Reproductive health of woman最新文献

{"title":"Influence of hysterectomy due to leiomyoma on woman’s psychological status","authors":"О. Proshchenko, I. Ventskivska","doi":"10.30841/2708-8731.1.2023.276247","DOIUrl":"https://doi.org/10.30841/2708-8731.1.2023.276247","url":null,"abstract":"The objective: to study the clinical-psychopathological features and psycho-emotional symptoms and borderline mental disorders in women of reproductive age after hysterectomy due to leiomyoma.Materials and methods. An assessment of the psychological state of 160 women after hysterectomy for leiomyoma was carried out. 90 patients of them (average age – 45.9±1.3 years old) had transvaginal hysterectomy, both classic and laparoscopically assisted one with opportunistic salpingectomy (I group) and 70 patients (average age – 47.2±1.6 years old) – abdominal hysterectomy with opportunistic salpingectomy (II group). The control group included 50 women 45.7±1.3 years old with asymptomatic leiomyoma. Clinical psychopathological, anamnestic and experimental psychological methods were used. Pathopsychological methods included methods of visual presentation of the personality profile using the Minnesota Multifaceted Personality Questionnaire. The survey was conducted at the pre-operative period, during the adaptation period and during 12 months. Statistical processing of monitoring data was carried out according to the φ-criterion using the statistical analysis software package STATISTICA v. 10 and Microsoft Office Excel application. Results. The results of the questionnaire determined that 44 (48.89 %) patients of the I group and 33 (47.14 %) women of the II group had disorders related to anxiety, and 6 (6.67 %) and 5 (7 .14 %) of the patients of both groups, respectively, were diagnosed depression before surgical treatment. After hysterectomy the number of patients with an anxiety disorder increased to 52 (57.78 %) in the I group and 41 (52.57 %) – II group, with depression – to 10 (11.11 %) and 8 (11.43 %) women, respectively. However, the psychopathological analysis with psychologists in 12 months after hysterectomy determined affective symptoms in 11 (15.7±7.0 %), and latent depression with a somatopsychic correlation, manifested by a feeling palpitation, cardialgias, vegetative disorders was found in 8 (11.4±6.0 %) cases. The type of personality accentuation influenced the development of psychoemotional manifestations. In this structure, the largest rate consisted of psychoasthenic and hysterical character traits. The age of the patient was important when analyzing additional psychological factors. Women under 44 years old associated hysterectomy with loss of femininity with premature aging of the organism. The patients with successful implementation of their role in the family and society had better postoperative psychological adaptation.Conclusions. There is a trend toward an increased number of anxiety and depressive disorders after hysterectomy in women with leiomyoma. After 12 months, affective symptoms were present in 11 (15.7±7.0 %) cases and in 8 (11.4±6.0 %) cases – hidden depression. Postoperative rehabilitation should include a consultation with a psychologist to identify and treat borderline mental disorders, which will lead to the initiatio","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78613412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planning and use of oncoplastic surgery for breast cancer","authors":"A. Samusieva, R. Liubota, V. Zaichuk, O.V. Ponomarova, I. Liubota","doi":"10.30841/2708-8731.1.2023.276256","DOIUrl":"https://doi.org/10.30841/2708-8731.1.2023.276256","url":null,"abstract":"Today, breast conserving surgery among women with different stages of breast cancer is increasing. In addition, these operations do not differ in oncological radicality and do not show differences in relation to survival compared to mastectomy, but their cosmetic and psychological benefits are significant. In search of a balance between the risk of local recurrence and cosmetic results in surgical interventions in breast cancer, new surgical variants were introduced – a combination of breast conserving surgery with plastic surgery, so-called oncoplastic surgery. Oncoplastic surgery has been widely developed in the surgical treatment of breast cancer in the last decade. In oncoplastic breast surgery, the tumors of the upper-inner quadrant of the breast are problematic and require more attention of the surgeon. In these cases the size and location of the tumor are two important factors for the post-operative cosmetic outcome. In this article we introduce a modified dermoglandular rotation flap technique, which