Reproductive health of woman最新文献

{"title":"Clinical effectiveness of preconception training in women with sexually transmitted infections after an IVF program","authors":"O. Krotik","doi":"10.30841/2708-8731.7.2022.272471","DOIUrl":"https://doi.org/10.30841/2708-8731.7.2022.272471","url":null,"abstract":"The objective: to prove the clinical effectiveness of preconception preparation of the women with a history of sexually transmitted infections (STIs) after pre-gravid training before assisted reproductive technology (ART) cycles.Materials and methods. 115 women received the suggested pre-gravid training, of which 56 women became pregnant after ART programme and were included in the 1st group and received medical and preventive measures offered by us; 132 women after standard pre-gravid training, of which 55 women became pregnant after ART program and were included in the II group and received generally accepted medical and preventive measures. A clinical analysis of the pregnancy course, childbirth and the condition of newborn children was conducted in 111 women (I and II groups). All patients in the I and II groups had STIs in medical history. Statistical processing of research results was carried out using standard programs “Microsoft Excel 5.0” and “Statistica 8.0”. Results. The rate of threat of pregnancy interruption was significantly lower in the I group – 6 (10.7 %) patients than in the II group – 19 (34.5 %; p<0.001); missed abortion was determined in 3 (5.3 %) cases in the I group versus 6 (10.9%) cases in the II group; spontaneous pregnancy interruption in the I trimester was in 2 (7.1 %) patients in the I group versus 4 (7.3%) women in the II group. Pregnancy was terminated in 5 (8.9 %) pregnant women in the I group and 10 (18.2 %) – in the II group (p<0.05). The threat of late abortion in women in the I group was found significantly less than in patients in the II group – 4 (7.8 %) versus 12 (26. 7%) persons, respectively (p<0.05). Fetal growth retardation (FGR) was diagnosed significantly less in the pregnant women of the I group than in pregnant women of the II group, – 11 (21.6 %) versus 17 (37.8 %) individuals, respectively (p<0.05). The results of cardiotocography (CTG) demonstrated that the satisfactory fetal state was determined in 40 (78.4 %) pregnant women in the I group, which is statistically significantly more than in the II group – 23 (51.1 %; p<0.05) cases.Doubtful non-stress test data were found in the I group more less – 10 (19.6 %) patients versus 15 (33.3 %) cases the II group (p<0.05). Pathological data of CTG were registered in 1 (2.0 %) pregnant women in the I group versus 7 (15.6%) cases in the II group (p<0.05). The risk of fetal distress in the pregnant women in the I group was 13.9 % (95 % CI 7.8-20.0), RR=0.5 (95% CI 0.16-0.66; p=0.002), which confirms the effect of the pre-gravid complex of medical and preventive measures on the fetal distress reducing in the pregnant women of the I group.Premature births were observed significantly less in patients in the I group, than in the II group, which amounted to 6 (11.7 %) versus 12 (26. 7 %) persons (p<0.05). The condition of newborns in the I group was satisfactory in 49 (85.9 %) cases, and the total level of children born with asphyxia in the I group decreased by","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84946106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women have clinical aspects of infertility with thyroid pathology","authors":"Dzhanetti Beraya","doi":"10.30841/2708-8731.7.2022.272469","DOIUrl":"https://doi.org/10.30841/2708-8731.7.2022.272469","url":null,"abstract":"The objective: to study the main clinical aspects of infertility in women with various variants of thyroid pathology.Materials and methods. A clinical screening examination of 496 women with infertility (main group), of which 238 were diagnosed the various thyroid pathologies, and 80 women with thyroid pathology without reproductive function disorders (control group) was carried out.Results. Primary infertility was diagnosed in 49.4 % of examined women, and secondary infertility – in 50.6 % of patients. Female infertility was diagnosed in 327 (65.9 %) patients, male infertility in 126 (25.4 %) women; infertility of unknown genesis was established during the examination of 43 married couples (8.7 %). In the structure of the causes of female infertility, the tubal-peritoneal factor prevailed (37 %), the frequency of external genital endometriosis was 36.4 %, the endocrine factor – 23.2 %, and the uterine factor – 3.4 %. A combination of infertility factors was determined in 23.8 % of women. The results of studying the reproductive