysfunction and preterm birth in patients of the studied cohort showed that in pregnant women with preterm birth (I group), the combination of risk factors was 5.2; in pregnant women who received pre-gravid training (IIA subgroup) – 3.2; in pregnant women who were included in the study in the I trimester of pregnancy (IIB subgroup) – 4.7, while in pregnant women of the control group – only 0.8 (p<0.05).The threat of early spontaneous miscarriage with the formation of a retrochorial hematoma as a clinical manifestation of primary placental dysfunction was determined in 43.8% of pregnant women whose premature delivery was carried out for medical reasons. Placenta abruption in these patients can be considered as decompensation of the primary dysfunction of the placenta with the transition to acute placental insufficiency.The formation of chronic placental dysfunction, clinically manifested by the syndrome of fetal growth retardation, was most often observed in patients whose pregnancy ended in spontaneous premature birth at 34–36+6 weeks in the presence of an untouched amnion, – 68.6% compared to births at 28–33+6 weeks of gestation – 25.9% and with childbirth at 22–37+6 weeks – 13.3%.Conclusions. Clinical manifestations of placental dysfunction were detected in 30.6% of patients with premature birth, with morphologic
尽管近几十年来围产医学取得了重大成就,但早产仍然是一个紧迫的全球和国家医疗及社会问题,因为它是围产期发病率和死亡率的主要原因。根据现代观点,胎盘功能障碍可能是早产的原因之一,根据随机研究,其发生率从 78% 到 91%不等,具体取决于胎龄。同时,迄今为止进行的研究并没有清楚地认识到及时诊断和预防胎盘功能异常在预防早产中的作用。目的:对有早产风险和有早产威胁的妇女中胎盘功能异常的发生率进行临床评估。180 名孕妇参与了研究。为实现研究目的,我们成立了三个研究小组。第一组--73 名有早产危险的孕妇;第二组--77 名有早产危险因素的孕妇。具有早产风险因素的妇女在计划怀孕阶段(IIA 分组,39 名妇女)或在向妇女门诊部申请监测妊娠过程时(IIB 分组,38 名孕妇)就被纳入研究范围。在妊娠 18-21+6 周和 28-30 周时进行了经腹超声波检查和彩色多普勒成像,并测定了血清中游离雌三醇、孕酮和胎盘泌乳素的水平。对研究队列中胎盘功能障碍和早产患者的危险因素发生率进行的分析表明,在早产孕妇(I 组)中,危险因素的组合为 5.2;在接受孕前培训的孕妇(IIA 亚组)中为 3.2;在怀孕三个月时参与研究的孕妇(IIB 亚组)中为 4.7;而在接受孕前培训的孕妇(IIA 亚组)中为 4.7。43.8%因医疗原因而早产的孕妇被确诊为早期自然流产,并伴有作为原发性胎盘功能障碍临床表现的脐后血肿的形成。这些患者的胎盘早剥可被视为胎盘原发性功能障碍向急性胎盘功能不全的过渡。慢性胎盘功能障碍的形成,临床表现为胎儿生长迟缓综合征,多见于妊娠 34-36+6 周自然早产且羊膜未破的患者,占 68.6%,而妊娠 28-33+6 周分娩的患者占 25.9%,妊娠 22-37+6 周分娩的患者占 13.3%。在 30.6%的早产患者中发现了胎盘功能障碍的临床表现,在 60.4%的病例中发现了胎盘功能障碍的形态学征兆,这表明胎盘功能不全在早产发生之前就已经存在。在 87.5%的医学原因早产病例中和 100.0%的妊娠 22-27+6 周自然分娩病例中(风险因素组合从 2.1 到 3.0),在妊娠 22-27+6 周自然分娩病例中(风险因素组合从 2.1 到 3.0),在妊娠 22-27+6 周自然分娩病例中(风险因素组合从 2.1 到 3.0),都发现了胎盘功能障碍的形态学征兆。胎盘功能障碍形态特征的固定频率与早期妊娠并发症的发生频率相关,主要与妊娠前半期脐后血肿的形成有关。
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引用次数: 0
Attitudes of pregnant Ukrainian women towards their child in the ІІІ trimester of pregnancy during wartime in Ukraine in relation to women’s reproductive health (Podillia region) 乌克兰孕妇在乌克兰战争期间怀孕三个月时对孩子的态度与妇女生殖健康的关系(波迪利亚州)
Pub Date : 2023-10-31 DOI: 10.30841/2708-8731.7.2023.292598
O. Cherepiekhina, A. Turubarova, G. Gorshkova, V. Bulanov
Pregnancy for a woman is a period of transformation of her personal, professional, sexual, gender, bodily and other identities. The state of bearing a child is a crisis stage in the formation of a woman’s personality. In wartime this crisis may intensify, which requires scientifically based research in the context of women’s reproductive health and the demographic policy of Ukraine.The objective: to study the image of the future child in women in the III trimester of pregnancy during martial law in relation to women’s reproductive health.Materials and methods. 