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Fatores de risco de NVPO após cesarianas 剖宫产后NVPO的危险因素
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.09.005
Gabriel Magalhães Nunes Guimarães
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引用次数: 0
Efeitos da musicoterapia sobre dor e estresse oxidativo na aspiração folicular: estudo clínico randomizado 音乐疗法对毛囊抽吸疼痛和氧化应激的影响:一项随机临床研究
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.04.015
Yavuz Orak , Suleyman Murat Bakacak , Asli Yaylali , Fatma Inanc Tolun , Hakan Kiran , Omer Faruk Boran , Akif Hakan Kurt , Adem Doganer

Background and objective

The aim was to investigate the effects of Turkish classical music on pain and oxidative stress in patients undergoing oocyte pick‐up.

Methods

The study was a randomized, controlled trial. The groups included were Group NM (Non‐Music), control group; Group PM, which comprised patients who listened to music before the operation; and Group CM, which comprised patients who listened to music both before and during the operation. Blood was drawn prior to the operation to measure the oxidative stress values. Pain, hemodynamic parameters, oxidative stress values were assessed postoperatively.

Results

The number of patients requiring additional propofol was higher in Group PM than in Groups NM and CM (p = 0.003). The postoperative Visual Analog Scale (VAS) score were lower in Groups PM and CM than in Group NM (p = 0.001, p = 0.007) in the 1st and 60th minutes. The postoperative VAS score was lower in Group CM than in Group NM (p = 0.045) in the 5th minute. The postoperative additional analgesic requirements were lower in Groups PM and CM than in Group NM (p = 0.045). The postoperative blood glutathione peroxidase values were significantly higher in Groups PM and CM than in Group NM (p = 0.001). The postoperative catalase values were significantly higher in Groups PM and CM than in Group NM (p = 0.008 and p ≤ 0.001). The preoperative malondialdehyde values were significantly lower in Groups PM and CM than in Group NM. The preoperative nitric oxide values were higher in Groups PM and CM than in Group NM (p ≤ 0.001), whereas the postoperative nitric oxide values were lower in Groups PM and CM than in Group NM (p ≤ 0.001).

Conclusion

Turkish classical music has beneficial effects on pain and oxidative stress in oocyte pick‐up patients.

背景与目的探讨土耳其古典音乐对接受卵母细胞提取的患者疼痛和氧化应激的影响。方法采用随机对照试验。各组包括:NM组(Non - Music),对照组;PM组,由术前听音乐的患者组成;CM组,患者在手术前和手术中都听音乐。术前抽血测定氧化应激值。术后评估疼痛、血流动力学参数、氧化应激值。结果PM组需加用异丙酚的患者数量高于NM组和CM组(p = 0.003)。PM组和CM组术后1、60分钟视觉模拟评分(VAS)低于NM组(p = 0.001, p = 0.007)。CM组术后第5分钟VAS评分低于NM组(p = 0.045)。PM组和CM组术后额外镇痛需求低于NM组(p = 0.045)。PM组和CM组术后血谷胱甘肽过氧化物酶值显著高于NM组(p = 0.001)。PM组和CM组术后过氧化氢酶值显著高于NM组(p = 0.008和p≤0.001)。PM组和CM组术前丙二醛值显著低于NM组。PM组和CM组术前一氧化氮值高于NM组(p≤0.001),而PM组和CM组术后一氧化氮值低于NM组(p≤0.001)。结论土耳其古典音乐对卵母细胞提取患者的疼痛和氧化应激有有益的影响。
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引用次数: 2
Correlação entre saturação venosa central de oxigênio perioperatória e mortalidade em cirurgia cardíaca: estudo prospectivo observacional 心脏手术围手术期中心静脉氧饱和度与死亡率的相关性:观察性前瞻性研究
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.04.014
César de Araujo Miranda , José F.A. Meletti , Laís H.N. Lima , Evaldo Marchi

Background

Cardiac surgery can produce persistent deficit in the ratio of Oxygen Delivery (DO2) to Oxygen Consumption (VO2). Central venous oxygen Saturation (ScvO2) is an accessible and indirect measure of DO2/VO2 ratio.

Objective

To monitor perioperative ScvO2 and assess its correlation with mortality during cardiac surgery.

Methods

This prospective observational study evaluated 273 patients undergoing cardiac surgery. Blood gas samples were collected to measure ScvO2 at three time points: T0 (after anesthetic induction), T1 (end of surgery), and T2 (24 hours after surgery). The patients were divided into two groups (survivors and nonsurvivors). The following outcomes were analyzed: intrahospital mortality, length of Intensive Care Unit (ICU) and hospital stay (LOS), and variation in ScvO2.

