There has been a significant increase in the incidence of multiple neurodegenerative and terminal diseases in the human population with life expectancy increasing in the current times. This highlights the urgent need for a more comprehensive understanding of how different aspects of lifestyle, in particular diet, may affect neural functioning and consequently cognitive performance as well as in enhancing overall health. Flavonoids, found in a variety of fruits, vegetables, and derived beverages, provide a new avenue of research that shows a promising influence on different aspects of brain function. However, despite the promising evidence, most bioactive compounds lack strong clinical research efficacy. In the current scoping review, we highlight the effects of Flavonoids on cognition and neural plasticity across vertebrates and invertebrates with special emphasis on the studies conducted in the pond snail, Lymnaea stagnalis, which has emerged to be a functionally dynamic model for studies on learning and memory. In conclusion, we suggest future research directions and discuss the social, cultural, and ethnic dependencies of bioactive compounds that influence how these compounds are used and accepted globally. Bridging the gap between preclinical and clinical studies about the effects of bioactive natural compounds on brain health will surely lead to lifestyle choices such as dietary Flavonoids being used complementarily rather than as replacements to classical drugs bringing about a healthier future.
{"title":"The multifaceted effects of flavonoids on neuroplasticity.","authors":"Veronica Rivi, Anuradha Batabyal, Ken Lukowiak","doi":"10.3233/RNN-230150","DOIUrl":"10.3233/RNN-230150","url":null,"abstract":"<p><p> There has been a significant increase in the incidence of multiple neurodegenerative and terminal diseases in the human population with life expectancy increasing in the current times. This highlights the urgent need for a more comprehensive understanding of how different aspects of lifestyle, in particular diet, may affect neural functioning and consequently cognitive performance as well as in enhancing overall health. Flavonoids, found in a variety of fruits, vegetables, and derived beverages, provide a new avenue of research that shows a promising influence on different aspects of brain function. However, despite the promising evidence, most bioactive compounds lack strong clinical research efficacy. In the current scoping review, we highlight the effects of Flavonoids on cognition and neural plasticity across vertebrates and invertebrates with special emphasis on the studies conducted in the pond snail, Lymnaea stagnalis, which has emerged to be a functionally dynamic model for studies on learning and memory. In conclusion, we suggest future research directions and discuss the social, cultural, and ethnic dependencies of bioactive compounds that influence how these compounds are used and accepted globally. Bridging the gap between preclinical and clinical studies about the effects of bioactive natural compounds on brain health will surely lead to lifestyle choices such as dietary Flavonoids being used complementarily rather than as replacements to classical drugs bringing about a healthier future.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141601426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 18th World Congress on Controversies in Neurology March 21-23, 2024 - London, UK.","authors":"","doi":"10.3233/RNN-249000","DOIUrl":"https://doi.org/10.3233/RNN-249000","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Theodoratou, Georgios A. Kougioumtzis, Anna Kaltsouda, Dimitra Katsarou, Zoi Siouti,, Maria Sofologi, George Tsitsas, Katerina Flora
Internet addiction poses a significant concern for adolescents, particularly those diagnosed with Asperger's syndrome. Although empirical research focusing on adolescents with Asperger's syndrome is limited, existing findings reveal several neurocognitive and mental health factors contributing to internet addiction. Impulsivity, attention deficits, social skills deficits, cognitive rigidity, and co-occurring anxiety and depression are among the key aspects identified. Understanding these factors is essential for developing effective interventions. This review discusses neurocognitive and mental health aspects of internet addiction in adolescents with Asperger's syndrome as well as potential interventions targeting these aspects to promote healthy internet use and overall well-being in this unique population.