180 pregnant women, most of whom were aged 24–29 years and were officially married and had no children, were examined using a questionnaire, a color test of attitudes by O. M. Atkind and the method of semantic differential by C. Osgood. 90 women who were registered in Vinnytsia and Vinnytsia region at the time of the survey took part in the study, and 90 women – in city of Zaporizhzhia and Zaporizhzhia region.To determine the relationship between women’s perceptions of themselves, the child, and the husband, Pearson’s r correlation coefficients were calculated in the statistical program IBM SPSS Statistics - Early Access, and the Kruskel–Wallis H test was also used.Results. Research conducted among women living in Vinnytsia and Vinnytsia region established that the attitude of pregnant women to themselves affects the attitude to the child (p=0.772), to the pregnancy (p=0.162), to the family (p=0.599) and to the child’s father (p=0.923). A statistically significant relationship was found between the pregnant woman’s attitude towards herself and her children (p=0.001), as well as between her attitude towards herself and motherhood (p=0.022). That is, the type of emotional attitude of a pregnant woman to herself affects the type of attitude towards children and motherhood. By having a positive attitude towards themselves, women have a positive attitude towards children and towards motherhood.Also, with the help of the Kruskel–Wallis H test, the trend of the influence of the attitude towards the child depending on the age of the woman was revealed (XI=7.424; df=3; p=0.060), the trend of the influence of the level of education of the pregnant woman on her perception of pregnancy (XI 10.373; df=5; p =0.065). The correlation between the categories “I am a child” is r=0.676; between “father-child” categories - r=0.528; between “I am the father of the child” - r=0.439. At df=30, these indicators are significant.It should be noted that among the three indicators, the highest level of significance was found between the categories “I am a child”. A comparative analysis of the obtained data between groups of women from the Vinnytsia and Zaporizhzhia regions as research participants from regions of Ukraine with different levels of security, that is, with active hostilities and relatively calm regions, shows specific differences, the description of which is given in the text of this article.Conclusions. T
对妇女来说,怀孕是其个人、职业、性、性别、身体和其他身份发生转变的时期。生儿育女是妇女人格形成过程中的一个危机阶段。在战争时期,这种危机可能会加剧,这就需要在妇女生殖健康和乌克兰人口政策的背景下进行科 学研究。目的:研究戒严期间怀孕三个月妇女未来孩子的形象与妇女生殖健康的关系。通过问卷调查、O.M. Atkind 的态度色彩测试和 C. Osgood 的语义差异法对 180 名孕妇进行了调查,其中大部分孕妇年龄在 24-29 岁之间,已正式结婚且无子女。为了确定妇女对自己、孩子和丈夫的看法之间的关系,在统计程序 IBM SPSS Statistics - Early Access 中计算了 Pearson's r 相关系数,还使用了 Kruskel-Wallis H 检验。对居住在文尼察和文尼察地区的妇女进行的研究表明,孕妇对自己的态度会影响到对孩子的态度 (P=0.772)、对怀孕的态度(P=0.162)、对家庭的态度(P=0.599)和对孩子父亲的态度(P=0.923)。孕妇对自己和孩子的态度(p=0.001)以及对自己和做母亲的态度(p=0.022)之间存在明显的统计学关系。也就是说,孕妇对自己的情感态度类型会影响对孩子和母亲的态度类型。此外,借助 Kruskel-Wallis H 检验,还显示了妇女年龄对孩子态度的影响趋势(XI=7.424;df=3;p=0.060),以及孕妇受教育程度对其怀孕观念的影响趋势(XI 10.373;df=5;p=0.065)。我是孩子 "类别之间的相关性为 r=0.676;"父亲-孩子 "类别之间的相关性为 r=0.528;"我是孩子的父亲 "类别之间的相关性为 r=0.439。值得注意的是,在这三个指标中,"我是孩子 "类别之间的显著性水平最高。文尼察州和扎波罗热州妇女群体作为乌克兰不同安全等级地区(即敌对行动活跃地区和相对平静地 区)的研究参与者,对所获数据进行的比较分析表明了具体差异,本文将对这些差异进行描述。对乌克兰两个地区(文尼察州和扎波罗热州)妇女的研究结果表明,怀孕三个月妇女态度的特殊性可 以通过她们在战时的居住地来确定。结果证明,有必要为战时孕妇提供综合医疗和心理援助,以加强妇女的生殖健康。这种援助应根据妇女的居住地区有针对性地提供,研究结果表明,居住地区决定了孕妇对孩子的态 度特点(分别对来自文尼察和扎波罗热地区的孕妇进行了抽样调查)。情感支持应包括鼓励孕妇通过言语和非言语方式公开表达自己的感受,教她们接受他人的帮助,以及确保情感健康的自我帮助。心理生理层面的护理包括教导准妈妈在压力情况下使用自发训练、艺术疗法和身体导向疗法等方法来调节自己的机能和精神状态。
