Seminars in nephrology最新文献

英文中文

The Importance of Improving Promotion of Kidney Health and Access to Kidney Care: Perspectives From Leaders of Patient Organizations in Honduras 改善促进肾脏健康和获得肾脏护理的重要性：洪都拉斯患者组织领导人的观点。

IF 2.8 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2025-01-01 DOI: 10.1016/j.semnephrol.2025.151600

Marianella Canales Mejia , Daniela Alejandra Ordóñez Quezada , Cristina Valeria Sequeira Navarro , Jossel Ivan Meza Rodriguez , Andrea Nicole Izaguirre Baday

Accessibility to kidney care is an essential component to ensure that patients with chronic kidney disease receive the necessary treatment in a timely and equitable manner. From our perspective as patients and/or leaders of patient organizations, we have observed how geographic, economic, informational, and psychosocial barriers negatively affect timely access to kidney health services, especially in Latin America. Improving access to kidney care is a complex challenge that requires a comprehensive approach, with an inclusive and equitable assertiveness. This includes not only the elimination of inequalities in access to treatments such as dialysis or kidney transplant, which is a reality that affects many patients, especially those in remote rural or low-income areas, but also access to prevention, early detection, and early treatment to prevent kidney failure. Improvements in education and information can make significant gains that benefit all people at risk of, or who suffer from, kidney disease at all stages of advancement, regardless of their location or socioeconomic status. Therefore, policies are needed that focus not only on access to technology and its proper use but also on bringing these solutions to everyone, without forgetting the importance of emotional and psychosocial support, thus humanizing health care. This is a call to action for all actors involved, from health authorities to service providers, medical and scientific societies, and patient organizations, to work together to build a more accessible and equitable kidney health system for all kidney patients.

获得肾脏护理是确保慢性肾脏疾病患者及时和公平地接受必要治疗的重要组成部分。从我们作为患者和/或患者组织领导人的角度来看，我们观察到地理、经济、信息和心理障碍如何对及时获得肾脏保健服务产生负面影响，特别是在拉丁美洲。改善获得肾脏护理的机会是一项复杂的挑战，需要采取全面的方法，具有包容性和公平的自信。这不仅包括消除在获得透析或肾移植等治疗方面的不平等现象，这是影响许多患者，特别是偏远农村或低收入地区患者的现实，而且还包括获得预防、早期发现和早期治疗以预防肾衰竭。改善教育和信息可以取得重大成果，使处于肾病发展各个阶段的所有面临肾病风险或患有肾病的人受益，无论其所在地区或社会经济地位如何。因此，需要制定政策，不仅注重技术的获取及其适当使用，而且注重将这些解决办法带给每个人，同时不忘记情感和社会心理支持的重要性，从而使卫生保健人性化。这是一项行动呼吁，呼吁从卫生当局到服务提供者、医学和科学学会以及患者组织等所有相关行为者共同努力，为所有肾脏患者建立一个更容易获得和公平的肾脏卫生系统。Semin Nephrol 36:x-xx©20XX Elsevier Inc.。版权所有。