Results

Of the 273 patients, 251 (92%) survived and 22 (8%) did not. There was a significant perioperative reduction of ScvO2 in both survivors (T0 = 78% ± 8.1%, T1 = 75.4% ± 7.5%, and T2 = 68.5% ± 9%; p < 0.001) and nonsurvivors (T0 = 74.4% ± 8.7%, T1 = 75.4% ± 7.7%, and T2 = 66.7% ± 13.1%; p < 0.001). At T0, the percentage of patients with ScvO2 < 70% was greater in the nonsurvivor group (31.8% vs. 13.1%; p = 0.046) and the multiple logistic regression showed that ScvO2 is an independent risk factor associated with death, OR = 2.94 (95% CI 1.10  7.89) (p = 0.032). The length of ICU and LOS were 3.6 ± 3.1 and 7.4 ± 6.0 days respectively and was not significantly associated with ScvO2.

Conclusions

Early intraoperative ScvO2 < 70% indicated a higher risk of death. A perioperative reduction of ScvO2 was observed in patients undergoing cardiac surgery, with high intraoperative and lower postoperative levels.

背景:心脏手术可造成持续的氧输送(DO2)与耗氧量(VO2)比不足。中心静脉氧饱和度(ScvO2)是DO2/VO2比值的一种可获得的间接测量方法。目的监测心脏手术围术期ScvO2并评价其与死亡率的相关性。方法本前瞻性观察性研究评估了273例接受心脏手术的患者。采集血气标本,在T0(麻醉诱导后)、T1(手术结束)和T2(手术后24小时)三个时间点测量ScvO2。患者分为两组(幸存者和非幸存者)。分析了以下结果:院内死亡率、重症监护病房(ICU)和住院时间(LOS)以及ScvO2的变化。结果273例患者中,251例(92%)存活,22例(8%)死亡。两名幸存者围手术期ScvO2均显著降低(T0 = 78%±8.1%,T1 = 75.4%±7.5%,T2 = 68.5%±9%;p & lt;0.001)和nonsurvivors (T0 = 74.4%±8.7%,T1 = 75.4%±7.7%,和T2 = 66.7%±13.1%;p & lt;0.001)。在T0时,ScvO2 <患者的百分比;非幸存者组的这一比例高于70% (31.8% vs. 13.1%;p = 0.046),多元logistic回归显示ScvO2是与死亡相关的独立危险因素,OR = 2.94 (95% CI 1.10 ~ 7.89) (p = 0.032)。ICU和LOS的时间分别为3.6±3.1和7.4±6.0 d,与ScvO2无显著相关性。结论术中早期ScvO2 <70%的人表示死亡风险更高。在接受心脏手术的患者中,观察到围手术期ScvO2的降低,术中较高,术后较低。
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引用次数: 3
Antagonistas do receptor da neurocinina‐1 no tratamento de náusea e vômito no pós‐operatório: Revisão sistemática e meta‐análise 神经激肽- 1受体拮抗剂治疗术后恶心呕吐:系统综述和meta分析
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.04.005
Chiaki Murakami , Nami Kakuta , Shiho Satomi , Ryuji Nakamura , Hirotsugu Miyoshi , Atsushi Morio , Noboru Saeki , Takahiro Kato , Naohiro Ohshita , Katsuya Tanaka , Yasuo M. Tsutsumi

Histórico

Náusea e Vômito no Pós‐Operatório (NVPO) é um evento adverso frequente da anestesia geral. Várias classes de antieméticos, incluindo antagonistas do receptor 5‐Hidroxitriptamina3 (5‐HT3) e antagonistas do receptor da Neurocinina‐1 (NK‐1), têm sido utilizados para tratar a NVPO.

Objetivo

Comparar o efeito antiemético dos antagonistas do receptor NK‐1, incluindo o fosaprepitanto.

Fontes de dados

Foram utilizadas bases de dados on‐line (PubMed, MEDLINE, Scopus, The Cochrane Library).

Critérios de elegibilidade do estudo, participantes e intervenções

Foram incluídos Estudos Clínicos Randomizados (ECR) realizados em pacientes acima de 18 anos classificação ASA I a III, com o objetivo de avaliar a eficácia de antieméticos que incluíssem antagonistas do receptor NK‐1 e antagonistas do receptor 5‐HT3, e que comparassem a incidência de NVPO.

