Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-5-3
V. A. Belozerov, N. N. Grigoriev, V. Prokopov, D.E. Belozerova
Aim: to evaluate the possibilities of diagnosed during endoscopic ultrasound (EUS) in clarifying diagnosis of peripapillary diverticula (PD) and optimization of treatment tactics depending on the type of mutual location of the diverticulum and the major duodenal papilla (MDP). Patients and Methods: the study included 304 patients (186 (61.2%) female patients) with peripapillary duodenal diverticulum (PDD). By the criterion of the diverticulum and MDP mutual location, patients were divided into three groups: 195 (64.1%) patients with suprapapillary diverticulum, 59 (19.4%) — with diverticulum of the "butterfly" type, 50 (16.5%) — with intradiverticular MDP. Anatomical features of various diverticula types and associated pathology of periampullary region were studied on the basis of endosonography data, as well as the treatment results of biliary diseases, technical success and complications of transpapillary interventions in various types of diverticula were analyzed. Results and Discussion: patients with intradiverticular MDP were significantly older (69.8±4.4 years). In this group, the size of diverticula (21 mm) and dilatation of choledochus (18 mm) were larger. Patients in this group were significantly more commonly diagnosed with stenosis of the MDP and secondary choledocholithiasis. Indications for endoscopic papillosphincterotomy in patients with PDD were choledocholithiasis — 124 (57.1%), stenosis of the MDP — 44 (20.3%), diverticular compression in terminal choledochus — 49 (22.6%), EUS. The complication rate of transpapillary interventions did not significantly differ and amounted to 2.8%. However, the share of failures during MDP standard biliary cannulation and lithoextraction was higher in the intradiverticular MDP and amounted to 34.5% and 8.8%, respectively, which forced the use of rendezvous procedures that were used in 10 (34.5%) patients of this group. Conclusion: EUS is a highly informative method of diagnostic clarification in PD, providing direct visual inspection of the papillary zone and its echocardiogram. The use of EUS at the initial stage of diagnostics allows to significantly optimize the treatment tactics, determining the indications for transpapillary interventions and ensuring their rational choice. The greatest technical difficulties and failures are expected to occur during manipulations on the intradiverticular MDP, which forces the use of rendezvous procedures, antegrade common bile duct access and laparotomic interventions. KEYWORDS: peripapillary diverticulum, endoscopic ultrasound, transpapillary interventions endoscopic papillosphincterotomy, biliary hypertension. FOR CITATION: Belozerov V.A., Grigoriev N.N., Prokopov V.A., Belozerova D.E. Endoscopic ultrasound and transpapillary interventions in patients with peripapillary diverticula. Russian Medical Inquiry. 2023;7(5):258–263 (in Russ.). DOI: 10.32364/2587-6821-2023-7-5-3.
{"title":"Endoscopic ultrasound and transpapillary interventions in patients with peripapillary diverticula","authors":"V. A. Belozerov, N. N. Grigoriev, V. Prokopov, D.E. Belozerova","doi":"10.32364/2587-6821-2023-7-5-3","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-5-3","url":null,"abstract":"Aim: to evaluate the possibilities of diagnosed during endoscopic ultrasound (EUS) in clarifying diagnosis of peripapillary diverticula (PD) and optimization of treatment tactics depending on the type of mutual location of the diverticulum and the major duodenal papilla (MDP). Patients and Methods: the study included 304 patients (186 (61.2%) female patients) with peripapillary duodenal diverticulum (PDD). By the criterion of the diverticulum and MDP mutual location, patients were divided into three groups: 195 (64.1%) patients with suprapapillary diverticulum, 59 (19.4%) — with diverticulum of the \"butterfly\" type, 50 (16.5%) — with intradiverticular MDP. Anatomical features of various diverticula types and associated pathology of periampullary region were studied on the basis of endosonography data, as well as the treatment results of biliary diseases, technical success and complications of transpapillary interventions in various types of diverticula were analyzed. Results and Discussion: patients with intradiverticular MDP were significantly older (69.8±4.4 years). In this group, the size of diverticula (21 mm) and dilatation of choledochus (18 mm) were larger. Patients in this group were significantly more commonly diagnosed with stenosis of the MDP and secondary choledocholithiasis. Indications for endoscopic papillosphincterotomy in patients with PDD were choledocholithiasis — 124 (57.1%), stenosis of the MDP — 44 (20.3%), diverticular compression in terminal choledochus — 49 (22.6%), EUS. The complication rate of transpapillary interventions did not significantly differ and amounted to 2.8%. However, the share of failures during MDP standard biliary cannulation and lithoextraction was higher in the intradiverticular MDP and amounted to 34.5% and 8.8%, respectively, which forced the use of rendezvous procedures that were used in 10 (34.5%) patients of this group. Conclusion: EUS is a highly informative method of diagnostic clarification in PD, providing direct visual inspection of the papillary zone and its echocardiogram. The use of EUS at the initial stage of diagnostics allows to significantly optimize the treatment tactics, determining the indications for transpapillary interventions and ensuring their rational choice. The greatest technical difficulties and failures are expected to occur during manipulations on the intradiverticular MDP, which forces the use of rendezvous procedures, antegrade common bile duct access and laparotomic interventions. KEYWORDS: peripapillary diverticulum, endoscopic ultrasound, transpapillary interventions endoscopic papillosphincterotomy, biliary hypertension. FOR CITATION: Belozerov V.A., Grigoriev N.N., Prokopov V.A., Belozerova D.E. Endoscopic ultrasound and transpapillary interventions in patients with peripapillary diverticula. Russian Medical Inquiry. 2023;7(5):258–263 (in Russ.). DOI: 10.32364/2587-6821-2023-7-5-3.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"28 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90588220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-2-65-74
O. Ukhanova, E. Bogomolova, P.V. Budnikov, E. Churyukina, M. Malakhova, M. S. Shogenova, E. A. Goloshubova, V. Popova, O. Puzikova