{"title":"The Importance of Improving Promotion of Kidney Health and Access to Kidney Care: Perspectives From Leaders of Patient Organizations in Honduras","authors":"Marianella Canales Mejia , Daniela Alejandra Ordóñez Quezada , Cristina Valeria Sequeira Navarro , Jossel Ivan Meza Rodriguez , Andrea Nicole Izaguirre Baday","doi":"10.1016/j.semnephrol.2025.151600","DOIUrl":"10.1016/j.semnephrol.2025.151600","url":null,"abstract":"<div><div>Accessibility to kidney care is an essential component to ensure that patients with chronic kidney disease receive the necessary treatment in a timely and equitable manner. From our perspective as patients and/or leaders of patient organizations, we have observed how geographic, economic, informational, and psychosocial barriers negatively affect timely access to kidney health services, especially in Latin America. Improving access to kidney care is a complex challenge that requires a comprehensive approach, with an inclusive and equitable assertiveness. This includes not only the elimination of inequalities in access to treatments such as dialysis or kidney transplant, which is a reality that affects many patients, especially those in remote rural or low-income areas, but also access to prevention, early detection, and early treatment to prevent kidney failure. Improvements in education and information can make significant gains that benefit all people at risk of, or who suffer from, kidney disease at all stages of advancement, regardless of their location or socioeconomic status. Therefore, policies are needed that focus not only on access to technology and its proper use but also on bringing these solutions to everyone, without forgetting the importance of emotional and psychosocial support, thus humanizing health care. This is a call to action for all actors involved, from health authorities to service providers, medical and scientific societies, and patient organizations, to work together to build a more accessible and equitable kidney health system for all kidney patients.</div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"45 1","pages":"Article 151600"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latin American Dialysis and Renal Transplantation Registry: Updates and Progress 拉丁美洲透析和肾移植登记处：更新和进展。

IF 2.8 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2025-01-01 DOI: 10.1016/j.semnephrol.2025.151602

María Carlota González-Bedat MD, Guillermo Javier Rosa-Diez MD

The Latin American Dialysis and Renal Transplantation Registry, funded in 1991, has collected data on patients on kidney replacement therapy since 1993 in the 20 countries members of the Latin American Society of Nephrology and Hypertension (SLANH). The training of national delegates and the joint cooperation between national societies, SLANH, and Pan American Health Organization has allowed the launch, continuity, and development of national registries. This article summarizes the evolution of the organizational and functional aspects of the Registry until 2022.

拉丁美洲透析和肾移植登记处于1991年获得资助，收集了自1993年以来拉丁美洲肾病和高血压学会（SLANH）的20个成员国中肾替代治疗患者的数据。对国家代表的培训以及各国学会、拉美国家卫生研究所和泛美卫生组织之间的联合合作，使国家登记处得以启动、延续和发展。本文总结了到2022年注册局在组织和职能方面的演变。

引用次数: 0

Multi-Omics Integration in Nephrology: Advances, Challenges, and Future Directions 肾病学中的多组学整合：进展、挑战和未来方向。

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2024-11-01 DOI: 10.1016/j.semnephrol.2025.151584

Afaf Saliba PhD , Yuheng Du MS , Tianqing Feng BS , Lana Garmire PhD

Omics technologies have transformed nephrology, providing deep insights into molecular mechanisms of kidney disease and enabling more precise diagnostic tools, therapeutic strategies, and prognostic markers. Multi-omics data integration, spanning bulk, single-cell, and spatial omics, offers a comprehensive view of kidney biology in health and disease. In this review, we explore methods and challenges for integrating transcriptomic, epigenomic, and spatial data. By combining omics layers, researchers can uncover novel molecular interactions and spatial tissue organization, advancing our understanding of diseases like diabetic kidney disease and autosomal polycystic kidney disease. This integrated approach is reshaping diagnostic and therapeutic strategies in nephrology and is critical for optimizing insights available from spatial and multi-omics analysis.

组学技术已经改变了肾脏病学，为肾脏疾病的分子机制提供了深入的见解，并使更精确的诊断工具、治疗策略和预后标记成为可能。多组学数据集成，跨越体组学、单细胞组学和空间组学，为健康和疾病中的肾脏生物学提供了全面的视角。在这篇综述中，我们探讨了整合转录组学、表观基因组学和空间数据的方法和挑战。通过组合组学层，研究人员可以发现新的分子相互作用和空间组织组织，促进我们对糖尿病肾病和常染色体多囊肾病等疾病的理解。这种综合方法正在重塑肾脏病学的诊断和治疗策略，对于优化空间和多组学分析的见解至关重要。Semin Nephrol 36:x-xx©20xx Elsevier Inc.。版权所有。

引用次数: 0

Multimodal Mass Spectrometry Imaging in Atlas Building: A Review 多模态质谱成像在地图集建设：综述。

