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Complications of percutaneous coronary intervention 经皮冠状动脉介入治疗的并发症。
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2024.12.005
Ahmed Al-Ogaili , Gauravpal S. Gill , Emmanouil S. Brilakis
Complications of percutaneous coronary intervention (PCI) can lead to significant morbidity and mortality. In-depth understanding of the mechanisms and management options of these complications as well as timely recognition and action can sometimes be lifesaving. In this review we discuss the mechanisms, prevention methods, diagnosis, and management of three major PCI complications: a) perforation b) acute vessel closure, and c) equipment loss.
经皮冠状动脉介入治疗(PCI)的并发症可导致显著的发病率和死亡率。深入了解这些并发症的机制和治疗方案,及时认识和采取行动,有时可以挽救生命。在这篇综述中,我们讨论了三种主要PCI并发症的机制、预防方法、诊断和处理:a)穿孔、b)急性血管关闭和c)设备丢失。
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引用次数: 0
Complex high-risk indicated percutaneous coronary intervention (CHIP): Introduction
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2025.01.006
Rajan A.G. Patel , Emmanouil S. Brilakis
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引用次数: 0
Recurrent drug eluting stent, in-stent restenosis (DES-ISR): Epidemiology, pathophysiology & treatment 复发性药物洗脱支架、支架内再狭窄(DES-ISR):流行病学、病理生理及治疗。
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2024.12.003
Aashish Gupta , Oscar Maitas , Rajan A.G. Patel
Coronary artery in-stent restenosis (ISR) is driven by neointimal hyperplasia and neo‐atherosclerosis in previously placed stents. Drug eluting stents (DES) have been adopted as first line therapy for the initial episode of ISR. However, recurrent ISR has limited durable salvage options. In this article we review the pathophysiology, incidence, and management options of recurrent DES- ISR.
冠状动脉支架内再狭窄(ISR)是由先前放置支架的内膜增生和新动脉粥样硬化驱动的。药物洗脱支架(DES)已被用作ISR初期发作的一线治疗。然而,经常性ISR具有有限的持久救助选择。在这篇文章中,我们回顾了复发性DES- ISR的病理生理、发病率和治疗选择。
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引用次数: 0
Calcified plaque modification during percutaneous coronary revascularization 经皮冠状动脉血运重建术中钙化斑块的改变。
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2024.12.001
Jarrod Frizzell, Dean J. Kereiakes
The presence and severity of calcified coronary plaque negatively impacts angiographic and clinical outcomes following percutaneous coronary intervention (PCI). Severe coronary calcification is associated with suboptimal stent delivery, deployment, apposition and expansion which can lead to in-stent restenosis and/or thrombosis. Severe coronary calcification is associated with incremental hazard for adverse clinical events, including death, during 5–10 years following PCI despite the use of new generation drug- eluting stents. Multiple technologies including high-pressure noncompliant and modified (cutting/scoring) balloons, atheroablative technologies (laser, rotational or orbital atherectomy), and more recently, intravascular lithotripsy have been used to modify calcified plaque and facilitate optimal coronary stent implantation. Intravascular imaging is critically important to determine the extent and distribution (superficial or deep) of coronary calcification and to aid selection and sequence for use of calcium modifying technologies. Unfortunately, large scale randomized comparative trials of calcium modifying technologies are limited and the relative safety and effectiveness of these modalities is poorly defined. Recent mechanistic and clinical data supporting the use of plaque modifying technologies are reviewed to provide insights into their optimal use.
冠状动脉钙化斑块的存在和严重程度会对经皮冠状动脉介入治疗(PCI)后的血管造影和临床结果产生负面影响。严重的冠状动脉钙化与不理想的支架置入、部署、放置和扩张相关,可导致支架内再狭窄和/或血栓形成。尽管使用了新一代药物洗脱支架,但在PCI术后5- 年期间,严重的冠状动脉钙化与不良临床事件(包括死亡)的风险增加相关。多种技术,包括高压非依从性和改良(切割/划伤)气球,动脉粥样硬化消融技术(激光,旋转或轨道动脉粥样硬化切除术),以及最近的血管内碎石术,已被用于改变钙化斑块并促进最佳冠状动脉支架植入。血管内成像对于确定冠状动脉钙化的范围和分布(浅表或深部)以及帮助选择和顺序使用钙修饰技术至关重要。不幸的是,钙修饰技术的大规模随机比较试验是有限的,这些模式的相对安全性和有效性也没有明确的定义。最近的机制和临床数据支持斑块修饰技术的使用进行了回顾,以提供见解,他们的最佳使用。
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引用次数: 0
Unprotected distal left main percutaneous intervention 无保护的左主干远端经皮介入治疗。
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2024.12.006
Imad Bagh , Rajan A.G. Patel
Revascularization has been demonstrated to be clearly superior to medical therapy for significant unprotected left main coronary artery (LMCA) disease. Coronary artery bypass graft surgery (CABG) has a class 1 indication in both the American and European society guidelines for the treatment of LMCA disease. However, for the population of patients who are declined CABG after a heart team evaluation, percutaneous coronary interventional (PCI) may be an efficacious alternative. This review summarizes the data on percutaneous coronary intervention of distal left main coronary artery disease including the various contemporary techniques and associated challenges.
对于严重的无保护的左主干冠状动脉(LMCA)疾病,血管重建术已被证明明显优于药物治疗。冠状动脉搭桥手术(CABG)在美国和欧洲治疗LMCA疾病的社会指南中都被列为1级适应症。然而,对于在心脏小组评估后拒绝冠脉搭桥的患者群体,经皮冠状动脉介入治疗(PCI)可能是一种有效的选择。本文综述了经皮冠状动脉介入治疗左主干远端疾病的资料,包括各种现代技术和相关挑战。
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引用次数: 0
Comparing the efficacy and safety of endovascular therapy versus surgical revascularization for critical limb-threatening ischemia: A systematic review and Meta-analysis 比较血管内治疗与手术血管重建治疗危重肢体缺血的疗效和安全性:系统回顾和荟萃分析。
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2024.06.008
Mohamad Riad Abouzid , Ankit Vyas , Ibrahim Kamel , Junaid Anwar , Shorouk Elshafei , Venkat Subramaniam , William Bennett , Carl J. Lavie , Chima Nwaukwa , Christopher J. White , Rajan A.G. Patel

