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[European Medicines Agency checks metamizole: stronger focus on agranulocytosis but also established use in treatment]. [欧洲药品管理局检查metamizole:更关注粒细胞缺乏症,但也确定用于治疗]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-06-01 Epub Date: 2025-05-22 DOI: 10.1007/s00482-025-00882-w
Claudia Bausewein, Frank Petzke
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引用次数: 0
[The headache questionnaire of the German Migraine and Headache Society (DMKG) : A new tool to improve headache care]. [德国偏头痛和头痛学会(DMKG)头痛问卷:改善头痛护理的新工具]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-06-01 Epub Date: 2025-02-13 DOI: 10.1007/s00482-025-00870-0
Ruth Ruscheweyh, Charly Gaul, Thomas Dresler, Tim Patrick Jürgens, David Lewis, Torsten Kraya, Lars Neeb, Victoria Ruschil, Gudrun Goßrau

To enable state-of-the-art diagnosis, therapy and monitoring of headache disorders, comprehensive history taking is necessary and can be time-consuming. This is facilitated substantially if the patient gathers the needed information beforehand, using a specialized questionnaire. To this end, experts of the German Migraine and Headache Society (DMKG) have developed the DMKG headache questionnaire. It assesses central information such as headache frequency, characteristics, accompanying symptoms and medication, as well as comorbidities and validated scales for psychological cofactors, disability and quality of life. The complete version for a first visit is complemented by a shorter version for follow-up visits and a specialized cluster headache module. For headache care professionals, the DMKG headache questionnaire is free after registration ( https://www.dmkg.de/dmkg-kopfschmerzfragebogen ). It is available for a printout or as fillable PDF and can be combined with the included PDF headache diary or with the DMKG-App (smartphone headache diary). A digital version is in the planning. The DMKG headache questionnaire is an important step towards quality assurance of headache care in Germany.

为了能够对头痛疾病进行最先进的诊断、治疗和监测,全面的病史记录是必要的,而且可能很耗时。如果患者事先使用专门的问卷收集所需的信息,这将大大促进。为此,德国偏头痛和头痛协会(DMKG)的专家开发了DMKG头痛问卷。它评估中心信息,如头痛频率、特征、伴随症状和药物,以及合并症和心理辅助因素、残疾和生活质量的有效量表。第一次访问的完整版本由后续访问的简短版本和专门的丛集头痛模块补充。对于头痛护理专业人员,注册后可免费获得DMKG头痛问卷(https://www.dmkg.de/dmkg-kopfschmerzfragebogen)。它可用于打印输出或可填写的PDF,可与附带的PDF头痛日记或与DMKG-App(智能手机头痛日记)结合使用。一个数字版本正在计划中。DMKG头痛问卷是德国头痛护理质量保证的重要一步。
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引用次数: 0
[Using electricity to combat headache : Electrotherapy and tDCS in the 1870s/1880s and today]. [用电对抗头痛:19世纪70年代/ 80年代和今天的电疗和tDCS]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-06-01 Epub Date: 2023-08-24 DOI: 10.1007/s00482-023-00746-1
Zhenya Wagner, Holger Steinberg

Headache can be a widespread symptom as well as a disorder in itself. Headache syndromes such as migraine cause a lot of distress, disability and overall socioeconomic costs. Pharmacological treatments are often limited in their efficacy as well as due to side effects. The therapeutic application of electricity for this medical indication was a relevant field of research in the 19th century and-in the form of transcranial direct current stimulation (tDCS)-is still widely studied today. This paper provides an overview of publications from the late 19th century (as the era of discovery and success of electrotherapy) as well as contemporary studies investigating the usage of weak currents for the treatment or prophylaxis of headache. Our results show a large number of highly favorable reports of treatment successes. However, the number of cases analysed is often rather small and the forms of electric stimulation applied were often highly heterogeneous. In summary, electric stimulation appears to be a promising field of research and a possible therapeutic agent for the treatment of headaches; however, further research is necessary, especially into the details of the stimulation techniques applied and the various indications in which it may be of use.

