Pub Date : 2024-01-12DOI: 10.21508/1027-4065-2023-68-6-61-66
A. I. Krapivkin, E. E. Yatskevich, K. V. Osipova
Purpose. The purpose of the publication was to conduct an epidemiological survey for a comprehensive study of the dental status in children with autism spectrum disorder to clarify the areas of medical and social work and the potential scope of dental intervention.Materials and Methods. We examined 98 children with autism spectrum disorders aged 3 to 7 years, 69 of them with temporary and 29 with mixed occlusion. A dental examination of patients was carried out, the state of oral hygiene, carious defects of the teeth, and the state of periodontal tissues were assessed. Results. It is shown that the state of oral hygiene in children with autism spectrum disorder is unsatisfactory. The need for dental care in 85±5.6% of patients was diagnosed; there was a high prevalence (78.6%) of caries of primary teeth against the background of a significant intensity of caries pathology (the share of the “D” component in the overall structure of caries intensity is 81±3.11%); The prevalence of gingivitis was 61%, and the proportion of children with healthy parodontium was 7.14%.Conclusion. The results of the study determine the need to provide children with autism spectrum disorders with qualified dental care and its significant volumes. A set of recommended therapeutic and preventive measures has been proposed, including strengthening oral hygiene with particular regard to the specific characteristics of the underlying disease (emphasis on the motivational factor, transferring manual actions to a game format, using gadgets), strengthening pathogenetic therapy with the daily use of remineralizing drugs, the use of special physical therapeutic techniques (programs) in combination with regular examinations at the dentist and an increase in the intensity of preventive measures.
{"title":"Features of dental status in children with autistic disorders","authors":"A. I. Krapivkin, E. E. Yatskevich, K. V. Osipova","doi":"10.21508/1027-4065-2023-68-6-61-66","DOIUrl":"https://doi.org/10.21508/1027-4065-2023-68-6-61-66","url":null,"abstract":"Purpose. The purpose of the publication was to conduct an epidemiological survey for a comprehensive study of the dental status in children with autism spectrum disorder to clarify the areas of medical and social work and the potential scope of dental intervention.Materials and Methods. We examined 98 children with autism spectrum disorders aged 3 to 7 years, 69 of them with temporary and 29 with mixed occlusion. A dental examination of patients was carried out, the state of oral hygiene, carious defects of the teeth, and the state of periodontal tissues were assessed. Results. It is shown that the state of oral hygiene in children with autism spectrum disorder is unsatisfactory. The need for dental care in 85±5.6% of patients was diagnosed; there was a high prevalence (78.6%) of caries of primary teeth against the background of a significant intensity of caries pathology (the share of the “D” component in the overall structure of caries intensity is 81±3.11%); The prevalence of gingivitis was 61%, and the proportion of children with healthy parodontium was 7.14%.Conclusion. The results of the study determine the need to provide children with autism spectrum disorders with qualified dental care and its significant volumes. A set of recommended therapeutic and preventive measures has been proposed, including strengthening oral hygiene with particular regard to the specific characteristics of the underlying disease (emphasis on the motivational factor, transferring manual actions to a game format, using gadgets), strengthening pathogenetic therapy with the daily use of remineralizing drugs, the use of special physical therapeutic techniques (programs) in combination with regular examinations at the dentist and an increase in the intensity of preventive measures.","PeriodicalId":21550,"journal":{"name":"Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)","volume":"56 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139533098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-12DOI: 10.21508/1027-4065-2023-68-6-41-49
A. Eremeeva, V. Dlin
