Shinjiro Yamamoto, Y. Sonoda, T. Kataoka, S. Hayashi, H. Miyasaka
We report here on hydrophobic ionic liquids (ILs) which enhance the productivity of paclitaxel and the related taxanes of 10-deacetyl baccatin III, baccatin III and cepharomannine with in situ extraction from an aqueous medium in the suspension cell culture of Taxus cuspidata in the IL-medium two phase culture system. Two aliphatic ILs of N-methyl-n-propylpiperidinium bis(trifluoromethane-sulfonyl)imide (PP13-TFSI) and N-methyl-n-butylpyrrolidinium bis(trifluoromethanesulfonyl)imide (P14-TFSI) were used. It was found that the two ILs had no cytotoxicity and enhanced productivity of paclitaxel and the related taxanes in the cell culture. In particular, the more hydrophobic P14-TFSI, which enhanced the productivity of paclitaxel and the total taxanes by a factor of more than 2 compared to PP13-TFSI, could be an effective extractant.
{"title":"Enhanced Productivity of Paclitaxel and Related Taxanes in Plant Cell Culture Including Aliphatic Ionic Liquids","authors":"Shinjiro Yamamoto, Y. Sonoda, T. Kataoka, S. Hayashi, H. Miyasaka","doi":"10.15261/SERDJ.25.125","DOIUrl":"https://doi.org/10.15261/SERDJ.25.125","url":null,"abstract":"We report here on hydrophobic ionic liquids (ILs) which enhance the productivity of paclitaxel and the related taxanes of 10-deacetyl baccatin III, baccatin III and cepharomannine with in situ extraction from an aqueous medium in the suspension cell culture of Taxus cuspidata in the IL-medium two phase culture system. Two aliphatic ILs of N-methyl-n-propylpiperidinium bis(trifluoromethane-sulfonyl)imide (PP13-TFSI) and N-methyl-n-butylpyrrolidinium bis(trifluoromethanesulfonyl)imide (P14-TFSI) were used. It was found that the two ILs had no cytotoxicity and enhanced productivity of paclitaxel and the related taxanes in the cell culture. In particular, the more hydrophobic P14-TFSI, which enhanced the productivity of paclitaxel and the total taxanes by a factor of more than 2 compared to PP13-TFSI, could be an effective extractant.","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"72 1","pages":"125-130"},"PeriodicalIF":0.7,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79408521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Sugita, Iori Fujiwara, H. Okamura, T. Oshima, Y. Baba, H. Naganawa, K. Shimojo
Tsuyoshi SUGITA1, Iori FUJIWARA1,2, Hiroyuki OKAMURA1, Tatsuya OSHIMA2, Yoshinari BABA2, Hirochika NAGANAWA1 and Kojiro SHIMOJO1,* 1Advance Science Research Center, Japan Atomic Energy Agency (JAEA), 2-4 Shirakata, Tokai-mura, Ibaraki 319-1195, Japan; 2Department of Applied Chemistry, University of Miyazaki, 1-1 Gakuen Kibanadai Nishi, Miyazaki 889-2192, Japan (Received December 28, 2016; Accepted March 3, 2017)
{"title":"A Comprehensive Extraction Study Using a Mono-alkylated Diglycolamic Acid Extractant: Comparison Between a Secondary Amide Group and a Tertiary Amide Group","authors":"T. Sugita, Iori Fujiwara, H. Okamura, T. Oshima, Y. Baba, H. Naganawa, K. Shimojo","doi":"10.15261/SERDJ.24.61","DOIUrl":"https://doi.org/10.15261/SERDJ.24.61","url":null,"abstract":"Tsuyoshi SUGITA1, Iori FUJIWARA1,2, Hiroyuki OKAMURA1, Tatsuya OSHIMA2, Yoshinari BABA2, Hirochika NAGANAWA1 and Kojiro SHIMOJO1,* 1Advance Science Research Center, Japan Atomic Energy Agency (JAEA), 2-4 Shirakata, Tokai-mura, Ibaraki 319-1195, Japan; 2Department of Applied Chemistry, University of Miyazaki, 1-1 Gakuen Kibanadai Nishi, Miyazaki 889-2192, Japan (Received December 28, 2016; Accepted March 3, 2017)","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"23 1","pages":"61-69"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74311588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Solvent extraction of valuable metals such as copper and nickel is often carried out from ammoniacal alkaline solutions with chelating extractants, during which coextraction of ammonia is inevitable. In the present study, as a basis of modeling of the whole ammoniacal extraction process, the equilibrium distribution ratios of ammonia between a 3 mol L-1 ammonium nitrate solution and LIX84I (the active component of which is 2-hydroxy-5-nonylacetophenone oxime, HR) dissolved in a nonpolar diluent were measured as a function of pH and LIX84I concentration at 298 K. We successfully modeled the measurement results by assuming the formation of two associated species, (HR)n・(NH3) and (HR・NH3)n, the aggregation of HR, and the dissociation of NH4. Fourier transform infrared spectroscopy results suggested that ammonia was extracted via hydrogen bonding with HR, and these results were in accord with the proposed equilibrium model.