头痛不仅是一种疾病,也是一种普遍的症状。偏头痛等头痛综合征会造成许多痛苦、残疾和总体社会经济成本。药物治疗往往在其疗效和副作用有限。在19世纪,将电用于这种医学适应症的治疗应用是一个相关的研究领域,并且以经颅直流电刺激(tDCS)的形式至今仍被广泛研究。本文概述了19世纪晚期(电疗的发现和成功的时代)的出版物,以及调查使用弱电治疗或预防头痛的当代研究。我们的结果显示了大量非常有利的治疗成功的报告。然而,分析的病例数量往往相当少,所采用的电刺激形式往往是高度不一致的。总之,电刺激似乎是一个很有前途的研究领域,也是治疗头痛的一种可能的治疗药物;然而,进一步的研究是必要的,特别是对所应用的刺激技术的细节和它可能使用的各种适应症。
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引用次数: 0
[On "collecting" migraine attacks]. [关于“收集”偏头痛发作]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI: 10.1007/s00482-025-00874-w
Peter Kropp
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引用次数: 0
[An instrument to assess biopsychosocial pain concepts in adults : Development and evaluation by experts]. [成人生物心理社会疼痛概念评估工具:专家开发与评估]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-06-01 Epub Date: 2024-02-13 DOI: 10.1007/s00482-024-00793-2
L Wickering, C Lautwein, A Fiegler, L Allerdißen, T Kloos, M Schneider, T Hechler

Background: The biopsychosocial model is fundamental for the understanding and treatment of chronic pain; however, little research has focused on whether those affected show a biopsychosocial understanding. The multidimensional questionnaire Biopsychosocial Pain Concept Matrix (BiPS matrix) is presented. The conception of the BiPS matrix is based on the biological, psychological and social areas as well as on the common sense model of self-regulation with five dimensions: (1) type of disorder, (2) assumptions on the causes, (3) consequences, (4) duration of the disease and (5) possibilities for control and treatment.

Objective: The present study aims to examine the content relevance and comprehension of the areas, dimensions and items, including the use of the BiPS matrix with children by interdisciplinary expert ratings. The questionnaire can be perspectively used by treating professionals for diagnostic purposes.

Method: In an online study 17 experts were questioned. In addition to descriptive statistics, comments were evaluated using qualitative content analysis according to Mayring.

Results: All experts rated the assessment of pain concepts with the BiPS matrix as well as the areas and dimensions as very relevant. With respect to the items, suggestions were made mainly regarding the wording of the items and adjustments for children.

Discussion: From an expert point of view the BiPS matrix represents a relevant instrument. Further research on the psychometric properties of the BiPS matrix in adults and children is indicated. In addition, the BiPS matrix can also be used to investigate pain concepts of medical and psychotherapeutic professional groups to demonstrate the biopsychosocial understanding of pain and the associated treatment options.

背景:生物-心理-社会模型是理解和治疗慢性疼痛的基础;然而,很少有研究关注受影响者是否表现出对生物-心理-社会的理解。本文介绍了多维问卷生物-心理-社会疼痛概念矩阵(BiPS matrix)。BiPS 矩阵的概念基于生物、心理和社会领域以及自我调节的常识模型,包括五个维度:(1) 疾病类型;(2) 病因假设;(3) 后果;(4) 病程;(5) 控制和治疗的可能性:本研究旨在通过跨学科专家的评分,检查各领域、各维度和各项目内容的相关性和理解程度,包括 BiPS 矩阵在儿童中的使用情况。该问卷可被专业治疗人员用于诊断目的:在一项在线研究中,17 位专家接受了问卷调查。结果:所有专家都对疼痛概念的评估进行了评分:结果:所有专家都认为使用 BiPS 矩阵评估疼痛概念以及领域和维度非常相关。关于项目,专家们主要就项目的措辞和针对儿童的调整提出了建议:讨论:从专家的角度来看,BiPS 矩阵是一个相关的工具。对生物心理学矩阵在成人和儿童中的心理测量特性进行进一步研究是有必要的。此外,BiPS 矩阵还可用于调查医疗和心理治疗专业群体的疼痛概念,以展示生物心理社会学对疼痛的理解以及相关的治疗方案。
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引用次数: 0
[Status survey of Austrian pain clinics 2023 : Impact of the COVID-19 pandemic on pain management services]. [奥地利疼痛诊所现状调查:2019冠状病毒病大流行对疼痛管理服务的影响]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-06-01 Epub Date: 2025-03-17 DOI: 10.1007/s00482-025-00871-z
Sascha Hammer, Anna Krawczyk, Brigitte Messerer, Stefan Neuwersch-Sommeregger, Patrick Reinbacher, Gregor Schittek, Andreas Sandner-Kiesling

Background: According to a 2020 report by the Austrian Pain Society (ÖSG), between 1.5 and 1.8 million people in Austria suffer from chronic pain. For the treatment of these patients, multimodal pain therapy in specialized pain therapy facilities should be considered. This study aimed to analyze the actual postpandemic state of care in pain clinics in 2022 and to show how it has changed in recent years.