Aim: to determine the concentration of mold spores and causative allergens of pollen-producing grasses in the cities of Southern Russia and to assess the prevalence of multisensitization in patients with severe allergic respiratory diseases, taking into consideration mold specific IgE results. Patients and Methods: from 2018 to 2020, concentrations of airborne allergens were evaluated in Stavropol, Krasnodar and Rostov-on-Don according to international techniques, using Burkard and Lanzoni volumetric spore and pollen traps. The levels of non-bacterial allergen- specific IgE were evaluated by allergen component testing in 143 patients (69 children and 74 adults) with allergic rhinitis and atopic asthma. Results: the results of aeropalynology studies demonstrated a high concentration of mold spores in the atmospheric air of all the studied cities co-occurring with seasonal increases in pollen allergen concentrations in the atmospheric air. The South of Russia is characterized by the year-round presence of mold allergens with sporulation peaks in July, August and September. The peak utilization of healthcare services coincided with the maximal concentration of plant pollen and mold spores. The results of comprehensive allergy diagnostic testing suggest that there is a predominance of patients with multisensitization (71%), including sensitization to pollen and mold spore allergens. As a result of the overlapping of the peaks of spreading airborne pollen allergens and mold sporulation, a frequent use of short-acting emergency β2-agonists and more calls for ambulance service are reported. Conclusion: the predominance of patients with multisensitization leads to the development of severe allergic respiratory diseases. Measures of timely management and prevention are needed for such patients. A daily monitoring of sporulation levels and pollen allergens in the air may help to avoid contacts with high concentrations of causative allergens and to implement the necessary preventive measures. The annual aeropalynology monitoring will provide an opportunity to predict allergen concentrations in the atmospheric air during the current year and to develop a statistically significant monitoring model in the future. KEYWORDS: molds, ragweed, aeromycology, aeropalynology, allergens, allergen component testing. FOR CITATION: Ukhanova O.P., Bogomolova E.V., Budnikov P.V. et al. Mycotic risk factors for the development of severe respiratory allergosis in the population of southern Russia. Russian Medical Inquiry. 2023;7(2):65–74 (in Russ.). DOI: 10.32364/2587-6821-2023-7-2-65-74.
{"title":"Mycotic risk factors for the development of severe respiratory allergosis in the population of southern Russia","authors":"O. Ukhanova, E. Bogomolova, P.V. Budnikov, E. Churyukina, M. Malakhova, M. S. Shogenova, E. A. Goloshubova, V. Popova, O. Puzikova","doi":"10.32364/2587-6821-2023-7-2-65-74","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-2-65-74","url":null,"abstract":"Aim: to determine the concentration of mold spores and causative allergens of pollen-producing grasses in the cities of Southern Russia and to assess the prevalence of multisensitization in patients with severe allergic respiratory diseases, taking into consideration mold specific IgE results. Patients and Methods: from 2018 to 2020, concentrations of airborne allergens were evaluated in Stavropol, Krasnodar and Rostov-on-Don according to international techniques, using Burkard and Lanzoni volumetric spore and pollen traps. The levels of non-bacterial allergen- specific IgE were evaluated by allergen component testing in 143 patients (69 children and 74 adults) with allergic rhinitis and atopic asthma. Results: the results of aeropalynology studies demonstrated a high concentration of mold spores in the atmospheric air of all the studied cities co-occurring with seasonal increases in pollen allergen concentrations in the atmospheric air. The South of Russia is characterized by the year-round presence of mold allergens with sporulation peaks in July, August and September. The peak utilization of healthcare services coincided with the maximal concentration of plant pollen and mold spores. The results of comprehensive allergy diagnostic testing suggest that there is a predominance of patients with multisensitization (71%), including sensitization to pollen and mold spore allergens. As a result of the overlapping of the peaks of spreading airborne pollen allergens and mold sporulation, a frequent use of short-acting emergency β2-agonists and more calls for ambulance service are reported. Conclusion: the predominance of patients with multisensitization leads to the development of severe allergic respiratory diseases. Measures of timely management and prevention are needed for such patients. A daily monitoring of sporulation levels and pollen allergens in the air may help to avoid contacts with high concentrations of causative allergens and to implement the necessary preventive measures. The annual aeropalynology monitoring will provide an opportunity to predict allergen concentrations in the atmospheric air during the current year and to develop a statistically significant monitoring model in the future. KEYWORDS: molds, ragweed, aeromycology, aeropalynology, allergens, allergen component testing. FOR CITATION: Ukhanova O.P., Bogomolova E.V., Budnikov P.V. et al. Mycotic risk factors for the development of severe respiratory allergosis in the population of southern Russia. Russian Medical Inquiry. 2023;7(2):65–74 (in Russ.). DOI: 10.32364/2587-6821-2023-7-2-65-74.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78474325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-2-89-95
S. I. Bardenikova, T. I. Rychkova, E. V. Kulikova, O. B. Dovgun, T. Belyaeva