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2024-11-01 DOI: 10.1016/j.semnephrol.2025.151578

Kyle A. Vanderschoot BS, Kayle J. Bender BS, Christopher M. De Caro, Kelli A. Steineman, Elizabeth K. Neumann PhD

In the era of precision medicine, scientists are creating atlases of the human body to map cells at the molecular level, providing insight into what fundamentally makes each cell different. In these atlas efforts, multimodal imaging techniques that include mass spectrometry imaging (MSI) have revolutionized the way biomolecules, such as lipids, peptides, proteins, and small metabolites, are visualized in the native spatial context of biological tissue. As such, MSI has become a fundamental arm of major cell atlasing efforts, as it can analyze the spatial distribution of hundreds of molecules in diverse sample types. These rich molecular data are then correlated with orthogonal assays, including histologic staining, proteomics, and transcriptomics, to analyze molecular classes that are not traditionally detected by MSI. Additional computational methods enable further examination of the correlations between biomolecular classes and creation of visualizations that serve as a powerful resource for researchers and clinicians trying to understand human health and disease. In this review, we examine modern multimodal imaging methods and how they contribute to precision medicine and the understanding of fundamental disease mechanisms.

在精准医疗时代，科学家们正在创建人体图谱，以便在分子水平上绘制细胞图谱，从而深入了解每个细胞的根本差异。在这些图谱工作中，包括质谱成像（MSI）在内的多模态成像技术已经彻底改变了生物分子（如脂质、多肽、蛋白质和小代谢物）在生物组织的天然空间背景下的可视化方式。因此，MSI已经成为主要细胞图谱工作的基本武器，因为它可以分析不同样品类型中数百个分子的空间分布。然后将这些丰富的分子数据与正交试验（包括组织学染色、蛋白质组学和转录组学）相关联，以分析传统上MSI无法检测到的分子类别。其他计算方法可以进一步检查生物分子类别之间的相关性，并创建可视化，作为研究人员和临床医生试图了解人类健康和疾病的强大资源。在这篇综述中，我们研究了现代多模态成像方法，以及它们如何有助于精确医学和对基本疾病机制的理解。Semin Nephrol 36:x-xx©20XX Elsevier Inc.。版权所有。

{"title":"Multimodal Mass Spectrometry Imaging in Atlas Building: A Review","authors":"Kyle A. Vanderschoot BS, Kayle J. Bender BS, Christopher M. De Caro, Kelli A. Steineman, Elizabeth K. Neumann PhD","doi":"10.1016/j.semnephrol.2025.151578","DOIUrl":"10.1016/j.semnephrol.2025.151578","url":null,"abstract":"<div><div>In the era of precision medicine, scientists are creating atlases of the human body to map cells at the molecular level, providing insight into what fundamentally makes each cell different. In these atlas efforts, multimodal imaging techniques that include mass spectrometry imaging (MSI) have revolutionized the way biomolecules, such as lipids, peptides, proteins, and small metabolites, are visualized in the native spatial context of biological tissue. As such, MSI has become a fundamental arm of major cell atlasing efforts, as it can analyze the spatial distribution of hundreds of molecules in diverse sample types. These rich molecular data are then correlated with orthogonal assays, including histologic staining, proteomics, and transcriptomics, to analyze molecular classes that are not traditionally detected by MSI. Additional computational methods enable further examination of the correlations between biomolecular classes and creation of visualizations that serve as a powerful resource for researchers and clinicians trying to understand human health and disease. In this review, we examine modern multimodal imaging methods and how they contribute to precision medicine and the understanding of fundamental disease mechanisms.</div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151578"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview: Spatial Metabolomics Review Series 综述：空间代谢组学综述系列。

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2024-11-01 DOI: 10.1016/j.semnephrol.2025.151576

Kumar Sharma MD, Ravi Iyengar PhD

引用次数: 0

Pathology of Chronic Kidney Disease and Spatial Metabolomics 慢性肾脏疾病病理与空间代谢组学。

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2024-11-01 DOI: 10.1016/j.semnephrol.2025.151579

