Russian Medical Inquiry最新文献

{"title":"Neuropathic pain component in patients with osteoarthritis","authors":"O. G. Filimonova","doi":"10.32364/2587-6821-2022-6-3-113-119","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-3-113-119","url":null,"abstract":"Background: chronic joint pain in osteoarthritis (OA) is an important factor of maladaptation. According to modern concepts, there are two variants presented in this pathology: nociceptive and nociplastic. Much less is known about the contribution of the neuropathic component (NC) to the pain syndrome formation. Aim: to study the pain syndrome patterns in patients with OA, as well as to identify NC in such patients and its impact on the life quality. Patients and Methods: the prospective study included 31 patients (mean age — 62.9±6.7 years, 26 (83.9%) women) with stage I–III OA of the knee and/or hip joint. The course of the articular syndrome corresponded to the pain syndrome course and ranged from 2 months to 30 years, averaging 10.6±9.9 years. All patients underwent general clinical examination. To detect neuropathic pain component (NPC), a neurological examination was performed using the DN4 and painDETECT questionnaires. The level of life quality was determined by the EQ-5D questionnaire. Results: NPC was detected in almost half (48%) of the examined patients. At the same time, the severity of radiological changes in the joints did not depend on its presence. However, in the presence of NC, the following manifestations were significantly more common in the area of the most affected joint (p<0.05): burning, numbness, electric shock, hypoesthesia, tingling, a feeling of crawling and/or tingling. There was practically no such symptom as itching, while the frequency of hypoesthesia in the groups did not significantly differ. According to the EQ-5D questionnaire, lower indicators were observed in patients with the NPC, their mobility assessment and daily activity were significantly worse. Mixed anxiety–depressive disorder were also observed (p<0.05) in such patients. Conclusion: for adequate treatment of pain syndrome, it is necessary to determine the presence of NPC in patients with OA and use antidepressants and anticonvulsants in complex therapy. KEYWORDS: osteoarthritis, chronic pain syndrome, nociceptive pain, nociplastic pain, neuropathic pain component, life quality. FOR CITATION: Filimonova O.G. Neuropathic pain component in patients with osteoarthritis. Russian Medical Inquiry. 2022;6(3):113–119 (in Russ.). DOI: 10.32364/2587-6821-2022-6-3-113-119.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77859391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic aspects of the comorbid course of non-alcoholic fatty liver disease and cholelithiasis: a review and the authors’ results","authors":"Т.С. Кролевец, М. А. Ливзан, М.И. Сыровенко, Н.А. Черкащенко, T. Krolevets, M. Livzan, M. I. Syrovenko, N. Cherkashchenko, Maria A. Livzan — Dr. Sc. Med","doi":"10.32364/2587-6821-2022-6-5-278-285","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-5-278-285","url":null,"abstract":"This paper reviews the pathogenic mechanisms of the development and progression of comorbid cholelithiasis (CL) and non-alcoholic fatty liver disease (NAFLD). The authors discuss gender and anatomic physiological patterns, and the effects of insulin resistance, obesity, adipose tissue hormones, and cholecystectomy on clinical morphological abnormalities in coexisting CL and NAFLD. In addition to lipid metabolism abnormalities, comorbid CL and NAFLD are characterized by deviations in the amount and proportions of fatty acids and hormonal imbalance (i.e., hyperleptinemia, leptin resistance, and insulin resistance). Cholecystectomy is an unfavorable factor for the progressive course of NAFLD and development of liver fibrosis. As a result, individualized management strategies are required in these cases. The authors present their own study that enrolled 183 patients with NAFLD. Their data demonstrate that coexisting NAFLD and CL have certain clinical laboratory signatures, while the postoperative period after cholecystectomy in patients with NAFLD is characterized by greater cardiovascular risk and liver fibrosis progression. The authors discuss the use of a combined preparation of ursodeoxycholic acid and sodium glycyrrhizinate in these patients. Two-component hepatoprotective treatment with this agent has pathogenically-target effect in comorbid NAFLD and CL. KEYWORDS: non-alcoholic fatty liver disease, cholelithiasis, comorbidity, liver fibrosis, cholecystectomy. FOR CITATION: Krolevets T.S., Livzan M.A., Syrovenko M.I., Cherkashchenko N.A. Pathogenic aspects of the comorbid course of non- alcoholic fatty liver disease and cholelithiasis: a review and the authors’ results. Russian Medical Inquiry. 