can be applied for relatively large tumors of inner quadrant of the breast without surgery of the contralateral breast for symmetrical effect. With this technique, a larger breast tumor could be removed without compromising the breast appearance. An important aspect of breast conserving surgery is preoperative evaluation of the clinical and biological features of the tumor as well as the morphological aspects of tumor allow the surgeon to make a decision if a conservative is possible and select the most effective oncoplastic surgical technique. Oncoplastic techniques may improve cosmetic view and patient satisfaction without compromising the oncological outcomes, which is confirms the clinical utility of this approach to the surgical management of patients with breast cancer. The article also presents clinical cases – 46 years old patient with left breast cancer (stage I cT1N0M0 pT1N0M0) and a patient of 42 years old with right breast cancer (stage I cT1NXM0 pT1N0M0) in the treatment of which the described technique was applied.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80327981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of isthmic-cervical insufficiency in miscarriage","authors":"О.V. Golyanovsky, O.Z. Morozova, K. Supruniuk, S. V. Frolov","doi":"10.30841/2708-8731.7.2022.272473","DOIUrl":"https://doi.org/10.30841/2708-8731.7.2022.272473","url":null,"abstract":"Cervical insufficiency (CI) is one of the main pathological conditions that leads to pregnancy loss, in particular, recurrence miscarriages and premature births, which account for up to 5 % of all obstetric cases. Recurrence pregnancy losses caused by CI lead to serious psychological trauma for both the woman and her family members, as well as significant economic losses for the society. However, many women in some regions of the world still do not know about this pathology, and clinicians do not always diagnose this condition in time.At the same time, etiology of CI remains uncertain, and there are still ambiguous points regarding the diagnosis of this pathology and its treatment. The diagnosis of CI should be established by analyzing the medical history, clinical manifestations and results of ultrasound examination. Treatment of CI mainly includes surgical and conservative methods. Surgical treatment is performed with cervical cerclage, while conservative techniques mainly include the use of vaginal progesterone and insertion of various types cervical pessaries. This article summarizes the potential risk factors associated with cervical insufficiency that are of great attention and may be useful for future researches. Also, the review of the literature considers modern methods of diagnosis and treatment of CI to understand this pathology of the cervix better. From a modern standpoint, a consensus and problematic issues are presented in accordance with the recently updated recommendations, which are of practical importance, and are also important for further deeper research on this topical issue of modern obstetrics.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88420505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actualization of differential diagnosis of chronic pelvic pain syndrome in women of reproductive age","authors":"O. Solomko, S. Shurpyak","doi":"10.30841/2708-8731.7.2022.272474","DOIUrl":"https://doi.org/10.30841/2708-8731.7.2022.272474","url":null,"abstract":"The objective: to study the significance of the levels of tumor necrosis factor α (TNF-α) and brain-derived neurotrophic factor (BDNF) in the blood of patients with chronic pelvic pain syndrome (CPPS).Materials and methods. The examined cohort included 150 patients with CPPS, who according to the clinical manifestations were divided into groups A and B: group A (n=74) included the patients with CPPS and suspicion of endometriosis and group B (n=76) – patients with CPPS and suspicion for benign proliferative diseases of reproductive organs. The control group included healthy women (n=50).Serum TNF-α and plasma BDNF levels were investigated by enzyme-linked immunosorbent assay. A visual analog scale (VAS) was used to study pain intensity.Results. The mean concentration of TNF-α in blood serum was significantly higher in women of group A (10.76±0.55 pg/ml) and group B (14.65±0.95 pg/ml) than in the control one (5.02±0.31 pg/ml). The mean concentration of BDNF in blood plasma was higher in women in group A (1473.88±53.02 pg/ml; p<0.001) and in group B (1711.65±66.79 pg/ml; p<0.01) compared to the control group (1082.91±56.24 pg/ml). The levels of TNF-α (p<0.001) and BDNF (p<0.01) are significantly higher in the blood of patients with CPPS and suspected