Currently, there is no unified system of anti-relapse treatment of pyelonephritis in children.Purpose. To assess the feasibility of prescribing and effectiveness of various anti-relapse therapy regimens to prevent exacerbations of the disease in children with chronic secondary pyelonephritis.Materials and Methods. The study involved 158 children with chronic secondary pyelonephritis aged 2 to 14 years, including 130 (82.3%) girls and 28 boys (17.7%). The children were divided into the following groups: Group A (n=32) — furazidine — 14 days, anti-relapse therapy after 12 months; Group B (n=34) — furazidine — 14 days, then — Canephron 1 month, anti–relapse therapy after 12 months; Group C (n=34) — Canephron 3 months, anti-relapse therapy after 12 months; Group D (n=30) — furazidine — 14 days, then — Canephron 1 month of anti–relapse therapy after 6 months; Group E (n=28) — furazidine — 14 days of anti-relapse therapy was not performed. Results. It was found that the recurrence rate of chronic secondary pyelonephritis for a 24-month follow-up in Group A was 28.1% (n=9), in Group B, 14.7% (n=5), in Group C, 20.5% (n=7), in Group D, 10% (n=3), in Group E, 42.9% (n=12). The timing of relapse of chronic secondary pyelonephritis was different, with the largest increase in the proportion of patients with exacerbations in the period from 6 to 12 months. The average recurrence rate per year in the catamnesis in all children (n=158) was 1.4 [1.2–1.6], during the prospective follow-up, a statistically significant (p=0.001) decrease in the recurrence rate to 0.36 [0.2–0.79] was noted. Conclusion. The data obtained confirm the feasibility of anti-relapse therapy in children with chronic secondary pyelonephritis.
{"title":"Anti-relapse therapy in children with chronic secondary pyelonephritis: evaluation of effectiveness and rationale for a differentiated approach","authors":"A. Eremeeva, V. Dlin","doi":"10.21508/1027-4065-2023-68-6-41-49","DOIUrl":"https://doi.org/10.21508/1027-4065-2023-68-6-41-49","url":null,"abstract":"Currently, there is no unified system of anti-relapse treatment of pyelonephritis in children.Purpose. To assess the feasibility of prescribing and effectiveness of various anti-relapse therapy regimens to prevent exacerbations of the disease in children with chronic secondary pyelonephritis.Materials and Methods. The study involved 158 children with chronic secondary pyelonephritis aged 2 to 14 years, including 130 (82.3%) girls and 28 boys (17.7%). The children were divided into the following groups: Group A (n=32) — furazidine — 14 days, anti-relapse therapy after 12 months; Group B (n=34) — furazidine — 14 days, then — Canephron 1 month, anti–relapse therapy after 12 months; Group C (n=34) — Canephron 3 months, anti-relapse therapy after 12 months; Group D (n=30) — furazidine — 14 days, then — Canephron 1 month of anti–relapse therapy after 6 months; Group E (n=28) — furazidine — 14 days of anti-relapse therapy was not performed. Results. It was found that the recurrence rate of chronic secondary pyelonephritis for a 24-month follow-up in Group A was 28.1% (n=9), in Group B, 14.7% (n=5), in Group C, 20.5% (n=7), in Group D, 10% (n=3), in Group E, 42.9% (n=12). The timing of relapse of chronic secondary pyelonephritis was different, with the largest increase in the proportion of patients with exacerbations in the period from 6 to 12 months. The average recurrence rate per year in the catamnesis in all children (n=158) was 1.4 [1.2–1.6], during the prospective follow-up, a statistically significant (p=0.001) decrease in the recurrence rate to 0.36 [0.2–0.79] was noted. Conclusion. The data obtained confirm the feasibility of anti-relapse therapy in children with chronic secondary pyelonephritis.","PeriodicalId":21550,"journal":{"name":"Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)","volume":"5 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139532511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-12DOI: 10.21508/1027-4065-2023-68-6-50-60
O. Chugunova, S. B. Amergulova, L. A. Kovalenko, L. A. Sukhodolova, O. I. Yaroshevskaya, V. Dlin, P. Shumilov
Purpose. The study aims at optimizing the diagnosis of acute kidney injury in children with poisoning of chemical etiology based on the use of early markers of kidney damage.Materials and Methods. The study enrolled 120 patients aged 1–18 years with poisoning of chemical etiology. Routine methods of kidney function estimation were supplemented by an investigation of urinary concentration of acute kidney injury early markers: lipocalin-2, kidney injury molecule-1. All children were hospitalized in a toxicology unit on the 1st day after exposure to toxic substance. Twenty practically healthy children aged 1–18 years were examined as control group.Results. Only one patient (0.8%) had acute kidney injury determined as increased serum creatinine at the time of admission, but at the same time 35 children (29.2%) had increased levels of one or more urinary markers. By the 3rd day 32 of those 35 children with increased urinary markers developed acute kidney injury stages 1 or 2, determined as significant rise of serum creatinine and decrease of renal blood flow according to Doppler ultrasound. On the contrary, no patient with initially normal level of urinary markers developed acute kidney injury. Thus, 32/120 patients hospitalized with poisoning of chemical etiology, developed acute kidney injury (26.7%).Conclusion. Increased urinary excretion of lipocalin-2 and kidney injury molecule-1 at the first day of acute chemical poisoning can be estimated as predictive marker of acute kidney injury development.