{"title":"Neuropsychological Aspects and Interventions for Internet Addiction in Adolescents with Asperger's Syndrome - Narrative Review","authors":"Maria Theodoratou, Georgios A. Kougioumtzis, Anna Kaltsouda, Dimitra Katsarou, Zoi Siouti,, Maria Sofologi, George Tsitsas, Katerina Flora","doi":"10.33425/2692-7918.1052","DOIUrl":"https://doi.org/10.33425/2692-7918.1052","url":null,"abstract":"Internet addiction poses a significant concern for adolescents, particularly those diagnosed with Asperger's syndrome. Although empirical research focusing on adolescents with Asperger's syndrome is limited, existing findings reveal several neurocognitive and mental health factors contributing to internet addiction. Impulsivity, attention deficits, social skills deficits, cognitive rigidity, and co-occurring anxiety and depression are among the key aspects identified. Understanding these factors is essential for developing effective interventions. This review discusses neurocognitive and mental health aspects of internet addiction in adolescents with Asperger's syndrome as well as potential interventions targeting these aspects to promote healthy internet use and overall well-being in this unique population.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: In tropical environments, the diagnostic certainty of vascular dementia is difficult to establish due to under-medicalization, delays in consultation and above all the inadequacy of exploration methods. Material and methods: We analyzed the records of 153 patients hospitalized for dementia syndrome over a period from January 1, 2016 to December 21, 2021 in the Neurology Department of the Centre Hospitalo-. Universitaire de Conakry. Dementia status was assessed according to the Clinical Evaluation Scale (ECD), Confirmed by Mini Mental State Examination (MMSE<24) cognitive tests or Neuro, behavioral Cognitive Status Examination (NCSE) score. Results: 26 (twenty-six) patients fulfilled the DSM-IV criteria for vascular dementia, based on the association of dementia and cerebrovascular disease certified by the presence of focal neurological signs of vascular origin and imaging data. Conclusion: this study shows a non-stereotyped clinical and etiological profile of the spectrum of vascular dementias in the tropics, in a context of under-medicalization. These results are useful for diagnostic and prognostic discussion.
{"title":"Probable Vascular Dementia in the Tropics: A Study of Twenty-Six (26) Observations at Conakry University Hospital","authors":"Barry Souleymane Djigué, Diallo Mohamed Tafsir, Touré Mohamed Lamine, Diallo Souleymane Mbara, Carlos Othon Guelngar, Diallo Bademba, Camara Namory, Sakadi Foksouna, Diallo Mariama Boubacar, Koné Adama, Hinami Madandi, Lamah Eugen, Barry Abdoul Karim Telico, Cissé Fodé Abass, Cissé Amara","doi":"10.33425/2692-7918.1055","DOIUrl":"https://doi.org/10.33425/2692-7918.1055","url":null,"abstract":"Introduction: In tropical environments, the diagnostic certainty of vascular dementia is difficult to establish due to under-medicalization, delays in consultation and above all the inadequacy of exploration methods. Material and methods: We analyzed the records of 153 patients hospitalized for dementia syndrome over a period from January 1, 2016 to December 21, 2021 in the Neurology Department of the Centre Hospitalo-. Universitaire de Conakry. Dementia status was assessed according to the Clinical Evaluation Scale (ECD), Confirmed by Mini Mental State Examination (MMSE<24) cognitive tests or Neuro, behavioral Cognitive Status Examination (NCSE) score. Results: 26 (twenty-six) patients fulfilled the DSM-IV criteria for vascular dementia, based on the association of dementia and cerebrovascular disease certified by the presence of focal neurological signs of vascular origin and imaging data. Conclusion: this study shows a non-stereotyped clinical and etiological profile of the spectrum of vascular dementias in the tropics, in a context of under-medicalization. These results are useful for diagnostic and prognostic discussion.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gracia Likinda, Freddy Mbuyi, Gédéon Bukasa, Marc Tshilanda, Rémy Kashala, , Grâce Atibu, Mike Madika, Marina Moanda, Wilfrid Mbombo