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引用次数: 0
COVID-19 as a multidisciplinary problem: impact on reproductive health (Literature review) 作为多学科问题的 COVID-19:对生殖健康的影响(文献综述)
Pub Date : 2023-10-31 DOI: 10.30841/2708-8731.7.2023.292604
S.M. Turyanytsia, N.O. Loya, O.O. Korchynska, A.V. Sabovа, V.V. Malyar
COVID-19 is an infectious disease which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). According to the WHO, on March 11, 2020, COVID-19 was declared a global pandemic. Undoubtedly, no one will deny that infectious pathology occupied and is occupying a significant place among all diseases of different age groups. The ongoing pandemic of coronavirus infection is a vivid proof of this.There is probably no such person in the world who would never “has his own little war” with infectious pathogens. Therefore, the disease is constantly looking for means that would give it an advantage in the fight against pathogens. Research in recent years indicates that COVID-19 affects not only the respiratory, circulatory and nervous systems, but also the reproductive system, in particular the female one.The article is devoted to a review of scientific publications that describe the impact of COVID-19 on women’s reproductive health. The COVID-19 pandemic has sparked debate in the scientific community focusing on the risk of menstrual changes in women with COVID-19, such as disorders in the duration, frequency, regularity, and volume of menstruation (including increased bleeding and clotting), increased severity of dysmenorrhea, and premenstrual syndrome. However, there is not enough data or information about the impact of COVID-19 on reproductive health.The problem of remote potential negative impact of the COVID-19 pandemic on women’s reproductive health is becoming more and more relevant in the practice of gynecologists. It is important to emphasize the need for high-quality work of gynecologists, which includes early diagnosis of reproductive disorders, adequate diagnosis and treatment in order to prevent complications in case of ovarian-menstrual cycle disorders, infertility and miscarriage.Unfortunately, to date there are no unambiguous data on the impact of SARS-CoV-2 on the reproductive system. Therefore, further research into the long-term consequences of the transferred coronavirus infection in women of reproductive age is critically important.
COVID-19 是一种由严重急性呼吸系统综合征冠状病毒-2(SARS-CoV-2)引起的传染病。世卫组织于 2020 年 3 月 11 日宣布 COVID-19 为全球大流行病。毫无疑问,没有人会否认传染病学在不同年龄组的所有疾病中占据着重要地位。冠状病毒感染的持续大流行就是生动的证明。因此,这种疾病一直在寻找能让它在与病原体的斗争中占据优势的手段。近年来的研究表明,COVID-19 不仅会影响呼吸系统、循环系统和神经系统,还会影响生殖系统,尤其是女性生殖系统。COVID-19 的流行引发了科学界的争论,争论的焦点是感染 COVID-19 的女性发生月经变化的风险,如月经持续时间、频率、规律性和经量的紊乱(包括出血和凝血增加)、痛经严重程度的增加以及经前综合征。然而,关于 COVID-19 对生殖健康的影响,目前还没有足够的数据或信息。COVID-19 大流行病对妇女生殖健康的潜在负面影响问题在妇科医生的临床实践中正变得越来越重要。必须强调的是,妇科医生必须开展高质量的工作,包括早期诊断生殖系统疾病,进行适当的诊断和治疗,以防止卵巢-月经周期紊乱、不孕和流产等并发症的发生。因此,进一步研究育龄妇女感染冠状病毒的长期后果至关重要。
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Reproductive health of woman
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