Movement Disorders最新文献

{"title":"Morphological Changes in Direct Pathway Striatal Neurons in a Rat Model of Tardive Dyskinesia","authors":"Hiroki Hikichi, Haruo Nishijima, Fumiaki Mori, Iku Kinoshita, Chieko Suzuki, Koichi Wakabayashi, Masahiko Tomiyama","doi":"10.1002/mds.70068","DOIUrl":"https://doi.org/10.1002/mds.70068","url":null,"abstract":"BackgroundTardive dyskinesia (TD) and drug‐induced parkinsonism (DIP) arise from prolonged dopamine antagonist use. Although D2 receptor hypersensitivity in the indirect pathway is a proposed mechanism, the role of the direct pathway remains unclear.ObjectivesTo investigate morphological changes in the direct pathway striatal neurons' axon terminals in a rat model of haloperidol‐induced TD and DIP.MethodsMale Wistar rats received haloperidol decanoate or placebo over 6 months. Behavioral tests assessed TD‐ and DIP‐like symptoms. Axon terminals forming synapses on dendrites in the internal (GPi) and external (GPe) segments of the globus pallidus were analyzed using electron and immunoelectron microscopy.ResultsHaloperidol‐treated rats exhibited both TD‐ and DIP‐like behaviors. Vesicular gamma‐aminobutyric acid (GABA) transporter (VGAT)‐positive terminals were selectively enlarged in the GPi, and substance <jats:italic>P</jats:italic> colocalization indicated a direct pathway origin.ConclusionsStructural alterations in direct pathway nerve terminals may contribute to TD, challenging conventional models that focus solely on the indirect pathway. © 2025 The Author(s). <jats:italic>Movement Disorders</jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"94 7 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"September Infographic","authors":"","doi":"10.1002/mds.29857","DOIUrl":"https://doi.org/10.1002/mds.29857","url":null,"abstract":"<p>\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 Low/high multi-frequency stimulation of the subthalamic nucleus improves verbal fluency maintaining motor control in Parkinson's Disease</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 9","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Movement Disorders: Volume 40, Number 9, September 2025","authors":"","doi":"10.1002/mds.70038","DOIUrl":"https://doi.org/10.1002/mds.70038","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 9","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Microglia Replacement in CSF1R-RD: Current Evidence and Future Priorities”","authors":"Hemmo A.F. Yska MD,&nbsp;Stéphanie Nguyen MD, PhD,&nbsp;Marianne Golse MD,&nbsp;Fanny Mochel MD, PhD,&nbsp;Violetta Zujovic PhD","doi":"10.1002/mds.70054","DOIUrl":"10.1002/mds.70054","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 10","pages":"2291-2292"},"PeriodicalIF":7.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Early Indian Age at Onset of Parkinson's: A Case for a Gene-Environment Lens”","authors":"Asha Kishore MD, DM,&nbsp;Rupam Borgohain DM,&nbsp;Divya Kalikavil Puthenveedu MD, DM,&nbsp;Roopa Rajan MD, DM,&nbsp;Pramod Kumar Pal MD, DM,&nbsp;Rukmini-Mridula Kandadai MD, DM,&nbsp;Ravi Yadav MD, DM,&nbsp;Sahil Mehta MD, DM,&nbsp;Hrishikesh Kumar MD, DM,&nbsp;Niraj Kumar MD, DM,&nbsp;Prashanth Lingappa Kukkle DM,&nbsp;Soaham Desai MD, DM,&nbsp;Kuldeep Shetty MD, DM,&nbsp;Pettarusp Murzban Wadia MD, DM,&nbsp;Annu Aggarwal MD, DM,&nbsp;Pankaj Ashok Agarwal MD, DM,&nbsp;Mirza Masoom Abbas MD, DM,&nbsp;Syam Krishnan MD, DM,&nbsp;Divya M. Radhakrishnan MD, DM,&nbsp;Gurusidheswar Mahadevappa Wali MD, DM,&nbsp;Achal Srivastava MD, DM,&nbsp;Nitish Kamble MD, DM,&nbsp;Teresa Maria D'Costa Ferreira MD, DM,&nbsp;Vivek Lal MD, DM,&nbsp;Ashwin Ashok Kumar Sreelatha MSc, MTech,&nbsp;Luis-Giraldo Gonzalez-Ricardo PhD,&nbsp;Manas Chacko MPH,&nbsp;Manu Sharma PhD","doi":"10.1002/mds.70053","DOIUrl":"10.1002/mds.70053","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 10","pages":"2287-2288"},"PeriodicalIF":7.