Background: Stroke is a fatal disease, and knowledge of the factors associated with this mortality in different environments is necessary in order to take appropriate action. This article presents data from a hospital located in an urban-rural setting in Kinshasa: The Monkole hospital centre. Methods: This is a cross-sectional study conducted at Monkole hospital Centre from 01/01/2020 to 31/01/2023 in all patients with a confirmed diagnosis of stroke admitted to intensive care, emergency or internal medicine. Sociodemographic, clinical, paraclinical, therapeutic and outcome data were collected from hospital registers and patient records. Student's t, Anova, Chi-squared or Fischer's exact tests and logistic regression were performed with SPSS 25.0 with p less than 5%. Ethical principles were respected. Results: Of 3,629 patients admitted during the study period, 148 (4%) were admitted for stroke. The mean age was 62.6 years and the predominant sex was male. 51.4% of patients were admitted from home, with the following comorbidities: arterial hypertension, diabetes mellitus and embolism-induced heart disease. Frequent reasons for consultation were: disturbed consciousness, increased blood pressure and convulsions. Frequent physical signs were: disturbed consciousness, increased blood pressure, neurological deficit and pupillary abnormalities. The average time to hospital was 13.6 ± 8.2 hours. The accident was ischaemic in 70.3% and haemorrhagic in 29.7%. Treatment was medical in 100% of cases, with no thrombolysis. Mortality was 11.5% and 36.5% of survivors had moderate to severe functional disability. Advanced age (OR 2.34, 95% CI 1.36-4.04), hypertension (OR 2.19, 95% CI 1.24-3.88) and low socio-economic status (OR 1.81, 95% CI 1.02-3.21) were associated with mortality. Conclusion: Mortality in this series was 11.5%, associated with advanced age, hypertension and low socioeconomic status. Controlling blood pressure and improving living conditions could reduce this mortality
背景:中风是一种致命疾病，了解不同环境下与这种死亡率相关的因素是必要的，以便采取适当的行动。本文介绍了位于金沙萨城乡环境中的一家医院的数据:Monkole医院中心。方法:这是一项横断面研究，于2020年1月1日至2023年1月31日在Monkole医院中心进行，纳入了所有确诊为中风的重症监护、急诊或内科患者。社会人口学、临床、临床辅助、治疗和结果数据从医院登记和患者记录中收集。采用SPSS 25.0进行学生t、方差分析、χ 2或Fischer精确检验和logistic回归，p < 5%。伦理原则得到尊重。结果:在研究期间入院的3,629例患者中，148例(4%)因中风入院。平均年龄62.6岁，以男性居多。51.4%的患者从家中入院，伴有以下合并症:动脉高血压、糖尿病和栓塞性心脏病。常见的问诊原因是:意识障碍、血压升高和抽搐。常见体征为意识障碍、血压升高、神经功能缺损和瞳孔异常。平均入院时间为13.6±8.2小时。70.3%为缺血性，29.7%为出血。100%的病例采用药物治疗，无溶栓。死亡率为11.5%，36.5%的幸存者有中度至重度功能残疾。高龄(OR 2.34, 95% CI 1.36-4.04)、高血压(OR 2.19, 95% CI 1.24-3.88)和低社会经济地位(OR 1.81, 95% CI 1.02-3.21)与死亡率相关。结论:该病例的死亡率为11.5%，与高龄、高血压和低社会经济地位有关。控制血压和改善生活条件可以降低这种死亡率
{"title":"Factors Associated With Stroke Mortality in an Urban-Rural Environment: The Case of the MONKOLE Hospital Centre","authors":"Gracia Likinda, Freddy Mbuyi, Gédéon Bukasa, Marc Tshilanda, Rémy Kashala, , Grâce Atibu, Mike Madika, Marina Moanda, Wilfrid Mbombo","doi":"10.33425/2692-7918.1056","DOIUrl":"https://doi.org/10.33425/2692-7918.1056","url":null,"abstract":"Background: Stroke is a fatal disease, and knowledge of the factors associated with this mortality in different environments is necessary in order to take appropriate action. This article presents data from a hospital located in an urban-rural setting in Kinshasa: The Monkole hospital centre. Methods: This is a cross-sectional study conducted at Monkole hospital Centre from 01/01/2020 to 31/01/2023 in all patients with a confirmed diagnosis of stroke admitted to intensive care, emergency or internal medicine. Sociodemographic, clinical, paraclinical, therapeutic and outcome data were collected from hospital registers and patient records. Student's t, Anova, Chi-squared or Fischer's exact tests and logistic regression were performed with SPSS 25.0 with p less than 5%. Ethical principles were respected. Results: Of 3,629 patients admitted during the study period, 148 (4%) were admitted for stroke. The mean age was 62.6 years and the predominant sex was male. 51.4% of patients were admitted from home, with the following comorbidities: arterial hypertension, diabetes mellitus and embolism-induced heart disease. Frequent reasons for consultation were: disturbed consciousness, increased blood pressure and convulsions. Frequent physical signs were: disturbed consciousness, increased blood pressure, neurological deficit and pupillary abnormalities. The average time to hospital was 13.6 ± 8.2 hours. The accident was ischaemic in 70.3% and haemorrhagic in 29.7%. Treatment was medical in 100% of cases, with no thrombolysis. Mortality was 11.5% and 36.5% of survivors had moderate to severe functional disability. Advanced age (OR 2.34, 95% CI 1.36-4.04), hypertension (OR 2.19, 95% CI 1.24-3.88) and low socio-economic status (OR 1.81, 95% CI 1.02-3.21) were associated with mortality. Conclusion: Mortality in this series was 11.5%, associated with advanced age, hypertension and low socioeconomic status. Controlling blood pressure and improving living conditions could reduce this mortality","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John J Haddad, Mark DeBrincat, Duane M North, Jay Dhaliwal, Peter Hurwitz