{"title":"Early diagnosis of acute kidney injury in children with poisoning of chemical etiology","authors":"O. Chugunova, S. B. Amergulova, L. A. Kovalenko, L. A. Sukhodolova, O. I. Yaroshevskaya, V. Dlin, P. Shumilov","doi":"10.21508/1027-4065-2023-68-6-50-60","DOIUrl":"https://doi.org/10.21508/1027-4065-2023-68-6-50-60","url":null,"abstract":"Purpose. The study aims at optimizing the diagnosis of acute kidney injury in children with poisoning of chemical etiology based on the use of early markers of kidney damage.Materials and Methods. The study enrolled 120 patients aged 1–18 years with poisoning of chemical etiology. Routine methods of kidney function estimation were supplemented by an investigation of urinary concentration of acute kidney injury early markers: lipocalin-2, kidney injury molecule-1. All children were hospitalized in a toxicology unit on the 1st day after exposure to toxic substance. Twenty practically healthy children aged 1–18 years were examined as control group.Results. Only one patient (0.8%) had acute kidney injury determined as increased serum creatinine at the time of admission, but at the same time 35 children (29.2%) had increased levels of one or more urinary markers. By the 3rd day 32 of those 35 children with increased urinary markers developed acute kidney injury stages 1 or 2, determined as significant rise of serum creatinine and decrease of renal blood flow according to Doppler ultrasound. On the contrary, no patient with initially normal level of urinary markers developed acute kidney injury. Thus, 32/120 patients hospitalized with poisoning of chemical etiology, developed acute kidney injury (26.7%).Conclusion. Increased urinary excretion of lipocalin-2 and kidney injury molecule-1 at the first day of acute chemical poisoning can be estimated as predictive marker of acute kidney injury development.","PeriodicalId":21550,"journal":{"name":"Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)","volume":"19 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139532616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-12DOI: 10.21508/1027-4065-2023-68-6-75-84
V. P. Novikova, A. N. Zavyalova, A. L. Balashov, T. Malanicheva, I. Churakova, S. B. Samigullina
The formation of taste preferences and diversity of a child’s diet, as well as the prevention of neophobia, are relevant and discussed issues in clinical practice and scientific literature. A group of authors from St. Petersburg and Kazan conducted a multicenter clinical study to study both food tolerance and taste perception of two complementary feeding products based on goat milk (vegetable and vegetable-grain). We studied eating behavior using a questionnaire and physical development in 92 healthy children aged 8 to 11 months. Statistical processing of the material was carried out using the IBM Stata 12 application package. The assessment of food tolerance showed good results for all products studied. The physical development of children in both regions met the standards both at the beginning of testing and at the end. At the same time, taste perception had regional characteristics, depended on the place of residence of the children and, probably, on the mother’s food preferences during pregnancy for a variety of vegetable and vegetable-grain components of dishes. It should be taken into account when expanding the infant’s diet.
