L. Wei, W. Wee, Julius Yong Fu Siong, Desy Fitrya Syamsumir
This study was carried out to characterize antimicrobial, antioxidant and anticancer activities of Michelia champaca seed and flower extracts. The main objective of the present study was to reveal the medicinal values of M. champaca seed and flower for human uses. Antimicrobial property of M. champaca seed and flower extracts were revealed by using two fold microdilution method whereas antioxidant activity of the extract was determined with DPPH radical scavenging method. The anticancer property of the plant extract was revealed through Colorimetric MTT (tetrazolium) assay. The minimum inhibitory concentration values of M. champaca seed and flower extracts ranged from 15.6 to 125mg/l and 7.8 to 62.5mg/l, respectively in which both of the plant extracts were found can inhibit the growth of all the tested bacterial isolates namely A. hydrophila, E. tarda, E. coli, Flavobacterium sp., Klebsiella sp., P. aeruginosa, Salmonella sp., V. alginolyticus, V. cholerae and V. parahaemolyticus. M. champaca flower extract was able to control the growth of E. tarda, E. coli, Flavobacterium sp., P. aeruginosa and V. cholerae at the concentration of 7.8mg/l whereas A. hydrophila, Klebsiella sp. and V. alginolyticus were failed to grow at the concentration 15.6mg/l. The M. champaca flower extract was also able to control the growth of Salmonella sp. and V. parahaemolyticus at the concentration of 62.5mg/l. At the maximum concentration of M. champaca seed and flower extracts were found can inhibit only 40% of DPPH whereas the IC50 value of M. champaca seed and flower extract against MCF-7 cells was 1.98 ±0.31μg/ml and 1.86 ± 0.21μg/ml, respectively. A total of 9 chemical compounds were successfully identified in M. champaca’s flower extract whereas 37 chemical compounds were found in the leaf extract. The findings of the present study indicated that medicinal values of M. champaca seed & flower extracts in terms of antimicrobial and anticancer are promising. Key words: Antioxidant; Anticancer; Antimicrobial; Chemical compound; Michelia champaca DOI: http://dx.doi.org/10.3329/sjps.v4i1.8862 SJPS 2011; 4(1): 19-24
{"title":"Characterization of Antimicrobial, Antioxidant, Anticancer Property and Chemical Composition of Michelia champaca Seed and Flower Extracts","authors":"L. Wei, W. Wee, Julius Yong Fu Siong, Desy Fitrya Syamsumir","doi":"10.3329/SJPS.V4I1.8862","DOIUrl":"https://doi.org/10.3329/SJPS.V4I1.8862","url":null,"abstract":"This study was carried out to characterize antimicrobial, antioxidant and anticancer activities of Michelia champaca seed and flower extracts. The main objective of the present study was to reveal the medicinal values of M. champaca seed and flower for human uses. Antimicrobial property of M. champaca seed and flower extracts were revealed by using two fold microdilution method whereas antioxidant activity of the extract was determined with DPPH radical scavenging method. The anticancer property of the plant extract was revealed through Colorimetric MTT (tetrazolium) assay. The minimum inhibitory concentration values of M. champaca seed and flower extracts ranged from 15.6 to 125mg/l and 7.8 to 62.5mg/l, respectively in which both of the plant extracts were found can inhibit the growth of all the tested bacterial isolates namely A. hydrophila, E. tarda, E. coli, Flavobacterium sp., Klebsiella sp., P. aeruginosa, Salmonella sp., V. alginolyticus, V. cholerae and V. parahaemolyticus. M. champaca flower extract was able to control the growth of E. tarda, E. coli, Flavobacterium sp., P. aeruginosa and V. cholerae at the concentration of 7.8mg/l whereas A. hydrophila, Klebsiella sp. and V. alginolyticus were failed to grow at the concentration 15.6mg/l. The M. champaca flower extract was also able to control the growth of Salmonella sp. and V. parahaemolyticus at the concentration of 62.5mg/l. At the maximum concentration of M. champaca seed and flower extracts were found can inhibit only 40% of DPPH whereas the IC50 value of M. champaca seed and flower extract against MCF-7 cells was 1.98 ±0.31μg/ml and 1.86 ± 0.21μg/ml, respectively. A total of 9 chemical compounds were successfully identified in M. champaca’s flower extract whereas 37 chemical compounds were found in the leaf extract. The findings of the present study indicated that medicinal values of M. champaca seed & flower extracts in terms of antimicrobial and anticancer are promising. Key words: Antioxidant; Anticancer; Antimicrobial; Chemical compound; Michelia champaca DOI: http://dx.doi.org/10.3329/sjps.v4i1.8862 SJPS 2011; 4(1): 19-24","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"79 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2011-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88527824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Alexander, M. Ajazuddin, M. Swarna, Mukesh C. Sharma, D. K. Tripathi
Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting dosage form residence time and contact time with the mucous membranes. Mucoadhesion occurs between two surfaces, one of which is a mucous membrane and another is drug delivery system. Pharmaceutical aspects of mucoadhesion have been the subject of great interest during recent years because mucoadhesion could be a solution for bioavailability problems that result from a too short length of stay of the pharmaceutical dosage form at the absorption site within the gastro-intestinal tract. It has been a great challenge to the pharmaceutical sciences in order to enhance localised drug delivery or to deliver ‘difficult’ molecules (proteins and oligonucleotides) into the systemic circulation. Mucoadhesive systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the site of action leading to increase in bioavailability (both local and systemic effects). Extending the residence time of a dosage form at a particular site and controlling the release of drug from the dosage form are useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The present review describes mucoadhesion, mucoadhesive polymers and use of these polymers in designing different types of mucoadhesive drug delivery systems. Key words : Mucoadhesion; Mucoadhesive polymers; Mucoadhesive force; Bioadhesive property. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8878 SJPS 2011; 4(1): 91-95
{"title":"Polymers and Permeation Enhancers: Specialized Components of Mucoadhesives","authors":"A. Alexander, M. Ajazuddin, M. Swarna, Mukesh C. Sharma, D. K. Tripathi","doi":"10.3329/SJPS.V4I1.8878","DOIUrl":"https://doi.org/10.3329/SJPS.V4I1.8878","url":null,"abstract":"Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting dosage form residence time and contact time with the mucous membranes. Mucoadhesion occurs between two surfaces, one of which is a mucous membrane and another is drug delivery system. Pharmaceutical aspects of mucoadhesion have been the subject of great interest during recent years because mucoadhesion could be a solution for bioavailability problems that result from a too short length of stay of the pharmaceutical dosage form at the absorption site within the gastro-intestinal tract. It has been a great challenge to the pharmaceutical sciences in order to enhance localised drug delivery or to deliver ‘difficult’ molecules (proteins and oligonucleotides) into the systemic circulation. Mucoadhesive systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the site of action leading to increase in bioavailability (both local and systemic effects). Extending the residence time of a dosage form at a particular site and controlling the release of drug from the dosage form are useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The present review describes mucoadhesion, mucoadhesive polymers and use of these polymers in designing different types of mucoadhesive drug delivery systems. Key words : Mucoadhesion; Mucoadhesive polymers; Mucoadhesive force; Bioadhesive property. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8878 SJPS 2011; 4(1): 91-95","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"141 1","pages":"91-95"},"PeriodicalIF":0.0,"publicationDate":"2011-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77232816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Halder, Madhabi Lata Shuma, A. Kabir, A. S. Rouf
The main aim of present investigation was to study the dissolution pattern of most commercially available formulations of Esomeprazole in Bangladesh. Commercially available ten national brands and originator brand of esomeprazole magnesium trihydrate tablets were studied in simulated gastric medium (pH 1.2) for first 15 minutes and simulated intestinal medium (pH 6.8) for next 30 minutes time period using USP reference dissolu-tion apparatus (Type II). No brands met the dissolution pattern like the originator brand (E1). But three brands (E3, E6 and E7) were found to be very close to it in terms of dissolution pattern. One brand E11 was found to be sub-standard compared to originator one. Drug release profiles were analyzed for zero order, first order and Higuchi equation to reveal the release kinetics perspective of Esomeprazole magnesium trihydrate enteric coated tablets. It was found that first order kinetics was predominant for E1 (Originator Brand). Zero order and Higuchi release kinetics was predominant release mechanism than first order release kinetics for E2, E4 and E11. First order release kinetics was predominant for rest of the brands (E3, E5, E6, E7, E8, E9 and E10). It was found that drug release of those brands followed moderately diffusion method and concentration dependant from the dosage form. Among all of these locally manufactured Esomeprazole brands E3, E6 and E7 showed compatible dissolution pattern and release kinetics compared with the originator brand. Key words : In vitro dissolution; Market preparations; Kinetics study; Esomeprazole; National brand; Originator brand. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8875 SJPS 2011; 4(1): 79-83
