Progress in cardiovascular diseases最新文献

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IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-11-01 DOI: 10.1016/S0033-0620(24)00157-9

引用次数: 0

Healthy and unhealthy plant-based diets and the risk of cardiovascular diseases: The Rotterdam study and updated meta-analysis 健康和不健康的植物性饮食与心血管疾病风险：鹿特丹研究和最新荟萃分析。

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-11-01 DOI: 10.1016/j.pcad.2024.10.008

Xiang Jun Wang , Trudy Voortman , Tosca O.E. de Crom , Martijn Tilly , Maryam Kavousi , M. Kamran Ikram , Marinka Steur

Background

Consumption of more plant-based foods is gaining popularity, but the role of healthy versus unhealthy plant-based diets in cardiovascular disease (CVD) risk remains inconclusive.

Objectives

We investigated associations of plant-based diet indices (PDIs) with incident CVDs in a prospective cohort study and conducted an updated meta-analysis.

Methods

We included 3507 men and 5345 women of the population-based Rotterdam Study. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for CVD, coronary heart disease (CHD) and stroke per SD increment of an overall PDI, healthy PDI (hPDI) and unhealthy PDI (uPDI), among men and women separately. We combined our findings with previously published effect estimates in an updated meta-analysis.

Results

We documented 2015 CVD cases (1231 CHD and 952 stroke) during 107,290 person-years follow-up. Among men, the PDI and hPDI were associated with a 7 % (HR 0.93, 95 % CI 0.87–0.99) and 8 % (HR 0.92, 95 % CI 0.86–0.98) lower CVD risk. Among women, there was evidence suggesting a U-shaped association of the PDI with stroke (p_{non-linearity} < 0.01). In meta-analyses including up to 43,067 incident CVD cases among 359,740 participants from nine studies, the PDI and hPDI, were associated with a lower CVD riskand the uPDI with a higher CVD risk (pooled HRs [95 % CI], per SD, PDI: 0.94 [0.91–0.97], I² = 50.4 %; hPDI: 0.94 [0.91–0.98], I² = 74.7 %; uPDI: 1.03 [1.01–1.06], I² = 49.0 %).

Conclusions

Our findings support recommendations to consume relatively more healthy plant-based foods for CVD prevention. Potential differences by sex and non-linear associations warrant further investigation.

背景：食用更多的植物性食品越来越受到人们的欢迎，但健康与不健康的植物性膳食在心血管疾病（CVD）风险中的作用仍无定论：我们在一项前瞻性队列研究中调查了植物性饮食指数（PDI）与心血管疾病发病率的关系，并进行了最新的荟萃分析：我们纳入了基于人群的鹿特丹研究中的 3507 名男性和 5345 名女性。我们使用多变量 Cox 比例危险模型分别估算了男性和女性在总体 PDI、健康 PDI（hPDI）和不健康 PDI（uPDI）每 SD 增量下心血管疾病、冠心病（CHD）和中风的危险比（HRs）和 95 % 置信区间（CIs）。我们在最新的荟萃分析中将我们的研究结果与之前发表的效果估计值相结合：在 107,290 人年的随访中，我们记录了 2015 例心血管疾病病例（1231 例冠心病和 952 例中风）。在男性中，PDI和hPDI分别与心血管疾病风险降低7%（HR 0.93，95% CI 0.87-0.99）和8%（HR 0.92，95% CI 0.86-0.98）相关。在女性中，有证据表明 PDI 与中风呈 U 型关系（非线性 2 = 50.4%；hPDI：0.94 [0.91-0.98]，I2 = 74.7%；uPDI：1.03 [1.01-1.06]，I2 = 49.0%）：我们的研究结果支持为预防心血管疾病而摄入相对较多的健康植物性食品的建议。潜在的性别差异和非线性关联值得进一步研究。

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引用次数: 0

Optical coherence tomography angiography in cardiovascular disease 心血管疾病的光学相干断层血管造影。

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-11-01 DOI: 10.1016/j.pcad.2024.10.011

Oluwapeyibomi I. Runsewe , Sunil K. Srivastava , Sumit Sharma , Pulkit Chaudhury , W.H. Wilson Tang