2022;6(5):278–285 (in Russ.). DOI: 10.32364/2587-6821-2022-6-5-278-285.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77644671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New look on the use of sodium escinate in patients with post-COVID conditions","authors":"Z. Shugushev, A. A. Akulova","doi":"10.32364/2587-6821-2022-6-1-33-38","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-1-33-38","url":null,"abstract":"The emergence of the COVID-19 infection associated with multisystem disorders, long-term-complications (post-COVID conditions), low productivity and reduced quality of life, the lack of a unified treatment resulted to the search of novel agents and expansion of indication for use of pre-existing medications. Escine is an active ingredient of Aesculus hippocastanum (horse chestnut) which is well-known in the phlebological pharmaceutical market. This paper reviews recent pharmacological and clinical data on anti-edematous, anti-inflammatory, and antioxidant effects of sodium escinate in post-COVID conditions. The anti-inflammatory and antiviral effects of sodium escinate involve inhibiting the secretion of proinflammatory cytokines (including tumor necrosis factor a and interleukin 1β) by LPS-induced RAW264.7 macrophages. In Russia, escine is a component of a combined formulation based on horse chestnut seed extract and thiamine (vitamin B1). Given efficacy of sodium escinate (based on the results of in vitro and in vivo experimental studies) and its antiviral and anti-inflammatory properties, this agent can be prescribed for the COVID-19 complications. KEYWORDS: sodium escinate, post-COVID conditions, anti-inflammatory effects, phlebological agent, SARS-CoV-2. FOR CITATION: Shugushev Z.Kh., Akulova A.A. New look on the use of sodium escinate in patients with post-COVID conditions. Russian Medical Inquiry. 2022;6(1):33–38 (in Russ.). DOI: 10.32364/2587-6821-2022-6-1-33-38.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"206 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76202622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart addition is multiplication: a review concerning combined use of hyaluronic acid and polynucleotides for intra-articular administration in osteoarthritis","authors":"I. S. Svintsitskaya, K. Volkov","doi":"10.32364/2587-6821-2022-6-4-182-186","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-4-182-186","url":null,"abstract":"The article presents an overview of modern methods to the treatment of osteoarthritis (OA). It is focused on intra-articular injections of hyaluronic acid and polynucleotides (PNs) of natural origin. Hyaluronic acid is a natural component of connective tissue that has the ability to restore the viscoelastic properties of synovial fluid. Besides, it also has anti-apoptotic, anti-inflammatory, anti-angiogenic and antifibrotic characteristics. PNs are natural macromolecules derived from DNA. They have trophic activity and promote cell growth and collagen production, as has been shown in preclinical and clinical studies concerning cartilage regeneration. When injected into the joint cavity, PNs are subjected to enzymatic cleavage with the release of nucleosides, nucleotides and nitrogenous bases, thereby, providing long-term moisturizing and viscoelastic properties of synovial fluid. The efficacy of a combination of hyaluronic acid preparations with PNs for intra-articular administration for the treatment of knee OA has been studied. It has been established that the combined therapy with PNs and hyaluronic acid leads to the development of a more persistent therapeutic effect for 2 years after the treatment course versus with hyaluronic acid monotherapy. KEYWORDS: osteoarthritis, synovial fluid, viscoelastic properties, synovial fluid substitute, intra-articular injections, hyaluronic acid, polynucleotides FOR CITATION: Svintsitskaya I.S., Volkov K.Yu. Smart addition is multiplication: a review concerning combined use of hyaluronic acid and polynucleotides for intra-articular administration in osteoarthritis. Russian Medical Inquiry. 