The conceptual framework of cognitive networks, or cognits, represents a system of working memory, especially long-term memory arrays that are intrinsically designed to attain certain behavioral ends and that are activated by a neural structure. Despite the fact that cognitions can be used in a plethora of systems, current technologies allow manipulations of the central nervous system (CNS) to execute certain sensory and motor functions. Sensation and tactual perception by the skin are an innate mechanism for human survival and represent our adaptive somatosensorial ability to apprehend information via haptics—the active touch for object recognition and perception by higher centers of the brain. The somatosensation, which is identified by a set of channels and receptors sensitive to a variety of stimuli (thermal, tactile, and mechanical), is critical to survival, balance control, cognition, and pain modulation. Cognits are cutting-edge tools and modalities that provide a landscape of theoretical assets, evidencebased experimental protocols, computational intelligence schemes, and direct empirical modalities that facilitate the understanding of the complex functionalities of the human brain. By evaluating neuroimaging data after somatosensory stimulation and collected via electroencephalogram (EEG), cognition response and change can be obtained that allows researchers to gain a better understanding of emerging scientific approaches aimed at understanding human behavioral outcomes. An emerging technology, haptic vibrotactile trigger technology (VTT), incorporates somatosensory patterns in compression sleeves. eSmartr Smart Compression Sleeves (Srysty Holdings Inc., Mississauga, ON, Canada) with VTT and its Cognitive Boost Technology (CBT) pattern is designed to optimize neural communications for improved mindful wellness. This technology has also been incorporated into patches, braces, apparel (socks), wrist bands, and other routes of delivery. Mindful wellness is considered an outcome of somatosensory intervention that modulates the behavioral responses associated with cognitive networks. Currently, there is limited research exploring these modalities, exposing the need to study new technologies and their influence on somatosensory pathways and cognitive networks. The purpose of this IRB-approved study was to explore the effects of forearm VTT stimulation patterns on cognitive networks by comparing a baseline EEG to an EEG after placing a sleeve incorporating VTT on the right or left forearm of adult healthy individuals. Materials and methods: A baseline EEG was recorded over 5 minutes from 19 scalp locations on 20 subjects ranging in age from 17.6 years to 41.9 years (n=7 females, 13 males). The subject’s dominant arm was then fitted with the eSmartr Smart Compression Sleeve for 20 minutes and another 5-minute EEG was recorded. Both the LORETA (Low Resolution Electromagnetic Tomography Analysis) inverse solution and a power spectral analysis of t
认知网络(cognits)的概念框架代表了一种工作记忆系统，尤其是长期记忆阵列，其本质上是为了达到某种行为目的而设计的，并由神经结构激活。尽管认知可以用于大量的系统，但目前的技术允许操纵中枢神经系统(CNS)来执行某些感觉和运动功能。皮肤的感觉和触觉感知是人类生存的一种先天机制，代表了我们通过触觉来理解信息的适应性体感能力，触觉是大脑高级中枢对物体识别和感知的主动触觉。躯体感觉是由一系列对各种刺激(热刺激、触觉刺激和机械刺激)敏感的通道和受体识别的，它对生存、平衡控制、认知和疼痛调节至关重要。认知是前沿工具和模式，提供了理论资产、基于证据的实验协议、计算智能方案和直接经验模式的景观，促进了对人类大脑复杂功能的理解。通过评估体感刺激后的神经成像数据，并通过脑电图(EEG)收集，可以获得认知反应和变化，使研究人员能够更好地理解旨在理解人类行为结果的新兴科学方法。一种新兴技术，触觉振动触觉触发技术(VTT)，将体感模式整合到压缩套管中。eSmartr智能压缩套筒(Srysty Holdings Inc.， Mississauga, ON, Canada)具有VTT及其认知促进技术(CBT)模式，旨在优化神经通信，以改善意识健康。这项技术也被应用到贴片、牙套、服装(袜子)、腕带和其他运输方式中。正念健康被认为是调节与认知网络相关的行为反应的体感干预的结果。目前，探索这些模式的研究有限，表明需要研究新技术及其对体感通路和认知网络的影响。本研究旨在探讨前臂VTT刺激模式对认知网络的影响，方法是通过比较健康人在右前臂或左前臂放置带有VTT的套筒后的基线脑电图与脑电图。材料和方法:对20名年龄17.6 ~ 41.9岁的受试者(女性7名，男性13名)的19个头皮位置进行5分钟的基线脑电图记录。然后，受试者的主臂安装eSmartr智能压缩套筒20分钟，并再次记录5分钟的脑电图。计算了低分辨率电磁层析分析(LORETA)逆解和表面脑电图的功率谱分析。此外，对于10个不同的网络，计算了来自88个Brodmann区域的电流源。变量是在10个频段(delta、theta、alpha-1、alpha-2、beta-1、beta-2、beta-3和hi-beta)中以1hz增量的绝对功率和绝对电流密度。对每个个体的所有脑电图参数进行配对t检验，并在基线脑电图和随访脑电图之间进行组配对t检验。结果:t检验差异有统计学意义(P <在基线测量和后续“套上”测量之间，表面脑电图和LORETA电流源均为0.01)。与基线相比，最大的差异是表面脑电图和LORETA电流源的α和β频率功率显著下调。此外，在α频率范围内，“套袖”条件对左额叶和左颞叶表面脑电图以及体感皮层内侧的影响最大。默认网络和注意网络的变化也很突出。结论:研究结果表明，这些非药物、非侵入性、触觉振动触觉触发技术(VTT)模式的压缩套筒引起了多个认知网络的反应。这些网络在执行功能、记忆、注意力、情绪和信息流中起着关键作用。触觉振动触觉触发技术与CBT模式套筒对主要位于α和β频段的脑电图有显著的影响。对臂向内侧体感皮层和默认网络的巨形投影的实质性影响表明，图案袖影响了活动。VTT套筒对大脑、神经通路和脑电图谱的作用机制仍在研究中。 如果结果得到进一步研究的证实，这种新型的VTT技术可能是一种有希望的非侵入性和非药物治疗方法，可用于各种疾病和治疗应用。