Aim: to assess changes in the patterns of sensitization to house dust allergens in a cohort of children with allergic disorders over the last 30 years. Patients and Methods: this retrospective analysis included 26,343 protocols of allergy tests to house dust and its allergenic components (house mix, D. pteronyssinus and D. farinae mites, library dust) that had been carried out in children 4–18 years old over the period from 1989 to 2019. Skin testing was performed using the generally accepted scarification technique on the anterior surface of the forearm through a drop of the tested allergen. Then, the test results are assessed by visual inspection with a score of 1 — 4. The results of continuous monitoring were summarized and statistically processed for all years of the observation period, but the article presents analysis of the "cross-section" indicators only for those years that were convenient for comparison. The authors calculated a percentage ratio of the number of patients sensitized to the studied allergen to the total number of patients tested for hypersensitivity to this allergen during a particular year. Then, they compared the percentage of patients with low (1–2) and high (3–4) scores. Results and Discussion: the analysis showed a steady increase in IgE hypersensitivity to the house dust mix (from 23.7% in 1989 to 71.2% in 2019). Also, it demonstrated an increase in the degree of sensitization (3 — 4 scores) to the integral dust mix (from 4.2% in 1989 to 16.6% in 2019), which was significantly higher than that to the dust mites themselves due to the diverse composition of specific proteins of epidermal, fungal, bacterial, and insect origin that can induce antibodies independently on each other. There was a similar 2.6-fold growth in sensitization to the library dust over the first 10 years of observation, and by 2019 hypersensitization developed in 57.2% of children from this cohort. However, a dramatic decline in high scores (3–4) of the detected level to 5% was reported in 2019 which was associated with the changes in the ways of in-house data storage. Conclusion: the study findings provide a rationale for the mandatory control of dynamic changes in sensitization among children with allergic disorders using an expended household allergen panel. The steady increase in sensitization to house dust allergens confirms a low effectiveness of elimination measures and suggests a progressive immune imbalance under the everyday pressure of urban ecology. KEYWORDS: children, house dust, allergens of house and library dust, household sensitization, mites. FOR CITATION: Bardenikova S.I., Rychkova T.I., Kulikova E.V. et al. House dust mites: the insidious symbiosis. Russian Medical Inquiry. 2023;7(2):89–95 (in Russ.). DOI: 10.32364/2587-6821-2023-7-2-89-95.
{"title":"House dust mites: the insidious symbiosis","authors":"S. I. Bardenikova, T. I. Rychkova, E. V. Kulikova, O. B. Dovgun, T. Belyaeva","doi":"10.32364/2587-6821-2023-7-2-89-95","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-2-89-95","url":null,"abstract":"Aim: to assess changes in the patterns of sensitization to house dust allergens in a cohort of children with allergic disorders over the last 30 years. Patients and Methods: this retrospective analysis included 26,343 protocols of allergy tests to house dust and its allergenic components (house mix, D. pteronyssinus and D. farinae mites, library dust) that had been carried out in children 4–18 years old over the period from 1989 to 2019. Skin testing was performed using the generally accepted scarification technique on the anterior surface of the forearm through a drop of the tested allergen. Then, the test results are assessed by visual inspection with a score of 1 — 4. The results of continuous monitoring were summarized and statistically processed for all years of the observation period, but the article presents analysis of the \"cross-section\" indicators only for those years that were convenient for comparison. The authors calculated a percentage ratio of the number of patients sensitized to the studied allergen to the total number of patients tested for hypersensitivity to this allergen during a particular year. Then, they compared the percentage of patients with low (1–2) and high (3–4) scores. Results and Discussion: the analysis showed a steady increase in IgE hypersensitivity to the house dust mix (from 23.7% in 1989 to 71.2% in 2019). Also, it demonstrated an increase in the degree of sensitization (3 — 4 scores) to the integral dust mix (from 4.2% in 1989 to 16.6% in 2019), which was significantly higher than that to the dust mites themselves due to the diverse composition of specific proteins of epidermal, fungal, bacterial, and insect origin that can induce antibodies independently on each other. There was a similar 2.6-fold growth in sensitization to the library dust over the first 10 years of observation, and by 2019 hypersensitization developed in 57.2% of children from this cohort. However, a dramatic decline in high scores (3–4) of the detected level to 5% was reported in 2019 which was associated with the changes in the ways of in-house data storage. Conclusion: the study findings provide a rationale for the mandatory control of dynamic changes in sensitization among children with allergic disorders using an expended household allergen panel. The steady increase in sensitization to house dust allergens confirms a low effectiveness of elimination measures and suggests a progressive immune imbalance under the everyday pressure of urban ecology. KEYWORDS: children, house dust, allergens of house and library dust, household sensitization, mites. FOR CITATION: Bardenikova S.I., Rychkova T.I., Kulikova E.V. et al. House dust mites: the insidious symbiosis. Russian Medical Inquiry. 2023;7(2):89–95 (in Russ.). DOI: 10.32364/2587-6821-2023-7-2-89-95.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82295859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-3-137-143
A. D. Meshkov, V. S. Ostapenko, V. S. Pykhtina
Aim: to assess the efficacy and safety of ixekizumab in the treatment of ankylosing spondyloarthritis (AS) and psoriatic arthritis (PA) in real clinical practice. Patients and Methods: this retrospective study included patients with AS and PA who received ixekizumab therapy from February 2021 to April 2022. Disease activity was evaluated every 3–6 months, using BASDAI and ASDAS scores for AS and DAPSA и PASI scores for PA. C-reactive protein (CRP) served as a serologic marker of disease activity. Results: the analysis included the data received for 27 patients, of whom 10 persons had AS and 17 — PA. The safety of treatment was assessed in all patients, and the data of 9 AS and 16 PA patients were included in the analysis of the treatment efficacy. In the AS group (4 males and 5 females), the median age at the therapy initiation was 34 [32; 41.5] years and in the PA group (11 males and 6 females — 40 [32.5; 48.5] years. Failure or intolerance of the standard therapy was reported in all patients. Prior to ixekizumab treatment, most patients did not receive targeted therapies. Of 27 