history showed that 251 patients with secondary infertility have a history of 279 pregnancies. The positive obstetrical outcomes such as term uncomplicated childbirth was established only in 48 (19.1 %) patients; the first term birth occurred in 28 (11.1 %) women, the second birth – in 16 (6.4 %) patients. Pregnancy ended with premature birth in 27 (10.7 %) women, induced abortions – in 41 (16.3 %), spontaneous abortions – in 58 (23.1 %), 41of them (16.3 %) had one spontaneous abortion; missed abortion – in 57 (22.7 %) patients, ectopic pregnancy – in 19.1 %.A comparative evaluation of thyroid screening results in infertile and fertile women demonstrated that the prevalence of thyroid pathology in infertile patients was 3.8 times higher compared to fertile women (48 % and 12.5 %, respectively). In the structure of the thyroid gland pathology in both groups the presence of antibodies to thyroperoxidase combined with echo signs of autoimmune thyroiditis prevailed, which is 2.8 times more often diagnosed in the group of infertile women compared to fertile women (24 % and 8.7 %, respectively).Conclusions. The prevalence of thyroid pathology in patients with infertility is 3.8 times higher compared to fertile women. In women with secondary infertility pregnancy loss in the I trimester of gestation is dominated in the structure of reproductive outcomes.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89904658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of gestataional hypertension on the ultrastructural structure of the placenta","authors":"A. Senchuk, V. Chermak, I. I. Chermak, T. Andriichuk","doi":"10.30841/2708-8731.6.2022.267685","DOIUrl":"https://doi.org/10.30841/2708-8731.6.2022.267685","url":null,"abstract":"The objective: to study pathological changes and compensatory-adaptive reactions in the structural and ultrastructural components of the placental barrier in pregnant women with gestational arterial hypertension, who received magnesium preparations. Materials and methods. 100 patients with gestational hypertension were examined. The presence of magnesium deficiency in these women was determined by the results of our questionnaires.Pathomorphological and electronic microscopic examination of 32 placentas of patients with gestational hypertension was carried out. 12 placentas of them were from pregnant women who received the proposed management of pregnancy, which included magnesium drugs (I group), and 11 placentas – from patients with risk of preeclampsia, who were observed with the use of standard approaches of pregnancy for women with the risk of preeclampsia (II group). Control group included the results of pathomorphological and electronic microscopic study of 9 placentas from healthy women.Results. Placental of women with gestational hypertension have structural features, which is manifested by the mosaic change of placental barrier in the form of uneven circulatory disorders with hemorrhages and stasis (at the ultrastructural level) in the fetal microvessels of the villi, reducing the placental functional area (rapprochement of the villi), presence of stromal sclerosis villi, foci of pathological immaturity, increase in calcium salts (mineral dystrophy) on the background of compensatory reactions. Electronic microscopic study of the placentas in the I group revealed an increase in the compensatory-adaptive reactions of the placenta – thinning of the placental barrier, activation of cytotrophoblast cells in the placental barrier, increase the number of syncytiocapillary membranes in terminal villi with syncytiotrophoblast organic activation, increase in the number of ribosomes, the appearance of orthodox configuration of mitochondria, increasing the number of capillary membranes and thinning of syncytia, reducing the number of sludge phenomena in microvessels, which leads to an increase in the possibility of nutrient transfer from mother to fetus, etc.Conclusions. The use of the proposed therapy, which involves magnesium, diosmin and others substances, leads to a significant decrease in the frequency of detection of pathological changes in structural and ultrastructural components of the placental barrier and increased compensatory-adaptive reactions which can be considered the result of the positive impact of the proposed therapy on the placental ultrastructural elements in women with risk of preeclampsia.