Jeffrey B. Hodgin MD, PhD , Soumya Maity PhD , Matthias Kretzler MD , Kumar Sharma MD

Chronic kidney disease (CKD) has diverse etiologies but exhibits common features in presentation and progression. These include glomerular sclerosis, tubular atrophy, and interstitial fibrosis, often with inflammation and vascular rarefaction. Although these pathologic features have been described in CKD for decades, the molecular drivers of the disease process remain poorly understood. In the era of multiomics and spatial biology, the spatial metabolomics platform could well be a critical technology to guide characterization of the shared cellular programs, capturing the important protective and destructive pathways that ultimately culminate in each of these pathologic features. In this review, we discuss the specific approaches and challenges to developing spatial metabolomics signatures for pathologic features in CKD.

慢性肾脏疾病（CKD）有多种病因，但在表现和进展方面表现出共同的特征。包括肾小球硬化、小管萎缩和间质纤维化，常伴有炎症和血管稀疏。尽管这些病理特征已经在CKD中被描述了几十年，但疾病过程的分子驱动因素仍然知之甚少。在多组学和空间生物学的时代，空间代谢组学平台很可能成为指导共享细胞程序表征的关键技术，捕获最终导致每种病理特征的重要保护性和破坏性途径。在这篇综述中，我们讨论了开发CKD病理特征的空间代谢组学特征的具体方法和挑战。

引用次数: 0

Spatial Metabolomics in Acute Kidney Injury 急性肾损伤的空间代谢组学研究。

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2024-11-01 DOI: 10.1016/j.semnephrol.2025.151580

Guanshi Zhang PhD , W. Brian Reeves MD

Acute kidney injury (AKI) is a common condition linked to increased morbidity, mortality, and substantial health care costs both in the United States and globally. Early diagnosis, prompt intervention, and effective therapeutic management of AKI are vital for improving patient outcomes. Recent advancements in renal imaging and omics technologies have provided new perspectives and deeper insights into kidney injury while also presenting challenges in developing a comprehensive cellular and molecular atlas of the condition. This review focuses on the application of mass spectrometry imaging-based spatial metabolomics in studying ischemia- and toxin-induced AKI in animal models and human patients. Spatial metabolomics offers a deeper understanding of the pathophysiological connections between various processes, such as dysregulated lipid metabolism and the shift from the tricarboxylic acid cycle to glycolytic flux, which contribute to functional impairment and structural damage in AKI. Continued research in renal multimodal imaging and omics is essential to further our understanding of kidney injury from diagnostic, mechanistic, and therapeutic perspectives.

在美国和全球范围内，急性肾损伤（AKI）是一种常见的疾病，与发病率、死亡率增加和大量医疗保健费用有关。AKI的早期诊断、及时干预和有效的治疗管理对于改善患者预后至关重要。肾脏成像和组学技术的最新进展为肾脏损伤提供了新的视角和更深入的见解，同时也提出了开发全面的细胞和分子图谱的挑战。本文综述了基于质谱成像的空间代谢组学在动物模型和人类患者缺血和毒素性AKI研究中的应用。空间代谢组学提供了对各种过程之间的病理生理联系的更深入的理解，例如脂质代谢失调和从三羧酸循环到糖酵解通量的转变，这些过程有助于AKI的功能损伤和结构损伤。肾多模态成像和组学的持续研究对于从诊断、机制和治疗角度进一步了解肾损伤至关重要。Semin Nephrol 36:x-xx©20XX Elsevier Inc.。版权所有。