Methods: In our survey, the heads or employees of all anesthesiology departments in Austria were asked via SurveyMonkey (SurveyMonkey Inc., San Mateo, CA, USA) using an access code to compare the pre- to postpandemic status of their pain clinics. Only anesthesiology departments were contacted, as pain clinics in Austria are almost entirely run by them. This survey was sent online by email to the heads of Austrian hospitals with an existing pain clinic and was open for completion from autumn 2022 to May 2023.

Results: Of the 109 surveyed clinics, 92 participated in our study. Only 51 currently operate a pain clinic, seven of which are full-time. Nine pain clinics had closed since 2014, while seven new ones have opened. According to our data, only one specialized hospital and two basic care hospitals offer multimodal pain therapy. Invasive procedures were used more often compared to multimodal pain therapy.

Conclusion: Despite the nominal increase of pain clinics in Austria, there is a multifactorial discrepancy between the recommendation of the Austrian Pain Society and the actual care of patients with chronic pain in Austria. Administrative and personnel obstacles must be overcome to meet the needs of this patient group. In addition, efforts to increase the interest of physicians in chronic pain management are needed. Greater support from healthcare policies and effective integration of pain clinics into the healthcare system could help improve the care situation.

背景:根据奥地利疼痛协会(ÖSG) 2020年的一份报告,奥地利有150万至180万人患有慢性疼痛。对于这些患者的治疗,应考虑在专门的疼痛治疗机构进行多模式疼痛治疗。本研究旨在分析2022年大流行后疼痛诊所的实际护理状况,并展示近年来的变化情况。方法:在我们的调查中,通过SurveyMonkey (SurveyMonkey Inc., San Mateo, CA, USA)使用访问码询问奥地利所有麻醉科的负责人或员工,以比较其疼痛诊所在大流行前后的状况。我们只联系了麻醉科,因为奥地利的疼痛诊所几乎完全由麻醉科经营。该调查通过电子邮件在线发送给奥地利现有疼痛诊所的医院负责人,并于2022年秋季至2023年5月开放完成。结果:在109个被调查的诊所中,有92个参与了我们的研究。目前只有51家医院开设了疼痛诊所,其中7家是全职的。自2014年以来,已经关闭了9家疼痛诊所,同时新开了7家。根据我们的数据,只有一家专科医院和两家基础护理医院提供多模式疼痛治疗。与多模式疼痛治疗相比,侵入性手术更常被使用。结论:尽管奥地利疼痛诊所名义上有所增加,但奥地利疼痛协会的建议与奥地利慢性疼痛患者的实际护理之间存在多因素差异。必须克服行政和人员方面的障碍,以满足这一患者群体的需要。此外,还需要努力提高医生对慢性疼痛管理的兴趣。来自医疗政策的更大支持和将疼痛诊所有效地整合到医疗保健系统中可以帮助改善护理状况。
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引用次数: 0
[Fear of migraine attacks: diagnosis and treatment]. [对偏头痛发作的恐惧:诊断和治疗]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-06-01 Epub Date: 2023-04-18 DOI: 10.1007/s00482-023-00711-y
Timo Klan, Anke Diezemann-Prößdorf, Anna-Lena Guth, Charly Gaul, Michael Witthöft

In the field of headache disorders, the term "fear of attacks" refers to the fear of a headache attack occurring. Excessive fear of attacks may worsen the course of a migraine and lead to an increase in migraine activity. In the assessment of attack-related fear, a categorical (fear of attacks as a specific phobia) and a dimensional approach (measuring the extent of fear using a questionnaire) are available. The 29-item Fear of Attacks in Migraine Inventory (FAMI) is an economic self-report questionnaire for the assessment of attack-related fear, and it has good psychometric properties. The treatment of attack-related fear includes behavioral interventions as well as pharmacological therapy. Behavioral interventions have few side effects and are based on the treatment of common anxiety disorders (e.g., agoraphobia). Although the evidence of existing treatments is sparse, attack-related fear should be considered in routine care.