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74428705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspects of the rehabilitation of the reproductive function of women after urgent gynecological surgery","authors":"Yu.R. Dyakunchak","doi":"10.30841/2708-8731.6.2022.267687","DOIUrl":"https://doi.org/10.30841/2708-8731.6.2022.267687","url":null,"abstract":"The objective: to assess the hormonal homeostasis and ovarian reserve in women of reproductive age after urgent gynecological operations due to the symptom complex of “acute abdomen”.Materials and methods. The studied cohort included 90 women 19–40 years old. The main group included 60 women after emergency surgery for ectopic pregnancy (23 patients), ovarian apoplexy (18 patients), complicated ovarian tumor (19 patients), and at the rehabilitation stage they refused to receive the proposed hormonal therapy; control group – 30 women of reproductive age without somatic and gynecological pathology. A complex study of the reproductive system was carried out: ultrasound (transvaginal) examination of the pelvic organs with the calculation of the number of antral follicles, determination of the levels of estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin, thyroid-stimulating hormone, free testosterone index, anti-Müllerian hormone (AMH), and 25(OH)D level in blood serum. The examinations were carried out 3 and 6 months after surgery. Statistical processing of the results was performed using the Microsoft Excel 7.0 and “Statistica 6.0” standard programs.Results. The average age of the patients was 26.4±3.5 years. Before the current surgical intervention, 21 % of patients in the main group were diagnosed premenstrual syndrome, dysmenorrhea, abnormal uterine bleeding, pelvic inflammatory disease, and ovarian tumors. In the postoperative period, the most often menstrual cycle (MC) disorder was an increase in its duration (56.7 % of patients). 63.3 % of patients after urgent gynecological operations had normogonadotropic dysfunction of the ovaries, which is characterized by anovulation, insufficiency of the luteal phase and the ovarian blood flow disorders. The restoration of normal two phases of MC after 6 months was found in 34.2 % of the patients who did not have the hormonal correction. In 18.3 % of patients with ovulatory MC, the insufficiency of the luteal phase is characterized by a decrease of progesterone concentration in the blood serum on the 18–20th day of MC and a disperancy in the endometrium structure. Transient hyperprolactinemia was found in 15.0 % of patients. The surgical injury of the ovary in some patients leads to a decrease in the ovarian reserve. AMH indicators in 61.1 % of patients with the effect of surgical energies on the affected ovary were significantly reduced (0.67±0.4 ng/ml) compared to controls (2.1±0.3 ng/ml; p<0.01) until the 6th month after the operation. Similar dynamics were absent in patients operated on for a ruptured tubal pregnancy. The recovery of the two phases of MC during a six-month observation was established in only 47.4 % of patients with torsion of an ovarian tumor.As a result of the lack of complex rehabilitation therapy, the repeated operations due to the ruptured tubal pregnancy happened in 13.5 % of patients, recurrence of apoplexy and/or ovarian tumors – in 25.8 % of women.Conclus","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83370081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet hemostasis in the implementation of placental dysfunction","authors":"I. Us, S. I. Zhuk, D. Korolova, O. Platonov, Yu.О. Tsaryk","doi":"10.30841/2708-8731.6.2022.267676","DOIUrl":"https://doi.org/10.30841/2708-8731.6.2022.267676","url":null,"abstract":"The objective: to study the state of the platelet link of hemostasis in pregnant women with placental dysfunction. Materials and methods. A clinical and laboratory analysis of 54 patients with placental dysfunction was carried out. The control group included 30 practically healthy women with a physiological course of pregnancy. Venous blood of the patients was collected for testing using vacuum systems in tubes with 3.8% sodium citrate. The functional activity of platelets was studied on a photooptical aggregometer AP2110 (Solar, Belarus), thrombocytogram was performed on a hematological analyzer H18 LIGHT (SFRI SAS, France), thromboelastometric tests were determined on the ROTEM delta system (Tem Innovations GmbH, Germany). Results. Platelet hemostasis has a significant effect on maximum clot firmness (MCF) according to ROTEM results in patients with placental dysfunction. This indicator can be effective in determination of the hyperreactivity of the platelet unit in patients with placental dysfunction. Although no statically significant difference was found in the optical aggregometry indicators induced by ADP and collagen between the patients with placental dysfunction and the control group, a clear tendency to a sharp