patients, 4 received genetically engineered biological drugs / targeted synthesized drugs which failed to achieve remission / low disease activity. In the AS group, the elevated levels of CRP were revealed in 7 (77.8%) patients, ASDAS demonstrated the presence of disease activity in all patients. According to BASDAI, disease activity was recorded in 7 (77.8%) cases. During the treatment, there was a downtrend in the percentage of patients with high disease activity as shown by ASDAS and BASDAI scores, as well as in the percentage of patients with elevated levels of CRP, while the BASDAI values were statistically significant (p=0.031). In the PA group, elevated CRP levels were reported in 62.5% of patients, and DAPSA scores represented moderate of high activity in 75.0% of patients. As a result of the treatment, there was a decrease in the percentage of patients with higher DAPSA scores and elevated CRP levels, but the changes did not achieve statistical significance. Side effects were reported in 7.4% of patients, but there were no serious adverse events. Conclusion: acording to our data ixekizumab has shown efficacy and safety in the treatment of PA and AS in real clinical practice. KEYWORDS: ixekizumab, real clinical practice, psoriatic arthritis, ankylosing spondyloarthritis, genetically engineered biological drugs. FOR CITATION: Meshkov A.D., Ostapenko V.S., Pykhtina V.S. The efficacy and safety of ixekizumab in the treatment of spondyloarthritis under the conditions of real clinical practice. Russian Medical Inquiry. 2023;7(3):137–143 (in Russ.). DOI: 10.32364/2587-6821- 2023-7-3-137-143.
{"title":"The efficacy and safety of ixekizumab in the treatment of spondyloarthritis under the conditions of real clinical practice","authors":"A. D. Meshkov, V. S. Ostapenko, V. S. Pykhtina","doi":"10.32364/2587-6821-2023-7-3-137-143","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-3-137-143","url":null,"abstract":"Aim: to assess the efficacy and safety of ixekizumab in the treatment of ankylosing spondyloarthritis (AS) and psoriatic arthritis (PA) in real clinical practice. Patients and Methods: this retrospective study included patients with AS and PA who received ixekizumab therapy from February 2021 to April 2022. Disease activity was evaluated every 3–6 months, using BASDAI and ASDAS scores for AS and DAPSA и PASI scores for PA. C-reactive protein (CRP) served as a serologic marker of disease activity. Results: the analysis included the data received for 27 patients, of whom 10 persons had AS and 17 — PA. The safety of treatment was assessed in all patients, and the data of 9 AS and 16 PA patients were included in the analysis of the treatment efficacy. In the AS group (4 males and 5 females), the median age at the therapy initiation was 34 [32; 41.5] years and in the PA group (11 males and 6 females — 40 [32.5; 48.5] years. Failure or intolerance of the standard therapy was reported in all patients. Prior to ixekizumab treatment, most patients did not receive targeted therapies. Of 27 patients, 4 received genetically engineered biological drugs / targeted synthesized drugs which failed to achieve remission / low disease activity. In the AS group, the elevated levels of CRP were revealed in 7 (77.8%) patients, ASDAS demonstrated the presence of disease activity in all patients. According to BASDAI, disease activity was recorded in 7 (77.8%) cases. During the treatment, there was a downtrend in the percentage of patients with high disease activity as shown by ASDAS and BASDAI scores, as well as in the percentage of patients with elevated levels of CRP, while the BASDAI values were statistically significant (p=0.031). In the PA group, elevated CRP levels were reported in 62.5% of patients, and DAPSA scores represented moderate of high activity in 75.0% of patients. As a result of the treatment, there was a decrease in the percentage of patients with higher DAPSA scores and elevated CRP levels, but the changes did not achieve statistical significance. Side effects were reported in 7.4% of patients, but there were no serious adverse events. Conclusion: acording to our data ixekizumab has shown efficacy and safety in the treatment of PA and AS in real clinical practice. KEYWORDS: ixekizumab, real clinical practice, psoriatic arthritis, ankylosing spondyloarthritis, genetically engineered biological drugs. FOR CITATION: Meshkov A.D., Ostapenko V.S., Pykhtina V.S. The efficacy and safety of ixekizumab in the treatment of spondyloarthritis under the conditions of real clinical practice. Russian Medical Inquiry. 2023;7(3):137–143 (in Russ.). DOI: 10.32364/2587-6821- 2023-7-3-137-143.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81261033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-1-30-35
A. B. Khadzegova
Over the last few years, there has been an increasing trend in the prevalence of chronic kidney diseases (CKD) in patients with chronic heart failure (CHF). CKD is a well-known comorbidity in chronic heart failure, associated with lower survival rates, while cardiovascular complications are the leading cause of death among patients with CKD. The ability to identify early CKD in patients with CHF is critical for estimating prognosis, developing treatment strategy and tactics, and ultimately for preventing cardiovascular and renal complications. Considering the CKD prevalence in CHF, it is important to develop strategies for the administration of renin-angiotensin-aldosterone system inhibitors in view of their nephroprotective action with antiproteinuric and antiproliferative effects that can be also associated with improved survival. An angiotensin converting enzyme inhibitor such as fosinopril appears particularly beneficial for the treatment of CHF patients. Fosinopril undergoes enzymatic hydrolysis primarily in the liver and gastrointestinal mucosa and is converted to fosinoprilat which is eliminated equally by the kidneys and liver. In patients with renal dysfunction, the decreased fosinoprilat elimination with urine is compensated by the increased hepatic metabolism. Fosinoprilat exhibits less accumulation than enalapril or lisinopril in patients with CDK. KEYWORDS: chronic heart failure, renal function, chronic kidney disease, fosinopril, fosinoprilat, nephroprotection. FOR CITATION: Khadzegova A.B. Renal function in patients with heart failure — a predictor for selecting RAAS inhibitors. Russian Medical Inquiry. 2023;7(1):30–35 (in Russ.). DOI: 10.32364/2587-6821-2023-7-1-30-35.