在临床实践和科学文献中，儿童口味偏好的形成和饮食的多样性以及新恐惧症的预防都是相关的讨论问题。来自圣彼得堡和喀山的一组作者开展了一项多中心临床研究，以研究两种基于羊奶的辅食产品（蔬菜和蔬菜谷物）的食物耐受性和味觉感知。我们对 92 名 8 至 11 个月大的健康儿童的饮食行为和身体发育情况进行了问卷调查。我们使用 IBM Stata 12 软件包对材料进行了统计处理。对所研究的所有产品进行的食物耐受性评估均显示出良好的结果。两个地区儿童的体格发育在测试开始和结束时均符合标准。同时，味觉感知具有地区特点，取决于儿童的居住地，也可能取决于母亲在怀孕期间对菜肴中各种蔬菜和蔬菜谷物成分的偏好。在扩大婴儿饮食时应考虑到这一点。
{"title":"Tolerance and taste perception of goat milk-based original complementary food products: results of a multicenter clinical study","authors":"V. P. Novikova, A. N. Zavyalova, A. L. Balashov, T. Malanicheva, I. Churakova, S. B. Samigullina","doi":"10.21508/1027-4065-2023-68-6-75-84","DOIUrl":"https://doi.org/10.21508/1027-4065-2023-68-6-75-84","url":null,"abstract":"The formation of taste preferences and diversity of a child’s diet, as well as the prevention of neophobia, are relevant and discussed issues in clinical practice and scientific literature. A group of authors from St. Petersburg and Kazan conducted a multicenter clinical study to study both food tolerance and taste perception of two complementary feeding products based on goat milk (vegetable and vegetable-grain). We studied eating behavior using a questionnaire and physical development in 92 healthy children aged 8 to 11 months. Statistical processing of the material was carried out using the IBM Stata 12 application package. The assessment of food tolerance showed good results for all products studied. The physical development of children in both regions met the standards both at the beginning of testing and at the end. At the same time, taste perception had regional characteristics, depended on the place of residence of the children and, probably, on the mother’s food preferences during pregnancy for a variety of vegetable and vegetable-grain components of dishes. It should be taken into account when expanding the infant’s diet.","PeriodicalId":21550,"journal":{"name":"Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)","volume":"20 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139532606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-10DOI: 10.21508/1027-4065-2023-68-6-15-23
T. S. Kursova, S. L. Morozov, S. V. Baiko, V. Dlin
Congenital anomalies of the kidney and urinary tract (CAKUT) include a wide range of structural anomalies that develop as a result of impaired morphogenesis of the kidneys and/or urinary tract. CAKUT accounts for about 40–50% of patients under 21 with chronic kidney disease worldwide. Most congenital anomalies of the urinary system are diagnosed in utero or during the first months of a child’s life, which determines further tactics for managing a child, depending on the severity of CAKUT and the degree of decrease in the filtration function of the kidneys. The article provides modern data on the causes of the development of anomalies of the urinary system, provides examples of the development of scientific areas that will be aimed at predicting the occurrence of malformations. In addition, early markers of the disease are considered. Thus, the problem of anomalies of the urinary system remains relevant to the present despite the significant contribution of genetics to understanding the pathogenesis and predicting the development of CAKUT.