combined benign proliferative diseases of the reproductive organs (group B) than in patients with CPPS and suspected endometriosis (group A).Between the intensity of pain according to VAS and the level of TNF-α in the blood a direct correlation of medium strength was found (r=0.56) in patients of group A and group B (r=0.62). A strong direct correlation between the intensity of pain according to VAS and the level of BDNF in the blood was established in women of group A (r=0.74) and group B (r=0.83).Between the disease duration and the level of TNF-α in the blood of patients a direct correlation of medium strength (r=0.65) in group A and a direct strong correlation (r=0.72) in group B were determined. Between the duration of the disease and the level of BDNF in the blood of patients a direct correlation of average strength was also establishe, a strong correlation (r=0.67) was determined in group A and a direct strong correlation (r=0.78) – group B.Conclusions. Women with CPPS and suspicion of benign proliferative diseases of the organs of the reproductive system have significantly higher concentrations of TNF-α and BDNF in the blood compared to healthy women (p<0.001).The existence of a direct correlation between the intensity of pain, the duration of the disease, and the levels of TNF-α and BDNF suggest the possibility of their use as objective markers of the effectiveness of diagnostic and therapeutic measures.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81066481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric complications in women who underwent conservative myomectomy before pregnancy","authors":"V. О. Zabolotnov, O.V. Astrayko, L. Olefir, R.O. Sorokotyaga","doi":"10.30841/2708-8731.8.2022.272542","DOIUrl":"https://doi.org/10.30841/2708-8731.8.2022.272542","url":null,"abstract":"The article presents a literature review devoted to the obstetric complications in pregnant women after conservative myomectomy. The attention is paid to such a complication as uterine rupture. The authors consider impractical to evaluate the uterine scar before pregnancy using ultrasound methods and hysteroscopy.Uterine rupture of any type should be documented in the medical history (published), which allows the clinicians and women to better understand factors associated with the risk for rupture and to inform the patient’s decision to deliver by cesarean section or through the vagina.A review and analysis of a case of uterine rupture in a patient after conservative myomectomy is also performed. A 40-weeks pregnant woman was taken to the operating room 12 hours after the start of the acute uterine rupture clinic and decrease of hemodynamic parameters. About 2 liters of blood was found in the abdominal cavity, and a tear up to 7 cm long was determined in the area of the uterine fundus, closer to the left uterine angle. In the female outpatient consultation, during the observation of a pregnant woman who had the laparoscopic intervention – myomectomy, a diagnosis of “scar on the uterus” was not established. Medical documentation providing information on prior surgery was ignored and was not required. During the observation of the pregnant woman, the method of childbirth was not considered by the doctor’s council, and prenatal hospitalization was not performed.By studying the modern scientific sources, there is very little data about factors what increase the risk of uterine rupture, such as penetration into the uterine cavity. Performance of laparoscopic intervention, as a rule, is associated with the implementation of reproductive function in the future. Obstetricians and gynecologists who perform surgical intervention should describe the operation protocol not formally, but taking into account the implementation of the reproductive function. For many women after myomectomy, vaginal delivery can be a safe and feasible option, with patient choice and informed consent regarding the mode of delivery is important. Women should be offered choice and provided with appropriate counseling using all available evidence and monitored during pregnancy and birth in health care institutions that support their choice. This article provides practical recommendations for the management of pregnancy and childbirth in patients who had conservative myomectomy.