Endothelial dysfunction and microvascular remodeling underly the development and progression of a host of cardiovascular disease (CVD). However, current methods to assess coronary epicardial microvascular function are invasive, time-intensive, and costly. Optical coherence tomography angiography (OCTA) is an established technology within ophthalmology that provides a quick, noninvasive assessment of vascular structures within the retina. As a growing body of evidence reveals strong associations between the retinal changes on OCTA and the development and progression of CVD, OCTA may indeed be a surrogate test for end-organ dysfunction. OCTA has potential to enhance diagnostic performance, refine cardiovascular risk assessment, strengthen prognostication, and ultimately, improve patient care. We explore the current literature on OCTA in cardiovascular diseases to summarize the clinical utility of retinal OCTA imaging and discuss next-generation cardiovascular applications.

内皮功能障碍和微血管重塑是一系列心血管疾病（CVD）发生和发展的基础。然而，目前评估冠状动脉心外膜微血管功能的方法都是侵入性的、耗时耗力且成本高昂。光学相干断层血管造影（OCTA）是眼科领域一项成熟的技术，可对视网膜内的血管结构进行快速、无创的评估。越来越多的证据表明，OCTA 所显示的视网膜变化与心血管疾病的发生和发展密切相关，因此 OCTA 可能确实是内脏器官功能障碍的替代检测方法。OCTA 具有提高诊断性能、完善心血管风险评估、加强预后判断以及最终改善患者护理的潜力。我们探讨了当前有关心血管疾病中 OCTA 的文献，总结了视网膜 OCTA 成像的临床实用性，并讨论了下一代心血管应用。

引用次数: 0

Cover 2 (Masthead) 封二（刊头）

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-09-01 DOI: 10.1016/S0033-0620(24)00131-2

引用次数: 0

Testosterone replacement therapy and cardiovascular risk: TRAVERSE with caution 睾酮替代疗法与心血管风险：慎用TRAVERSE。

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-09-01 DOI: 10.1016/j.pcad.2024.07.003

Srikanth Krishnan , Jairo Aldana-Bitar , Ilana Golub , Sina Kianoush , Travis Benzing , Keishi Ichikawa , Matthew J. Budoff

引用次数: 0

Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions 不确定潜能克隆造血与心血管疾病：发病机制、临床表现和未来方向。

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-09-01 DOI: 10.1016/j.pcad.2024.09.001

Saivaroon Gajagowni , Steven Hopkins , Yusuf Qadeer , Salim S. Virani , Job A.J. Verdonschot , Catherine C. Coombs , Christopher I. Amos , Kevin T. Nead , Siddhartha Jaiswal , Chayakrit Krittanawong

Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (CVD). The relationship between CHIP and CVD appears to be bidirectional, with traditional risk factors for cardiovascular disease increasing the mutation burden in CHIP, and CHIP itself effecting the incidence or prognosis of a variety of CVD. The purpose of this review is to understand the epidemiology, risk factors, and pathogenesis of CHIP in the context of various CVD conditions.

具有不确定潜能的克隆性造血（CHIP）是血液系统恶性肿瘤中一种被广泛研究的现象。随着基因取样和分析技术的进步以及大型队列研究的应用，CHIP 最近被认为与心血管疾病（CVD）有关。CHIP 与心血管疾病之间的关系似乎是双向的，心血管疾病的传统风险因素会增加 CHIP 的突变负担，而 CHIP 本身则会影响各种心血管疾病的发病率或预后。本综述旨在从各种心血管疾病的角度了解 CHIP 的流行病学、风险因素和发病机制。

引用次数: 0

Stemming the chronic disease pandemic through a generational shift in public health policy and practice 通过公共卫生政策和实践的世代转变遏制慢性病的流行。

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-09-01 DOI: 10.1016/j.pcad.2024.09.004

Ross Arena , Annamaria Arena

引用次数: 0

Substances use and risk of hypertension before midlife in military young adults: CHIEF cohort study, 2014–2020 军队青壮年中年前的药物使用与高血压风险：首席队列研究，2014-2020 年。

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-09-01 DOI: 10.1016/j.pcad.2024.08.005

Gen-Min Lin , Kun-Zhe Tsai , Yun-Chen Chang , Pang-Yen Liu , Xuemei Sui , Carl J. Lavie , Po-Shun Hsu

Background

The use of substances, e.g., tobacco and betel nut, are prevalent among military personnel in Taiwan, whereas some specific substances such as alcohol use are forbidden in military base. There were inconsistent findings for the incidence of hypertension with habitual substances use in diverse populations, while no studies were carried out in the military.