Métodos de avaliação e síntese do estudo

Todas as avaliações estatísticas foram realizadas por abordagem de efeito aleatório e foram calculadas razões de chances e Intervalos de Confiança de 95%.

Resultados

As doses de 40 mg e 80 mg de aprepitanto reduziram significantemente a incidência de vômito no período de 0 a 24 horas pós‐operatórias (razão de chances [OR = 0,40]; Intervalo de Confiança de 95% [95% IC] 0,30‐0,54; p < 0,001 e OR = 0,32; 95% IC 0,19‐0,56; p < 0,001). O fosaprepitanto pode também reduzir significantemente a incidência de vômito tanto de 0‐24 horas como no período de 0‐48 horas pós‐operatórias (OR = 0,07; 95% IC 0,02‐0,24; p < 0,001 e OR = 0,07; 95% IC 0,02‐0,23; p < 0,001).

Limitações

Os fatores de risco para NVPO não foram analisados, ECRs usando múltiplos antieméticos foram incluídos, ECRs para fosaprepitanto tinham amostras pequenas, podendo haver algum viés.

Conclusões e implicações dos principais achados

Aprepitanto e fosaprepitanto podem ser drogas antieméticas profiláticas efetivas para vômito no pós‐operatório. No entanto, são necessários mais estudos para elaboração de meta‐análises de melhor qualidade.

Número de registro da revisão sistemática

CRD42019120188.

Background

Postoperative Nausea and Vomiting (PONV) is a common complication of general anesthesia. Several kinds of antiemetics, including 5‐Hydroxytryptamine3 (5‐HT3) receptor antagonists and Neurokinin‐1 (NK‐1) receptor antagonists, have been used to treat PONV.

Objectives

To compare the antiemetic effect of NK‐1 receptor antagonists, including fosaprepitant.

Data sources

Online databases (PubMed, MEDLINE, Scopus, The Cochrane Library databases) were used.