{"title":"Cognitive Network Changes After Exposure to Haptic Vibrotactile Trigger Technology: Results From The ENHANCE Study","authors":"John J Haddad, Mark DeBrincat, Duane M North, Jay Dhaliwal, Peter Hurwitz","doi":"10.33425/2692-7918.1054","DOIUrl":"https://doi.org/10.33425/2692-7918.1054","url":null,"abstract":"The conceptual framework of cognitive networks, or cognits, represents a system of working memory, especially long-term memory arrays that are intrinsically designed to attain certain behavioral ends and that are activated by a neural structure. Despite the fact that cognitions can be used in a plethora of systems, current technologies allow manipulations of the central nervous system (CNS) to execute certain sensory and motor functions. Sensation and tactual perception by the skin are an innate mechanism for human survival and represent our adaptive somatosensorial ability to apprehend information via haptics—the active touch for object recognition and perception by higher centers of the brain. The somatosensation, which is identified by a set of channels and receptors sensitive to a variety of stimuli (thermal, tactile, and mechanical), is critical to survival, balance control, cognition, and pain modulation. Cognits are cutting-edge tools and modalities that provide a landscape of theoretical assets, evidencebased experimental protocols, computational intelligence schemes, and direct empirical modalities that facilitate the understanding of the complex functionalities of the human brain. By evaluating neuroimaging data after somatosensory stimulation and collected via electroencephalogram (EEG), cognition response and change can be obtained that allows researchers to gain a better understanding of emerging scientific approaches aimed at understanding human behavioral outcomes. An emerging technology, haptic vibrotactile trigger technology (VTT), incorporates somatosensory patterns in compression sleeves. eSmartr Smart Compression Sleeves (Srysty Holdings Inc., Mississauga, ON, Canada) with VTT and its Cognitive Boost Technology (CBT) pattern is designed to optimize neural communications for improved mindful wellness. This technology has also been incorporated into patches, braces, apparel (socks), wrist bands, and other routes of delivery. Mindful wellness is considered an outcome of somatosensory intervention that modulates the behavioral responses associated with cognitive networks. Currently, there is limited research exploring these modalities, exposing the need to study new technologies and their influence on somatosensory pathways and cognitive networks. The purpose of this IRB-approved study was to explore the effects of forearm VTT stimulation patterns on cognitive networks by comparing a baseline EEG to an EEG after placing a sleeve incorporating VTT on the right or left forearm of adult healthy individuals. Materials and methods: A baseline EEG was recorded over 5 minutes from 19 scalp locations on 20 subjects ranging in age from 17.6 years to 41.9 years (n=7 females, 13 males). The subject’s dominant arm was then fitted with the eSmartr Smart Compression Sleeve for 20 minutes and another 5-minute EEG was recorded. Both the LORETA (Low Resolution Electromagnetic Tomography Analysis) inverse solution and a power spectral analysis of t","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Shadow Psyche in Leadership & Decision- Making: A Praxeology Perspective on the Collective Unconscious Psyche","authors":"Rose-Marie Boylan","doi":"10.33425/2692-7918.1053","DOIUrl":"https://doi.org/10.33425/2692-7918.1053","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Carpal and cubital tunnel syndromes are common entrapment neuropathies [1]. Some previous studies showed that carpal tunnel syndrome and, to a lesser extent, cubital tunnel syndrome can impair sleep and quality of life [2-4]. But there are only few studies comparing these two syndromes [5]. However, no study, which evaluates hand dexterity, sleep quality, quality of life, and neuropathic pain in relation to the severity of compression determined by Electroneurography (ENMG) in both syndromes, could be found in the literature. Thus, it was aimed in the present study to investigate the relationship between hand dexterity, sleep quality, quality of life, neuropathic pain, and anxiety-depression symptoms with different levels of compression severity in patients clinically and electro-physiologically diagnosed with carpal tunnel syndrome and cubital tunnel syndrome. Materials and methods: This study involved patients, who applied to the ENMG laboratory and were18 years or older and clinically and electro-physiologically diagnosed with carpal tunnel syndrome and cubital tunnel syndrome. The sociodemographic and clinical data of the patients who agreed to participate in the study were recorded. Carpal tunnel syndrome was classified as mild, moderate, and severe by using the American Association of Electrodiagnostic Medicine Classification [12] based on electrophysiological data, whereas the classification of cubital tunnel syndrome was performed by using the electrodiagnostic grading system created by Zeidman and Pandey based on the American Association of Electrodiagnostic Medicine practice guidelines [13]. The Pittsburgh Sleep Quality Index [14,15] and Epworth