Methods

A total of 2419 Taiwanese military personnel, aged 18–39 years, who were not taking any antihypertensive agents and did not have a baseline systolic blood pressure (SBP) ≥130 mmHg and/or diastolic blood pressure (DBP) ≥80 mmHg were followed for incidence of hypertension from baseline (2014) through the end of 2020. Alcohol, tobacco and betel nut use status (active vs. former/never) were self-reported by each participant at baseline. New-onset hypertension of each participant was defined by an average of two resting BP measurements in the annual health examinations (2015–2020). Multivariable Cox regression analysis with adjustments for baseline BP and other potential covariates were performed to determine the risk of incident hypertension with each substance use. Five-year absolute changes in BP level with specific substance use were compared using analysis of covariance (ANCOVA).

Results

There were 867 active smokers (35.8 %), 237 active betel nut chewers (9.8 %) and 961 active alcohol consumers (39.7 %) at baseline. During a median follow-up of 5.8 years, 911 new-onset hypertension events (37.7 %) were observed. While compared to those without any substances use, merely active holiday alcohol users had a significantly lower risk of incident hypertension [hazard ratio (HR) and 95 % confidence interval: 0.72 (0.58–0.89)]. The 5-year diastolic BP increase (mmHg) was borderline significantly lower in active alcohol users on holidays as compared to former/never alcohol users (4.02 (standard deviation =9.01) and 4.76 (9.42), p = 0.07). The risk of incident hypertension was not significant in active smokers and active betel nut users, while the 5-year BP increase level was significantly greater in active smokers than former/never smokers (5.60 (9.96) vs. 4.42 (9.22), p = 0.03).

Conclusion

Our findings suggest that military young personnel consuming alcohol only allowed on holidays had a lower incidence of new-onset hypertension. On the contrary, the 5-year BP change may increase greater with habitual smoking, though the risk of new-onset hypertension was not affected.

背景：台湾军人普遍使用烟草和槟榔等物质，而一些特定物质如酒精在军事基地是禁止使用的。关于高血压发病率与习惯性使用药物的关系，在不同人群中的研究结果不一致，而在军队中则没有研究：方法：从基线（2014 年）到 2020 年底，对未服用任何降压药且基线收缩压 (SBP) ≥130 mmHg 和/或舒张压 (DBP) ≥80 mmHg 的 2419 名 18-39 岁台湾军人进行了高血压发病率跟踪调查。酒精、烟草和槟榔的使用状况（活跃与曾经/从未）由每位参与者在基线时自我报告。每位参与者新发高血压的定义是在年度健康检查（2015-2020 年）中两次静息血压测量的平均值。在对基线血压和其他潜在协变量进行调整后，进行了多变量 Cox 回归分析，以确定每种药物使用导致的高血压发病风险。使用协方差分析（ANCOVA）比较了使用特定药物五年后血压水平的绝对变化：结果：基线时有 867 名活跃的吸烟者（35.8%）、237 名活跃的槟榔咀嚼者（9.8%）和 961 名活跃的饮酒者（39.7%）。在 5.8 年的中位随访期间，共观察到 911 例新发高血压（37.7%）。与未使用任何药物的人群相比，仅在节假日积极饮酒的人群发生高血压的风险明显较低[危险比（HR）和 95% 置信区间：0.72 (0.58-0.89)]。与以前/从未饮酒者相比，节假日积极饮酒者的 5 年舒张压升幅（毫米汞柱）明显低于以前/从未饮酒者（4.02（标准差=9.01）和 4.76（9.42），P = 0.07）。积极吸烟者和积极槟榔使用者发生高血压的风险并不明显，而积极吸烟者的 5 年血压升高水平明显高于曾经/从不吸烟者（5.60 (9.96) vs. 4.42 (9.22)，p = 0.03）：我们的研究结果表明，只允许在节假日饮酒的青年军人新发高血压的发病率较低。结论：我们的研究结果表明，只允许在节假日饮酒的军队青年新发高血压的发病率较低，相反，习惯性吸烟者的 5 年血压变化可能会更大，但新发高血压的风险不受影响。

