{"title":"Front & Back Matter","authors":"J. Fluhr, M. Lane","doi":"10.1159/000520584","DOIUrl":"https://doi.org/10.1159/000520584","url":null,"abstract":"","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"34 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65298653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acknowledgement to the Reviewers","authors":"","doi":"10.1159/000520104","DOIUrl":"https://doi.org/10.1159/000520104","url":null,"abstract":"<br />Skin Pharmacol Physiol 2021;34:375–376","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"31 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138533395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"J. Fluhr, B. Lange‐Asschenfeldt, R. Neubert","doi":"10.1159/000518116","DOIUrl":"https://doi.org/10.1159/000518116","url":null,"abstract":"","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49496745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"J. Fluhr, B. Lange‐Asschenfeldt, R. Neubert","doi":"10.1159/000516580","DOIUrl":"https://doi.org/10.1159/000516580","url":null,"abstract":"","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44956226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"J. Fluhr, B. Lange‐Asschenfeldt, R. Neubert","doi":"10.1159/000516373","DOIUrl":"https://doi.org/10.1159/000516373","url":null,"abstract":"","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49127531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"J. Fluhr, B. Lange‐Asschenfeldt, R. Neubert","doi":"10.1159/000515847","DOIUrl":"https://doi.org/10.1159/000515847","url":null,"abstract":"","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43589744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"J. Fluhr, B. Lange‐Asschenfeldt, R. Neubert","doi":"10.1159/000515488","DOIUrl":"https://doi.org/10.1159/000515488","url":null,"abstract":"","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"1 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41554468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter M. Elias – University of California San Francisco, San Francisco, CA, USA Howard I. Maibach – University of California San Francisco, San Francisco, CA, USA Hassan Mukhtar – University of Wisconsin, Madison, WI, USA Michael S. Roberts – The University of Queensland, Brisbane, QLD, Australia Christian Surber – Spirig Pharma Ltd., Basel, Switzerland Peter C.M. van de Kerkhof – Radboud University, Nijmegen, The Netherlands
Peter M.Elias–加利福尼亚大学旧金山，美国加州旧金山Howard I.Maibach–加利福尼亚大学旧金山，美国加州旧金山Hassan Mukhtar–威斯康星大学，美国威斯康星州麦迪逊Michael S.Roberts–昆士兰大学，澳大利亚昆士兰州布里斯班Christian Surber–Spirig Pharma有限公司，巴塞尔，瑞士Peter C.M.van de Kerkhof–荷兰奈梅亨拉德布大学
{"title":"Contents Vol. 33, 2020","authors":"K. Paepe, B. Lange‐Asschenfeldt, R. Neubert","doi":"10.1159/000515098","DOIUrl":"https://doi.org/10.1159/000515098","url":null,"abstract":"Peter M. Elias – University of California San Francisco, San Francisco, CA, USA Howard I. Maibach – University of California San Francisco, San Francisco, CA, USA Hassan Mukhtar – University of Wisconsin, Madison, WI, USA Michael S. Roberts – The University of Queensland, Brisbane, QLD, Australia Christian Surber – Spirig Pharma Ltd., Basel, Switzerland Peter C.M. van de Kerkhof – Radboud University, Nijmegen, The Netherlands","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"33 1","pages":"I - VI"},"PeriodicalIF":2.7,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000515098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49193635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acknowledgement to the Reviewers","authors":"","doi":"10.1159/000512678","DOIUrl":"https://doi.org/10.1159/000512678","url":null,"abstract":"","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"33 1","pages":"342 - 344"},"PeriodicalIF":2.7,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000512678","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47300919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-05-06DOI: 10.1159/000514321
Jiayi Huang, Yahua Cui, Yanling Yang, Huahua Li, Yi Zhang, Haiju Yang, Shouying Du, Jie Bai
Background: To understand the cumulative effect of topical formulations after medication, evaluate the therapeutic effect of microneedle-assisted (MN-assisted) paeoniflorin-loaded ethosomes (TGP-E), and explore the potential for deep penetration of drugs, this paper uses microdialysis to systematically study the percutaneous pharmacokinetics of TGP-E.
Methods: First, optical coherence tomography (OCT) was used to study the effectiveness of microneedle puncture. Second, a microdialysis method and a UPLC-MS method for determining the amount of paeoniflorin (Pae) in dialysate were established. Finally, the transdermal pharmacokinetics of TGP-E was studied using in vivo microdialysis in rats under the above MN-assisted conditions.
Results: The optimal MN-assisted conditions were obtained at a microneedle length of 500 μm, a pressure of 3 N, and an action time of 3 min. The pharmacokinetic results demonstrated that the maximum drug concentration (Cmax) and the area under the curve (AUC) of the TGP-E gel were higher than the TGP-saline solution gel, and the mean retention time was lower. These indicated that microneedle can promote the entry of the ethosomes into the skin for in vivo experiments and greatly improve the possibility of deep penetration of the water-soluble Pae.
Conclusion: Therefore, the microneedle-ethosomes delivery system is a more ideal means for promoting the deep penetration of Pae. These findings may provide a reference for the combination of multiple penetration-enhancement ways to promote drug absorption, and also provide a new insight to realize the development of novel, safe, and more effective dosage forms and administration routes of drugs.
{"title":"Optical Coherence Tomography and Microdialysis for Microneedle-Mediated Penetration Enhancement Study of Paeoniflorin-Loaded Ethosomes.","authors":"Jiayi Huang, Yahua Cui, Yanling Yang, Huahua Li, Yi Zhang, Haiju Yang, Shouying Du, Jie Bai","doi":"10.1159/000514321","DOIUrl":"https://doi.org/10.1159/000514321","url":null,"abstract":"<p><strong>Background: </strong>To understand the cumulative effect of topical formulations after medication, evaluate the therapeutic effect of microneedle-assisted (MN-assisted) paeoniflorin-loaded ethosomes (TGP-E), and explore the potential for deep penetration of drugs, this paper uses microdialysis to systematically study the percutaneous pharmacokinetics of TGP-E.</p><p><strong>Methods: </strong>First, optical coherence tomography (OCT) was used to study the effectiveness of microneedle puncture. Second, a microdialysis method and a UPLC-MS method for determining the amount of paeoniflorin (Pae) in dialysate were established. Finally, the transdermal pharmacokinetics of TGP-E was studied using in vivo microdialysis in rats under the above MN-assisted conditions.</p><p><strong>Results: </strong>The optimal MN-assisted conditions were obtained at a microneedle length of 500 μm, a pressure of 3 N, and an action time of 3 min. The pharmacokinetic results demonstrated that the maximum drug concentration (Cmax) and the area under the curve (AUC) of the TGP-E gel were higher than the TGP-saline solution gel, and the mean retention time was lower. These indicated that microneedle can promote the entry of the ethosomes into the skin for in vivo experiments and greatly improve the possibility of deep penetration of the water-soluble Pae.</p><p><strong>Conclusion: </strong>Therefore, the microneedle-ethosomes delivery system is a more ideal means for promoting the deep penetration of Pae. These findings may provide a reference for the combination of multiple penetration-enhancement ways to promote drug absorption, and also provide a new insight to realize the development of novel, safe, and more effective dosage forms and administration routes of drugs.</p>","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"34 4","pages":"183-193"},"PeriodicalIF":2.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000514321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38955514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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