2022;6(4):182–186 (in Russ.). DOI: 10.32364/2587-6821-2022-6-4-182-186","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74265744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of IL-1β, TNF-α, IL-10, IL-17, and IL-4 gene polymorphisms in the pathogenesis of chronic rhinosinusitis with nasal polyps","authors":"N. Baranova, B. Molotilov, L. Ashchina, N. Shkurova","doi":"10.32364/2587-6821-2022-6-2-57-61","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-2-57-61","url":null,"abstract":"Background: chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease, those mechanisms are not fully understood. A significant role of cytokines, e.g., interleukin (IL)-1β, tumor necrosis factor (TNF) α, IL-10, IL-17А, IL-4, and their genes, in the pathogenesis and predisposition to CRSwNP and treatment efficacy is established. Aim: to investigate IL-1β (Т-31С), TNF-α (G-308A), IL-10 (G-1082A), IL-17(G-197A), and IL-4 (С-589Т) gene polymorphisms and their role in CRSwNP pathogenesis. Patients and Methods: this open-label, prospective, randomized study enrolled 100 patients with CRSwNP. The control group included 72 healthy volunteers. DNA was isolated from the whole venous blood. IL-1β (Т-31С), TNF-α (G-308A), IL-10 (G-1082A), IL-17 (G-197A), and IL-4 (С-589Т) gene polymorphisms were assessed by the real-time polymerase chain reaction (PCR). Results: the analysis of IL-4 (С-589Т) gene polymorphism has demonstrated that 589С/С genotype is more common in CRSwNP patients compared to the controls (р=0.021, odds ratio/OR=1.248 [0.449–3.465]). The analysis of IL-10 (G-1082A) gene polymorphism has demonstrated that 1082А/A genotype is more common in CRSwNP patients compared to the controls (p=0.043, OR=1.027 [0.374–2.830]). The analysis of IL-17 (G-197A) gene polymorphism has demonstrated that 197A/А genotype is more common in CRSwNP patients than in the controls (p=0.046, OR=7.250 [0.863–2.532]). The analysis of TNF-α (G-308A) gene polymorphism has demonstrated that 308 G/G genotype is more common in CRSwNP patients compared to the controls (p=0.045, OR=1.789 [0.892–4.776]). Conclusion: the most relevant predictors of the increased risk of CRSwNP are 589С/С genotype of IL-4 gene, 1082А/A genotype of IL-10 gene, 197A/А genotype of IL-17 gene, and 308 G/G genotype of TNF-α gene. The analysis of essential cytokine gene polymorphisms, i.e., IL- 1β (Т-31С), TNF-α (G-308A), IL-10 (G-1082A), IL-17 (G-197A), and IL-4 (С-589Т), allows assessing genetic predisposition to CRSwNP. This technique is an important tool for predicting treatment efficacy. KEYWORDS: chronic rhinosinusitis with nasal polyps, cytokines, genotype, gene polymorphism, pathogenic mechanisms. FOR CITATION: Baranova N.I., Molotilov B.A., Ashchina L.A., Shkurova N.A. Role of IL-1β, TNF-α, IL-10, IL-17, and IL-4 gene polymorphisms in the pathogenesis of chronic rhinosinusitis with nasal polyps. Russian Medical Inquiry. 2022;6(2):57–61 (in Russ.). DOI: 10.32364/2587-6821-2022-6-2-57-61.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75196742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota pattern in Crohn’s disease depending on the presence of small intestinal bacterial overgrowth","authors":"Y. Kulygina, M. Osipenko, T. Alikina","doi":"10.32364/2587-6821-2022-6-5-221-226","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-5-221-226","url":null,"abstract":"Aim: to evaluate microbiota in Crohn’s disease depending on the presence/absence of small intestinal bacterial overgrowth (SIBO). Patients and Methods: thirteen patients with Crohn’s disease affecting the small intestine were enrolled. Gut microbiota composition was analyzed using the 16S rRNA gene sequencing. 16S rDNA clone libraries were generated similarly. All patients underwent lactulose hydrogen breath test using Gastroplus+ monitor to establish SIBO. A positive lactulose hydrogen breath test indicated SIBO. Results: hydrogen breath test revealed SIBO in 8 patients with Crohn’s disease affecting the small intestine (61.5%). All these patients were women (mean age 40.5 [34.5; 51.2] years). In 5 patients (mean age 32.4 [28.7; 36.5] years), SIBO was not detected. The metagenome analysis of intestinal bacteria identified certain significant differences in microbiota composition in patients with Crohn’s disease depending on the presence/absence of SIBO. In Crohn’s disease affecting the small intestine, SIBO was associated with greater occurrence of Chryseobacterium spp. (р=0.045), Klebsiella spp. (р=0.045), Phocaecola operational taxonomic unit (OTU) (р=0.045), Enterobacteriaceae OTU (р=0.045), Pasteurellales. (р=0.031), Peptoniphilaceae (р=0,023), Solobacterium spp. (р=0.002), Haemophilus spp. (р=0.031), Lachnospiracea OTU (р=0.045), and Bifidobacterium spp. (р=0.019). Conclusions: a taxonomic shift with the reduction of Firmicutes and Bifidobacterium and increase of Proteobacteria (i.e., Klebsiella spp. and Enterobacteriaceae OTU) was revealed in patients with Crohn’s disease and SIBO. KEYWORDS: inflammatory bowel disease, Crohn’s disease, microbiota, small intestinal bacterial overgrowth, hydrogen respiratory test. FOR CITATION: Kulygina Yu.A., Osipenko M.F., Alikina T.Yu. Microbiota pattern in Crohn’s disease depending on the presence ofsmall intestinal bacterial overgrowth. Russian Medical Inquiry. 