Sleepiness Scale [16,17] were used in evaluating the sleep quality of the patients, the EuroQuol-5D Quality of Life Scale [18,19] for quality of life, the 4-item neuropathic pain scale [20,21] for neuropathic pain, the Hospital Anxiety and Depression Scale [22,23] for anxiety and depression levels, and the 9-Hole Peg Test [24] for hand dexterity. After the forms were filled in, the data of the patients having carpal tunnel syndrome and those of patients having cubital tunnel syndrome were compared statistically. Moreover, after staging them as mild, moderate, and severe, the findings of patients in both groups were compared within each group, and their relationships were investigated. Results: Sleep disorders, neuropathic pain, depression, and anxiety disorders were observed to be much more prevalent among patients with CTS when compared to the patients with CuTS and the severity of these disorders increases together with an increase in the severity of the disease. It was also determined that CTS patients lag behind CuTS patients in fine motor skills. Conclusion: It should be noted that all of these parameters negatively affect the quality of life of patients. Early physiotherapy and rehabilitation can be beneficial in the treatment of patients and can contribute to their quality of l
{"title":"Relationship Between Compression Severity and Hand Dexterity, Sleep, Quality of Life, Neuropathic Pain, and Anxiety-Depression in Patients with Carpal and Cubital Tunnel Syndrome","authors":"Buket Özkara Yılmaz","doi":"10.33425/2692-7918.1050","DOIUrl":"https://doi.org/10.33425/2692-7918.1050","url":null,"abstract":"Objective: Carpal and cubital tunnel syndromes are common entrapment neuropathies [1]. Some previous studies showed that carpal tunnel syndrome and, to a lesser extent, cubital tunnel syndrome can impair sleep and quality of life [2-4]. But there are only few studies comparing these two syndromes [5]. However, no study, which evaluates hand dexterity, sleep quality, quality of life, and neuropathic pain in relation to the severity of compression determined by Electroneurography (ENMG) in both syndromes, could be found in the literature. Thus, it was aimed in the present study to investigate the relationship between hand dexterity, sleep quality, quality of life, neuropathic pain, and anxiety-depression symptoms with different levels of compression severity in patients clinically and electro-physiologically diagnosed with carpal tunnel syndrome and cubital tunnel syndrome. Materials and methods: This study involved patients, who applied to the ENMG laboratory and were18 years or older and clinically and electro-physiologically diagnosed with carpal tunnel syndrome and cubital tunnel syndrome. The sociodemographic and clinical data of the patients who agreed to participate in the study were recorded. Carpal tunnel syndrome was classified as mild, moderate, and severe by using the American Association of Electrodiagnostic Medicine Classification [12] based on electrophysiological data, whereas the classification of cubital tunnel syndrome was performed by using the electrodiagnostic grading system created by Zeidman and Pandey based on the American Association of Electrodiagnostic Medicine practice guidelines [13]. The Pittsburgh Sleep Quality Index [14,15] and Epworth Sleepiness Scale [16,17] were used in evaluating the sleep quality of the patients, the EuroQuol-5D Quality of Life Scale [18,19] for quality of life, the 4-item neuropathic pain scale [20,21] for neuropathic pain, the Hospital Anxiety and Depression Scale [22,23] for anxiety and depression levels, and the 9-Hole Peg Test [24] for hand dexterity. After the forms were filled in, the data of the patients having carpal tunnel syndrome and those of patients having cubital tunnel syndrome were compared statistically. Moreover, after staging them as mild, moderate, and severe, the findings of patients in both groups were compared within each group, and their relationships were investigated. Results: Sleep disorders, neuropathic pain, depression, and anxiety disorders were observed to be much more prevalent among patients with CTS when compared to the patients with CuTS and the severity of these disorders increases together with an increase in the severity of the disease. It was also determined that CTS patients lag behind CuTS patients in fine motor skills. Conclusion: It should be noted that all of these parameters negatively affect the quality of life of patients. Early physiotherapy and rehabilitation can be beneficial in the treatment of patients and can contribute to their quality of l","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Migraine is a very common,recurring, usually unilateral, severe, pulsating, and transient headache