{"title":"Spatial Metabolomics in Acute Kidney Injury","authors":"Guanshi Zhang PhD , W. Brian Reeves MD","doi":"10.1016/j.semnephrol.2025.151580","DOIUrl":"10.1016/j.semnephrol.2025.151580","url":null,"abstract":"<div><div><span>Acute kidney injury (AKI) is a common condition linked to increased morbidity, mortality, and substantial health care costs both in the United States and globally. Early diagnosis, prompt intervention, and effective therapeutic management of AKI are vital for improving patient outcomes. Recent advancements in renal imaging and </span>omics<span><span><span><span><span> technologies have provided new perspectives and deeper insights into kidney injury while also presenting challenges in developing a comprehensive cellular and molecular atlas of the condition. This review focuses on the application of mass spectrometry imaging-based spatial </span>metabolomics in studying ischemia- and toxin-induced AKI in </span>animal models<span> and human patients. Spatial metabolomics offers a deeper understanding of the pathophysiological connections between various processes, such as dysregulated </span></span>lipid metabolism and the shift from the </span>tricarboxylic acid cycle<span><span> to glycolytic flux, which contribute to functional impairment and structural damage in AKI. Continued research in renal multimodal imaging and </span>omics is essential to further our understanding of kidney injury from diagnostic, mechanistic, and therapeutic perspectives.</span></span></div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151580"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Spatial Metabolomics and Proteomics for Functional Tissue Unit and Single-Cell Resolution 功能性组织单元和单细胞分辨率的空间代谢组学和蛋白质组学的挑战。

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2024-11-01 DOI: 10.1016/j.semnephrol.2025.151583

Kevin J. Zemaitis PhD , Ljiljana Paša-Tolić PhD

In the last decade, advanced developments of mass spectrometry–based assays have made spatial measurements of hundreds of metabolites and thousands of proteins not only possible, but routine. The information obtained from such mass spectrometry imaging experiments traces metabolic events and helps decipher feedback loops across anatomical regions, connecting genetic and metabolic networks that define phenotypes. Herein we overview developments in the field over the past decade, highlighting several case studies demonstrating direct measurement of metabolites, proteins, and proteoforms from thinly sliced tissues at the level of functional tissue units, approaching single-cell levels. Much of this work is feasible due to multidisciplinary team science, and we offer brief perspectives on paths forward and the challenges that persist with adoption and application of these spatial omics techniques at the single-cell level on mammalian kidneys. Data analysis and reanalysis still pose issues that plague spatial omics, but many mass spectrometry imaging platforms are commercially available. With greater harmonization across platforms and rigorous quality control, greater adoption of these platforms will undoubtedly provide major insights in complex diseases.

在过去的十年中，基于质谱分析的先进发展使得数百种代谢物和数千种蛋白质的空间测量不仅成为可能，而且成为常规。从这样的质谱成像实验中获得的信息追踪代谢事件，并帮助破译跨解剖区域的反馈回路，连接定义表型的遗传和代谢网络。在此，我们概述了过去十年来该领域的发展，重点介绍了几个案例研究，这些研究展示了在功能组织单位水平上直接测量薄切片组织中的代谢物、蛋白质和蛋白质形态，接近单细胞水平。由于多学科团队科学，这项工作的大部分是可行的，我们提供了关于在哺乳动物肾脏单细胞水平上采用和应用这些空间组学技术的前进道路和挑战的简要观点。数据分析和再分析仍然是困扰空间组学的问题，但许多质谱成像平台已经商业化。随着平台之间的更大协调和严格的质量控制，这些平台的更广泛采用无疑将为复杂疾病提供重要的见解。Semin Nephrol 36:x-xx©20xx Elsevier Inc.。版权所有。