{"title":"Renal function in patients with heart failure — a predictor for selecting RAAS inhibitors","authors":"A. B. Khadzegova","doi":"10.32364/2587-6821-2023-7-1-30-35","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-1-30-35","url":null,"abstract":"Over the last few years, there has been an increasing trend in the prevalence of chronic kidney diseases (CKD) in patients with chronic heart failure (CHF). CKD is a well-known comorbidity in chronic heart failure, associated with lower survival rates, while cardiovascular complications are the leading cause of death among patients with CKD. The ability to identify early CKD in patients with CHF is critical for estimating prognosis, developing treatment strategy and tactics, and ultimately for preventing cardiovascular and renal complications. Considering the CKD prevalence in CHF, it is important to develop strategies for the administration of renin-angiotensin-aldosterone system inhibitors in view of their nephroprotective action with antiproteinuric and antiproliferative effects that can be also associated with improved survival. An angiotensin converting enzyme inhibitor such as fosinopril appears particularly beneficial for the treatment of CHF patients. Fosinopril undergoes enzymatic hydrolysis primarily in the liver and gastrointestinal mucosa and is converted to fosinoprilat which is eliminated equally by the kidneys and liver. In patients with renal dysfunction, the decreased fosinoprilat elimination with urine is compensated by the increased hepatic metabolism. Fosinoprilat exhibits less accumulation than enalapril or lisinopril in patients with CDK. KEYWORDS: chronic heart failure, renal function, chronic kidney disease, fosinopril, fosinoprilat, nephroprotection. FOR CITATION: Khadzegova A.B. Renal function in patients with heart failure — a predictor for selecting RAAS inhibitors. Russian Medical Inquiry. 2023;7(1):30–35 (in Russ.). DOI: 10.32364/2587-6821-2023-7-1-30-35.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81035170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-3-144-149
I. Viktorova, D. S. Ivanova, A.M. Poltavtseva, D.B. Tulkibaevа, A. M. Adyrbaev
Chernogubov-Ehlers-Danlos and Marfan syndromes are among the most prevalent disorders of connective tissue, and health care providers of various specialties may deal with such patients. The agreed diagnostic criteria have been devised for these diseases and they should be used for conducting a thorough medical examination. The article refers to some difficulties associated with the application of these criteria to clinical practice. As a result, in Russian-language literature the patients with these syndromes are formally excluded from the research, and in this context a term "non-differentiated connective tissue dysplasia" is commonly used. As noted, multisystem dysplasia disorders with the involvement of different organs that occur in patients with monogenic syndromes are not fully reflected in the modern diagnostic criteria. At the same time a delayed diagnosis may lead to the absence of alert about the conditions that potentially complicate the course of physiological processes (e.g. pregnancy) or even cause lethal outcomes. The authors emphasize the need for developing intellectual technologies to support physician's decisions that are focused on a broader and timely diagnosis of monogenic syndrome as they will help to improve the quality of medical care. KEYWORDS: Marfan syndrome, Chernogubov-Ehlers-Danlos syndrome, dysplasia of connective tissue, dysplasia phenotype, dural ectasia, Ghent criteria, Villefranche criteria. FOR CITATION: Viktorova I.A., Ivanova D.S., Poltavtseva A.M. et al. Modern criteria of diagnosis of the main dysplasia phenotypes (Marfan and Chernogubov-Ehlers-Danlos syndromes): sufficiency and applicability to medical practice. Russian Medical Inquiry. 2023;7(3):144–149 (in Russ.). DOI: 10.32364/2587-6821-2023-7-3-144-149.