reduction in the lag-period of collagen-induced platelet aggregation in patients with placental dysfunction should be mentioned. Conclusions. Disorders in the platelet chain of hemostasis can play a significant role in the formation of a thrombophilic state in patients with placental dysfunction, as well as the damage of the endothelium and coagulation changes. The use of a test based on collagen-induced platelet aggregation may be a perspective method for effective diagnosis of platelet hyperreactivity. The study of the platelet link should become an additional element of the laboratory examination in order to resolve the issue of the need to prescribe antiplatelet agents to prevent the development of placental dysfunction.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81651332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of detection of lymph nodes in breast cancer","authors":"R. Nikitenko","doi":"10.30841/2708-8731.6.2022.267679","DOIUrl":"https://doi.org/10.30841/2708-8731.6.2022.267679","url":null,"abstract":"The objective: improve the quality of sentinel lymph nodes detection in patients with malignant neoplasms of the mammary glands.Materials and methods. At the period from 2009 to 2016, 400 patients with T1-T3N0M0 breast cancer were operated in Odessa Regional Clinical Hospital, using two dyes Patent Blue and ICG.The patients who had mastectomy with sentinel lymph node biopsy were diagnosed T2-T3N0M0 breast cancer more frequently. The exceptions were T3-T4 tumors, tumor diameter > 5 cm, invasion into the skin and chest wall, palpable axillary lymph nodes, 3 or more affected lymph nodes during sentinel lymph node biopsy.100 patients in the first group had sentinel lymph node biopsy. Lymph node staining was performed using Patent Blue dye.In the patients in the second group, sentinel lymph node biopsy was performed using Patent Blue dye and another fluorescent ICG dye, which was injected intravenously into the arm on the affected side of the mammary gland, along the outflow from the arm to the mammary gland.Results. The total five-year survival after axillary lymph node dissection and sentinel lymph node biopsy was 91 % and 92 %, respectively. The five-year recurrence-free survival after axillary lymph node dissection was approximately 82.2 %, and after the sentinel lymph node biopsy – 83.9 %. Regional recurrence in the sentinel lymph nodes on the affected side was determined only in 1.1 %. The time of observation of the patients was from 60 to 180 months. The recurrence was registered in 0.2 % patients as isolated metastases into the axillary lymph nodes. Not a single case of lymphostasis of the upper limbs from the side of the biopsy was registered. Conclusions. The simplicity of fluorescent dyes usage makes it possible to implement this method in the everyday work of oncologists-surgeons, the advantages of which are the absence of radiation exposure and quick intraoperative detection of lymph nodes.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82434541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis. Is spontaneous pregnancy possible with ovarian endometriosis?","authors":"O. Slobodyanik, A. S. Demyanenko, O. Kostenko, I.V. Poladych, I.V. Guzhevska","doi":"10.30841/2708-8731.6.2022.267682","DOIUrl":"https://doi.org/10.30841/2708-8731.6.2022.267682","url":null,"abstract":"Endometriosis is one of the most relevant problems in modern gynecology. This pathology often leads not only to structural and functional changes in the reproductive system and cause infertility (35-50 %), but also generally significantly worsens physical health, the work capacity and can affect the psycho-emotional state of women. As endometriosis is diagnosed in almost every third of women and there is a trend for its rate increase, it remains a subject of special interest not only for scientists, but also for practical doctors. Despite of a lot of literature data, currently, there is no protocol, international guideline, which provides uniform algorithms for the diagnosis and treatment of endometriosis with subsequent realization of reproductive function. The experts pay attention to an individual approach for the comprehensive solution of the problem regarding the age of the woman, the localization and extent of the process, the severity of symptoms, the state of fertility and the necessity to restore reproductive function, the presence of concomitant gynecological and somatic pathology, and the effectiveness of previous treatment. The article provides a clinical description of a case of spontaneous pregnancy with bilateral endometriosis of the ovaries, which was diagnosed before pregnancy, with