Pub Date : 2023-10-01DOI: 10.55453/rjmm.2023.126.5.6
O. Voinea, A. E. Ranetti, Lucian G. Eftimie, Adrian V. Dumitru, Teodor I. Constantin, A. Mirică
"Lynch syndrome, also known as hereditary non-polyposis cancer syndrome, represents the most common autosomal dominant genetic predisposition for the early onset development of several malignancies. Nearly three decades ago, the discovery of microsatellite instability, a distinctive feature of pathogenic variants within genes encoding mismatch repair proteins, marked a significant leap forward in understanding cancer biology and the underlying spectrum of cancers triggered by these mutations – typical of Lynch syndrome. In recent years, a new treatment paradigm, using immune checkpoint inhibitors, as well as preventive measures has drastically improved the survival rates. Identifying individuals with an inherent predisposition to cancer, through diagnostic protocols followed by personalized screening and treatment algorithms, holds the potential to mitigate premature cancer-related fatalities as well as preventable mortality. It is estimated that only a limited number of patients have been diagnosed, underscoring the importance of implementing specific screening programs for early detection of malignancies to which these patients are susceptible. This article aims to underline the importance of a national protocol tailored to guide a Western-inspired practice for Lynch syndrome patient management, the main aim of the Romanian Society for Lynch Syndrome, by providing an overview of similar initiatives throughout the world."
{"title":"Lynch Syndrome – An Overview of the Worldwide Management of This Silent Killer Within Our Genes","authors":"O. Voinea, A. E. Ranetti, Lucian G. Eftimie, Adrian V. Dumitru, Teodor I. Constantin, A. Mirică","doi":"10.55453/rjmm.2023.126.5.6","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.6","url":null,"abstract":"\"Lynch syndrome, also known as hereditary non-polyposis cancer syndrome, represents the most common autosomal dominant genetic predisposition for the early onset development of several malignancies. Nearly three decades ago, the discovery of microsatellite instability, a distinctive feature of pathogenic variants within genes encoding mismatch repair proteins, marked a significant leap forward in understanding cancer biology and the underlying spectrum of cancers triggered by these mutations – typical of Lynch syndrome. In recent years, a new treatment paradigm, using immune checkpoint inhibitors, as well as preventive measures has drastically improved the survival rates. Identifying individuals with an inherent predisposition to cancer, through diagnostic protocols followed by personalized screening and treatment algorithms, holds the potential to mitigate premature cancer-related fatalities as well as preventable mortality. It is estimated that only a limited number of patients have been diagnosed, underscoring the importance of implementing specific screening programs for early detection of malignancies to which these patients are susceptible. This article aims to underline the importance of a national protocol tailored to guide a Western-inspired practice for Lynch syndrome patient management, the main aim of the Romanian Society for Lynch Syndrome, by providing an overview of similar initiatives throughout the world.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"34 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139326229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.55453/rjmm.2023.126.5.4
Livia Ș. Drăgan, Cristian Gheorghe
"Colorectal cancer is one of the main causes of death by cancer in the European Union and in Romania. Lynch Syndrome is an autosomal dominant inherited disease that affects around 3% of all colorectal cancer patients, defined by mutations in the mismatch repair genes (MLH1, MSH2, MSH6, PMS2). Aside from the high risk for colorectal cancer (CRC), they exhibit a high risk for endometrial cancer, ovarian cancer, gastric cancer, pancreatic cancer, brain cancer, small bowel cancer, and sebaceous gland cancer. Diagnosis is often made by the gastroenterologist, usually when he meets a young patient with symptoms suggesting the presence of a colonic tumor and a family history of CRC. The role of the gastroenterologist is to investigate the best practices in order to have an early diagnosis and to prevent interval cancers according to the newest guidelines or other gastrointestinal tract tumors associated with Lynch Syndrome. Registries play an important role in the optimal surveillance of these particular categories of patients and should be put into place in every country. They will allow clinicians to have a better understanding of the disease and a more standardized quality of care for them."