Introduction

Critical limb-threatening ischemia (CLTI) is a severe manifestation of peripheral artery disease (PAD) that can lead to limb amputation and significantly reduce quality of life. In addition to guideline-directed medical therapy (GDMT), endovascular therapy and surgical revascularization are the two revascularization options for CLTI. In recent years, there has been an ongoing debate about the best approach for CLTI patients. The purpose of this meta-analysis is to examine the current evidence and compare the clinical outcomes of endovascular therapy and surgical revascularization for CLTI.

Methods

We conducted a systematic search of electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) for studies comparing the outcomes of endovascular therapy versus surgery in patients with CLTI. The primary outcomes were major adverse limb events (MALE) and major adverse cardiovascular events (MACE), while secondary outcomes included risk of bleeding, wound complications, readmission, unplanned reoperation, acute renal failure, and length of hospital stay. Pooled data was analyzed using the fixed-effect model or the random-effect model in Review Manager 5.3. The Newcastle-Ottawa Scale and Cochrane risk of bias assessment tool were used to assess the bias of included studies.

Results

A total of 16 studies (47,609 patients) were included in this meta-analysis. The overall effect favors surgery over endovascular intervention in terms of MALE [odds ratio (OR) 1.13, 95% CI (1.01–1.28), P = 0.04]. Endovascular therapy is associated with lower MACE rates compared to surgery [OR 0.62, 95% CI (0.51–0.76), P < 0.00001]. Furthermore, the risk of bleeding, wound complications, readmission, unplanned reoperation, acute renal failure as well as the length of hospital stay was lower for endovascular intervention. Finally, there was no statistically significant difference in 30-day mortality between the two groups [OR 0.94, 95% CI 0.79–1.12, P = 0.52; Fig. 3i], and the pooled studies were homogeneous [P = 0.39; I2 = 5%].

