{"title":"Antimicrobial and Cytotoxicity Studies of the Aerial Part of Arachis hypogea Linn.","authors":"Most. Nazma Parvin, S. Chowdhury","doi":"10.3329/SJPS.V3I2.8034","DOIUrl":"https://doi.org/10.3329/SJPS.V3I2.8034","url":null,"abstract":"Key words: Arachis hypogea; Papilionaceae; Cytotoxicity; Antimicrobial DOI: http://dx.doi.org/10.3329/sjps.v3i2.8034 S.J. Pharm. Sci 3(2): 25-28","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"9 1","pages":"25-28"},"PeriodicalIF":0.0,"publicationDate":"2011-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84922374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of Anemia in Khulna, Bangladesh and Comparative Study among Available Hemantinic Preparations","authors":"Y. Jhanker, N. Huda, R. Uddin","doi":"10.3329/SJPS.V3I2.8038","DOIUrl":"https://doi.org/10.3329/SJPS.V3I2.8038","url":null,"abstract":"","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"54 1","pages":"47-48"},"PeriodicalIF":0.0,"publicationDate":"2011-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90668044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Q-Analysis Methods for the Simultaneous Spectrophotometric Estimation of Levofloxacin Hemihydrate and Ornidazole in Tablet Dosage Form","authors":"R. Kumar, P. R. Kumar","doi":"10.3329/SJPS.V3I2.8032","DOIUrl":"https://doi.org/10.3329/SJPS.V3I2.8032","url":null,"abstract":"Key words: Levofloxacin; Ornidazole; UV-spectrophotometry; Q-Analysis DOI: http://dx.doi.org/10.3329/sjps.v3i2.8032 S.J. Pharm. Sci 3(2): 16-19","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"9 1","pages":"16-19"},"PeriodicalIF":0.0,"publicationDate":"2011-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82580337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study was to prepare and characterize solid dispersions of the NSAID Ibuprofen with PEG 6000, Poloxomer 188 and Poloxomer 407 with the intention of improving its dissolution properties. The solid dispersions were prepared by the fusion method. Evaluation of the properties of the dispersions was performed using dissolution studies. The results obtained showed that the rate of dissolution of Ibuprofen was considerably improved when formulated in solid dispersions with PEG 6000 and poloxomer 188. Solid dispersions with poloxomer 407 showed drug retarding capability which may trigger more research in the intension of exploiting this feature to prepare sustained release dosage form. Key words: Ibuprofen; polyethylene glycol; poloxomer; solid dispersion; fusion method; dissolution DOI: 10.3329/sjps.v3i1.6801 S. J. Pharm. Sci. 3(1): 63-67
本研究的目的是制备含PEG 6000、Poloxomer 188和Poloxomer 407的非甾体抗炎药布洛芬固体分散体并对其进行表征，以改善其溶出性能。采用熔合法制备固体分散体。通过溶出度研究对分散体的性能进行了评价。结果表明，与PEG 6000和poloxomer 188组成固体分散体时，布洛芬的溶出速度明显提高。含有poloxomer 407的固体分散体具有药物缓释能力，利用这一特性制备缓释剂型的研究可能会引起更多的关注。关键词:布洛芬;聚乙二醇;poloxomer;固体分散;融合方法;溶解DOI: 10.3329/sjps.v3i1.6801 S. J. Pharm。科学通报3(1):63-67
{"title":"Effect of Water Soluble Polymers on Dissolution Enhancement of Ibuprofen Solid Dispersion Prepared by Fusion Method","authors":"R. Uddin, Nadia Saffoon, N. Huda, Y. Jhanker","doi":"10.3329/SJPS.V3I1.6801","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6801","url":null,"abstract":"The purpose of this study was to prepare and characterize solid dispersions of the NSAID Ibuprofen with PEG 6000, Poloxomer 188 and Poloxomer 407 with the intention of improving its dissolution properties. The solid dispersions were prepared by the fusion method. Evaluation of the properties of the dispersions was performed using dissolution studies. The results obtained showed that the rate of dissolution of Ibuprofen was considerably improved when formulated in solid dispersions with PEG 6000 and poloxomer 188. Solid dispersions with poloxomer 407 showed drug retarding capability which may trigger more research in the intension of exploiting this feature to prepare sustained release dosage form. Key words: Ibuprofen; polyethylene glycol; poloxomer; solid dispersion; fusion method; dissolution DOI: 10.3329/sjps.v3i1.6801 S. J. Pharm. Sci. 3(1): 63-67","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"284 1","pages":"63-67"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72649554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Nahar, Muhammad Ashikur Rahman, Most. Nazma Parvin, Shammy Sarwar
Development of anthelmintic resistance and high cost of conventional anthelmintic drugs led to the evaluation of medicinal plants as an alternative source of anthelmintics. The current study was aimed to evaluate the possible anthelmintic effects of crude fresh juice of leaves of Clitoria ternatea Linn. using of adult earth worm Pheretima Posthuma . Three concentrations (25, 50, 100mg/ml) of juice were studied for the determination of time of paralysis and death of the earth worms. Albendazole in same concentration as that of juice was considered as standard reference and normal saline as control. The result of the present study reveals that fresh juice significantly showed paralysis and also caused death of worms especially at higher concentraton of 100mg/ml, as compared to standard reference Albendazole. Key words: Clitoria ternatea ; anthelmintic; earthworm; paralysis; Albendazole. DOI: 10.3329/sjps.v3i1.6797 S. J. Pharm. Sci. 3(1): 46-48