{"title":"Lynch Syndrome: Approach from the Gastroenterologist’s Point of View","authors":"Livia Ș. Drăgan, Cristian Gheorghe","doi":"10.55453/rjmm.2023.126.5.4","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.4","url":null,"abstract":"\"Colorectal cancer is one of the main causes of death by cancer in the European Union and in Romania. Lynch Syndrome is an autosomal dominant inherited disease that affects around 3% of all colorectal cancer patients, defined by mutations in the mismatch repair genes (MLH1, MSH2, MSH6, PMS2). Aside from the high risk for colorectal cancer (CRC), they exhibit a high risk for endometrial cancer, ovarian cancer, gastric cancer, pancreatic cancer, brain cancer, small bowel cancer, and sebaceous gland cancer. Diagnosis is often made by the gastroenterologist, usually when he meets a young patient with symptoms suggesting the presence of a colonic tumor and a family history of CRC. The role of the gastroenterologist is to investigate the best practices in order to have an early diagnosis and to prevent interval cancers according to the newest guidelines or other gastrointestinal tract tumors associated with Lynch Syndrome. Registries play an important role in the optimal surveillance of these particular categories of patients and should be put into place in every country. They will allow clinicians to have a better understanding of the disease and a more standardized quality of care for them.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.55453/rjmm.2023.126.5.3
Silvia N. Rădulescu
"Lynch syndrome (LS) is one of the most common inherited cancer predisposition syndromes and the most important cause of hereditary colorectal and endometrial cancers. It is inherited in an autosomal dominant pattern, caused by a pathogenic germline variant in one of the mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2), which encode proteins responsible for maintaining genome stability. A defective MMR system confers an elevated risk of developing certain types of cancer, at a younger age than in the general population and at a high rate of multiple primary neoplasia. Lynch syndrome is not just one disease, but a collection of different subtypes of underlying molecular aspects with specific clinical implications. A better understanding of these subgroup profiles could offer better care for each patient, leading to more personalized risk-reduction and surveillance strategies. Lynch syndrome is a frequent but yet underdiagnosed condition that needs multidisciplinary increased awareness for correct diagnosis and management. The aim of this review is to provide a summary of available literature data on the genetic aspects of Lynch syndrome together with geno-type-phenotype correlations and its clinical implications in the detection, genetic counseling, genetic testing, risk stratification, and management of this condition."
{"title":"Overview of the Genetic Aspects of Lynch Syndrome","authors":"Silvia N. Rădulescu","doi":"10.55453/rjmm.2023.126.5.3","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.3","url":null,"abstract":"\"Lynch syndrome (LS) is one of the most common inherited cancer predisposition syndromes and the most important cause of hereditary colorectal and endometrial cancers. It is inherited in an autosomal dominant pattern, caused by a pathogenic germline variant in one of the mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2), which encode proteins responsible for maintaining genome stability. A defective MMR system confers an elevated risk of developing certain types of cancer, at a younger age than in the general population and at a high rate of multiple primary neoplasia. Lynch syndrome is not just one disease, but a collection of different subtypes of underlying molecular aspects with specific clinical implications. A better understanding of these subgroup profiles could offer better care for each patient, leading to more personalized risk-reduction and surveillance strategies. Lynch syndrome is a frequent but yet underdiagnosed condition that needs multidisciplinary increased awareness for correct diagnosis and management. The aim of this review is to provide a summary of available literature data on the genetic aspects of Lynch syndrome together with geno-type-phenotype correlations and its clinical implications in the detection, genetic counseling, genetic testing, risk stratification, and management of this condition.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139328761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.55453/rjmm.2023.126.5.2
M. Licu, C. G. Ionescu, F. Golu
"The purpose of this article is to investigate the role of emotional regulation (ER) as a process underlying a variety of symptoms associated with Lynch syndrome (depression, anxiety, fear of cancer recurrence (FCR), insomnia, fatigue, pain, and subjective cognitive difficulties in patients with Lynch syndrome. Firstly, we provided an overview of the main psychopathological symptoms found in cancer patients and their impact, and then an overview of emotional regulation strategies and discussed the main impact ER strategies have on cancer patients, especially emotional suppression and experiential avoidance, as found in evidence-based studies. Recent research has shown that two ER strategies generally considered maladaptive, emotional suppression and experiential avoidance were significantly associated with higher levels of anxiety, depression, FCR, fatigue, and cognitive difficulties. We propose that experiential avoidance and emotional suppression may be common transdiagnostic mechanisms for a common set of psychological symptoms in Lynch syndrome patients, a hypothesis to be tested in a future study."