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72984237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential evaluation of the quality of life of women with chronic pelvic pain syndrome depending on concomitant pathologies.","authors":"O. Solomko, S. Shurpyak","doi":"10.30841/2708-8731.8.2022.273295","DOIUrl":"https://doi.org/10.30841/2708-8731.8.2022.273295","url":null,"abstract":"The World Health Organization defines quality of life as a person’s perception of his position in life in the context of the culture and value systems in which he lives, as well as in relation to his goals, expectations, standards and problems. Today, chronic pelvic pain is considered a condition that can significantly affect the quality of life. At the same time, there are significant prospects for using this method to evaluate the effectiveness of treatment. The objective: to evaluate of changes in the quality of life of patients with chronic pelvic pain syndrome (CPPS) depending on accompanying pathologies. Materials and methods. The examined cohort included 150 patients with CPPS, who according to the clinical manifestations were divided into groups A and B: group A (n=74) – patients with CPPS and suspicion for endometriosis and group B (n=76) – patients with CPPS and suspicion for combined benign proliferative diseases of reproductive organs. The control group included healthy women (n=50).SF-36 questionnaire which involves the use of eight scales of questions to determine the level of quality of life was used to assess the quality of life.Results. A decrease in quality of life was found in all the scales of the SF-36 questionnaire in patients with CPPS. A statistically significant difference was found in all scales between A and B groups compared to the control group (p<0.001).In addition, a significant difference was found in all scales of the questionnaire between the group with CPPS and combined benign proliferative diseases of the reproductive organs compared to the group with CPPS and endometriosis (p<0.05). At the same time, the most significant changes were found in the scale of physical role functioning and the scale of social role functioning.Conclusions. The decrease in indicators on all scales of the SF-36 questionnaire in patients of the studied cohort confirms that CPPS significantly affects all areas of their quality of life. Significantly lower indicators were observed in the group with CPPS and combined hyperproliferative pathology compared to the group with CPPS and endometriosis (p<0.05).","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86940604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The features of psychological status of pregnant women with an allogeneic fetus","authors":"T. Romanenko, N. Yesyp","doi":"10.30841/2708-8731.8.2022.273297","DOIUrl":"https://doi.org/10.30841/2708-8731.8.2022.273297","url":null,"abstract":"The objective: to establish the peculiarities of the psychological status of pregnant women with an allogeneic fetus.Materials and methods. The psychological status of 120 pregnant women, who were divided into two groups, was assessed. I group included 80 patients after in vitro fertilization (IVF) programs with the formation of an allogeneic fetus, II group (control one) included 40 pregnant women after IVF with the woman’s own oocytes.The psychological state of pregnant women was assessed using the Spielberger-Hanin questionnaire, the Holmes and Rahe stress event scale, the assessment of well-being, activity and mood, the Edinburgh Postnatal Depression Scale, and the SF-36 quality of life questionnaire.Results. A high level of reactive anxiety was significantly more often determined in pregnant women with an allogeneic fetus compared to the pregnant women in the control group (32.50 % and 12.50 %, respectively), as well as uncertain indicators according to the Edinburgh Postnatal Depression Scale (72.50 % and 52.50 %, respectively).During the evaluation of the quality of life in patients of the I group, significantly lower indicators of role-emotional functioning (41.13±5.29 points), social functioning (72.76±4.88 points), as well as role-physical functioning (35.12±7.22 points) and vitality (38±7.11 points) than in the examined women of the II group (62.43±5.45, 84.4±5.02, 46.89±6.51 and 59.56±9.78 points, respectively) were established. The indicators of well-being and mood were also significantly lower in the I group (3.88±1.40 and 4.21±1.27 points, respectively) compared to the II group (4.83±1.55 and 5.13±1.49 points, respectively).Conclusions. The psychological status of pregnant women with an allogeneic fetus is characterized by the presence of statistically significant deviations not only compared to the control group, but also to the normative indicators provided by standardized survey methods. This indicates the necessity for further study of the relationship between these factors and the frequency of complications during pregnancy, childbirth and the postpartum period, as well as the condition of newborns in these women and possible ways of correcting the psychological status to reduce the frequency of obstetric and perinatal complications.