favorable maternal and fetal outcomes. An ultrasound description of endometrioid changes in the pelvic organs during the pregnancy is presented. The authors developed an individual management plan for the patient in accordance with her young age, high ovarian reserve, which in the presence of patency of the fallopian tubes and normal indicators of the man’s spermogram can be considered as prognostic factors for evaluating the appropriate reaction of the ovaries in case of spontaneous conception. During the operative delivery (caesarean section), the surgical treatment of endometriosis of the ovaries was performed at the same time. The patient and the newborn were discharged from the hospital under the supervision of a gynecologist in a satisfactory condition.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77763758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the colpocytological state and biocenosis of the vagina in menopausal women with atrophic vaginitis","authors":"V. Benyuk, V. Goncharenko, I. Usevych, N. Korniets, V. Oleshko, A. Momot, M. Puchko","doi":"10.30841/2708-8731.6.2022.267688","DOIUrl":"https://doi.org/10.30841/2708-8731.6.2022.267688","url":null,"abstract":"The objective: to study and evaluate the colpocytological state of the mucous membrane and the biocenosis of the vagina in women with atrophic vaginitis (AV) before CO2 laser therapy. Materials and methods. A prospective clinical and statistical examination of 160 patients with AV was conducted. The main group was formed from 55 women of menopausal age with clinical manifestations of AV, who were treated only by the therapy with CO2 laser. The comparison group included 40 women of menopausal age who had for the correction of AB manifestations CO2 laser therapy in combination with local hormonal therapy – suppositories which contain 0.5 mg of estriol. The control group included 65 women of menopausal age who were treated with the therapy with the local application of suppositories with 0.5 mg of estriol once a day. The standard hormonal colpocytology was performed in all the women to assess the colpocytological state of the vaginal mucosa. Diagnostic test strips were used to determine the condition of the vagine (pH). In the case of a shift in the pH of the vaginal contents ≥ 4.4, the degree of vaginal purity and the number of leukocytes were studied using a microscopic examination. An amine test was performed to determine the presence of bacterial vaginosis in patients with AB. The microbiological study was performed using the “Femoflor-16” method. Results. The hypoestrogenic and atrophic types of smears were found in all 160 (100.0 %) women. The inflammatory type of colpocytological smear was determined in 116 (72.5 %) patients, cytolytic type – in 14 (8.6 %), mixed type of vaginal smears – in 30 (18.6 %) persons. In 126 (78.6 %) women, the pH index shifted to the alkaline side and ranged from 4.9 to 5.6, and the average value was 5.2±0.31. The bacterioscopic analysis of vaginal discharges indicates that in 83 (65.9 %) women with pathological pH values, the third degree of purity of the vaginal smear according to Herlin was found. In every third of women – 37 (29.4 %) – the presence of Candida fungi was determined. A significant decrease in the number of Lactobacillus spp. was established, a sufficient number of which was found in 9 (10.8 %) of the examined women. Facultative anaerobic microorganisms were found in 34 (40.6 %) women with AB. Obligate anaerobic microflora – Gardnerella vaginalis in combination with Prevotella bivia and Porphyromonas spp., which was found in 23 (27.7 %) women, was in the first place among the detected microorganisms; Mobiluncus spp. in association with Corynebacterium spp. were in the second place in prevalence, and were determined in 18 (21.7 %) persons, in third place – Atopobium vaginae, which was diagnosed in 10 (12.0 %) of the examined women. A qualitative analysis of the culture study results demonstrates a high level of cultivation of facultative anaerobic and obligate anaerobic microorganisms in women with AB, the quantitative value of which reached lg 3.1 – lg 3.9 CFU/ml and lg 3.4 – lg 4.7 CFU/ ml, respec","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72799849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical features of expression of progesterone receptors of placental structures in premature birth","authors":"V.O. Tkalich, I.V. Poladych","doi":"10.30841/2708-8731.6.2022.267680","DOIUrl":"https://doi.org/10.30841/2708-8731.6.2022.267680","url":null,"abstract":"The objective: to study the immunohistochemical features of placenta in women with premature birth in 28–33 weeks of pregnancy. Materials and methods. 