{"title":"Modern criteria of diagnosis of the main dysplasia phenotypes (Marfan and Chernogubov-Ehlers-Danlos syndromes): sufficiency and applicability to medical practice","authors":"I. Viktorova, D. S. Ivanova, A.M. Poltavtseva, D.B. Tulkibaevа, A. M. Adyrbaev","doi":"10.32364/2587-6821-2023-7-3-144-149","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-3-144-149","url":null,"abstract":"Chernogubov-Ehlers-Danlos and Marfan syndromes are among the most prevalent disorders of connective tissue, and health care providers of various specialties may deal with such patients. The agreed diagnostic criteria have been devised for these diseases and they should be used for conducting a thorough medical examination. The article refers to some difficulties associated with the application of these criteria to clinical practice. As a result, in Russian-language literature the patients with these syndromes are formally excluded from the research, and in this context a term \"non-differentiated connective tissue dysplasia\" is commonly used. As noted, multisystem dysplasia disorders with the involvement of different organs that occur in patients with monogenic syndromes are not fully reflected in the modern diagnostic criteria. At the same time a delayed diagnosis may lead to the absence of alert about the conditions that potentially complicate the course of physiological processes (e.g. pregnancy) or even cause lethal outcomes. The authors emphasize the need for developing intellectual technologies to support physician's decisions that are focused on a broader and timely diagnosis of monogenic syndrome as they will help to improve the quality of medical care. KEYWORDS: Marfan syndrome, Chernogubov-Ehlers-Danlos syndrome, dysplasia of connective tissue, dysplasia phenotype, dural ectasia, Ghent criteria, Villefranche criteria. FOR CITATION: Viktorova I.A., Ivanova D.S., Poltavtseva A.M. et al. Modern criteria of diagnosis of the main dysplasia phenotypes (Marfan and Chernogubov-Ehlers-Danlos syndromes): sufficiency and applicability to medical practice. Russian Medical Inquiry. 2023;7(3):144–149 (in Russ.). DOI: 10.32364/2587-6821-2023-7-3-144-149.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88692139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-5-9
M. Livzan, M. I. Syrovenko, T. Krolevets
This article is aimed to summarize data on the incidence and patterns of the non-alcoholic fatty liver disease (NAFLD) course among women of different age. The prevalence of NAFLD is growing worldwide. In general, the incidence of this liver disease in men is higher than in women. However, a detailed examination of various age groups revealed that in women of reproductive age, the NAFLD incidence was lower than in men; at the same time, after menopause, the disease incidence in women became equal to the incidence in men, even exceeded it according to some data. Ongoing epidemiological, clinical and experimental studies indicate a higher risk of NAFLD and liver fibrosis in women with postmenopause versus woman with premenopause, as well as that older women with NAFLD have a higher mortality rate than men. One of the key roles in metabolic changes that contribute, in particular, to the NAFLD development is assigned to estrogens. The relevance of the NAFLD detection and treatment in women is due to a significantly higher prevalence of age-adjusted cardiovascular diseases, 5-year mortality from all causes and 5-year cardiovascular mortality versus women without NAFLD. KEYWORDS: non-alcoholic fatty liver disease, fibrosis, steatosis, menopause, premenopause, pregnancy, estrogens, ursodeoxycholic acid. FOR CITATION: Livzan M.A., Syrovenko M.I., Krolevets T.S. Non-alcoholic fatty liver disease and women's health. Russian Medical Inquiry. 2023;7(5):310–317 (in Russ.). DOI: 10.32364/2587-6821-2023-7-5-9.
{"title":"Non-alcoholic fatty liver disease and women's health","authors":"M. Livzan, M. I. Syrovenko, T. Krolevets","doi":"10.32364/2587-6821-2023-7-5-9","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-5-9","url":null,"abstract":"This article is aimed to summarize data on the incidence and patterns of the non-alcoholic fatty liver disease (NAFLD) course among women of different age. The prevalence of NAFLD is growing worldwide. In general, the incidence of this liver disease in men is higher than in women. However, a detailed examination of various age groups revealed that in women of reproductive age, the NAFLD incidence was lower than in men; at the same time, after menopause, the disease incidence in women became equal to the incidence in men, even exceeded it according to some data. Ongoing epidemiological, clinical and experimental studies indicate a higher risk of NAFLD and liver fibrosis in women with postmenopause versus woman with premenopause, as well as that older women with NAFLD have a higher mortality rate than men. One of the key roles in metabolic changes that contribute, in particular, to the NAFLD development is assigned to estrogens. The relevance of the NAFLD detection and treatment in women is due to a significantly higher prevalence of age-adjusted cardiovascular diseases, 5-year mortality from all causes and 5-year cardiovascular mortality versus women without NAFLD. KEYWORDS: non-alcoholic fatty liver disease, fibrosis, steatosis, menopause, premenopause, pregnancy, estrogens, ursodeoxycholic acid. FOR CITATION: Livzan M.A., Syrovenko M.I., Krolevets T.S. Non-alcoholic fatty liver disease and women's health. Russian Medical Inquiry. 2023;7(5):310–317 (in Russ.). DOI: 10.32364/2587-6821-2023-7-5-9.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80714618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-3-150-159
A. Babaeva, E. Kalinina, M.S. Zvonorenk, K. Solodenkova, M. A. Osadchuk
Cardiovascular and metabolic comorbidities in patients with rheumatic diseases (RD) determine the risk of adverse outcomes. Gout is one of the diseases which significantly increase the cardiovascular risk (CVR). The authors present a literature review elucidating the prevalence and spectrum of cardiovascular (CVD) and metabolic diseases, as well as the proven CVR factors in persons with RDs, including gout. As demonstrated, the increased CVR amid RDs is caused not only by a higher prevalence of the traditional CVR factors but is also related to multiple specific disease-associated risk factors. Chronic systemic inflammation, the development of internal organ lesions and the long-term use of anti-inflammatory therapy contribute negatively to the overall CVR. Thus, RDs are considered as important CVR re-classifiers and require a compulsory revision of the risk factors. Currently, the national and international guidelines for the CVR prevention in persons with RD have been developed and used in practice. Among RDs, a special place is held by gout which is characterized by common cardiovascular comorbidities and reduced glomerular filtration rate. The recent studies have demonstrated that in the management of patients with hyperuricemia (HU) and gout it is necessary to achieve a sustained target level of uric acid for preventing adverse effects on the organ systems and reducing CVR. Among the recommended therapeutic options for patients with cardiovascular and renal comorbidities, the preference is given to febuxostat, a urate-lowering drug with high activity and proven safety. KEYWORDS: comorbidities, rheumatic diseases, gout, cardiovascular risk, febuxostat. FOR CITATION: Babaeva A.R., Kalinina E.V., Zvonorenko M.S. et al. Cardiovascular and metabolic comorbidities associated with rheumatic diseases: focus on hyperuricemia and gout. Russian Medical Inquiry. 2023;7(3):150–159 (in Russ.). DOI: 10.32364/2587- 6821-2023-7-3-150-159.