{"title":"Modeling of Equilibria for the Solvent Extraction of Ammonia with LIX84I","authors":"Shubin Wang, Jie Li, H. Narita, Mikiya Tanaka","doi":"10.15261/SERDJ.24.71","DOIUrl":"https://doi.org/10.15261/SERDJ.24.71","url":null,"abstract":"Solvent extraction of valuable metals such as copper and nickel is often carried out from ammoniacal alkaline solutions with chelating extractants, during which coextraction of ammonia is inevitable. In the present study, as a basis of modeling of the whole ammoniacal extraction process, the equilibrium distribution ratios of ammonia between a 3 mol L-1 ammonium nitrate solution and LIX84I (the active component of which is 2-hydroxy-5-nonylacetophenone oxime, HR) dissolved in a nonpolar diluent were measured as a function of pH and LIX84I concentration at 298 K. We successfully modeled the measurement results by assuming the formation of two associated species, (HR)n・(NH3) and (HR・NH3)n, the aggregation of HR, and the dissociation of NH4. Fourier transform infrared spectroscopy results suggested that ammonia was extracted via hydrogen bonding with HR, and these results were in accord with the proposed equilibrium model.","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"160 1","pages":"71-76"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86733962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhanced Extraction of Tris(pentane-2,4-dionato)cobalt(III) in Supercritical Carbon Dioxide/Water Systems by Association with Fluorinated Phenols","authors":"Ohashi Akira, Shiratori Kiyohiro, Kim Haeng‐Boo","doi":"10.15261/SERDJ.24.1","DOIUrl":"https://doi.org/10.15261/SERDJ.24.1","url":null,"abstract":"","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"70 1","pages":"10"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88866666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Xingbin, Liu Daijun, Ji Junyi, C. Jianjun, Yang Tao
An ultrasound-assisted extraction (UAE) method was developed for the extraction of Fe (III) from wet-process phosphoric acid with di (2-ethylhexyl) phosphoric acid (D2EHPA). The influences of UAE parameters, including ultrasonic power, extraction time, concentration of D2EHPA and extraction temperature, were systematically studied. The response surface methodology, a statistical technique, was used to obtain the optimal conditions and evaluate the significance of variables affecting the extraction efficiency of the UAE. It was found that ultrasound could markedly improve the extraction rate of Fe (III) with D2EHPA, the largest improvement is up to 7 times compared with the traditional solvent extraction method. However, the extraction equilibrium of the extraction system was not affected by ultrasound. It is believed that the cavitation effect of ultrasound, along with the increased interfacial surface area, contribute to the enhancement of the extraction rate.
{"title":"Ultrasound-assisted Extraction of Fe(III) from Wet-process Phosphoric Acid","authors":"Li Xingbin, Liu Daijun, Ji Junyi, C. Jianjun, Yang Tao","doi":"10.15261/SERDJ.24.11","DOIUrl":"https://doi.org/10.15261/SERDJ.24.11","url":null,"abstract":"An ultrasound-assisted extraction (UAE) method was developed for the extraction of Fe (III) from wet-process phosphoric acid with di (2-ethylhexyl) phosphoric acid (D2EHPA). The influences of UAE parameters, including ultrasonic power, extraction time, concentration of D2EHPA and extraction temperature, were systematically studied. The response surface methodology, a statistical technique, was used to obtain the optimal conditions and evaluate the significance of variables affecting the extraction efficiency of the UAE. It was found that ultrasound could markedly improve the extraction rate of Fe (III) with D2EHPA, the largest improvement is up to 7 times compared with the traditional solvent extraction method. However, the extraction equilibrium of the extraction system was not affected by ultrasound. It is believed that the cavitation effect of ultrasound, along with the increased interfacial surface area, contribute to the enhancement of the extraction rate.","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"2 1","pages":"22"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81868463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fukiko Kubota, Eiko Shigyo, Wataru Yoshida, M. Goto