2022;6(5):221–226 (in Russ.). DOI: 10.32364/2587-6821-2022-6-5-221-226.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80820814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute respiratory infections: current clinical recommendations. Focus on the issues of phytotherapy","authors":"V. Belov, E. P. Karpova, A. Zaplatnikov, A. Girina, I. V. Lepiseva, V. I. Svintsitskaya","doi":"10.32364/2587-6821-2022-6-7-376-386","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-7-376-386","url":null,"abstract":"Since January 1, 2022, the provision of medical care in most common infectious and inflammatory human diseases as acute respiratory infections (ARI) has already been carried out according to the relevant clinical recommendations (CRs) approved by the Ministry of Health of the Russian Federation. Due to the fact that ARI in the vast majority of cases are caused by viruses, much attention is paid to rational antibiotic therapy and the use of phytopreparations as a reasonable alternative to down the growth rate of antibiotic resistance. The article highlights the therapeutic possibilities of modern phytotherapy in the treatment of children with the most common manifestations of ARI (rhinosinusitis, tonsillopharyngitis, bronchitis) based on the CRs. A brief description of etiological factors, clinical symptoms, and diagnostic characteristics is given. The article also presents the results of in vitro and in vivo work, pathogenetically substantiating the expediency of using phytopreparations in ARI, as well as clinical research data confirming their efficacy and safety, including in children. It is particularly noted that following the CRs concerning patient management with ARI will reduce the frequency of unjustified prescribing of antibacterial drugs and polypragmasia in general, as well as improve the medical care quality. KEYWORDS: acute respiratory infections, rhinosinusitis, tonsillopharyngitis, bronchitis, clinical recommendations, phytotherapy, evidence- based medicine. FOR CITATION: Belov V.A., Karpova E.P., Zaplatnikov A.L. et al. Acute respiratory infections: current clinical recommendations. Focus on the issues of phytotherapy. Russian Medical Inquiry. 2022;6(7):376–386 (in Russ.). DOI: 10.32364/2587-6821-2022-6-7-376-386.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80255386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-coated balloon angioplasty in peripheral arterial disease","authors":"S. Papoyan, A. A. Shchegolev, D. Gromov, K. Asaturyan","doi":"10.32364/2587-6821-2022-6-4-177-181","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-4-177-181","url":null,"abstract":"The prevalence of peripheral arterial disease requires the search for an optimal solution for preserving blood flow by using devices of various modifications. Drug-coated balloons are widely used in the surgical treatment of peripheral arterial disease. The article aims at the summarization of the study results on the efficacy and safety of the various drug-coated balloons, in particular, with paclitaxel, in the treatment of steno-occlusive lesions in the peripheral arterial disease. Comparing the study results is fraught with certain difficulties, given the differences in the study endpoints, the demographic characteristics of patients and the lesion patterns. Nevertheless, the study results of percutaneous transluminal angioplasty (PTA) with drug-eluting ballons on the femoropopliteal segment are superior to the results obtained using conventional PTA and other endovascular interventions in the same vascular bed. PTA with drug-eluting balloons has a Class 1 recommendation in accordance with the issued recommendations of the SCAI (Society for Cardiovascular Angiography and Interventions). However, conducting PTA with paclitaxel-eluting balloons requires further determination of the possibilities of its use. KEYWORDS: drug-coated balloons, paclitaxel, percutaneous transluminal angioplasty, angioplasty, atherosclerosis, peripheral arterial disease. FOR CITATION: Papoyan S.A., Shchegolev A.A., Gromov D.G., Asaturyan K.S. Drug-coated balloon angioplasty in peripheral arterial disease. Russian Medical Inquiry. 2022;6(4):177–181 (in Russ.). DOI: 10.32364/2587-6821-2022-6-4-177-181.