Conclusion

Surgery may be the preferred treatment option for CLTI patients, as it is associated with a lower risk of MALE than endovascular therapy. However, endovascular therapy may be associated with a lower risk of MACE and lower rates of bleeding, wound complications, readmission, unplanned reoperation, acute renal failure, and shorter hospital stays. There was no statistically significant difference in 30-day mortality between the two groups. Ultimately, the decision to use endovascular therapy or surgery as the primary treatment strategy should be based on a multi-disciplinary team approach with careful consideration of patient characteristics and anatomy.
导言:危重肢体缺血(CLTI)是外周动脉疾病(PAD)的一种严重表现,可导致肢体截肢并显著降低生活质量。除指南指导的药物治疗(GDMT)外,血管内治疗和手术血管重建是治疗 CLTI 的两种血管重建方案。近年来,关于 CLTI 患者的最佳治疗方法一直存在争议。本荟萃分析的目的是研究现有证据,并比较血管内治疗和手术血管重建治疗 CLTI 的临床效果:我们对电子数据库(PubMed、Embase、Cochrane Library 和 Web of Science)进行了系统性检索,比较了血管内治疗与手术治疗 CLTI 患者的疗效。主要结果是肢体主要不良事件(MALE)和心血管主要不良事件(MACE),次要结果包括出血风险、伤口并发症、再入院、计划外再次手术、急性肾功能衰竭和住院时间。汇总数据使用Review Manager 5.3中的固定效应模型或随机效应模型进行分析。采用纽卡斯尔-渥太华量表和 Cochrane 偏倚风险评估工具评估纳入研究的偏倚:本荟萃分析共纳入16项研究(47 609名患者)。就MALE而言,手术治疗优于血管内介入治疗[几率比(OR)1.13,95% CI (1.01-1.28),P = 0.04]。与手术相比,血管内治疗的 MACE 发生率更低[OR 0.62,95% CI (0.51-0.76),P 结论:手术可能是CLTI患者的首选治疗方案,因为与血管内治疗相比,手术的MALE风险更低。然而,血管内治疗可能与较低的MACE风险、较低的出血率、伤口并发症、再入院、计划外再次手术、急性肾功能衰竭和较短的住院时间有关。两组患者的 30 天死亡率在统计学上没有明显差异。最终,决定使用血管内治疗还是手术作为主要治疗策略,应基于多学科团队的方法,并仔细考虑患者的特征和解剖结构。
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引用次数: 0
Use of mechanical circulatory support in high-risk percutaneous coronary interventions 在高风险经皮冠状动脉介入手术中使用机械循环支持。
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2024.10.007
Zaid Al Jebaje, Ahmad Jabri, Tushar Mishra, Adnan Halboni, Asem Ayyad, Anas Alameh, Rama Ellauzi, Francisco B. Alexandrino, Khaldoon Alaswad, Mir Babar Basir
As the field of percutaneous coronary intervention grows in volume, expertise, and available tools, interventional cardiologists are increasingly performing more complex and higher-risk coronary artery procedures. Mechanical circulatory support devices, previously used only in urgent situations, are now being utilized as supplementary tools to enhance outcomes in elective complex cases. This shift has sparked significant discussions about patient and device selection, as well as the potential risks involved. In this article, we explore the various devices and their distinct features. Additionally, we also introduce algorithms for device selection, placement and weaning to help guide physicians during their care for their high-risk PCI patients.
随着经皮冠状动脉介入治疗领域在数量、专业技术和可用工具方面的增长,介入心脏病专家越来越多地开展更复杂、风险更高的冠状动脉手术。以前只在紧急情况下使用的机械循环支持装置,现在被用作辅助工具,以提高择期复杂病例的治疗效果。这一转变引发了有关患者和设备选择以及潜在风险的重要讨论。在本文中,我们将探讨各种设备及其独特功能。此外,我们还介绍了器械选择、放置和断流的算法,以帮助指导医生对高风险 PCI 患者进行护理。
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引用次数: 0
Retrograde approach to chronic total occlusion percutaneous coronary interventions- Technique and outcomes 慢性全闭塞经皮冠状动脉介入治疗的逆行入路-技术和结果。
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2024.12.002
Salman S. Allana , Keerthi Gondi , Amit Goyal , Saraschandra Vallabhajosyula
The retrograde approach to chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has significantly contributed to the success rates of CTO PCI. It is usually performed in complex CTO lesions, in which the antegrade approach is not feasible or fails. In this article we discuss the steps to perform retrograde CTO PCI and its complications and success rates. Considering the moderate to high success rates of the retrograde approach in the hands of experienced operators and higher complication rates than antegrade only procedures, optimizing the safety of retrograde CTO PCI is of paramount importance.
慢性全闭塞(CTO)经皮冠状动脉介入治疗(PCI)逆行入路显著提高了CTO PCI的成功率。通常在复杂的CTO病变中进行,其中顺行入路不可行或失败。在本文中,我们讨论了行逆行CTO PCI的步骤及其并发症和成功率。考虑到逆行入路在经验丰富的操作人员的操作下具有中高的成功率和比单纯逆行手术更高的并发症发生率,优化逆行CTO PCI的安全性至关重要。
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引用次数: 0
The efficacy of revascularization in ischemic cardiomyopathy 血运重建术治疗缺血性心肌病的疗效。
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2024.12.007
Kais Hyasat , Chieh-Shou Su , Ajay J. Kirtane , Margaret McEntegart
Ischemic cardiomyopathy (ICM) is characterized by myocardial dysfunction due to myocardial ischemia, associated with the presence of significant coronary artery disease (CAD). We provide a comprehensive review of the current evidence for coronary revascularization in ICM, including consideration of the different modalities of coronary artery bypass grafting and percutaneous coronary intervention. In addition to a contemporary assessment of the literature, we aim to provide real-world insights and perspectives to guide clinical decision-making in this heterogeneous and complex patient population.
缺血性心肌病(ICM)以心肌缺血引起的心肌功能障碍为特征,并伴有明显的冠状动脉疾病(CAD)。我们对ICM中冠状动脉血运重建的现有证据进行了全面的回顾,包括考虑冠状动脉旁路移植术和经皮冠状动脉介入治疗的不同方式。除了对文献进行当代评估外,我们的目标是提供真实世界的见解和观点,以指导这种异质性和复杂患者群体的临床决策。
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引用次数: 0
Vascular access: Femoral, radial and large-bore alternative access
IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-01 DOI: 10.1016/j.pcad.2024.12.009
Kaushik Darbha , Vincent J. Long , Caleb M. Lowe , Edem J. Abotsi , Antony Anandaraj , Arnold H. Seto
Vascular access for coronary, peripheral, and structural interventions has changed significantly over the past two decades. The evolving demand for both large-bore access for valvular interventions and mechanical support devices, and for safer access for coronary interventions, in patients with comorbidities have driven progress in these areas. This review will provide an overview of the techniques of arterial access in the femoral, forearm (radial and ulnar), and alternative (transcarotid, transaxillary, and transcaval) locations based on the latest evidence and experience.
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引用次数: 0
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Progress in cardiovascular diseases
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