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87433049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental factors in the development of preterm birth in pregnant women with comorbidity","authors":"S. Heryak, N. Petrenko, V. Dobrianska","doi":"10.30841/2708-8731.8.2022.272543","DOIUrl":"https://doi.org/10.30841/2708-8731.8.2022.272543","url":null,"abstract":"Premature birth (PB) is a polyetiological problem that depends on many factors, accompanied by violations of the placenta functional competence, changes in its metabolic, hormone-producing and protective functions. The objective: to establish the importance of placental factors in the development of PB in pregnant women with comorbid pathology. Materials and methods. The levels of fetal and placental proteins (placental alfa microglobulin-1, α2-microglobulin of fertility, trophoblastic β1-glycoprotein) and hormones (estriol, placental lactogen, progesterone) were determined in 33 pregnant women with threat of PB at 26–34 weeks of gestation (main group), who had concomitant comorbid pathology in the stage of unstable remission. The control group included 26 healthy pregnant women who were representative for gestational age. Results. In pregnant women with comorbid pathology a decrease of the placenta protein-synthesizing function and the hormone-producing function of the trophoblast was found, which makes it difficult to launch the syntoxic adaptation programs of the mother’s organism, which are responsible for maintaining the pregnancy with the subsequent development of placental dysfunction, the result of which is PB.The markers of these disorders are a 3-fold decrease in the level of trophoblastic β1-glycoprotein (p<0.0001) and a 1.7-fold decrease in the concentration of α2-microglobulin of fertility (p<0.0001) with a simultaneous 4-fold increase of placental alfa microglobulin-1 concentration (p<0.0001) and a decrease in the levels of placental lactogen by 1.6 times (p<0.0001), estradiol by 40 % (p<0.0001) and progesterone by more than 2 times (p<0.0001) compared to healthy pregnant women.Conclusions. In patients with comorbid pathology there are disorders in the secretion of pregnancy proteins due to a decrease in the levels of trophoblastic β1-glycoprotein and α2-microglobulin of fertility and an increase in the level of placental alfa microglobulin-1 and disorders of the hormone-producing function of the trophoblast due to a decrease in the secretion of placental lactogen, progesterone, and estradiol. The disturbance of the secretion of the pregnancy zone proteins and hormones are the early markers for the initiation of premature birth caused by placental dysfunction in pregnant women with comorbid pathology.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79160243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the clinical course of pregnancy, childbirth and the condition of newborns in women with HCV infection","authors":"K. Chaika, Y.M. Zapopadna","doi":"10.30841/2708-8731.8.2022.273289","DOIUrl":"https://doi.org/10.30841/2708-8731.8.2022.273289","url":null,"abstract":"The objective: to conduct a retrospective clinical and statistical analysis of the pregnancy course, childbirth and the condition of newborns in women with HCV infection.Materials and methods. A retrospective clinical and statistical analysis of the pregnancy course, childbirth and the condition of newborns was carried out according to the data of 351 birth histories of women with HCV infection based on the materials of the archive of the communal non-commercial enterprise “Kyiv Municipal Center of Reproductive and Perinatal Medicine” for the period from 2016 to 2021. The control group (CG) included 50 healthy pregnant women. Statistical processing of research results was carried out using standard programs “Microsoft Excel 5.0” and “Statistica 8.0”. Results. In women with HCV infection compared to the group of healthy pregnant women a significantly high frequency (p<0.001) of such pregnancy complications was found: threat of pregnancy interruption – 64 (18.2 %) patients versus 2 (4.0 %) persons, edema of pregnant women – 72 (20.5 %) and 4 (8.0 %), respectively; preeclampsia – 45 (12.8 %) versus 2 (4.0 %), gestational anemia – 131 (37.3 %) versus 6 (12.0 %), as well as placental insufficiency with fetal growth retardation syndrome (FGR) – 69 (19.6 %) versus 3 (6.0 %; p<0.05) and intrahepatic cholestasis of pregnant women – 42 (11.9 %) versus 1 (2.0 %; p<0.05). In 73 (20.8 %) pregnant women with HCV infection the childbirth was