"本文旨在研究情绪调节（ER）作为林奇综合征相关症状（林奇综合征患者的抑郁、焦虑、癌症复发恐惧（FCR）、失眠、疲劳、疼痛和主观认知困难）的基础过程所起的作用。首先，我们概述了在癌症患者中发现的主要精神病理症状及其影响，然后概述了情绪调节策略，并讨论了循证研究中发现的 ER 策略对癌症患者的主要影响，尤其是情绪抑制和体验回避。最近的研究表明，通常被认为是适应不良的两种情绪调节策略--情绪压抑和体验回避与较高程度的焦虑、抑郁、FCR、疲劳和认知困难有显著关联。我们认为，体验性回避和情感压抑可能是林奇综合征患者常见心理症状的共同跨诊断机制，这一假设将在未来的研究中得到验证"。
{"title":"Emotional Regulation Strategies in Lynch Syndrome Diagnosis Psychological Adjustment – A Review","authors":"M. Licu, C. G. Ionescu, F. Golu","doi":"10.55453/rjmm.2023.126.5.2","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.2","url":null,"abstract":"\"The purpose of this article is to investigate the role of emotional regulation (ER) as a process underlying a variety of symptoms associated with Lynch syndrome (depression, anxiety, fear of cancer recurrence (FCR), insomnia, fatigue, pain, and subjective cognitive difficulties in patients with Lynch syndrome. Firstly, we provided an overview of the main psychopathological symptoms found in cancer patients and their impact, and then an overview of emotional regulation strategies and discussed the main impact ER strategies have on cancer patients, especially emotional suppression and experiential avoidance, as found in evidence-based studies. Recent research has shown that two ER strategies generally considered maladaptive, emotional suppression and experiential avoidance were significantly associated with higher levels of anxiety, depression, FCR, fatigue, and cognitive difficulties. We propose that experiential avoidance and emotional suppression may be common transdiagnostic mechanisms for a common set of psychological symptoms in Lynch syndrome patients, a hypothesis to be tested in a future study.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"57 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139327772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.55453/rjmm.2023.126.5.1
Bogdan-Viorel Vîlceleanu, O. Voinea, C. Buzilă, Diana M. Ciobanu, Liviu Stan, S. I. Dumitrescu
"Chemotherapy is an important treatment in oncological disease, with a vast number of side effects. The cardiotoxicity of several chemotherapeutic agents and appropriate risk stratification and patient follow-up must be ensured by a multidisciplinary team which must include an oncologist and a cardiologist. Lynch syndrome is associated with younger-onset malignant tumors of various localizations, requiring aggressive chemotherapy. FOLFOX chemotherapy which is frequently used in Lynch syndrome-associated colorectal cancer has several cardiotoxic effects with mechanisms ranging from increased reactive oxidative species to Krebs cycle blockade or coronary vasospasm. These complex effects on the cardiovascular system have varied clinical effects, such as heart failure, arrhythmias, or acute ischemic events"
{"title":"Cardiotoxicity of Chemotherapy in Lynch Syndrome – A Literature Review","authors":"Bogdan-Viorel Vîlceleanu, O. Voinea, C. Buzilă, Diana M. Ciobanu, Liviu Stan, S. I. Dumitrescu","doi":"10.55453/rjmm.2023.126.5.1","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.1","url":null,"abstract":"\"Chemotherapy is an important treatment in oncological disease, with a vast number of side effects. The cardiotoxicity of several chemotherapeutic agents and appropriate risk stratification and patient follow-up must be ensured by a multidisciplinary team which must include an oncologist and a cardiologist. Lynch syndrome is associated with younger-onset malignant tumors of various localizations, requiring aggressive chemotherapy. FOLFOX chemotherapy which is frequently used in Lynch syndrome-associated colorectal cancer has several cardiotoxic effects with mechanisms ranging from increased reactive oxidative species to Krebs cycle blockade or coronary vasospasm. These complex effects on the cardiovascular system have varied clinical effects, such as heart failure, arrhythmias, or acute ischemic events\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"24 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139330781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.55453/rjmm.2023.126.5.5
A. Mirică, Emil A. Ranetti, O. Voinea, I. Badarau, Raluca I. Papacocea, Diana L. Păun
"Background: A germline mutation of the MisMatch Repairgene that causes a malfunctioning DNA system is the defining feature of the hereditary illness known as Lynch syndrome. This review will discuss the endocrine aspects of LS and highlight current advancements in the area. Methods: We searched the available literature of the last 10 years for terms such as endocrine tumors and LS. Our goal is to provide a summary of the most recent information available on the endocrine perspective in Lynch syndrome. Results: The hormonal chemoprevention methods cited are the use of combined oral contraceptives, the use of progestogen-releasing intrauterine devices, and the use of progesterone-only drugs. In addition, after surgical exclusion of the uterus and ovaries, a method frequently adopted for LS patients, it is necessary to start hormonal menopausal therapy, taking into account certain age-specific features. In addition, numerous LS-associated endocrine tumor types have been described. Conclusions: Many hormonal variants are available that are useful in the chemoprevention involved in the treatment of LS. Menopausal hormone therapy is imperative for LS patients who need it. Clinicians need to be aware of the possible association of certain types of aggressive endocrine cancers associated with LS."