{"title":"In vitro release kinetics study of Esomeprazole Magnesium Trihydrate tablet available in Bangladesh and comparison with the originator brand (Nexium","authors":"S. Halder, Madhabi Lata Shuma, A. Kabir, A. S. Rouf","doi":"10.3329/SJPS.V4I1.8875","DOIUrl":"https://doi.org/10.3329/SJPS.V4I1.8875","url":null,"abstract":"The main aim of present investigation was to study the dissolution pattern of most commercially available formulations of Esomeprazole in Bangladesh. Commercially available ten national brands and originator brand of esomeprazole magnesium trihydrate tablets were studied in simulated gastric medium (pH 1.2) for first 15 minutes and simulated intestinal medium (pH 6.8) for next 30 minutes time period using USP reference dissolu-tion apparatus (Type II). No brands met the dissolution pattern like the originator brand (E1). But three brands (E3, E6 and E7) were found to be very close to it in terms of dissolution pattern. One brand E11 was found to be sub-standard compared to originator one. Drug release profiles were analyzed for zero order, first order and Higuchi equation to reveal the release kinetics perspective of Esomeprazole magnesium trihydrate enteric coated tablets. It was found that first order kinetics was predominant for E1 (Originator Brand). Zero order and Higuchi release kinetics was predominant release mechanism than first order release kinetics for E2, E4 and E11. First order release kinetics was predominant for rest of the brands (E3, E5, E6, E7, E8, E9 and E10). It was found that drug release of those brands followed moderately diffusion method and concentration dependant from the dosage form. Among all of these locally manufactured Esomeprazole brands E3, E6 and E7 showed compatible dissolution pattern and release kinetics compared with the originator brand. Key words : In vitro dissolution; Market preparations; Kinetics study; Esomeprazole; National brand; Originator brand. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8875 SJPS 2011; 4(1): 79-83","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"34 1","pages":"79-83"},"PeriodicalIF":0.0,"publicationDate":"2011-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80807551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Uddin, M. I. Wahid, Tasbira Jasmeen, N. Huda, K. B. Sutradhar
Fish is an important food stuff and source of protein all over the world. In Bangladesh fisheries sector contributes a lot in case of earning foreign currency and meeting domestic need of animal protein. To meet the domestic need Bangladesh imports fish and fish products from neighboring countries. But it is evident from several studies that fish items in Bangladesh contain formalin which is a highly hazardous and carcinogenic chemical. An attempt was taken to detect the extent of formalin use in fish available in Dhaka city. From five different local markets five species of fishes were collected and presence of formalin was detected using the “formalin detection kit in fish” developed by Bangladesh Council of Scientific and Industrial Research (BCSIR). The study indicates that 70% Rui fish is formalin contaminated and almost 50% of fish samples contain formalin. Key words : Formaldehyde; BCSIR; Formalin detection kit; Carcinogen; Fisheries; Livestock. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8866 SJPS 2011; 4(1): 49-52
{"title":"Detection of Formalin in Fish Samples Collected from Dhaka City, Bangladesh","authors":"R. Uddin, M. I. Wahid, Tasbira Jasmeen, N. Huda, K. B. Sutradhar","doi":"10.3329/SJPS.V4I1.8866","DOIUrl":"https://doi.org/10.3329/SJPS.V4I1.8866","url":null,"abstract":"Fish is an important food stuff and source of protein all over the world. In Bangladesh fisheries sector contributes a lot in case of earning foreign currency and meeting domestic need of animal protein. To meet the domestic need Bangladesh imports fish and fish products from neighboring countries. But it is evident from several studies that fish items in Bangladesh contain formalin which is a highly hazardous and carcinogenic chemical. An attempt was taken to detect the extent of formalin use in fish available in Dhaka city. From five different local markets five species of fishes were collected and presence of formalin was detected using the “formalin detection kit in fish” developed by Bangladesh Council of Scientific and Industrial Research (BCSIR). The study indicates that 70% Rui fish is formalin contaminated and almost 50% of fish samples contain formalin. Key words : Formaldehyde; BCSIR; Formalin detection kit; Carcinogen; Fisheries; Livestock. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8866 SJPS 2011; 4(1): 49-52","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"449 1","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"2011-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82860923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The PDF for this article was updated on 18/11/2011. YM Jhanker and KB Sutradhar were added as authors to this paper on 18/11/2011. The Objective of the present study was to develop a simple, reproducible and economical spectrophotometric method for simultaneous determination of Ciprofloxacin and Naproxen. Both Drugs obey Beer's law in the range of 1-5μg/ml concentration. The Standard curve of Ciprofloxacin and Naproxen in the media of 0.1N HCl, Distilled water and Phosphate buffer are obtained by plotting absorbance versus concentration where calibration curve was found to be linear (R 2 >0.99) with optimum value of standard error for the entire analytical medium used. The plot of the residuals was normally distributed around the regression line, which reflects the accuracy of the method. For simultaneous determination of Ciprofloxacin and Naproxen, the linear plot was found in the media of distilled water and 0.1N HCl acid. The maximum absorbance was found in the media of distilled water for Ciprofloxacin at wavelength 278nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R 2 >0.99 and for Naproxen as R 2 >0.99.The maximum absorbance was found in the media of 0.1N HCl for Ciprofloxacin at wavelength 277nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R 2 >0.98 and for Naproxen as R 2 >0.99. Key words : Ciprofloxacin; Naproxen; Spectrophotometric analysis; Simultaneous equation method. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8876 SJPS 2011; 4(1): 84-90
{"title":"Development of an Assay Method for Simultaneous Determination of Ciprofloxacin and Naproxen by UV Spectrophotometric Method","authors":"Rajia Sultana Nijhu, Y. Jhanker, K. B. Sutradhar","doi":"10.3329/SJPS.V4I1.8876","DOIUrl":"https://doi.org/10.3329/SJPS.V4I1.8876","url":null,"abstract":"The PDF for this article was updated on 18/11/2011. YM Jhanker and KB Sutradhar were added as authors to this paper on 18/11/2011. The Objective of the present study was to develop a simple, reproducible and economical spectrophotometric method for simultaneous determination of Ciprofloxacin and Naproxen. Both Drugs obey Beer's law in the range of 1-5μg/ml concentration. The Standard curve of Ciprofloxacin and Naproxen in the media of 0.1N HCl, Distilled water and Phosphate buffer are obtained by plotting absorbance versus concentration where calibration curve was found to be linear (R 2 >0.99) with optimum value of standard error for the entire analytical medium used. The plot of the residuals was normally distributed around the regression line, which reflects the accuracy of the method. For simultaneous determination of Ciprofloxacin and Naproxen, the linear plot was found in the media of distilled water and 0.1N HCl acid. The maximum absorbance was found in the media of distilled water for Ciprofloxacin at wavelength 278nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R 2 >0.99 and for Naproxen as R 2 >0.99.The maximum absorbance was found in the media of 0.1N HCl for Ciprofloxacin at wavelength 277nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R 2 >0.98 and for Naproxen as R 2 >0.99. Key words : Ciprofloxacin; Naproxen; Spectrophotometric analysis; Simultaneous equation method. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8876 SJPS 2011; 4(1): 84-90","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"63 1","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"2011-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83445156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antimicrobial Activity of Different Extracts of Geodorum densiflorum (Lam) Schltr. pseudobulb","authors":"Saleha Akter, M. Z. Imam, T. Akter","doi":"10.3329/SJPS.V3I2.8037","DOIUrl":"https://doi.org/10.3329/SJPS.V3I2.8037","url":null,"abstract":"","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"1 1","pages":"49-50"},"PeriodicalIF":0.0,"publicationDate":"2011-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86785344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phytochemical and Cytotoxic Investigation of Codiaeum variegatum Linn. leaf","authors":"Nadia Saffoon, A. Alam, G. M. Uddin","doi":"10.3329/SJPS.V3I2.8039","DOIUrl":"https://doi.org/10.3329/SJPS.V3I2.8039","url":null,"abstract":"","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"16 1","pages":"51-53"},"PeriodicalIF":0.0,"publicationDate":"2011-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75043571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Qualitative and Quantitative Estimation of Water Insoluble Drugs from its Formulations Simultaneously: a Hydrotropic Approach","authors":"Rajesh Sharma, Geetam Pathodiya, G. P. Mishra","doi":"10.3329/SJPS.V3I2.6541","DOIUrl":"https://doi.org/10.3329/SJPS.V3I2.6541","url":null,"abstract":"Key words: Derivative spectrophotometry method; area under curve method; multi-component method; ciprofloxacin hydrochloride; tinidazole; hydrotropic agent DOI: http://dx.doi.org/10.3329/sjps.v3i2.6541 S.J. Pharm. Sci 3(2): 37-42","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"71 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2011-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89981518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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