{"title":"Genetic aspects of the development of congenital anomalies of the kidney and urinary tract","authors":"T. S. Kursova, S. L. Morozov, S. V. Baiko, V. Dlin","doi":"10.21508/1027-4065-2023-68-6-15-23","DOIUrl":"https://doi.org/10.21508/1027-4065-2023-68-6-15-23","url":null,"abstract":"Congenital anomalies of the kidney and urinary tract (CAKUT) include a wide range of structural anomalies that develop as a result of impaired morphogenesis of the kidneys and/or urinary tract. CAKUT accounts for about 40–50% of patients under 21 with chronic kidney disease worldwide. Most congenital anomalies of the urinary system are diagnosed in utero or during the first months of a child’s life, which determines further tactics for managing a child, depending on the severity of CAKUT and the degree of decrease in the filtration function of the kidneys. The article provides modern data on the causes of the development of anomalies of the urinary system, provides examples of the development of scientific areas that will be aimed at predicting the occurrence of malformations. In addition, early markers of the disease are considered. Thus, the problem of anomalies of the urinary system remains relevant to the present despite the significant contribution of genetics to understanding the pathogenesis and predicting the development of CAKUT.","PeriodicalId":21550,"journal":{"name":"Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)","volume":"60 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-10DOI: 10.21508/1027-4065-2023-68-6-5-14
G. Volynets, A. I. Khavkin, A. Potapov, A. Nikitin
Etiology of autoimmune gastritis, particularly in children, is still unknown. However, the role of Helicobacter pylori and Epstein–Barr virus in the development of autoimmune gastritis is being considered. The formation of autoimmune gastritis is based on an autoimmune reaction mediated by CD4+ T-lymphocytes and the formation of antibodies to gastric parietal cells, the target of which is gastric Н+/К+-АТPase, with subsequent destruction of parietal cells and the development of mucosal atrophy. Autoimmune gastritis is considered a precancerous condition. The clinical picture of autoimmune gastritis in children is not associated with any specific symptoms of the digestive organs. Abdominal pain is uncommon. Specific manifestations of a dyspeptic nature are rare. Often there is a syndrome of chronic nonspecific intoxication. Red blood counts in most children with autoimmune gastritis are within the age norm. Iron deficiency anemia occurs in 13.8% of patients. Vitamin B12 deficiency anemia does not occur in children. Autoantibodies to the parietal cells of the stomach are considered to be a serum marker and diagnostic criterion for autoimmune gastritis in children. Treatment of autoimmune gastritis is aimed at preventing iron and/or vitamin B12 deficiency. No specific methods of treatment have been developed so far. Conclusion. The incidence of autoimmune gastritis in children is underestimated. The role of Helicobacter pylori in autoimmune gastritis has not been confirmed. There is a close correlation of antibodies to gastric parietal cells with Epstein–Barr viral DNA. Due to adverse outcomes and the risk of malignancy, early diagnosis of the disease is important. Atrophic gastritis and intestinal metaplasia are precancerous conditions, although extremely rare in childhood, they should not be neglected.