背景MisMatch Repairgene 的种系突变会导致 DNA 系统功能失常，这是被称为林奇综合征的遗传性疾病的主要特征。本综述将讨论林奇综合征的内分泌问题，并重点介绍该领域的最新进展。研究方法我们搜索了过去 10 年中有关内分泌肿瘤和 LS 等术语的现有文献。我们的目标是提供林奇综合征内分泌方面的最新信息摘要。结果：所引用的激素化学预防方法包括使用复方口服避孕药、使用释放孕激素的宫内节育器和使用纯黄体酮药物。此外，LS 患者常采用的一种方法是手术切除子宫和卵巢，在手术切除后，有必要开始激素绝经治疗，同时考虑到某些年龄特征。此外，还描述了许多与LS相关的内分泌肿瘤类型。结论：有许多激素变体可用于治疗LS的化学预防。对于有需要的 LS 患者来说，绝经期激素治疗势在必行。临床医生需要意识到某些类型的侵袭性内分泌癌症可能与LS有关"。
{"title":"An Endocrine Perspective on Lynch Syndrome","authors":"A. Mirică, Emil A. Ranetti, O. Voinea, I. Badarau, Raluca I. Papacocea, Diana L. Păun","doi":"10.55453/rjmm.2023.126.5.5","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.5","url":null,"abstract":"\"Background: A germline mutation of the MisMatch Repairgene that causes a malfunctioning DNA system is the defining feature of the hereditary illness known as Lynch syndrome. This review will discuss the endocrine aspects of LS and highlight current advancements in the area. Methods: We searched the available literature of the last 10 years for terms such as endocrine tumors and LS. Our goal is to provide a summary of the most recent information available on the endocrine perspective in Lynch syndrome. Results: The hormonal chemoprevention methods cited are the use of combined oral contraceptives, the use of progestogen-releasing intrauterine devices, and the use of progesterone-only drugs. In addition, after surgical exclusion of the uterus and ovaries, a method frequently adopted for LS patients, it is necessary to start hormonal menopausal therapy, taking into account certain age-specific features. In addition, numerous LS-associated endocrine tumor types have been described. Conclusions: Many hormonal variants are available that are useful in the chemoprevention involved in the treatment of LS. Menopausal hormone therapy is imperative for LS patients who need it. Clinicians need to be aware of the possible association of certain types of aggressive endocrine cancers associated with LS.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"102 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139326197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.55453/rjmm.2023.126.4.4
Mihai Vintilă, D. Spînu, D. Marcu, D. Mischianu, S. Nica
Background: The highlighting of possible risk factors for urinary colonization in patients with obstructive urolithiasis that needed double J catheters implanted to preserve renal function. Methods: We performed a descriptive, retrospective study, carried
{"title":"Risk Factors for Urinary Colonization in Patients with Double J Catheters Implanted for Treating Obstructive Urolithiasis","authors":"Mihai Vintilă, D. Spînu, D. Marcu, D. Mischianu, S. Nica","doi":"10.55453/rjmm.2023.126.4.4","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.4.4","url":null,"abstract":"Background: The highlighting of possible risk factors for urinary colonization in patients with obstructive urolithiasis that needed double J catheters implanted to preserve renal function. Methods: We performed a descriptive, retrospective study, carried","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44016006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.55453/rjmm.2023.126.4.20
A. C. Regueros, Á. Bustamante-Sánchez, V. Clemente-Suárez
"Background: The effect of stress on sympathetic modulation measured by HRV has been studied in various population groups exposed to different stressors. HRV measurement tools are based on the electrocardiogram (ECG), portable tools such as POLAR V800, and recently photoplethysmography (PPG). The aim of this study was to analyze the validity of a PPG mobile app to measure HRV with a validated V800 system in a tactical athlete population. Methods HRV of 53 professional militaries were analyzed by POLAR V800 and an HRV Camera app with a smartphone during 5 min and 30 s protocol respectively. Results: The HRV values obtained by the PPG presented a significant negative significant correlation in the HRVI index, LF, HF, LF (n.u.), HF (n.u.), and a positive significant correlation in TINN index by the Polar V800 system with the application of a regression equation over the data obtained. Conclusions: HRV Camera PPG App 30s record analysis protocol could be applied using a regression formula depending on the HRV variables after the comparison with a standard 5-minute test conducted with a validated Polar V800. In future research, it is suggested to validate PPG protocols with longer durations."