{"title":"Extraction and Separation of Pt and Pd by an Imidazolium-Based Ionic Liquid Combined with Phosphonium Chloride","authors":"Fukiko Kubota, Eiko Shigyo, Wataru Yoshida, M. Goto","doi":"10.15261/SERDJ.24.97","DOIUrl":"https://doi.org/10.15261/SERDJ.24.97","url":null,"abstract":"","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"18 1","pages":"97-104"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72713046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xing Li, Jun Li, Jianhong Luo, Yang Jin, Da-Jiang Zou
{"title":"Purification of Wet Process Phosphoric Acid by Solvent Extraction using Cyclohexanol","authors":"Xing Li, Jun Li, Jianhong Luo, Yang Jin, Da-Jiang Zou","doi":"10.15261/SERDJ.24.23","DOIUrl":"https://doi.org/10.15261/SERDJ.24.23","url":null,"abstract":"","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"24 1","pages":"23-35"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86701340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Extraction selectivity of In (III) and Ga (III) was investigated using 2-ethylhexyl thioglycolate (EHTG) with a thiol group and an oxygen atom to recover these metals from zinc refinery residue and waste solar panels. The extraction order with EHTG was Cu(II)>In(III)>Ga(III)>Zn(II), while Al (III) was hardly extracted at all. While In(III) and Ga(III) were not extracted at all with 1-dodecanethiol (DDT) with contains only a thiol group although Zn (II) and Cu (II) were extracted. This indicates that the oxygen atom in the EHTG ester plays an important role in the extraction of these metals. The mutual separation of In(III), Ga(III), Zn(II) and Cu(II) is possible in almost one step with EHTG. The extraction equilibria of In(III) and Ga(III) with EHTG are also discussed. Furthermore, the stripping of In(III) and Ga(III) extracted into the organic phase was achieved using appropriate concentrations of NaOH and acids.
研究了含巯基和氧原子的2-乙基己基硫代糖酸酯(EHTG)对锌精炼厂废渣和废太阳能电池板中铟(III)和镓(III)的萃取选择性。EHTG萃取顺序为Cu(II)>In(III)>Ga(III)>Zn(II)， Al (III)几乎不被萃取。而仅含一个硫基的1-十二烷硫醇(DDT)则完全不能提取In(III)和Ga(III)，但可以提取Zn (II)和Cu (II)。这表明EHTG酯中的氧原子在这些金属的提取中起着重要的作用。In(III)， Ga(III)， Zn(II)和Cu(II)的相互分离几乎可以在EHTG的一个步骤中实现。讨论了用EHTG萃取In(III)和Ga(III)的平衡。此外，在适当浓度的NaOH和酸的作用下，将萃取的In(III)和Ga(III)溶出到有机相中。
{"title":"Selective Extraction of Indium(III) and Gallium(III) with 2-Ethylhexyl Thioglycolate","authors":"Rieko Miura, Megumi Tokumaru, T. Oshima, Y. Baba","doi":"10.15261/SERDJ.24.123","DOIUrl":"https://doi.org/10.15261/SERDJ.24.123","url":null,"abstract":"Extraction selectivity of In (III) and Ga (III) was investigated using 2-ethylhexyl thioglycolate (EHTG) with a thiol group and an oxygen atom to recover these metals from zinc refinery residue and waste solar panels. The extraction order with EHTG was Cu(II)>In(III)>Ga(III)>Zn(II), while Al (III) was hardly extracted at all. While In(III) and Ga(III) were not extracted at all with 1-dodecanethiol (DDT) with contains only a thiol group although Zn (II) and Cu (II) were extracted. This indicates that the oxygen atom in the EHTG ester plays an important role in the extraction of these metals. The mutual separation of In(III), Ga(III), Zn(II) and Cu(II) is possible in almost one step with EHTG. The extraction equilibria of In(III) and Ga(III) with EHTG are also discussed. Furthermore, the stripping of In(III) and Ga(III) extracted into the organic phase was achieved using appropriate concentrations of NaOH and acids.","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"49 1","pages":"123-130"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86014393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
2, 2017) The formation and aggregation of the Pd(II) complex with 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (HL) at the heptane-water interface was investigated by UV-vis absorption and resonance Raman spectrometry using the centrifugal liquid membrane (CLM) method. The interfacial aggregate had an absorption maximum wavelength at 488 nm, showing a hypsochromic shift from the absorption maximum wavelength at 580 nm of the complex monomer (PdLCl). The critical aggregation concentration of PdLCl was determined to be 2.6 10 -10 mol cm -2 . The observed UV-vis absorption and resonance Raman spectra implied that the ligand in the interfacial aggregate was mainly in the state of azo form, because the spectra were very similar to those of the PdLCl complex obtained in a low-polarity solvent