{"title":"Cardiovascular and metabolic comorbidities associated with rheumatic diseases: focus on hyperuricemia and gout","authors":"A. Babaeva, E. Kalinina, M.S. Zvonorenk, K. Solodenkova, M. A. Osadchuk","doi":"10.32364/2587-6821-2023-7-3-150-159","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-3-150-159","url":null,"abstract":"Cardiovascular and metabolic comorbidities in patients with rheumatic diseases (RD) determine the risk of adverse outcomes. Gout is one of the diseases which significantly increase the cardiovascular risk (CVR). The authors present a literature review elucidating the prevalence and spectrum of cardiovascular (CVD) and metabolic diseases, as well as the proven CVR factors in persons with RDs, including gout. As demonstrated, the increased CVR amid RDs is caused not only by a higher prevalence of the traditional CVR factors but is also related to multiple specific disease-associated risk factors. Chronic systemic inflammation, the development of internal organ lesions and the long-term use of anti-inflammatory therapy contribute negatively to the overall CVR. Thus, RDs are considered as important CVR re-classifiers and require a compulsory revision of the risk factors. Currently, the national and international guidelines for the CVR prevention in persons with RD have been developed and used in practice. Among RDs, a special place is held by gout which is characterized by common cardiovascular comorbidities and reduced glomerular filtration rate. The recent studies have demonstrated that in the management of patients with hyperuricemia (HU) and gout it is necessary to achieve a sustained target level of uric acid for preventing adverse effects on the organ systems and reducing CVR. Among the recommended therapeutic options for patients with cardiovascular and renal comorbidities, the preference is given to febuxostat, a urate-lowering drug with high activity and proven safety. KEYWORDS: comorbidities, rheumatic diseases, gout, cardiovascular risk, febuxostat. FOR CITATION: Babaeva A.R., Kalinina E.V., Zvonorenko M.S. et al. Cardiovascular and metabolic comorbidities associated with rheumatic diseases: focus on hyperuricemia and gout. Russian Medical Inquiry. 2023;7(3):150–159 (in Russ.). DOI: 10.32364/2587- 6821-2023-7-3-150-159.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"16 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79291720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-1-22-29
O. Tsygankova, N. Evdokimova, L. Latyntseva
Aim: to assess the fat depot compartments and some cardiometabolic risk markers in patients with chronic heart failure with preserved ejection fraction (CHFpEF), prediabetes and abdominal obesity. Patients and Methods: this randomized open single-center study was carried out in the Research Institute for Therapy and Preventive Medicine — Branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the RAS and included 64 subjects (32 of them were males) with CHFpEF, prediabetes and abdominal obesity. The standard general clinical examination and laboratory tests, measurements of NT-proBNP and high-sensitivity C-reactive protein (CRP) in blood plasma, as well as ultrasonography for imaging epicardial and preperitoneal fat depots (lipometry) were used to evaluate patients. Results: median age of the studied male patients was 58.00 [54.25; 60.00] years, female patients — 58.00 [56.00; 59.00] years. Males had a higher body weight as compared to females (р=0.036). The level of NT-proBNP in women was lower than in men (p=0.036), just as the glomerular filtration rate (р=0.034). The thickness of the epicardial and preperitoneal fat layers were similar in men and women, while the subcutaneous fat layer was thicker in women (р=0.001). Male patients with grade 3 obesity had the lowest NT-proBNP concentration in blood plasma. In women with grade 2 and 3 obesity the concentration of high-sensitivity C-reactive protein (CRP) in blood plasma was higher than in women with overweight and grade 1 obesity (р=0.047). A moderate linear relationship between NT-proBNP and high-sensitivity CRP levels was found in female patients (r=0.375, p=0.034). Conclusion: body weight measurements, glomerular filtration rates and NT-proBNP concentrations in blood plasma were higher in the studied sample of men as compared to those in women. Male patients with grade 3 obesity had the minimal NT-proBNP level (just slightly above the diagnostic limit). The highest high-sensitivity CRP measurements were reported in women with grade 2 and 3 obesity which underscores their proinflammatory status. No significant differences in the visceral epicardial and preperitoneal fat compartments were found between male and female patients. KEYWORDS: chronic heart failure with preserved ejection fraction, prediabetes, obesity, NT-proBNP, C-reactive protein, epicardial fat, premesenteric fat, subcutaneous fat, males, females. FOR CITATION: Tsygankova O.V., Evdokimova N.E., Latyntseva L.D. Chronic heart failure with preserved ejection fraction amid prediabetes and abdominal obesity: fat depot compartments and cardiometabolic risk markers. Russian Medical Inquiry. 2023;7(1):22–29 (in Russ.). DOI: 10.32364/2587-6821-2023-7-1-22-29.