背景：HRV测量的压力对交感神经调节的影响已经在暴露于不同压力源的不同人群中进行了研究。HRV测量工具基于心电图（ECG）、便携式工具（如POLAR V800）和最近的光体积描记术（PPG）本研究的目的是分析PPG移动应用程序在战术运动员群体中使用经验证的V800系统测量HRV的有效性。方法采用POLAR V800和HRV Camera应用软件，分别在5分钟和30秒的时间内对53名职业军人的HRV进行分析。结果：通过PPG获得的HRV值在HRVI指数LF、HF、LF（n.u.）、HF（n.u.）中呈现出显著的负相关，并且通过Polar V800系统对所获得的数据应用回归方程，在TINN指数中呈现出正相关。结论：在与经验证的Polar V800进行的标准5分钟测试进行比较后，根据HRV变量，可以使用回归公式应用HRV Camera PPG App 30s记录分析方案。在未来的研究中，建议验证具有更长持续时间的PPG协议。“
{"title":"Validity of Photoplethysmography Mobile Analysis to Test the Autonomic Stress Status of Tactical Athletes","authors":"A. C. Regueros, Á. Bustamante-Sánchez, V. Clemente-Suárez","doi":"10.55453/rjmm.2023.126.4.20","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.4.20","url":null,"abstract":"\"Background: The effect of stress on sympathetic modulation measured by HRV has been studied in various population groups exposed to different stressors. HRV measurement tools are based on the electrocardiogram (ECG), portable tools such as POLAR V800, and recently photoplethysmography (PPG). The aim of this study was to analyze the validity of a PPG mobile app to measure HRV with a validated V800 system in a tactical athlete population. Methods HRV of 53 professional militaries were analyzed by POLAR V800 and an HRV Camera app with a smartphone during 5 min and 30 s protocol respectively. Results: The HRV values obtained by the PPG presented a significant negative significant correlation in the HRVI index, LF, HF, LF (n.u.), HF (n.u.), and a positive significant correlation in TINN index by the Polar V800 system with the application of a regression equation over the data obtained. Conclusions: HRV Camera PPG App 30s record analysis protocol could be applied using a regression formula depending on the HRV variables after the comparison with a standard 5-minute test conducted with a validated Polar V800. In future research, it is suggested to validate PPG protocols with longer durations.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49001247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.55453/rjmm.2023.126.4.3
Raluca Sirbu Prisecaru, L. Riahi, M. Abagiu, O. Purcar, I. Manițiu
Background: The 12-lead electrocardiogram (ECG) is an extremely useful tool for analyzing cardiac arrhythmias and numerous ECG algorithms have been developed to predict the origin of right ventricular outflow tract (RVOT) arrhythmias. Aim: To determine if using complex, time-consuming analysis, and difficult-to-memorize ECG algorithms is feasible and preferable before the ablation procedure when compared with the use of multipolar mapping catheter use during the ablation procedure. Methods: 47 consecutive patients admitted for radiofrequency catheter ablation of idiopathic PVC were included prospectively in this study. Of the algorithms selected for comparison, three have a memorable design and easy applicability (Dixit, Joshi, Pytkowski) and the fourth has a complex, detailed design and is more difficult to memorize (Zhang). Results: The greatest accuracy was observed for the algorithms proposed by Dixit and Pytkowski – 92. 3%. However, when the algorithms were compared for their accuracy, specificity, and sensitivity, no significant differences were found (p=0. 96). Conclusions: 3-D guided mapping using a conventional ablation catheter in a narrower, precise area of interest in the RVOT, based on ECG algorithms is not inferior compared to the multielectrode catheter mapping in the whole RVOT, in terms of mapping time, total procedural time, and radiofrequency application time.