2, 2017)采用离心液膜(CLM)方法，采用紫外-可见吸收和共振拉曼光谱法研究了Pd(II)与2-(5-溴-2-吡啶偶氮)-5-二乙基氨基苯酚(HL)配合物在庚烷-水界面的形成和聚集。界面聚集体的最大吸收波长为488 nm，与络合单体(PdLCl)的最大吸收波长580 nm相比发生了次色移。PdLCl的临界聚集浓度为2.610 -10 mol cm -2。紫外-可见吸收光谱和共振拉曼光谱与低极性溶剂中得到的PdLCl配合物的光谱非常相似，表明界面聚集体中的配体主要处于偶氮态
{"title":"Structural Evaluation of the Aggregate of Palladium(II)-Pyridylazophenol Complex at the Heptane-Water Interface by the Centrifugal Liquid Membrane Method","authors":"A. Ohashi, Takafusa Kiminarita, H. Watarai","doi":"10.15261/SERDJ.24.105","DOIUrl":"https://doi.org/10.15261/SERDJ.24.105","url":null,"abstract":"2, 2017) The formation and aggregation of the Pd(II) complex with 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (HL) at the heptane-water interface was investigated by UV-vis absorption and resonance Raman spectrometry using the centrifugal liquid membrane (CLM) method. The interfacial aggregate had an absorption maximum wavelength at 488 nm, showing a hypsochromic shift from the absorption maximum wavelength at 580 nm of the complex monomer (PdLCl). The critical aggregation concentration of PdLCl was determined to be 2.6 10 -10 mol cm -2 . The observed UV-vis absorption and resonance Raman spectra implied that the ligand in the interfacial aggregate was mainly in the state of azo form, because the spectra were very similar to those of the PdLCl complex obtained in a low-polarity solvent","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"135 1","pages":"105-111"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87137903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Matsumoto, M. Shibazaki, Ryohei Yuasa, Kazuo Kondo
3-Hydroxypropionic acid (3-HP) is an isomer of 2-hydroxypropionic acid (2-HP) and an important platform molecule. A biological production route of 3-HP has become of interest as a sustainable alternative to the chemical route. However, its hydrophilic property makes the separation of 3-HP from the fermentation broth difficult. In this study, reactive solvent extraction and an aqueous two phase system (ATPS) were utilized to extract 3-HP from an aqueous solution. In the reactive extraction system, synergism, which was found in the reactive extraction of 2-HP, was not observed with mixed extractants of TBP and TOA diluted in heptane. TOA diluted in 1-octanol gave the highest extractability in the reactive extraction system. There was little effect on the extractability of 3-HP by the addition of salt to the system. In an ATPS composed of alcohols and salts, binodal curves and tie lines were measured, and then 3-HP was extracted with the ATPS. The highest extractability and distribution ratio were obtained by using an ATPS composed of t-BuOH and Na2SO4. The maximum distribution ratios in both systems were similar.
{"title":"Salting-out Extraction of 3-Hydroxypropionic Acid with Reactive Extraction and Aqueous Two-phase Systems","authors":"M. Matsumoto, M. Shibazaki, Ryohei Yuasa, Kazuo Kondo","doi":"10.15261/SERDJ.24.141","DOIUrl":"https://doi.org/10.15261/SERDJ.24.141","url":null,"abstract":"3-Hydroxypropionic acid (3-HP) is an isomer of 2-hydroxypropionic acid (2-HP) and an important platform molecule. A biological production route of 3-HP has become of interest as a sustainable alternative to the chemical route. However, its hydrophilic property makes the separation of 3-HP from the fermentation broth difficult. In this study, reactive solvent extraction and an aqueous two phase system (ATPS) were utilized to extract 3-HP from an aqueous solution. In the reactive extraction system, synergism, which was found in the reactive extraction of 2-HP, was not observed with mixed extractants of TBP and TOA diluted in heptane. TOA diluted in 1-octanol gave the highest extractability in the reactive extraction system. There was little effect on the extractability of 3-HP by the addition of salt to the system. In an ATPS composed of alcohols and salts, binodal curves and tie lines were measured, and then 3-HP was extracted with the ATPS. The highest extractability and distribution ratio were obtained by using an ATPS composed of t-BuOH and Na2SO4. The maximum distribution ratios in both systems were similar.","PeriodicalId":21805,"journal":{"name":"Solvent Extraction Research and Development, Japan","volume":"34 1","pages":"141-147"},"PeriodicalIF":0.7,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73124407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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