Study eligibility criteria, participants, and interventions

Randomized

术后病史和呕吐是全身麻醉常见的不良事件。几种止吐药物,包括5‐羟色胺受体拮抗剂(5‐HT3)和神经激肽受体1拮抗剂(NK‐1),已被用于治疗NVPO。目的比较NK - 1受体拮抗剂的止吐作用,包括福萨普吡坦。数据来源使用在线数据库(PubMed, MEDLINE, Scopus, The Cochrane Library)。合格标准的研究,参与者和intervençõesForam包括随机临床试验(ECR)大于18岁病人进行分类(翼第三,以评估治疗的有效性包括NK受体1、受体拮抗剂5‐‐HT3 ponv发生率比较是否。评价方法和研究综合所有统计评价均采用随机效应法,计算优势比和95%置信区间。结果40 mg和80 mg阿瑞吡坦剂量可显著降低术后0 - 24小时内呕吐发生率(几率[OR = 0.40];95%置信区间[95% ci] 0.30 - 0.54;p <0.001, OR = 0.32;95% ci 0.19‐0.56;p <0.001)。福萨prepitanto还可显著降低术后0 - 24小时和0 - 48小时的呕吐发生率(或= 0.07;95% ci 0.02 - 0.24;p <0.001, OR = 0.07;95% ci 0.02 - 0.23;p <0.001)。局限性未分析NVPO的危险因素,包括使用多种止吐剂的rcs,鼻前皮质的rcs样本小,可能存在一些偏差。结论和主要发现的意义:术前和术后呕吐可能是有效的预防性止吐药物。然而,还需要更多的研究来发展更好质量的荟萃分析。系统修订注册编号acrd42019120188。BackgroundPostoperative恶心和Vomiting (PONV)是通用的共同语言complication麻醉。几种类型的抗吐药物,包括5 -羟色胺- 3 (5 - HT3)受体拮抗剂和神经激酶- 1 (NK - 1)受体拮抗剂,已被用于治疗PONV。目的比较包括fosaprepitant在内的NK‐1受体拮抗剂的止吐作用。使用了在线数据来源数据库(PubMed, MEDLINE, Scopus, Cochrane图书馆数据库)。研究资格标准、参与者和干预对照试验(rct)在18年以上ASA - PS I - III患者中进行,旨在评估包括NK - 1受体拮抗剂和5 - HT3受体拮抗剂在内的抗吐药物的有效性,并比较PONV的发生率。研究评估和综合方法采用随机效应法进行统计评估,计算优势比和95%置信区间。结果prepitant 40mg和80mg显著降低术后0 - 24小时呕吐发生率(比值比[OR = 0.40];95%置信区间[95% CI 0.30 - 0.54];p <0.001,或= 0.32;95% CI 0.19 - 0.56;p <0001)。Fosaprepitant还可显著降低术后0 - 24小时和0 - 48小时的呕吐发生率(或= 0.07;95% CI 0.02 - 0.24;p <0.001和或= 0.07;95% CI 0.02 - 0.23;p <0001)。没有考虑PONV的限制因素,包括使用多种抗吐药的rct,用于fosaprepitant的rct很小,可能存在一些偏见。关键发现前药和福萨前药可有效预防术后呕吐的结论和意义。然而,需要更多的研究来进行更高质量的荟萃分析。系统评审注册编号crd42019120188
{"title":"Antagonistas do receptor da neurocinina‐1 no tratamento de náusea e vômito no pós‐operatório: Revisão sistemática e meta‐análise","authors":"Chiaki Murakami ,&nbsp;Nami Kakuta ,&nbsp;Shiho Satomi ,&nbsp;Ryuji Nakamura ,&nbsp;Hirotsugu Miyoshi ,&nbsp;Atsushi Morio ,&nbsp;Noboru Saeki ,&nbsp;Takahiro Kato ,&nbsp;Naohiro Ohshita ,&nbsp;Katsuya Tanaka ,&nbsp;Yasuo M. Tsutsumi","doi":"10.1016/j.bjan.2020.04.005","DOIUrl":"10.1016/j.bjan.2020.04.005","url":null,"abstract":"<div><h3>Histórico</h3><p>Náusea e Vômito no Pós‐Operatório (NVPO) é um evento adverso frequente da anestesia geral. Várias classes de antieméticos, incluindo antagonistas do receptor 5‐Hidroxitriptamina3 (5‐HT3) e antagonistas do receptor da Neurocinina‐1 (NK‐1), têm sido utilizados para tratar a NVPO.</p></div><div><h3>Objetivo</h3><p>Comparar o efeito antiemético dos antagonistas do receptor NK‐1, incluindo o fosaprepitanto.</p></div><div><h3>Fontes de dados</h3><p>Foram utilizadas bases de dados <em>on‐line</em> (PubMed, MEDLINE, Scopus, The Cochrane Library).</p></div><div><h3>Critérios de elegibilidade do estudo, participantes e intervenções</h3><p>Foram incluídos Estudos Clínicos Randomizados (ECR) realizados em pacientes acima de 18 anos classificação ASA I a III, com o objetivo de avaliar a eficácia de antieméticos que incluíssem antagonistas do receptor NK‐1 e antagonistas do receptor 5‐HT3, e que comparassem a incidência de NVPO.</p></div><div><h3>Métodos de avaliação e síntese do estudo</h3><p>Todas as avaliações estatísticas foram realizadas por abordagem de efeito aleatório e foram calculadas razões de chances e Intervalos de Confiança de 95%.</p></div><div><h3>Resultados</h3><p>As doses de 40<!--> <!-->mg e 80<!--> <!-->mg de aprepitanto reduziram significantemente a incidência de vômito no período de 0 a 24 horas pós‐operatórias (razão de chances [OR = 0,40]; Intervalo de Confiança de 95% [95% IC] 0,30‐0,54; <em>p</em> &lt; 0,001 e OR = 0,32; 95% IC 0,19‐0,56; <em>p</em> &lt; 0,001). O fosaprepitanto pode também reduzir significantemente a incidência de vômito tanto de 0‐24<!--> <!-->horas como no período de 0‐48 horas pós‐operatórias (OR = 0,07; 95% IC 0,02‐0,24; <em>p</em> &lt; 0,001 e OR = 0,07; 95% IC 0,02‐0,23; <em>p</em> &lt; 0,001).</p></div><div><h3>Limitações</h3><p>Os fatores de risco para NVPO não foram analisados, ECRs usando múltiplos antieméticos foram incluídos, ECRs para fosaprepitanto tinham amostras pequenas, podendo haver algum viés.</p></div><div><h3>Conclusões e implicações dos principais achados</h3><p>Aprepitanto e fosaprepitanto podem ser drogas antieméticas profiláticas efetivas para vômito no pós‐operatório. No entanto, são necessários mais estudos para elaboração de meta‐análises de melhor qualidade.</p></div><div><h3>Número de registro da revisão sistemática</h3><p>CRD42019120188.</p></div><div><h3>Background</h3><p>Postoperative Nausea and Vomiting (PONV) is a common complication of general anesthesia. Several kinds of antiemetics, including 5‐Hydroxytryptamine3 (5‐HT3) receptor antagonists and Neurokinin‐1 (NK‐1) receptor antagonists, have been used to treat PONV.</p></div><div><h3>Objectives</h3><p>To compare the antiemetic effect of NK‐1 receptor antagonists, including fosaprepitant.</p></div><div><h3>Data sources</h3><p>Online databases (PubMed, MEDLINE, Scopus, The Cochrane Library databases) were used.</p></div><div><h3>Study eligibility criteria, participants, and interventions</h3><p>Randomized","PeriodicalId":21261,"journal":{"name":"Revista brasileira de anestesiologia","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjan.2020.04.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38237893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Desafios perioperatórios e pontos de atenção no bloqueio neuromuscular durante timectomia robótica para miastenia gravis 重症肌无力机器人胸廓切除术中神经肌肉阻滞的围手术期挑战与注意事项
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.05.004
Atish Pal, Vikas Gogia, Chetan Mehra