自身免疫性胃炎，尤其是儿童自身免疫性胃炎的病因尚不清楚。不过，人们正在考虑幽门螺杆菌和 Epstein-Barr 病毒在自身免疫性胃炎发病中的作用。自身免疫性胃炎的形成是基于由 CD4+ T 淋巴细胞介导的自身免疫反应以及胃顶叶细胞抗体的形成，其靶点是胃Н+/К+-АТPase，随后顶叶细胞被破坏，粘膜萎缩。自身免疫性胃炎被认为是一种癌前病变。儿童自身免疫性胃炎的临床表现与消化器官的任何特殊症状无关。腹痛并不常见。消化不良的特殊表现很少见。通常会出现慢性非特异性中毒综合征。大多数患有自身免疫性胃炎的儿童的红细胞计数都在正常年龄范围内。13.8%的患者会出现缺铁性贫血。儿童不会出现维生素B12缺乏性贫血。胃顶叶细胞自身抗体被认为是儿童自身免疫性胃炎的血清标志物和诊断标准。治疗自身免疫性胃炎的目的是预防铁和/或维生素 B12 缺乏症。迄今为止，尚未开发出具体的治疗方法。结论儿童自身免疫性胃炎的发病率被低估了。幽门螺杆菌在自身免疫性胃炎中的作用尚未得到证实。胃顶叶细胞抗体与 Epstein-Barr 病毒 DNA 密切相关。由于存在不良后果和恶性肿瘤的风险，疾病的早期诊断非常重要。萎缩性胃炎和肠化生是癌前病变，虽然在儿童期极为罕见，但不应忽视。
{"title":"Autoimmune gastritis in children","authors":"G. Volynets, A. I. Khavkin, A. Potapov, A. Nikitin","doi":"10.21508/1027-4065-2023-68-6-5-14","DOIUrl":"https://doi.org/10.21508/1027-4065-2023-68-6-5-14","url":null,"abstract":"Etiology of autoimmune gastritis, particularly in children, is still unknown. However, the role of Helicobacter pylori and Epstein–Barr virus in the development of autoimmune gastritis is being considered. The formation of autoimmune gastritis is based on an autoimmune reaction mediated by CD4+ T-lymphocytes and the formation of antibodies to gastric parietal cells, the target of which is gastric Н+/К+-АТPase, with subsequent destruction of parietal cells and the development of mucosal atrophy. Autoimmune gastritis is considered a precancerous condition. The clinical picture of autoimmune gastritis in children is not associated with any specific symptoms of the digestive organs. Abdominal pain is uncommon. Specific manifestations of a dyspeptic nature are rare. Often there is a syndrome of chronic nonspecific intoxication. Red blood counts in most children with autoimmune gastritis are within the age norm. Iron deficiency anemia occurs in 13.8% of patients. Vitamin B12 deficiency anemia does not occur in children. Autoantibodies to the parietal cells of the stomach are considered to be a serum marker and diagnostic criterion for autoimmune gastritis in children. Treatment of autoimmune gastritis is aimed at preventing iron and/or vitamin B12 deficiency. No specific methods of treatment have been developed so far. Conclusion. The incidence of autoimmune gastritis in children is underestimated. The role of Helicobacter pylori in autoimmune gastritis has not been confirmed. There is a close correlation of antibodies to gastric parietal cells with Epstein–Barr viral DNA. Due to adverse outcomes and the risk of malignancy, early diagnosis of the disease is important. Atrophic gastritis and intestinal metaplasia are precancerous conditions, although extremely rare in childhood, they should not be neglected.","PeriodicalId":21550,"journal":{"name":"Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)","volume":"59 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-16DOI: 10.21508/1027-4065-2023-68-5-126-130
R. Khakimova, A. Kamalova, Yu. M. Akhmatova, D. E. Tarasova, N. S. Poliakov, A. R. Khabibullina, A. G. Kuznetsova
Despite the availability of current Russian clinical guidelines for the management of eosinophilic esophagitis, this disease is a difficult diagnostic and therapeutic problem. The article presents a clinical observation of a teenager with recurrent eosinophilic esophagitis. The importance of clarifying the patient’s compliance with an emphasis on adherence to the regimen and the adequacy of the dose of the therapy used is emphasized. Despite the ongoing complex therapy administered to the patient with eosinophilic esophagitis, including an elimination diet, proton pump inhibitors and topical steroids, the patient has relapses of the disease, confirmed endoscopically and morphologically. The absence of a regulated duration of therapy with topical steroids, the need for endoscopic and morphological monitoring of the effectiveness of treatment also complicates the management of this group of patients.