{"title":"Challenges in Spatial Metabolomics and Proteomics for Functional Tissue Unit and Single-Cell Resolution","authors":"Kevin J. Zemaitis PhD , Ljiljana Paša-Tolić PhD","doi":"10.1016/j.semnephrol.2025.151583","DOIUrl":"10.1016/j.semnephrol.2025.151583","url":null,"abstract":"<div><div><span>In the last decade, advanced developments of mass spectrometry–based assays have made spatial measurements of hundreds of metabolites and thousands of proteins not only possible, but routine. The information obtained from such mass spectrometry imaging experiments traces metabolic events and helps decipher feedback loops across anatomical regions, connecting </span>genetic<span> and metabolic networks<span> that define phenotypes. Herein we overview developments in the field over the past decade, highlighting several case studies demonstrating direct measurement of metabolites, proteins, and proteoforms from thinly sliced tissues at the level of functional tissue units, approaching single-cell levels. Much of this work is feasible due to multidisciplinary team science, and we offer brief perspectives on paths forward and the challenges that persist with adoption and application of these spatial omics<span> techniques at the single-cell level on mammalian kidneys. Data analysis and reanalysis still pose issues that plague spatial omics, but many mass spectrometry imaging platforms are commercially available. With greater harmonization across platforms and rigorous quality control, greater adoption of these platforms will undoubtedly provide major insights in complex diseases.</span></span></span></div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151583"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Metabolomics and Lipidomics in Kidney Disease 肾脏疾病的空间代谢组学和脂质组学。

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2024-11-01 DOI: 10.1016/j.semnephrol.2025.151582

Brittney L. Gorman PhD , Jessica K. Lukowski PhD

Kidney disease is a global health issue that affects over 850 million people, and early detection is key to preventing severe disease and complications. Kidney diseases are associated with complex and dysregulation of lipid metabolism. Spatial metabolomics through mass spectrometry imaging (MSI) enables spatial mapping of the lipids in tissue and includes a variety of techniques that can be used to image lipids. In the kidney, MSI studies often seek to resolve individual functional tissue units such as glomeruli and proximal tubules. Several different MSI techniques, such as matrix-assisted laser desorption/ionization (MALDI) and desorption electrospray ionization (DESI), have been used to characterize lipids and small molecules in chronic kidney disease, acute kidney injury, genetic kidney disease, and cancer. In this review we provide several examples of how spatial metabolomics data can provide critical information concerning the localization of changes in various disease states. Additionally, when combined with pathology, transcriptomics, or proteomics, the metabolomic changes can illuminate underlying mechanisms and provide new clinical insights into disease mechanisms.

肾脏疾病是一个影响超过8.5亿人的全球健康问题，早期发现是预防严重疾病和并发症的关键。肾脏疾病与脂质代谢的复杂和失调有关。通过质谱成像（MSI）的空间代谢组学能够对组织中的脂质进行空间测绘，并包括各种可用于脂质成像的技术。在肾脏中，MSI研究通常寻求解决单个功能组织单位，如肾小球和近端小管。几种不同的MSI技术，如基质辅助激光解吸/电离（MALDI）和解吸电喷雾电离（DESI），已被用于表征慢性肾脏疾病、急性肾损伤、遗传性肾脏疾病和癌症中的脂质和小分子。在这篇综述中，我们提供了几个例子，说明空间代谢组学数据如何提供有关各种疾病状态变化定位的关键信息。此外，当与病理学、转录组学或蛋白质组学相结合时，代谢组学的变化可以阐明潜在的机制，并为疾病机制提供新的临床见解。Semin Nephrol 36:x-xx©20xx Elsevier Inc.。版权所有。

{"title":"Spatial Metabolomics and Lipidomics in Kidney Disease","authors":"Brittney L. Gorman PhD , Jessica K. Lukowski PhD","doi":"10.1016/j.semnephrol.2025.151582","DOIUrl":"10.1016/j.semnephrol.2025.151582","url":null,"abstract":"<div><div><span><span><span>Kidney disease is a global health issue that affects over 850 million people, and early detection is key to preventing severe disease and complications. Kidney diseases are associated with complex and dysregulation of </span>lipid metabolism<span>. Spatial metabolomics<span> through mass spectrometry imaging<span><span> (MSI) enables spatial mapping of the lipids<span> in tissue and includes a variety of techniques that can be used to image lipids. In the kidney, MSI studies often seek to resolve individual functional tissue units such as glomeruli and proximal tubules. Several different </span></span>MSI techniques, such as matrix-assisted laser desorption/ionization (MALDI) and </span></span></span></span>desorption electrospray ionization<span><span><span> (DESI), have been used to characterize lipids and small molecules in </span>chronic kidney disease, </span>acute kidney injury, </span></span>genetic<span><span><span> kidney disease, and cancer. In this review we provide several examples of how spatial metabolomics data can provide critical information concerning the localization of changes in various disease states. Additionally, when combined with pathology, </span>transcriptomics, or </span>proteomics, the metabolomic changes can illuminate underlying mechanisms and provide new clinical insights into disease mechanisms.</span></div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151582"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Glycomics and Kidney Disease 空间糖组学与肾脏疾病。