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vagus Nerve Stimulation in Movement Disorders, from Principles to a Systematic Review of Evidence.","authors":"Francesca Proietti,Matteo Maria Ottaviani,Elisabetta Burchi,Giorgio Vivacqua,Gaia Anzini,Riccardo Antonio Ricciuti,Fioravante Capone,Vaughan G Macefield,Vincenzo Di Lazzaro,Massimo Marano","doi":"10.1002/mds.70044","DOIUrl":"https://doi.org/10.1002/mds.70044","url":null,"abstract":"BACKGROUNDThe vagus nerve (VN), the principal component of the parasympathetic branch of the autonomic nervous system (ANS), mediates bidirec communication between the central nervous system (CNS) and peripheral organs. Vagus nerve stimulation (VNS), delivered through invasive (iVNS) or non-invasive (transcutaneous cervical [tcVNS] and transcutaneous auricular [taVNS]), exerts multimodal effects on multiple circuits and neurotransmitters, and is currently under investigation in movement disorders.OBJECTIVESThis systematic review evaluates the therapeutic potential of VNS in movement disorders (MDs), with a focus on Parkinson's disease (PD), parkinsonism, tremor and essential tremor (ET), cervical dystonia (CD), and Tourette's syndrome (TS).METHODSA systematic search of PubMed, Web of Science, and Scopus was conducted for studies published between 2020 and 2025, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines.RESULTSThirty-two studies met the inclusion criteria: 22 on PD or parkinsonism (14 clinical and 8 preclinical on PD, 1 clinical on multisystem atrophy), 6 on tremor and ET (4 clinical, 2 preclinical), 2 clinical studies on CD, and 1 clinical study on TS. Across conditions, VNS was reported to improve motor and non-motor, enhance synaptic plasticity, modulate neurotransmitter activity relevant to MDs (GABA, norepinephrine, dopamine, and acetylcholine), and reduce neuroinflammation.CONCLUSIONSCurrent evidence supports the multimodal effect of VNS in MDs, particularly in PD, where the most consistent benefits were observed. Non-invasive taVNS represents a promising, safer alternative to iVNS. Larger randomized controlled trials with standardized protocols are needed to validate efficacy, optimize stimulation parameters, and determine long-term clinical and biological impact. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"65 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Blood-Biomarker-Based Assessment of Brain Injury in Patients Undergoing Deep Brain Stimulation and Magnetic Resonance-Guided Focused Ultrasound.","authors":"Justina Dargvainiene,Ann-Kristin Helmers,Juliana Naumann,Carl Alexander Gless,Bettina Möller,Julius Welzel,Frank Leypoldt,Johannes Hensler,Ina Tesseur,Klaus-Peter Wandinger,Günther Deuschl,Daniela Berg,Steffen Paschen","doi":"10.1002/mds.70071","DOIUrl":"https://doi.org/10.1002/mds.70071","url":null,"abstract":"BACKGROUNDDeep brain stimulation (DBS) and magnetic resonance-guided focused ultrasound (MRgFUS) are associated with neuroaxonal damage and astroglial activation; yet their extent and timing remain unclear despite clinical relevance for monitoring and outcome assessment.OBJECTIVEThis study assessed neuroaxonal damage and astroglial activation after DBS (n = 21) and MRgFUS (n = 19) reflected by serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP).METHODSSamples were collected at baseline, 24 h, 7 days, and 3/6/9 months posttreatment. Biomarker levels were measured using a single-molecule array (Simoa).RESULTSsNfL peaked at day 7 and sGFAP at 24 h post-intervention in both groups. sNfL normalized at 6 months in DBS and 3 months in MRgFUS. sGFAP normalized within 7 days in both groups. Biomarker elevations were higher in DBS patients.CONCLUSIONSDBS and MRgFUS cause transient neuroaxonal injury and astroglial activation, with greater extent in DBS. Biomarker monitoring suggests final clinical evaluation should be performed 6 months after treatment at the earliest. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"19 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Indian Age at Onset of Parkinson's: A Case for a Gene-Environment Lens","authors":"Halil Onder MD,&nbsp;Zeynep Pekgoz MD,&nbsp;Mehmet Fevzi Oztekin MD","doi":"10.1002/mds.70055","DOIUrl":"10.1002/mds.70055","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 10","pages":"2285-2286"},"PeriodicalIF":7.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglia Replacement in CSF1R-RD: Current Evidence and Future Priorities","authors":"Tomasz Chmiela MD, PhD,&nbsp;Zbiegniew K. Wszolek MD","doi":"10.1002/mds.70050","DOIUrl":"10.1002/mds.70050","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 10","pages":"2289-2290"},"PeriodicalIF":7.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Long-Read Nanopore Sequencing for Precision Resolution of Genomic Variants in Dystonia.","authors":"Ugo Sorrentino,Martin Pavlov,Nazanin Mirza-Schreiber,Melanie Brugger,Theresa Brunet,Eugenia Tsoma,Alice Saparov,Ivana Dzinovic,Philip Harrer,Antonia M Stehr,Matias Wagner,Erik Tilch,Barbara Wallacher,Shiraz Alhasan,Anne Koy,Alessio Di Fonzo,Miriam Kolnikova,Katarina Kusikova,Petra Havrankova,Raushana Tautanova,Sandy Lösecke,Sebastian Eck,Sylvia Boesch,Jan Necpal,Matej Skorvanek,Robert Jech,Holger Prokisch,Juliane Winkelmann,Konrad Oexle,Elisabeth Graf,Michael Zech","doi":"10.1002/mds.70072","DOIUrl":"https://doi.org/10.1002/mds.70072","url":null,"abstract":"BACKGROUNDAlthough many individuals with dystonia present with features indicative of single-gene etiologies, obtaining definitive genetic diagnoses can be challenging.OBJECTIVEWe assessed the value of nanopore-based long-read sequencing (LRS) in achieving molecular clarification of dystonic syndromes.METHODSFrom a large dystonia cohort with short-read sequencing (SRS) data, 14 cases with unclear, difficult-to-evaluate, or missing causative variants were recruited. Long-read whole-genome sequencing was performed according to Oxford Nanopore Technologies (ONT) protocols.RESULTSONT sequencing produced long-range haplotypes, variant calls inaccessible to short-read technology, as well as methylation data. Phase inference allowed for changes in variant classification, establishing compound heterozygosity of causative variants in four cases. We illustrate an important advantage of LRS compared with SRS in (re)defining the identity of dystonia-causing structural variants and repeat expansions for seven individuals. One patient was found to harbor a novel exonic LINE-1 insertion in SGCE, expanding the genetic mechanism in myoclonus-dystonia. ONT data also provided unexpected insights into apparent mosaic expanded repeats in FMR1 in a subject with isolated focal dystonia. We further showed that LRS outperformed SRS in avoiding erroneous calls resulting from confounding pseudogene sequences and in discovering pathogenic alterations missed by conventional pipeline utilization (three cases). Moreover, simultaneous methylome analysis aided in directing the interpretation of three variants, including a KMT2B variant of uncertain significance that was reclassified as causal by LRS-based episignature profiling.CONCLUSIONSONT-based LRS uniquely improves analysis of dystonia-associated variations that had not previously been resolved by SRS, implying broad utility for future exploration of the molecular origins of the condition. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"7 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}