Myasthenia Gravis (MG) is an autoimmune disease characterized by weakness and fatigability of skeletal muscles, with improvement following rest. It is a disease of great significance to the anesthesiologist because it affects the neuromuscular junction. Robotic thymectomy has come up in recent times due to the minimally invasive nature and its advantages. This presents a new set of challenges for the anesthesia team, and here we present the various anesthesia considerations and perioperative management in a series of 20 patients who underwent robotic thymectomy. As it is a recent upcoming procedure, there is a paucity of literature on this topic, and most of the available literature talks about One‐Lung Ventilation (OLV) and thoracic epidurals. To our notice, this is the first literature without the use of OLV and thoracic epidural for the management of robotic thymectomy.

重症肌无力(MG)是一种自身免疫性疾病,其特征是骨骼肌无力和疲劳,休息后改善。这是一种对麻醉师意义重大的疾病,因为它影响神经肌肉连接处。机器人胸腺切除术由于其微创性和优点近年来兴起。这对麻醉团队提出了一系列新的挑战,在这里,我们介绍了20例接受机器人胸腺切除术的患者的各种麻醉注意事项和围手术期管理。由于这是一种新近的手术,关于这一主题的文献很少,大多数可用的文献都是关于单肺通气(OLV)和胸硬膜外麻醉的。值得注意的是,这是第一篇没有使用OLV和胸廓硬膜外手术来治疗机器人胸腺切除术的文献。
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引用次数: 1
Cisto hidático na medula cervical complicada por via aérea difícil com potencial risco de vida: relato de caso 颈椎包虫性囊肿合并困难气道危及生命:病例报告
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.08.004
Dmitriy Viderman , Aisa Nurpeisov , Omirzhan Balabayev , Yermek Urunbayev , Guilherme de Almeida , Federico Bilotta

Hydatid cyst in the cervical region is an extremely rare condition that can create challenges for anesthesiologists. Timely recognition of difficult airway and preparing the management plan is crucial to avoid life‐threatening complications such as hypoxic brain damage. We describe a case of difficult airway management in a patient with massive cervical hydatid cyst. We used a low‐dose ketamine‐propofol sedation and lidocaine spray for local oropharyngeal anesthesia. Muscular relaxants were not used, and spontaneous breathing was maintained during intubation. Recognition, assessment, and perioperative planning are essential for difficult airway management in patients with cervical hydatid cyst.

宫颈包虫病是一种极为罕见的疾病,它给麻醉师带来了挑战。及时识别气道困难并制定治疗计划对于避免缺氧脑损伤等危及生命的并发症至关重要。我们描述了一例困难的气道管理的病人与巨大的宫颈包虫囊肿。我们使用低剂量氯胺酮-异丙酚镇静和利多卡因喷雾进行局部口咽麻醉。未使用肌肉松弛剂,插管期间保持自主呼吸。识别、评估和围手术期计划对宫颈包虫病患者气道管理困难至关重要。
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引用次数: 2
Comparação entre anestesia intravenosa e inalatória na náusea e vômito pós‐operatórios em laparotomia: estudo clínico randomizado 静脉麻醉与吸入麻醉对开腹术后恶心呕吐的比较:一项随机临床研究
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.04.019
Amir Ahmadzadeh Amiri , Kasra Karvandian , Mohammad Ashouri , Mojgan Rahimi , Ali Ahmadzadeh Amiri

Background

Postoperative Nausea and Vomiting (PONV) is a multifactorial surgical complication with an unclear underlying cause. Anesthetic methods, patients’ characteristics and the type of surgery are considered as factors affecting PONV. This study was designed to compare the effect of inhalational and intravenous anesthesia in abdominal surgery on the incidence and severity of PONV.