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology

Pub Date : 2024-11-01 DOI: 10.1016/j.semnephrol.2025.151581

Dušan Veličković PhD, Christopher R. Anderton PhD

Glycans are critical for the kidney's physiological and pathological cellular functions, and our ability to see their spatial distributions within tissues has helped us reveal how these carbohydrate moieties are involved in many of these processes. This review discusses the role of different types of glycans in kidney biology and disease, common approaches used for glycan imaging, and how glycan imaging has helped us better understand kidney pathology. We mainly focus on emerging methods using mass spectrometry imaging (MSI) because this technology is untargeted and provides complete information on glycan composition compared to the other methods, such as lectin and metabolite labeling, which are targeted and often inform only on the specific part of a glycan structure. We especially focus on protein N-glycosylation, as this is one of the most common post-translational modifications, and these moieties play a vital role in renal structure and function. The recent advancements in MSI of N-glycans we reviewed have provided new insights into the pathophysiology of the kidney and paved the way for clinical application.

聚糖对于肾脏的生理和病理细胞功能至关重要，我们能够看到它们在组织内的空间分布，这有助于我们揭示这些碳水化合物部分是如何参与这些过程的。本文讨论了不同类型的聚糖在肾脏生物学和疾病中的作用，常用的聚糖成像方法，以及聚糖成像如何帮助我们更好地了解肾脏病理。我们主要关注使用质谱成像（MSI）的新兴方法，因为这种技术是非靶向的，与其他方法（如凝集素和代谢物标记）相比，它提供了关于聚糖组成的完整信息，这些方法是靶向的，通常只提供聚糖结构的特定部分。我们特别关注蛋白质n -糖基化，因为这是最常见的翻译后修饰之一，这些部分在肾脏结构和功能中起着至关重要的作用。我们回顾了n -聚糖MSI的最新进展，为肾脏病理生理学提供了新的见解，并为临床应用铺平了道路。Semin Nephrol 36:x-xx©20xx Elsevier Inc.。版权所有。

{"title":"Spatial Glycomics and Kidney Disease","authors":"Dušan Veličković PhD, Christopher R. Anderton PhD","doi":"10.1016/j.semnephrol.2025.151581","DOIUrl":"10.1016/j.semnephrol.2025.151581","url":null,"abstract":"<div><div><span>Glycans<span> are critical for the kidney's physiological and pathological cellular functions, and our ability to see their spatial distributions within tissues has helped us reveal how these carbohydrate moieties are involved in many of these processes. This review discusses the role of different types of glycans in kidney biology and disease, common approaches used for glycan imaging, and how glycan imaging has helped us better understand kidney pathology. We mainly focus on emerging methods using mass spectrometry imaging<span> (MSI) because this technology is untargeted and provides complete information on glycan composition compared to the other methods, such as lectin and metabolite labeling, which are targeted and often inform only on the specific part of a glycan structure. We especially focus on protein </span></span></span><em>N</em>-glycosylation, as this is one of the most common post-translational modifications, and these moieties play a vital role in renal structure and function. The recent advancements in MSI of <em>N</em><span>-glycans we reviewed have provided new insights into the pathophysiology of the kidney and paved the way for clinical application.</span></div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151581"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Seminars in nephrology

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