随着抗虫药耐药性的发展和常规驱虫药的高成本，药用植物被认为是一种替代的驱虫药来源。本研究旨在评价阴蒂叶粗鲜汁可能的驱虫作用。蚯蚓成虫的利用。研究了25、50、100mg/ml三种浓度果汁对蚯蚓麻痹和死亡时间的测定。以与果汁浓度相同的阿苯达唑为标准参比，生理盐水为对照。本研究结果表明，与标准参比阿苯达唑相比，鲜果汁在100mg/ml浓度较高时具有明显的麻痹作用，并引起蠕虫死亡。关键词:阴蒂;打虫药;蚯蚓;瘫痪;阿苯达唑。DOI: 10.3329/sjps.v3i1.6797 S. J. Pharm。科学通报3(1):46-48
{"title":"Evaluation of Anthelmintic Activity of Aqueous Leaf Extract of Clitoria ternatea Linn.","authors":"K. Nahar, Muhammad Ashikur Rahman, Most. Nazma Parvin, Shammy Sarwar","doi":"10.3329/SJPS.V3I1.6797","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6797","url":null,"abstract":"Development of anthelmintic resistance and high cost of conventional anthelmintic drugs led to the evaluation of medicinal plants as an alternative source of anthelmintics. The current study was aimed to evaluate the possible anthelmintic effects of crude fresh juice of leaves of Clitoria ternatea Linn. using of adult earth worm Pheretima Posthuma . Three concentrations (25, 50, 100mg/ml) of juice were studied for the determination of time of paralysis and death of the earth worms. Albendazole in same concentration as that of juice was considered as standard reference and normal saline as control. The result of the present study reveals that fresh juice significantly showed paralysis and also caused death of worms especially at higher concentraton of 100mg/ml, as compared to standard reference Albendazole. Key words: Clitoria ternatea ; anthelmintic; earthworm; paralysis; Albendazole. DOI: 10.3329/sjps.v3i1.6797 S. J. Pharm. Sci. 3(1): 46-48","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"1 1","pages":"46-48"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89414611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fast disintegrating tablets of Verapamil Hydrochloride were designed to achieve increased absorption as well as quick onset of pharmacological action of the active ingredient with a view to enhance patient compliance by effervescent method. Different combinations and ratios of sodium bicarbonate, anhydrous citric acid, sodium starch glycolate, Micro-crystalline cellulose (MCC) and lactose were used in order to get optimum result. The prepared formulations were evaluated for hardness, friability, thickness, diameter, taste of the solution to be administered and in-vitro dispersion time. The acceptable dispersion time was achieved by using a combination of citric acid and sodium bi carbonate in the same amount along with sodium starch glycolate, micro-crystalline cellulose (MCC) & lactose. Acceptable taste of the solution to be administered was obtained with a combination of sucrose, aspartame and sodium saccharine. Key words: Effervescent method; Verapamil Hydrochloride; Dispersion time DOI: 10.3329/sjps.v3i1.6795 S. J. Pharm. Sci. 3(1): 34-37
采用泡腾法设计盐酸维拉帕米快速崩解片，目的是增加吸收，使有效成分快速起效，提高患者的依从性。以碳酸氢钠、无水柠檬酸、淀粉乙醇酸钠、微晶纤维素和乳糖为原料，采用不同的组合和配比进行了优化。对制备的配方进行硬度、脆度、厚度、直径、给药溶液的口感和体外分散时间的评价。通过使用等量的柠檬酸和碳酸氢钠以及乙醇酸淀粉钠、微晶纤维素(MCC)和乳糖的组合，达到了可接受的分散时间。将蔗糖、阿斯巴甜和糖精钠混合后，得到了可接受的溶液味道。关键词:泡腾法;盐酸维拉帕米;色散时间DOI: 10.3329/sjps.v3i1.6795 S. J. Pharm。科学通报3(1):34-37
{"title":"Formulation Development of Verapamil Hydrochloride Tablet by Effervescent Method","authors":"A. Kabir, N. Huda, Y. Jhanker, Kamrunnahar Shamin","doi":"10.3329/SJPS.V3I1.6795","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6795","url":null,"abstract":"Fast disintegrating tablets of Verapamil Hydrochloride were designed to achieve increased absorption as well as quick onset of pharmacological action of the active ingredient with a view to enhance patient compliance by effervescent method. Different combinations and ratios of sodium bicarbonate, anhydrous citric acid, sodium starch glycolate, Micro-crystalline cellulose (MCC) and lactose were used in order to get optimum result. The prepared formulations were evaluated for hardness, friability, thickness, diameter, taste of the solution to be administered and in-vitro dispersion time. The acceptable dispersion time was achieved by using a combination of citric acid and sodium bi carbonate in the same amount along with sodium starch glycolate, micro-crystalline cellulose (MCC) & lactose. Acceptable taste of the solution to be administered was obtained with a combination of sucrose, aspartame and sodium saccharine. Key words: Effervescent method; Verapamil Hydrochloride; Dispersion time DOI: 10.3329/sjps.v3i1.6795 S. J. Pharm. Sci. 3(1): 34-37","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"5 1","pages":"34-37"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88738194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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