{"title":"Value of Electrocardiogram Algorithms Predicting Right Ventricular Outflow Tract Origin in the Era of Catheter Mapping","authors":"Raluca Sirbu Prisecaru, L. Riahi, M. Abagiu, O. Purcar, I. Manițiu","doi":"10.55453/rjmm.2023.126.4.3","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.4.3","url":null,"abstract":"Background: The 12-lead electrocardiogram (ECG) is an extremely useful tool for analyzing cardiac arrhythmias and numerous ECG algorithms have been developed to predict the origin of right ventricular outflow tract (RVOT) arrhythmias. Aim: To determine if using complex, time-consuming analysis, and difficult-to-memorize ECG algorithms is feasible and preferable before the ablation procedure when compared with the use of multipolar mapping catheter use during the ablation procedure. Methods: 47 consecutive patients admitted for radiofrequency catheter ablation of idiopathic PVC were included prospectively in this study. Of the algorithms selected for comparison, three have a memorable design and easy applicability (Dixit, Joshi, Pytkowski) and the fourth has a complex, detailed design and is more difficult to memorize (Zhang). Results: The greatest accuracy was observed for the algorithms proposed by Dixit and Pytkowski – 92. 3%. However, when the algorithms were compared for their accuracy, specificity, and sensitivity, no significant differences were found (p=0. 96). Conclusions: 3-D guided mapping using a conventional ablation catheter in a narrower, precise area of interest in the RVOT, based on ECG algorithms is not inferior compared to the multielectrode catheter mapping in the whole RVOT, in terms of mapping time, total procedural time, and radiofrequency application time.","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47066777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.55453/rjmm.2023.126.4.1
R. Costache, R. Nica, S. Nica, Robert M. Sionel, S. Spandole-Dinu, Oana Costianu, I. Radu, Mirela Oancea, Matei I. Nica, D. Cimponeriu, L. Berca
"The cytogenetic aberrations induced by doxorubicin (DOX) may be influenced by diet. Investigation regarding effects of low doses of DOX on chromosomal aberrations frequency in mice bone marrow. The study explored a possible relationship between diet, follow-up period, and cytostatic doses. Four mice groups received normal or high-fat (pork) diet. At the beginning of the 8th day mice from each group received a single intraperitoneal injection with DOX (dose range: 1.7-7.7 mg/kg b.w.) or isotonic saline solution (0.02 mL/g control mice). In the 10th (groups I, II) and 14th (groups III, IV) days from the beginning of the experiment, the mice were euthanized and chromosome aberrations were tested in bone marrow cells. The body weight of all mice who received DOX decreases, especially at higher doses. In the first three days post-injection, weight loss percentage was significantly influenced by DOX doses and/or type of diet (p<0.003). The interaction between the type of diet and DOX doses was not statistically significant in the follow-up period (p interactions >0.05). DOX doses were able to increase the frequency of chromosomal aberrations. DOX acts as a potent inductor of cytogenetic aberrations in bone marrow cells, regardless of the type of diet."
{"title":"Assessment of Low-Doses Doxorubicin Effects in Mice Using Chromosomal Aberration Assay","authors":"R. Costache, R. Nica, S. Nica, Robert M. Sionel, S. Spandole-Dinu, Oana Costianu, I. Radu, Mirela Oancea, Matei I. Nica, D. Cimponeriu, L. Berca","doi":"10.55453/rjmm.2023.126.4.1","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.4.1","url":null,"abstract":"\"The cytogenetic aberrations induced by doxorubicin (DOX) may be influenced by diet. Investigation regarding effects of low doses of DOX on chromosomal aberrations frequency in mice bone marrow. The study explored a possible relationship between diet, follow-up period, and cytostatic doses. Four mice groups received normal or high-fat (pork) diet. At the beginning of the 8th day mice from each group received a single intraperitoneal injection with DOX (dose range: 1.7-7.7 mg/kg b.w.) or isotonic saline solution (0.02 mL/g control mice). In the 10th (groups I, II) and 14th (groups III, IV) days from the beginning of the experiment, the mice were euthanized and chromosome aberrations were tested in bone marrow cells. The body weight of all mice who received DOX decreases, especially at higher doses. In the first three days post-injection, weight loss percentage was significantly influenced by DOX doses and/or type of diet (p<0.003). The interaction between the type of diet and DOX doses was not statistically significant in the follow-up period (p interactions >0.05). DOX doses were able to increase the frequency of chromosomal aberrations. DOX acts as a potent inductor of cytogenetic aberrations in bone marrow cells, regardless of the type of diet.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48431790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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