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"56 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91484789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of the novel coronavirus infection in HIV-positive patient with underlying chronic hepatitis C","authors":"I.A. Matyazh, E. V. Ivakhnenko, A.V. Grokhotova","doi":"10.32364/2587-6821-2022-6-11-656-658","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-11-656-658","url":null,"abstract":"In view of the global pandemic caused by the novel coronavirus disease, HIV-infected people fall into a higher risk group, as they have a weakened immune system and underlying health conditions. Currently, much research focuses on the clinical characteristics of the coronavirus infection in various population groups with comorbidities, including HIV-positive patients. The article describes the clinical course of the novel coronavirus diseases in a male patient, 44 years of age, newly diagnosed with HIV at the time of hospitalization, who also had chronic hepatitis C with low specific enzyme levels. The chest CT scans demonstrated multiple polygonal sites of increased attenuation of the lung parenchyma (ground glass opacities) in segments S2, S3, S4, S5, S6–S10 of the right lung and in S3, S6–S10 segments of the left lung; these changes were more pronounced in the right lung. Most of the sites were detected in the subpleural region and close to the lung roots. The absence of highly active antiretroviral therapy resulted in a severe immunosuppression — during patient’s stay at the hospital the number of leucocytes decreased from 3.62×109/l to 2.54×109/l. However, in the entire period of illness, his condition remained stable (moderate severity), and no complications were reported. KEYWORDS: HIV-infection, chronic hepatitis C, COVID-19, novel coronavirus infection. FOR CITATION: Matyazh I.A., Ivakhnenko E.V., Grokhotova A.V. Clinical characteristics of the novel coronavirus infection in HIV- positive patient with underlying chronic hepatitis C. Russian Medical Inquiry. 2022;6(11):656–658 (in Russ.). DOI: 10.32364/2587- 6821-2022-6-11-656-658.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90290737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sarcopenia and carotid atherosclerosis in elderly male patients with knee osteoarthritis","authors":"L. Alekseeva, E. Taskina, T. Raskina, M. Letaeva, O. Malyshenko, M. Koroleva, Yu. V. Averkieva, I. I. Grigorieva","doi":"10.32364/2587-6821-2022-6-3-120-125","DOIUrl":"https://doi.org/10.32364/2587-6821-2022-6-3-120-125","url":null,"abstract":"Aim: to evaluate the association of sarcopenia and carotid atherosclerosis in elderly male patients with knee osteoarthritis (OA). Materials and Methods: the study included 36 patients (mean age — 68.9 (66; 71) years) with an established diagnosis of grade II–III knee OA according to the Kellgren-Lawrence scale. Diagnosis of sarcopenia was conducted on the basis of the European Working Group on Sarcopenia in Older People (EWGSOP, 2010) recommendations with the determination of three parameters: muscle strength, muscle mass and muscle function. The severity of carotid atherosclerotic lesions was assessed by duplex color scanning with examination of the intima-media thickness (IMT), the presence of atherosclerotic plaques and the degree of aortic stenosis. Comparative analysis was performed in 3 groups: group 1 — 10 patients without sarcopenia, group 2— 12 patients with presarcopenia, and group 3 — 14 patients with sarcopenia. Results: IMT in group 3 with sarcopenia was statistically significantly (p=0.005) higher versus the same indicator in men without sarcopenia. The majority (23 (63.9%)) of the patients included in the study had carotid atherosclerotic lesions. The most severe carotid lesion with multiple atherosclerotic plaques and stenosis not less than 50% was significantly more commonly detected in patients with sarcopenia: 35.7% versus group 2 with presarcopenia (8.3%, p=0.015) and without sarcopenia (10.0%, p=0.013). According to the correlation analysis, a significant negative association was established between the severity of carotid atherosclerosis and the musculoskeletal index (r=-0.227, p=0.047). Conclusion: the association between carotid atherosclerosis and body composition disorders in men with knee OA allows discussing atherosclerosis and sarcopenia as two conditions with common pathogenetic mechanisms that potentially increase the risk of adverse outcomes. KEYWORDS: sarcopenia, presarcopenia, carotid atherosclerosis, osteoarthritis, elderly, male. FOR CITATION: Alekseeva L.I., Taskina E.A., Raskina T.A. et al. Association of sarcopenia and carotid atherosclerosis in elderly male patients with knee osteoarthritis. Russian Medical Inquiry. 2022;6(3):120–125 (in Russ.). DOI: 10.32364/2587-6821-2022-6-3-120-125.","PeriodicalId":21378,"journal":{"name":"Russian Medical Inquiry","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76727714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}