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引用次数: 0

Predictors of short-term and long-term effects of mavacamten in obstructive hypertrophic cardiomyopathy 阻塞性肥厚型心肌病患者服用马伐康坦短期和长期疗效的预测因素。

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-09-01 DOI: 10.1016/j.pcad.2024.05.008

引用次数: 0

COVID-19 susceptibility causally related to stroke risk: Using SARS-CoV-2 infection as a natural test of disease predisposition? COVID-19 易感性与中风风险存在因果关系：将 SARS-CoV-2 感染作为疾病易感性的自然测试？

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases

Pub Date : 2024-09-01 DOI: 10.1016/j.pcad.2024.09.002

Ming Zheng , Carl J. Lavie

The COVID-19 pandemic, caused by SARS-CoV-2, has sparked recurring outbreaks and remains endemic, posing ongoing health risks. In addition to its immediate effects, COVID-19 has been linked to cardiovascular complications, including stroke. However, it remains unclear whether COVID-19 causally increases future stroke risk. This study used Mendelian randomization (MR) analysis to explore the causal link between COVID-19 susceptibility and stroke risk. By analyzing genome-wide association study (GWAS) data, genetically determined susceptibility to COVID-19 was identified and linked to various stroke subtypes, including cardioembolic, small-vessel, and large-artery ischemic stroke. Results indicated a significant association between COVID-19 susceptibility and increased stroke risk, particularly for large-artery ischemic stroke. These findings suggest that SARS-CoV-2 infection could serve as a natural indicator of disease predisposition, revealing inherent cardiovascular vulnerabilities. This revolutionizes the way we view pathogen infections—not only as harmful threats, but also as opportunities to assess individual health risks. By analyzing how people respond to infections, we can gain valuable insights into their predisposition to other diseases later in life, offering an analytical framework for early diagnosis and prevention. This perspective—using pathogen infections as natural tests of disease predisposition—offers a transformative way to view human diseases as a continuum. Instead of merely treating infections as isolated diseases, we can exploit natural infections to assess broader population health, thus paving the way for precision medicine and personalized healthcare interventions.

由 SARS-CoV-2 引起的 COVID-19 大流行引发了反复的疫情爆发，目前仍在流行，对健康构成持续的威胁。除了直接影响外，COVID-19 还与包括中风在内的心血管并发症有关。然而，COVID-19 是否会增加未来的中风风险，目前仍不清楚。本研究利用孟德尔随机化（MR）分析来探讨 COVID-19 易感性与中风风险之间的因果联系。通过分析全基因组关联研究（GWAS）数据，确定了由基因决定的 COVID-19 易感性，并将其与各种中风亚型（包括心肌栓塞性中风、小血管性中风和大动脉缺血性中风）联系起来。结果表明，COVID-19 易感性与中风风险增加之间存在明显关联，尤其是大动脉缺血性中风。这些发现表明，SARS-CoV-2 感染可作为疾病易感性的自然指标，揭示心血管的内在脆弱性。这彻底改变了我们看待病原体感染的方式--不仅将其视为有害威胁，还将其视为评估个人健康风险的机会。通过分析人们对感染的反应，我们可以获得有关他们日后易患其他疾病的宝贵见解，为早期诊断和预防提供分析框架。这种视角--将病原体感染作为疾病易感性的自然测试--为将人类疾病视为一个连续体提供了一种变革性的方法。我们可以利用自然感染来评估更广泛的人群健康状况，而不是仅仅将感染作为孤立的疾病来治疗，从而为精准医疗和个性化医疗干预铺平道路。

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