Methods

A single‐blinded prospective randomized clinical trial on 105 patients aged 18  65 years was carried out. Patients were divided in two groups of Total Intravenous Anesthesia (TIVA) and Inhalational anesthesia. The incidence and severity of PONV were examined at 0, 2, 6, 12, and 24 hours after the surgery. The use of a rescue antiemetic was also evaluated.

Results

Fifty point nine percent of the patients in the inhalation group and 17.3% of the patients in the intravenous group developed PONV (p < 0.001). The incidence of vomiting was reported in 11.3% of the Inhalational group and 3.8% of the TIVA group (p = 0.15), and 24.5% of patients in the Inhalation group and 9.6% of patients in the intravenous group needed an antiemetic medication (p = 0.043).

Conclusion

The incidence of postoperative nausea and vomiting and the need for administration of an antiemetic rescue drug, and the severity of nausea in patients were significantly lower in the TIVA group.

背景术后恶心呕吐(PONV)是一种多因素的手术并发症,病因不明。麻醉方法、患者特点和手术类型是影响PONV的因素。本研究旨在比较腹部手术中吸入麻醉和静脉麻醉对PONV发生率和严重程度的影响。方法对105例18 ~ 65岁的患者进行单盲前瞻性随机临床试验。患者分为全静脉麻醉组(TIVA)和吸入麻醉组。分别于术后0、2、6、12和24小时检查PONV的发生率和严重程度。还评估了抢救止吐剂的使用。结果吸入组和静脉注射组分别有50.9%和17.3%的患者发生了PONV (p <0.001)。吸入组呕吐发生率为11.3%,TIVA组为3.8% (p = 0.15),吸入组24.5%,静脉注射组9.6%需要止吐药物(p = 0.043)。结论TIVA组患者术后恶心呕吐发生率、止吐抢救药物使用需求及恶心严重程度均明显降低。
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引用次数: 2
Comparação entre palonosetrona‐dexametasona e ondansetrona‐dexametasona na prevenção de náuseas e vômitos no pós‐operatório de cirurgia do ouvido médio: estudo clínico randomizado 帕洛诺司琼-地塞米松与恩丹司琼-地塞米松预防中耳手术后恶心呕吐的比较:一项随机临床研究
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.04.016
Vinit Kumar Srivastava , Saima Khan , Sanjay Agrawal , Sweta Anil Deshmukh , Pooja Shree , Partha Pratim Misra

Background

Postoperative nausea and vomiting is the second most common complaint in the postoperative period after pain. The incidence of postoperative nausea and vomiting was 60−80% in middle ear surgeries in the absence of antiemetic prophylaxis. Because of this high incidence of postoperative nausea and vomiting, we aimed to assess the effect of palonosetron‐dexamethasone and ondansetron‐dexamethasone combination for the prevention of postoperative nausea and vomiting in patients of middle ear surgery.

Methods

Sixty‐four patients, scheduled for middle ear surgery, were randomized into two groups to receive the palonosetron‐dexamethasone and ondansetron‐dexamethasone combination intravenously before induction of anesthesia. Anesthesia technique was standardized in all patients. Postoperatively, the incidences and severity of nausea and vomiting, the requirement of rescue antiemetic, side effects and patient satisfaction score were recorded.

Results

Demographics were similar in the study groups. The incidence difference of nausea was statistically significant between groups O and P at a time interval of 2−6 hours only (p = 0.026). The incidence and severity of vomiting were not statistically significant between groups O and P during the whole study period. The overall incidence of postoperative nausea and vomiting (0−24 hours postoperatively) was 37.5% in group O and 9.4% in group P (p = 0.016). Absolute risk reduction with palonosetron‐dexamethasone was 28%, the relative risk reduction was 75%, and the number‐needed‐to‐treat was 4. The patient's satisfaction score was higher in group P than group O (p = 0.016). The frequency of rescue medication was more common in group O than in group P patients (p = 0.026).

Conclusion

The combination of palonosetron‐dexamethasone is superior to ondansetron‐dexamethasone for the prevention of postoperative nausea and vomiting after middle ear surgeries.