120 pregnant women (the main group) who were hospitalized and delivered in the Kyiv Perinatal Center during 2018–2020 at a gestation period of 23–33 weeks were examined. The women of the main group were divided into two subgroups depending on the term of birth – the 1st group included patients who delivered at 23–28 weeks of pregnancy, the patients of the 2nd group had labors at 29–33 weeks. Placentas of women in the main group were examined using morphological (histological method – staining with hematoxylin and eosin and van Gieson) and immunohistochemical methods (indirect streptavidin-peroxidase method for determining the expression level of progesterone receptors – PR). Results. Premature maturation of chorionic villi was found in 40 % of placentas of women in the 1st group 1, in 20 % – blood circulation disorders and the presence of acute inflammatory infiltration in the fetal membranes, decidual and chorionic membranes, 10 % – pathological immaturity of the placenta according to the variant of chaotic sclerosed villi. During the immunohistochemical study of RP, an unexpressed reaction was found in the epithelium and stromal cells of stem, intermediate and terminal villi – 1 point; in fetal membranes and extravillous cytotrophoblast – 2 points; in the endothelium of vessels – 0–1 point. In the placentas of women in the 2nd group premature maturation of villi was found in 70 % of cases, pseudoinfarcts of villi which are embedded in fibrinoid occupying a significant area – 45 %, afunctional zones – 55 %, blood circulation disorders – 35 %, pathological immaturity placenta according to the variant of chaotic, sclerosed villi – 20 %, acute inflammatory infiltration in the fetal membranes – 15 %. Immunohistochemical analysis of the placental barrier revealed the highest expression of RP in the nuclei of decidual cell which belong to the maternal structure. It should be noted the presence of expression of progesterone receptors in stem villi, fibroblasts and nuclei of the vessel wall. Minimal or absent expression was determined in the nuclei of other villous structures and their vessels. Conclusions. It was established that the receptivity of progesterone has its own characteristics in placental structures depending on the gestation period, which is an important factor in the choice of management for the prevention and reduction of perinatal losses for this contingent of pregnant women.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76340710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative characteristics of the effect of mono and bipolar energy during hysteroresectoscopy","authors":"О.V. Golyanovskiy, O.A. Voloshin, A. Novosad","doi":"10.30841/2708-8731.6.2022.267686","DOIUrl":"https://doi.org/10.30841/2708-8731.6.2022.267686","url":null,"abstract":"The objective: to evaluate of postoperative complications, duration of surgical intervention and hospital stay of patients after hysteroscopic surgery using monopolar or bipolar electrodes.Materials and methods. Eighty gynecological patients who had hysteroscopic surgery were divided into two groups of 40 women each. Patients of the I (main) group had hysteroscopic procedures using a bipolar electrode, the persons in the II (comparison) group – a monopolar electrode. The registration of operative complications was carried out – bleeding, perforation, excess fluid and hyponatremia. The time of operation and stay in a gynecological hospital were also taken into account.Results. There were no statistically significant differences between the two groups regarding patient’s characteristics, ultrasound findings, serum sodium levels before and after surgery, uterine perforation, and intraoperative bleeding. Fluid overload was significantly higher in patients of the II group (p<0.03). Postoperative hyponatremia was also significantly pronounced in the II group (p<0.05). The average operation time was significantly shorter in women of the I group compared to the II group (p=0.01), and the hospital stay was significantly shorter for patients after hysteroscopic intervention using bipolar energy compared to the group in which monopolar energy was used (p=0.04). Conclusions. Hysteroresectoscopy with the use of bipolar electrodes is accompanied by a significant decrease in cases of hyponatremia, reduction of the duration of surgical intervention and the stay of gynecological patients in the hospital after surgery. Therefore, this method is safe and effective compared to the use of monopolar electrodes.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83107442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}