在头痛疾病领域,“害怕发作”一词指的是害怕头痛发作。对偏头痛发作的过度恐惧可能会加重偏头痛的病程,并导致偏头痛活动的增加。在评估与攻击相关的恐惧时,可以使用分类方法(将攻击恐惧作为一种特定的恐惧症)和维度方法(使用问卷来测量恐惧的程度)。29项偏头痛发作恐惧量表(FAMI)是一份经济的评估偏头痛发作相关恐惧的自我报告问卷,具有良好的心理测量特性。攻击相关恐惧的治疗包括行为干预和药物治疗。行为干预几乎没有副作用,并且是基于对常见焦虑症(如广场恐怖症)的治疗。尽管现有治疗方法的证据很少,但在常规护理中应考虑与攻击有关的恐惧。
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引用次数: 0
[Opportunities and risks of advance directives : An appraisal of the practice in Germany after legal regulation in 2009]. [预先指示的机遇与风险:2009 年德国法律规范后的实践评估]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-04-01 Epub Date: 2024-01-02 DOI: 10.1007/s00482-023-00771-0
Christoph G Dietrich, Konrad Schoppmeyer

Background: Living wills/advance directives (AD) are an important tool for specifying patient wishes regarding medical care in the case of future inability to consent. Since 2009, German legislation defines framework conditions for the creation and validity of such directives in § 1901a BGB.

Methods: An extensive literature search in an international and a German-language database was conducted to identify, analyze, and evaluate scientific articles on opportunities, risks, and problems in the creation and implementation of living wills.

Results: Between 10 and 40% of patients have an AD. Among the stipulations in the AD, the demand for sufficient pain therapy is very important. However, numerous problems in the preparation and implementation of ADs reduce their value in everyday clinical practice. In particular, unclear conditions of validity, unspecific instructions for action, and lack of availability of the directives prevent practitioners from determining the patient's will. Other fundamental problems include frequent patient ambivalence and clinical ethical dissent. In addition, the framework condition of unlimited coverage set by the law carries the risk that changes of opinion in the course of life or disease are not taken into account.

Conclusion: Preparing an AD requires a high level of information, consultation, and time, as well as regular review or adjustment of its content. These factors are often not considered, thus complicating implementation and reducing the value of living wills. Possible solutions to these problems or alternative concepts for different patient settings are discussed in this review.

背景:生前预嘱(Advance Directives,AD)是一种重要的工具,可在患者未来无法表示同意的情况下明确其对医疗护理的意愿。自 2009 年起,德国立法在《德国民法典》第 1901a 条中规定了创建此类指令及其有效性的框架条件:在一个国际数据库和一个德语数据库中进行了广泛的文献检索,以确定、分析和评估有关生前预嘱的创建和实施中的机遇、风险和问题的科学文章:10%至 40% 的患者有生前预嘱。在《生前预嘱》的规定中,充分的疼痛治疗要求非常重要。然而,生前预嘱的准备和实施过程中存在的诸多问题降低了其在日常临床实践中的价值。特别是,有效性条件不明确、行动指示不具体以及无法获得指令等问题阻碍了医生确定患者的意愿。其他基本问题还包括患者经常出现的矛盾心理和临床伦理异议。此外,法律规定的无限制覆盖范围的框架条件也有可能使生命或疾病过程中的意见变化得不到考虑:编写 AD 需要大量的信息、咨询和时间,还需要定期审查或调整其内容。这些因素往往没有得到考虑,从而使生前预嘱的执行变得复杂,降低了生前预嘱的价值。本综述讨论了解决这些问题的可能方案或适用于不同患者环境的替代概念。
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引用次数: 0
[Development and validation of a questionnaire to assess physiotherapists' postural-structural-biomechanical-oriented beliefs about pain]. [开发和验证一份问卷,以评估理疗师对疼痛的姿势结构生物力学导向的信念]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-04-01 Epub Date: 2023-10-16 DOI: 10.1007/s00482-023-00757-y
Ahura Bassimtabar, Martin Alfuth

Background: Therapists frequently use the postural-structural-biomechanical (PSB) model in clinical practice to explain the symptom of pain using biomechanical deficits. Adequate knowledge about pain encompasses not only the neurophysiology of pain but also knowledge that existing PSB-oriented explanations of the development and enhancement of pain are outdated. There is no assessment to evaluate physiotherapists' PSB-oriented beliefs about pain.