背景术后恶心和呕吐是术后疼痛之后的第二大常见主诉。在未进行止吐预防的中耳手术中,术后恶心和呕吐的发生率为60 ~ 80%。由于术后恶心和呕吐的发生率很高,我们的目的是评估帕洛诺司琼-地塞米松和昂丹司琼-地塞米松联合用药预防中耳手术患者术后恶心和呕吐的效果。方法64例中耳手术患者随机分为两组,分别在麻醉诱导前静脉给予帕洛诺司琼-地塞米松和昂丹司琼-地塞米松联合用药。所有患者麻醉技术均标准化。记录术后恶心呕吐发生率、严重程度、抢救止吐药需求、不良反应及患者满意度评分。结果各研究组的人口统计学特征相似。在2 ~ 6小时的时间间隔内,O组和P组的恶心发生率差异有统计学意义(P = 0.026)。在整个研究期间,O组和P组呕吐的发生率和严重程度比较,差异均无统计学意义。术后0 ~ 24小时恶心呕吐发生率O组为37.5%,P组为9.4% (P = 0.016)。帕洛诺司琼-地塞米松的绝对风险降低率为28%,相对风险降低率为75%,需要治疗的人数为4人。P组患者满意度评分高于O组(P = 0.016)。O组抢救用药频次高于P组(P = 0.026)。结论帕洛诺司琼-地塞米松联合用药预防中耳术后恶心呕吐的效果优于昂丹司琼-地塞米松。
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引用次数: 5
Atualização sobre reações de hipersensibilidade perioperatória: documento conjunto da Sociedade Brasileira de Anestesiologia (SBA) e Associação Brasileira de Alergia e Imunologia (ASBAI) – Parte I: tratamento e orientação pós‐crise 围手术期超敏反应更新:巴西麻醉学会(SBA)和巴西过敏和免疫学协会(ASBAI)的联合文件-第一部分:危机后的治疗和指导
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.06.004
Maria Anita Costa Spindola , Dirceu Solé , Marcelo Vivolo Aun , Liana Maria Tôrres de Araújo Azi , Luiz Antonio Guerra Bernd , Daniela Bianchi Garcia , Albertina Varandas Capelo , Débora de Oliveira Cumino , Alex Eustáquio Lacerda , Luciana Cavalcanti Lima , Edelton Flávio Morato , Rogean Rodrigues Nunes , Norma de Paula Motta Rubini , Jane da Silva , Maria Ângela Tardelli , Alexandra Sayuri Watanabe , Erick Freitas Curi , Flávio Sano

Experts from the Brazilian Association of Allergy and Immunology (ASBAI) and the Brazilian Society of Anesthesiology (SBA) interested in the issue of perioperative anaphylaxis, and aiming to strengthen the collaboration between the two societies, combined efforts to study the topic and to prepare a joint document to guide specialists in both areas. The purpose of the present series of two articles was to report the most recent evidence based on the collaborative assessment between both societies. This first article will consider the updated definitions, treatment and guidelines after a perioperative crisis. The following article will discuss the major etiologic agents, how to proceed with the investigation, and the appropriate tests.

来自巴西过敏和免疫学协会(ASBAI)和巴西麻醉学会(SBA)的专家对围手术期过敏反应问题感兴趣,并旨在加强两个学会之间的合作,共同努力研究该主题并编写一份联合文件,以指导这两个领域的专家。本系列两篇文章的目的是报告基于两个学会之间合作评估的最新证据。第一篇文章将考虑围手术期危像的最新定义、治疗和指南。下面的文章将讨论主要的病因,如何进行调查,以及适当的检查。
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引用次数: 0
Bloqueio do plexo cervical como técnica anestésica alternativa para tireoplastia tipo I: relato de caso [颈神经丛阻滞作为I型甲状腺成形术的替代麻醉方法:1例报告]。
IF 1 Q3 Medicine Pub Date : 2020-09-01 DOI: 10.1016/j.bjan.2020.08.002
Antoine Abi Lutfallah , Khalil Jabbour , Afrida Gergess , Gemma Hayeck , Nayla Matar , Samia Madi‐Jebara

Introdução

O papel da tireoplastia tipo I (TPI) está bem estabelecido no tratamento de insuficiência glótica após a paralisia das pregas vocais, mas o manejo anestésico ideal para a TPI ainda é controverso. Descrevemos uma nova técnica anestésica para a TPI usando o Bloqueio do Plexo Cervical (BPC) superficial e o BPC intermediário associados, em presença de analgo‐sedação leve e intermitente.