{"title":"Recurrent eosinophilic esophagitis in an adolescent patient","authors":"R. Khakimova, A. Kamalova, Yu. M. Akhmatova, D. E. Tarasova, N. S. Poliakov, A. R. Khabibullina, A. G. Kuznetsova","doi":"10.21508/1027-4065-2023-68-5-126-130","DOIUrl":"https://doi.org/10.21508/1027-4065-2023-68-5-126-130","url":null,"abstract":"Despite the availability of current Russian clinical guidelines for the management of eosinophilic esophagitis, this disease is a difficult diagnostic and therapeutic problem. The article presents a clinical observation of a teenager with recurrent eosinophilic esophagitis. The importance of clarifying the patient’s compliance with an emphasis on adherence to the regimen and the adequacy of the dose of the therapy used is emphasized. Despite the ongoing complex therapy administered to the patient with eosinophilic esophagitis, including an elimination diet, proton pump inhibitors and topical steroids, the patient has relapses of the disease, confirmed endoscopically and morphologically. The absence of a regulated duration of therapy with topical steroids, the need for endoscopic and morphological monitoring of the effectiveness of treatment also complicates the management of this group of patients.","PeriodicalId":21550,"journal":{"name":"Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139268040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-16DOI: 10.21508/1027-4065-2023-68-5-89-94
A. V. Ishbuldina, R. Rakhmaeva, A. Kamalova, D. V. Usova, A. M. Khazieva, A. M. Nigmatullina, M. S. Zainetdinova
The article describes a clinical example of the development of sarcopenic obesity in a child with type IXa glycogen disease. The reasons for the development of sarcopenic obesity were, on the one hand, the lack of control over the child’s nutrition: excess consumption of easily digestible carbohydrates, fats and lack of protein in the actual diet and inactivity due to a child’s motor activity restriction in view of surgical interventions for Perthes’ disease, on the other. The article provides practical recommendations on the example of prescribing diet therapy to a child with a complex combination of type IX glycogenosis, sarcopenic obesity, Perthes disease, and eosinophilic esophagitis.
文章描述了一个患有 IXa 型糖原病的儿童出现肌松性肥胖的临床案例。造成肌松性肥胖的原因一方面是缺乏对患儿营养的控制：在实际饮食中摄入过多易消化的碳水化合物、脂肪和缺乏蛋白质；另一方面是由于对珀尔特氏病进行手术治疗而限制了患儿的运动量。文章以患有 IX 型糖原病、肌肉松弛性肥胖症、珀尔特氏病和嗜酸性食管炎的复杂综合征儿童为例，提供了饮食治疗处方的实用建议。
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Pub Date : 2023-11-16DOI: 10.21508/1027-4065-2023-68-5-138-143
A. Kamalova, G. A. Garina, I. K. Valeeva, A. Gaifutdinova
Calprotectin is a calcium- and zinc-binding protein belonging to the S100 protein family. This protein is found mainly in the cytoplasm of neutrophils, and, to a lesser extent, in monocytes and macrophages, which can be found in any human organs, but mainly in blood, cerebrospinal fluid, feces, saliva, and synovial fluid. Calprotectin is an effective tool forthe differential diagnosis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). There is a connection of fecal calprotectin (FC) with the endoscopic activity of IBD, however, the available literature shows significant differences in the sensitivity and specificity of FC for predicting the endoscopic activity of the disease. In addition, FC can be considered as a predictor of histological mucosal healing and as a marker for assessing the response to treatment, including surgical, but there is still no consensus on the threshold value of a biomarker for these purposes. Conflicting data are presented in reports on FC as a predictor of IBD recurrence. FC seems to be effective for detecting relapse, however, there is no specific threshold value, therefore, the marker cannot completely replace endoscopic examination methods. In addition, there is intraindividual variability in the concentration of FC in patients, depending on age, type of feeding in the first year of life, taking medications, which significantly complicates the interpretation of the results.