disorder, which causes temporary disability. Migraine has two main types: with aura and without aura. Abnormal retinal and optic disc pathologies in migraine patients were previously reported by using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). In the present study, it was suggested that the changes foundin the retina and optic disc mightindicate a functional disorder in chronic (with and without aura) and episodic (with and without aura) migraine. It is also emphasized that these changes might be useful for early diagnosis and follow-up of the disease, as well as for the development of new treatments. Method: In total, 60 individuals were involved in the present study, including 28 chronic migraine patients (24 female, 4 male, 16 with aura, 12 without aura) and 32 episodic migraine patients (26 female, 6 male, 21 with aura, 11 without aura), who were diagnosed with migraine and whose migraine types were determinedby using the criteria set by the International Headache Society (IHS) in 2013. The control group consisted of 48 healthy volunteers (34 female, 14 male) aged between 18 and 45 years, who applied to the ophthalmology clinic. The retinas and optic discs of the patients were examined by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) at our ophthalmology clinic. A double-blind randomized analysis was performed for the patient data and the data were compared to control group data of similar gender and age groups. Results: Examining the demographic data, no statistically significant difference was found between the migraine patients and the healthy controls in terms of age, gender, migraine history, and migraine type. However, using Optical Coherence Tomography (OCT), it was determined that the mean vertical and horizontal cup-to-disk (c/d) ratios at the optic disc were significantly impaired in patients compared to the control group. Moreover, using Optical Coherence Tomography Angiography (OCTA), significant reductions in vessel density (VD) were detected in the foveal, parafoveal, perifoveal areas and in the superficial and deep capillary plexuses (SCP and DCP) of the patients. Conclusion: It is thought that these findings might be associated with a vasculopathy developing due to a pathology in the autonomic nervous system or impairments in the cerebral, ocular, or systemic circulation. The authors believe that the results achieved in the present study could be useful in the diagnosis, monitoring, and treatment of the disease.
{"title":"Evaluation of the Retina and Optic Discs of Patients with Chronic and Episodic Migraine using Optical Coherence Tomography and Optical Coherence Tomography Angiography","authors":"Buket Yılmaz,, Ali Karnaz","doi":"10.33425/2692-7918.1048","DOIUrl":"https://doi.org/10.33425/2692-7918.1048","url":null,"abstract":"Objective: Migraine is a very common,recurring, usually unilateral, severe, pulsating, and transient headache disorder, which causes temporary disability. Migraine has two main types: with aura and without aura. Abnormal retinal and optic disc pathologies in migraine patients were previously reported by using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). In the present study, it was suggested that the changes foundin the retina and optic disc mightindicate a functional disorder in chronic (with and without aura) and episodic (with and without aura) migraine. It is also emphasized that these changes might be useful for early diagnosis and follow-up of the disease, as well as for the development of new treatments. Method: In total, 60 individuals were involved in the present study, including 28 chronic migraine patients (24 female, 4 male, 16 with aura, 12 without aura) and 32 episodic migraine patients (26 female, 6 male, 21 with aura, 11 without aura), who were diagnosed with migraine and whose migraine types were determinedby using the criteria set by the International Headache Society (IHS) in 2013. The control group consisted of 48 healthy volunteers (34 female, 14 male) aged between 18 and 45 years, who applied to the ophthalmology clinic. The retinas and optic discs of the patients were examined by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) at our ophthalmology clinic. A double-blind randomized analysis was performed for the patient data and the data were compared to control group data of similar gender and age groups. Results: Examining the demographic data, no statistically significant difference was found between the migraine patients and the healthy controls in terms of age, gender, migraine history, and migraine type. However, using Optical Coherence Tomography (OCT), it was determined that the mean vertical and horizontal cup-to-disk (c/d) ratios at the optic disc were significantly impaired in patients compared to the control group. Moreover, using Optical Coherence Tomography Angiography (OCTA), significant reductions in vessel density (VD) were detected in the foveal, parafoveal, perifoveal areas and in the superficial and deep capillary plexuses (SCP and DCP) of the patients. Conclusion: It is thought that these findings might be associated with a vasculopathy developing due to a pathology in the autonomic nervous system or impairments in the cerebral, ocular, or systemic circulation. The authors believe that the results achieved in the present study could be useful in the diagnosis, monitoring, and treatment of the disease.