complicated by premature rupture of the membranes, of which almost half of the cases (42 (11.9 %) of the patients) finished with premature birth, while in CG only some women had such complications. Fetal distress during childbirth was reliably detected more often in pregnant women with HCV infection than in CG women (χ2=4.76; p=0.024). Caesarean section was performed in 86 (24.5 %) patients with HCV infection versus 2 (4.0 %) persons in CG (p<0.001).The newborns from mothers with HCV infection had lower indicators of physical development and decreased Apgar score assessment, increased frequency of conjugation jaundice.Conclusions. Pregnant women with HCV infection are characterized by a significant increase in the number of pregnancy complications, such as the threat of pregnancy interruption, the threat of premature birth, gestational anemia, placental dysfunction, fetal growth retardation syndrome, and preeclampsia; during childbirth – premature and antepartum rupture of amniotic membranes, premature birth, weakness of uterine activity in labor, increased blood loss. The condition of newborns from women with HCV infection is characterized by a significant increase in the frequency of asphyxia during childbirth, CNS hypoxic-ischemic damage, prematurity and conjugation jaundice.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74652684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine tube cancer in the practice of an obstetrician-gynecologist","authors":"О. Korchynska, D. Stryzhak","doi":"10.30841/2708-8731.8.2022.273274","DOIUrl":"https://doi.org/10.30841/2708-8731.8.2022.273274","url":null,"abstract":"Fallopian tube cancer (FTC) is an actual problem in oncology. Despite the low frequency of FTC, it is quite easy to confuse it with other malignant diseases of the female genital organs, namely, ovarian and endometrial cancer. It is quite difficult to diagnose FTC in time, since the absence of specific symptoms determines the detection of malignant tumors of fallopian tubes only during surgical interventions for benign gynecological pathology or in case of suspicion of ovarian or endometrial cancer. The final diagnosis and primary origin of the tumor can be established only by postoperative histological study.The article presents a review of the literature of scientometric databases on the etiology, diagnosis, and treatment of FTC. Based on the analysis of data from the scientific literature, the problem of FTC as a rare and deceptive malignant disease with a rather aggressive course is highlighted, which causes the formation of oncological awareness among obstetricians-gynecologists regarding this type of cancer.According to the literature, it is established that FTC is diagnosed very rarely. Among all cases of malignant tumors of the female genital organs, the frequency of FTC is only 0.14–1.8 %. It was also established that it is possible to diagnose FTC in a time only in 0–21 % of cases, according to other data– up to 10 %.Due to the aggressive course of tubal cancer, the five-year survival rate ranges from 22 till 57 %. Intraoperatively, it is possible to detect malignant tumors of the fallopian tubes only in 50 % of cases. The article provides data on the possible causes of development, clinical symptoms that can be manifested by FTC, as well as methods of diagnosis and treatment of this cancer.FTC is a very deceptive oncological pathology, which can be caused by chronic inflammatory changes in the fallopian tubes, infertility, fallopian tube endometriosis, and BRCA1 and BRCA2 mutations. First of all, obstetrician-gynecologists should pay attention on abnormal uterine bleeding in the patient, purulent-bloody discharge, pain in the lower abdomen, the phenomenon of “watery tubal discharge”, since these pathological manifestations are typical for FTC. The tumor marker CA-125 and β-subunit of hCG have important meaning, the levels of which are increased by FTC.Significant similarity of clinical symptoms with ovarian and endometrial cancer leads to significant errors in establishing the correct diagnosis. Since malignant tumors of the fallopian tubes can metastasize to groups of lymphatic lymph nodes that are completely atypical for them, it is also necessary to carry out a differential diagnosis with breast cancer, because FTC can manifest itself in the form of axillary lymphadenopathy, and with stomach cancer, in which an isolated increase of the left supraclavicular lymph node (Virchow’s metastasis) can also be observed, which is also characteristic of fallopian tube carcinomas.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91489276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}