钙粘蛋白是一种钙锌结合蛋白，属于 S100 蛋白家族。这种蛋白主要存在于中性粒细胞的细胞质中，其次存在于单核细胞和巨噬细胞中，可在人体任何器官中发现，但主要存在于血液、脑脊液、粪便、唾液和滑液中。钙黏蛋白是鉴别诊断炎症性肠病（IBD）和肠易激综合征（IBS）的有效工具。粪便钙蛋白（FC）与 IBD 的内镜活动有关联，但现有文献显示，FC 预测疾病内镜活动的敏感性和特异性存在显著差异。此外，FC 还可被视为粘膜组织学愈合的预测指标，以及评估治疗（包括手术治疗）反应的标志物，但对于用于这些目的的生物标志物的阈值仍未达成共识。关于 FC 预测 IBD 复发的报告中提供了相互矛盾的数据。FC 似乎对检测复发有效，但没有具体的阈值，因此该标记物不能完全取代内镜检查方法。此外，患者体内的 FC 浓度因年龄、出生后第一年的喂养方式、服用药物等因素而存在个体差异，这使得结果的解释变得非常复杂。
{"title":"Fecal calprotectin as a marker of inflammatory bowel diseases","authors":"A. Kamalova, G. A. Garina, I. K. Valeeva, A. Gaifutdinova","doi":"10.21508/1027-4065-2023-68-5-138-143","DOIUrl":"https://doi.org/10.21508/1027-4065-2023-68-5-138-143","url":null,"abstract":"Calprotectin is a calcium- and zinc-binding protein belonging to the S100 protein family. This protein is found mainly in the cytoplasm of neutrophils, and, to a lesser extent, in monocytes and macrophages, which can be found in any human organs, but mainly in blood, cerebrospinal fluid, feces, saliva, and synovial fluid. Calprotectin is an effective tool forthe differential diagnosis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). There is a connection of fecal calprotectin (FC) with the endoscopic activity of IBD, however, the available literature shows significant differences in the sensitivity and specificity of FC for predicting the endoscopic activity of the disease. In addition, FC can be considered as a predictor of histological mucosal healing and as a marker for assessing the response to treatment, including surgical, but there is still no consensus on the threshold value of a biomarker for these purposes. Conflicting data are presented in reports on FC as a predictor of IBD recurrence. FC seems to be effective for detecting relapse, however, there is no specific threshold value, therefore, the marker cannot completely replace endoscopic examination methods. In addition, there is intraindividual variability in the concentration of FC in patients, depending on age, type of feeding in the first year of life, taking medications, which significantly complicates the interpretation of the results.","PeriodicalId":21550,"journal":{"name":"Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139270513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-16DOI: 10.21508/1027-4065-2023-68-5-131-134
E. A. Kurmaeva, G. A. Kulakova, N. A. Solovieva, S. Y. Volgina, R. V. Ivanov
Neuroblastoma (NB) is a malignant extracranial solid tumor of childhood. The peak incidence occurs in the first year of life. In 50% of cases, the disease already has signs of metastasis at the time of diagnosis. The clinical picture in neuroblastoma is varied; the symptoms are not specific and depend on the localization. The diagnosis is confirmed by histological examination of the biopsy of the primary tumor and metastasis. A specific method for the topical diagnosis of neuroblastoma is 123I-labeled metaiodobenzylguanidine scintigraphy, which makes it possible to detect the primary tumor, the presence of regional and distant metastases. Combinations of high-dose chemotherapy and transplantation of autologous stem cells and differentiating agents, as well as immunotherapy with anti-GD2 monoclonal antibodies, can increase the life expectancy of patients.
{"title":"Diagnostic problems in pediatrics on the example of a clinical case of neuroblastoma","authors":"E. A. Kurmaeva, G. A. Kulakova, N. A. Solovieva, S. Y. Volgina, R. V. Ivanov","doi":"10.21508/1027-4065-2023-68-5-131-134","DOIUrl":"https://doi.org/10.21508/1027-4065-2023-68-5-131-134","url":null,"abstract":"Neuroblastoma (NB) is a malignant extracranial solid tumor of childhood. The peak incidence occurs in the first year of life. In 50% of cases, the disease already has signs of metastasis at the time of diagnosis. The clinical picture in neuroblastoma is varied; the symptoms are not specific and depend on the localization. The diagnosis is confirmed by histological examination of the biopsy of the primary tumor and metastasis. A specific method for the topical diagnosis of neuroblastoma is 123I-labeled metaiodobenzylguanidine scintigraphy, which makes it possible to detect the primary tumor, the presence of regional and distant metastases. Combinations of high-dose chemotherapy and transplantation of autologous stem cells and differentiating agents, as well as immunotherapy with anti-GD2 monoclonal antibodies, can increase the life expectancy of patients.","PeriodicalId":21550,"journal":{"name":"Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)","volume":"69 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139269238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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