Aim: The aim of the present study was to develop a questionnaire to assess physiotherapists' PSB-oriented beliefs about pain and to evaluate its reliability (internal consistency), validity, and agreement.

Methods: The Essential Knowledge of Pain Questionnaire (EKPQ) was constructed on the basis of a literature search and discussions between experts. In a pilot study, 32 pupils of a physiotherapy school were then asked to complete the German version of the revised Neurophysiology of Pain Questionnaire (rNPQ-D) and the EKPQ using the SoSci Survey in order to assess their knowledge and beliefs about pain.

Results: The internal consistency of the EKPQ was acceptable with a Cronbach's α = 0.784. There was a strong positive significant correlation between the questionnaires (r = 0.518; p = 0.002). The Bland-Altman analysis revealed a mean difference of 28.9% (± standard deviation of the difference 15.3%) with an upper limit of 95% agreement of 58.8% and a lower limit of 95% agreement of -1.0% between the questionnaires. Participants achieved a mean score of 60.7% in the rNPQ‑D and a mean score of 31.8% in the EKPQ.

Conclusion: The newly developed EKPQ questionnaire seems to be a reliable and valid assessment to determine physiotherapists' PSB-oriented beliefs about pain. The results also confirm that a high level of knowledge about the neurophysiology of pain does not exclude a PSB orientation. Whether the EKPQ can be used alongside the rNPQ as an additional assessment to evaluate beliefs about pain should be investigated in the future with suitable study designs, e.g. Delphi study.

背景:治疗师在临床实践中经常使用姿势结构生物力学(PSB)模型来利用生物力学缺陷来解释疼痛症状。关于疼痛的充分知识不仅包括疼痛的神经生理学,还包括现有的以PSB为导向的对疼痛发展和增强的解释已经过时的知识。没有评估物理治疗师对疼痛的PSB导向信念。目的:本研究的目的是开发一份问卷,以评估理疗师对疼痛的PSB导向信念,并评估其可靠性(内部一致性)、有效性和一致性。方法:在文献检索和专家讨论的基础上,编制疼痛基本知识调查表(EKPQ)。在一项试点研究中,一所物理治疗学校的32名学生被要求使用SoSci调查完成德国版修订的疼痛神经生理学问卷(rNPQ-D)和EKPQ,以评估他们对疼痛的知识和信念。结果:EKPQ的内部一致性与Cronbachα = 0.784。调查问卷之间存在极强的正相关(r = 0.518;p = 0.002)。Bland-Altman分析显示,两份问卷之间的平均差异为28.9%(差异的±标准差15.3%),95%的一致性上限为58.8%,95%的符合性下限为-1.0%。参与者在rNPQ-D中的平均得分为60.7%,在EKPQ中的平均分数为31.8%。结论:新开发的EKPQ问卷似乎是一种可靠有效的评估,可以确定理疗师对疼痛的PSB导向信念。研究结果还证实,对疼痛神经生理学的高水平了解并不排除PSB定向。EKPQ是否可以与rNPQ一起用作评估疼痛信念的额外评估,应在未来采用合适的研究设计进行调查,例如德尔菲研究。
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引用次数: 0
[Drug safety and mandatory reporting]. [药品安全和强制报告]。
IF 1.1 4区 医学 Q3 ANESTHESIOLOGY Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI: 10.1007/s00482-024-00857-3
Christian Behles, Robert Hoffmann, Dennis Lex

The spontaneous reporting system for cases of suspected side effects is a central instrument for detecting possible side effects after a pharmaceutical preparation has received marketing authorization. It provides important information (signals) on the occurrence of rare, previously unknown side effects, on increases in the frequency of known side effects that may also be due to quality defects, or on changes in the type or severity of known side effects. In recent decades, this system has made a significant contribution to the identification of drug-related risks that only arise upon widespread use following approval and to the introduction of appropriate measures to minimize risk.

疑似副作用病例的自发报告系统是在药物制剂获得上市许可后检测可能副作用的核心工具。它提供了以下方面的重要信息(信号):罕见的、以前未知的副作用的发生,可能由质量缺陷引起的已知副作用的频率增加,或已知副作用的类型或严重程度的变化。近几十年来,这一制度对查明只有在批准后广泛使用时才会出现的与药物有关的风险和采取适当措施尽量减少风险作出了重大贡献。
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引用次数: 0
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