{"title":"Chronic heart failure with preserved ejection fraction amid prediabetes and abdominal obesity: fat depot compartments and cardiometabolic risk markers","authors":"O. Tsygankova, N. Evdokimova, L. Latyntseva","doi":"10.32364/2587-6821-2023-7-1-22-29","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-1-22-29","url":null,"abstract":"Aim: to assess the fat depot compartments and some cardiometabolic risk markers in patients with chronic heart failure with preserved ejection fraction (CHFpEF), prediabetes and abdominal obesity. Patients and Methods: this randomized open single-center study was carried out in the Research Institute for Therapy and Preventive Medicine — Branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the RAS and included 64 subjects (32 of them were males) with CHFpEF, prediabetes and abdominal obesity. The standard general clinical examination and laboratory tests, measurements of NT-proBNP and high-sensitivity C-reactive protein (CRP) in blood plasma, as well as ultrasonography for imaging epicardial and preperitoneal fat depots (lipometry) were used to evaluate patients. Results: median age of the studied male patients was 58.00 [54.25; 60.00] years, female patients — 58.00 [56.00; 59.00] years. Males had a higher body weight as compared to females (р=0.036). The level of NT-proBNP in women was lower than in men (p=0.036), just as the glomerular filtration rate (р=0.034). The thickness of the epicardial and preperitoneal fat layers were similar in men and women, while the subcutaneous fat layer was thicker in women (р=0.001). Male patients with grade 3 obesity had the lowest NT-proBNP concentration in blood plasma. In women with grade 2 and 3 obesity the concentration of high-sensitivity C-reactive protein (CRP) in blood plasma was higher than in women with overweight and grade 1 obesity (р=0.047). A moderate linear relationship between NT-proBNP and high-sensitivity CRP levels was found in female patients (r=0.375, p=0.034). Conclusion: body weight measurements, glomerular filtration rates and NT-proBNP concentrations in blood plasma were higher in the studied sample of men as compared to those in women. Male patients with grade 3 obesity had the minimal NT-proBNP level (just slightly above the diagnostic limit). The highest high-sensitivity CRP measurements were reported in women with grade 2 and 3 obesity which underscores their proinflammatory status. No significant differences in the visceral epicardial and preperitoneal fat compartments were found between male and female patients. KEYWORDS: chronic heart failure with preserved ejection fraction, prediabetes, obesity, NT-proBNP, C-reactive protein, epicardial fat, premesenteric fat, subcutaneous fat, males, females. FOR CITATION: Tsygankova O.V., Evdokimova N.E., Latyntseva L.D. Chronic heart failure with preserved ejection fraction amid prediabetes and abdominal obesity: fat depot compartments and cardiometabolic risk markers. Russian Medical Inquiry. 2023;7(1):22–29 (in Russ.). DOI: 10.32364/2587-6821-2023-7-1-22-29.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"270 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85193172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32364/2587-6821-2023-7-3-181-186
I. Gordeev, V. I. Vechorko, S. M. Otarova, V.P. Rauzheva, A. R. Yunyaev
The article describes the clinical onset of Takayasu's arteritis (non-specific aortoarteritis) which occurred after coronavirus disease in a young woman with Still's disease in her medical history. Takayasu's arteritis primarily affects young women, most commonly of Asian race. Clinical manifestations of the disease can be conditionally divided into two groups: non-specific symptoms, indicating a systemic inflammatory response, and specific symptoms associated with the damage of the aorta and its branches. Physical examination plays an important role in diagnosing Takayasu's arteritis. Characteristic signs of the disease include vascular bruits over the large arteries, arterial blood pressure differentials in the right and left extremities, and failure to palpate pulse on the radial arteries (therefore it is also called pulseless disease). Imaging diagnostic techniques include contrast-enhanced angiography and Duplex sonography of the vessels. Etiology of the disease is not fully understood. Research papers present data showing that novel coronavirus infection could be a triggering factor in the emergence of vasculitis of the large vessels, including Takayasu's arteritis. This should be taken into consideration in the management of patients belonging to the risk group. KEYWORDS: Takayasu's arteritis, non-specific aortoarteritis, COVID-19, post-COVID-19 syndrome, vasculitis, Stills' disease. FOR CITATION: Gordeev I.G., Vechorko V.I., Otarova S.M. et al. Takayasu's arteritis after coronavirus disease in young woman: case report. Russian Medical Inquiry. 2023;7(3):181–186 (in Russ.). DOI: 10.32364/2587-6821-2023-7-3-181-186.
{"title":"Takayasu's arteritis after coronavirus disease in young woman: case report","authors":"I. Gordeev, V. I. Vechorko, S. M. Otarova, V.P. Rauzheva, A. R. Yunyaev","doi":"10.32364/2587-6821-2023-7-3-181-186","DOIUrl":"https://doi.org/10.32364/2587-6821-2023-7-3-181-186","url":null,"abstract":"The article describes the clinical onset of Takayasu's arteritis (non-specific aortoarteritis) which occurred after coronavirus disease in a young woman with Still's disease in her medical history. Takayasu's arteritis primarily affects young women, most commonly of Asian race. Clinical manifestations of the disease can be conditionally divided into two groups: non-specific symptoms, indicating a systemic inflammatory response, and specific symptoms associated with the damage of the aorta and its branches. Physical examination plays an important role in diagnosing Takayasu's arteritis. Characteristic signs of the disease include vascular bruits over the large arteries, arterial blood pressure differentials in the right and left extremities, and failure to palpate pulse on the radial arteries (therefore it is also called pulseless disease). Imaging diagnostic techniques include contrast-enhanced angiography and Duplex sonography of the vessels. Etiology of the disease is not fully understood. Research papers present data showing that novel coronavirus infection could be a triggering factor in the emergence of vasculitis of the large vessels, including Takayasu's arteritis. This should be taken into consideration in the management of patients belonging to the risk group. KEYWORDS: Takayasu's arteritis, non-specific aortoarteritis, COVID-19, post-COVID-19 syndrome, vasculitis, Stills' disease. FOR CITATION: Gordeev I.G., Vechorko V.I., Otarova S.M. et al. Takayasu's arteritis after coronavirus disease in young woman: case report. Russian Medical Inquiry. 2023;7(3):181–186 (in Russ.). DOI: 10.32364/2587-6821-2023-7-3-181-186.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73851659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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