Relato de caso

Paciente de 51 anos de idade com paralisia da prega vocal esquerda e apneia obstrutiva do sono foi agendada para TPI. BPC intermediário guiado por ultrassom foi realizado usando acesso posterior, e 15 mL de ropivacaína a 0,5% foram injetados no espaço cervical posterior entre o músculo esternocleidomastoideo e a fáscia prevertebral. A seguir, para o BPC superficial, 10 mL de ropivacaína a 0,5% foram injetados na região subcutânea adjacente à borda posterior do músculo esternocleidomastoideo, sem transfixar a fáscia de revestimento. Analgo‐sedação intermitente com infusão alvo‐controlada de remifentanil (alvo de 0,5 ng.mL‐1) foi usada para facilitar a inserção da prótese e a laringoscopia com fibra ótica. A técnica ofereceu via aérea segura durante a anestesia, boa condição para o cirurgião, possibilidade de monitorar a voz, além de ótimo conforto à paciente.

Conclusões

O uso de anestesia regional é uma técnica promissora para o cuidado anestésico durante a TPI, especialmente em pacientes com via aérea comprometida.

Background

The role of type I thyroplasty (TIP) is well established as the treatment for glottal insufficiency due to vocal fold paralysis, but the ideal anesthetic management for this procedure is still largely debated. We present the case of a novel anesthetic approach for TIP using combined intermediate and superficial Cervical Plexus Block (CPB) and intermittent mild sedation analgesia.

Case report

A 51‐year‐old presenting with left vocal fold paralysis and obstructive sleep apnea was scheduled for TIP. An ultrasound‐guided intermediate CPB was performed using the posterior approach, and 15 mL of ropivacaine 0.5% were injected in the posterior cervical space between the sternocleidomastoid muscle and the prevertebral fascia. Then, for the superficial CPB, a total of 10 mL 0.5% ropivacaine was injected subcutaneously, adjacently to the posterior border of the sternocleidomastoid muscle, without penetrating the investing fascia. An intermittent sedation analgesia with a target‐controlled infusion of remifentanyl (target 0.5 ng.mL‐1) was used to facilitate prosthesis insertion and the fiberoptic laryngoscopy. This technique offered a safe anesthetic airway and good operating conditions for the surgeon, as well as feasible voice monitoring and optimal patient comfort.

Conclusion

The use of regional technique is a promising method for the anesthetic management in TIP, espe

I型甲状腺成形术(ipt)在声带瘫痪后声门功能不全的治疗中的作用已得到证实,但ipt的最佳麻醉处理仍有争议。我们描述了一种新的ipt麻醉技术,使用颈部神经丛阻滞(BPC)浅表和相关的中间BPC,在analgo -轻度和间歇镇静的存在下。一名51岁的左声带瘫痪和阻塞性睡眠呼吸暂停患者被安排在ipt。超声引导的中间BPC采用后入路,在胸锁乳突肌与椎前筋膜之间的颈后间隙注射15ml 0.5%罗哌卡因。然后,对于浅表BPC,在胸锁乳突肌后缘附近的皮下注射10ml 0.5%罗哌卡因,而不移植膜筋膜。间歇性镇静,靶向控制瑞芬太尼输注(靶向0.5 ng.mL‐1),以促进假体插入和光纤喉镜检查。该技术在麻醉过程中提供了安全的气道,为外科医生提供了良好的条件,监测声音的可能性,以及极大的患者舒适度。结论区域麻醉的使用是一种很有前途的技术,在ipt期间的麻醉护理,特别是在气道受损的患者。在此背景下,I型甲状腺成形术(TIP)作为治疗声带瘫痪引起的声门功能不全的一种方法已得到很好的证实,但对这种手术的最佳麻醉管理仍有广泛的讨论。我们介绍了一种新型的颈部麻醉方法,采用中间和浅表颈神经丛阻滞(CPB)和间歇性轻度镇静镇痛。病例报告51岁,左声带折叠瘫痪和阻塞性睡眠呼吸暂停,计划进行TIP。超声引导的中间CPB采用后入法,15 mL 0.5%罗哌卡因注射到胸锁乳突肌和椎前筋膜之间的颈椎后间隙。然后,对于表面CPB,共注射10ml 0.5%罗匹卡因,靠近胸骨cleidomastoid肌肉的后边界,而不穿过投资筋膜。间歇性镇静镇痛与目标控制注射瑞芬太尼(目标0.5 ng.mL‐1)用于促进假体插入和光纤喉镜检查。该技术为外科医生提供了安全的麻醉气道和良好的手术条件,以及可行的声音监测和最佳的患者舒适。结论区域技术的应用是一种很有前途的针头麻醉管理方法,特别是对气道受损患者。
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引用次数: 0
期刊
Revista brasileira de anestesiologia
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