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burzynski Stanislaw, Burzynski Gregory,, Janicki Tomasz, Beenken Samuel
Rationale: Anaplastic astrocytoma (AA), a malignant brain tumor that arises from astrocytic cells, has a poor prognosis. It accounts for 6–7% of gliomas and 1-2% of brain tumors. Objectives: A 31-year and 11-month-old female with an AA is presented to discuss the efficacy of Antineoplastons A10 (Atengenal) and AS2-1 (Astugenal) in the treatment of AA. She presented to the Burzynski Clinic (BC) for treatment and was enrolled in Protocol BT-08, “Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients with Anaplastic Astrocytoma”, receiving both intravenous (IV) and oral Antineoplastons A10 and AS2-1 (ANP therapy). IV ANP therapy was delivered continuously via subclavian catheter and infusion pump. Tumor response was determined by comparison of baseline brain magnetic resonance imaging (MRI) to sequential brain MRIs during therapy. Findings: The patient presented to the BC with no prior treatment and a one-month history of right arm clumsiness and right leg weakness. Brain MRI and stereotactic biopsy performed elsewhere had demonstrated an AA. Baseline MRI at the BC showed a 2.0 cm2 nonenhancing lesion and two enhancing lesions (0.02 cm2 and 0.15 cm2 ) in the left parietal lobe. IV ANP therapy was given over 56 days, and a complete response (CR) was demonstrated after one month of therapy. Oral ANP therapy was subsequently provided for 17 months. At last follow-up, in June 2023, the patient was healthy and showed no evidence of recurrent disease. She had an overall survival (OS) of > 23 years and one month since diagnosis and an OS of > 23 years since the start of IV ANP therapy. Conclusions: The utilization of ANP therapy in an adult female patient with AA is presented. The patient achieved a CR and prolonged OS, suggesting that ANP therapy may be an effective therapeutic option for adults with AA.
{"title":"Newly Diagnosed Anaplastic Astrocytoma: > 23 Year Survival in a 31-Year and 11-Month-Old Female Treated with Antineoplastons","authors":"Burzynski Stanislaw, Burzynski Gregory,, Janicki Tomasz, Beenken Samuel","doi":"10.33425/2692-7918.1051","DOIUrl":"https://doi.org/10.33425/2692-7918.1051","url":null,"abstract":"Rationale: Anaplastic astrocytoma (AA), a malignant brain tumor that arises from astrocytic cells, has a poor prognosis. It accounts for 6–7% of gliomas and 1-2% of brain tumors. Objectives: A 31-year and 11-month-old female with an AA is presented to discuss the efficacy of Antineoplastons A10 (Atengenal) and AS2-1 (Astugenal) in the treatment of AA. She presented to the Burzynski Clinic (BC) for treatment and was enrolled in Protocol BT-08, “Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients with Anaplastic Astrocytoma”, receiving both intravenous (IV) and oral Antineoplastons A10 and AS2-1 (ANP therapy). IV ANP therapy was delivered continuously via subclavian catheter and infusion pump. Tumor response was determined by comparison of baseline brain magnetic resonance imaging (MRI) to sequential brain MRIs during therapy. Findings: The patient presented to the BC with no prior treatment and a one-month history of right arm clumsiness and right leg weakness. Brain MRI and stereotactic biopsy performed elsewhere had demonstrated an AA. Baseline MRI at the BC showed a 2.0 cm2 nonenhancing lesion and two enhancing lesions (0.02 cm2 and 0.15 cm2 ) in the left parietal lobe. IV ANP therapy was given over 56 days, and a complete response (CR) was demonstrated after one month of therapy. Oral ANP therapy was subsequently provided for 17 months. At last follow-up, in June 2023, the patient was healthy and showed no evidence of recurrent disease. She had an overall survival (OS) of > 23 years and one month since diagnosis and an OS of > 23 years since the start of IV ANP therapy. Conclusions: The utilization of ANP therapy in an adult female patient with AA is presented. The patient achieved a CR and prolonged OS, suggesting that ANP therapy may be an effective therapeutic option for adults with AA.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号